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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANAPC5-ADAM15

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANAPC5-ADAM15
FusionPDB ID: 4296
FusionGDB2.0 ID: 4296
HgeneTgene
Gene symbol

ANAPC5

ADAM15

Gene ID

51433

8751

Gene nameanaphase promoting complex subunit 5ADAM metallopeptidase domain 15
SynonymsAPC5MDC15
Cytomap

12q24.31

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 5cyclosome subunit 5disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Modification date2020031320200320
UniProtAcc

Q9UJX4

Q13444

Ensembl transtripts involved in fusion geneENST idsENST00000261819, ENST00000344395, 
ENST00000441917, ENST00000536366, 
ENST00000541887, ENST00000535482, 
ENST00000544314, 		ENST00000472434, 
ENST00000447332, ENST00000271836, 
ENST00000355956, ENST00000356955, 
ENST00000359280, ENST00000368410, 
ENST00000368413, ENST00000449910, 
ENST00000531455, ENST00000360674, 
ENST00000368412, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 11 X 6=5943 X 3 X 3=27
# samples 113
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANAPC5 [Title/Abstract] AND ADAM15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANAPC5(121783642)-ADAM15(155034721), # samples:3
Anticipated loss of major functional domain due to fusion event.ANAPC5-ADAM15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-ADAM15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-ADAM15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-ADAM15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC5-ADAM15 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANAPC5-ADAM15 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC5

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneADAM15

GO:0002418

immune response to tumor cell

22505472

TgeneADAM15

GO:0006915

apoptotic process

22505472

TgeneADAM15

GO:0045087

innate immune response

22505472

TgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check buttonFusion gene breakpoints across ANAPC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-QB-AA9O-06AANAPC5chr12

121783642

-ADAM15chr1

155034721

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541887ANAPC5chr12121783642-ENST00000368412ADAM15chr1155034721+106263848749233
ENST00000541887ANAPC5chr12121783642-ENST00000360674ADAM15chr1155034721+106263848749233
ENST00000261819ANAPC5chr12121783642-ENST00000368412ADAM15chr1155034721+1136712122823233
ENST00000261819ANAPC5chr12121783642-ENST00000360674ADAM15chr1155034721+1136712122823233
ENST00000344395ANAPC5chr12121783642-ENST00000368412ADAM15chr1155034721+7172930404134
ENST00000344395ANAPC5chr12121783642-ENST00000360674ADAM15chr1155034721+7172930404134
ENST00000536366ANAPC5chr12121783642-ENST00000449910ADAM15chr1155034721+6512273740125
ENST00000536366ANAPC5chr12121783642-ENST00000359280ADAM15chr1155034721+6512273740125
ENST00000536366ANAPC5chr12121783642-ENST00000356955ADAM15chr1155034721+6512273740125
ENST00000536366ANAPC5chr12121783642-ENST00000355956ADAM15chr1155034721+6512273740125
ENST00000536366ANAPC5chr12121783642-ENST00000368410ADAM15chr1155034721+6692273740125
ENST00000536366ANAPC5chr12121783642-ENST00000271836ADAM15chr1155034721+6682270338112
ENST00000536366ANAPC5chr12121783642-ENST00000368413ADAM15chr1155034721+6622270338112
ENST00000536366ANAPC5chr12121783642-ENST00000531455ADAM15chr1155034721+5622273740125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541887ENST00000368412ANAPC5chr12121783642-ADAM15chr1155034721+0.0035371890.9964629
ENST00000541887ENST00000360674ANAPC5chr12121783642-ADAM15chr1155034721+0.0035371890.9964629
ENST00000261819ENST00000368412ANAPC5chr12121783642-ADAM15chr1155034721+0.0030408390.9969592
ENST00000261819ENST00000360674ANAPC5chr12121783642-ADAM15chr1155034721+0.0030408390.9969592
ENST00000344395ENST00000368412ANAPC5chr12121783642-ADAM15chr1155034721+0.0132493470.98675066
ENST00000344395ENST00000360674ANAPC5chr12121783642-ADAM15chr1155034721+0.0132493470.98675066
ENST00000536366ENST00000449910ANAPC5chr12121783642-ADAM15chr1155034721+0.0975187050.9024813
ENST00000536366ENST00000359280ANAPC5chr12121783642-ADAM15chr1155034721+0.0975187050.9024813
ENST00000536366ENST00000356955ANAPC5chr12121783642-ADAM15chr1155034721+0.0975187050.9024813
ENST00000536366ENST00000355956ANAPC5chr12121783642-ADAM15chr1155034721+0.0975187050.9024813
ENST00000536366ENST00000368410ANAPC5chr12121783642-ADAM15chr1155034721+0.112720850.88727915
ENST00000536366ENST00000271836ANAPC5chr12121783642-ADAM15chr1155034721+0.107790810.8922092
ENST00000536366ENST00000368413ANAPC5chr12121783642-ADAM15chr1155034721+0.0965665060.9034335
ENST00000536366ENST00000531455ANAPC5chr12121783642-ADAM15chr1155034721+0.10695540.8930446

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4296_4296_1_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000261819_ADAM15_chr1_155034721_ENST00000360674_length(amino acids)=233AA_BP=194
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLA
NSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR

--------------------------------------------------------------

>4296_4296_2_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000261819_ADAM15_chr1_155034721_ENST00000368412_length(amino acids)=233AA_BP=194
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLA
NSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR

--------------------------------------------------------------

>4296_4296_3_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000344395_ADAM15_chr1_155034721_ENST00000360674_length(amino acids)=134AA_BP=95
MAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSRDEGERKMEK

--------------------------------------------------------------

>4296_4296_4_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000344395_ADAM15_chr1_155034721_ENST00000368412_length(amino acids)=134AA_BP=95
MAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSRDEGERKMEK

--------------------------------------------------------------

>4296_4296_5_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000271836_length(amino acids)=112AA_BP=73
MLSPCLSSYFVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSRDEGERKMEKEELDVSVSLRGQPSPHPQGSHC

--------------------------------------------------------------

>4296_4296_6_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000355956_length(amino acids)=125AA_BP=1
MSEAVALVWRVPLGAGFQPLGRAGHPMGTGPGGRQAVASLGVGAWLAPETYRYIKFFFFHFSFTLISTGQFHISILHCLFLTILEVLLKG

--------------------------------------------------------------

>4296_4296_7_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000356955_length(amino acids)=125AA_BP=1
MSEAVALVWRVPLGAGFQPLGRAGHPMGTGPGGRQAVASLGVGAWLAPETYRYIKFFFFHFSFTLISTGQFHISILHCLFLTILEVLLKG

--------------------------------------------------------------

>4296_4296_8_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000359280_length(amino acids)=125AA_BP=1
MSEAVALVWRVPLGAGFQPLGRAGHPMGTGPGGRQAVASLGVGAWLAPETYRYIKFFFFHFSFTLISTGQFHISILHCLFLTILEVLLKG

--------------------------------------------------------------

>4296_4296_9_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000368410_length(amino acids)=125AA_BP=1
MSEAVALVWRVPLGAGFQPLGRAGHPMGTGPGGRQAVASLGVGAWLAPETYRYIKFFFFHFSFTLISTGQFHISILHCLFLTILEVLLKG

--------------------------------------------------------------

>4296_4296_10_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000368413_length(amino acids)=112AA_BP=73
MLSPCLSSYFVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSRDEGERKMEKEELDVSVSLRGQPSPHPQGSHC

--------------------------------------------------------------

>4296_4296_11_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000449910_length(amino acids)=125AA_BP=1
MSEAVALVWRVPLGAGFQPLGRAGHPMGTGPGGRQAVASLGVGAWLAPETYRYIKFFFFHFSFTLISTGQFHISILHCLFLTILEVLLKG

--------------------------------------------------------------

>4296_4296_12_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000536366_ADAM15_chr1_155034721_ENST00000531455_length(amino acids)=125AA_BP=1
MSEAVALVWRVPLGAGFQPLGRAGHPMGTGPGGRQAVASLGVGAWLAPETYRYIKFFFFHFSFTLISTGQFHISILHCLFLTILEVLLKG

--------------------------------------------------------------

>4296_4296_13_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000541887_ADAM15_chr1_155034721_ENST00000360674_length(amino acids)=233AA_BP=194
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLA
NSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR

--------------------------------------------------------------

>4296_4296_14_ANAPC5-ADAM15_ANAPC5_chr12_121783642_ENST00000541887_ADAM15_chr1_155034721_ENST00000368412_length(amino acids)=233AA_BP=194
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLA
NSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121783642/chr1:155034721)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC5

Q9UJX4

ADAM15

Q13444

FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114509_656465.0521.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114657_685465.0521.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821815_821759.0815.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821850_856759.0815.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922815_821784.0840.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922850_856784.0840.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023815_821808.0864.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023850_856808.0864.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922815_821783.0839.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922850_856783.0839.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720815_821735.6666666666666812.6666666666666MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720850_856735.6666666666666812.6666666666666MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821815_821759.6666666666666836.6666666666666MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821850_856759.6666666666666836.6666666666666MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114484_486465.0521.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114815_821465.0521.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114850_856465.0521.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023815_821807.0863.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023850_856807.0863.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821815_821769.0825.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821850_856769.0825.0MotifSH3-binding
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114718_863465.0521.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114697_717465.0521.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417209_249196.66666666666666756.0RepeatNote=TPR 1
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417250_300196.66666666666666756.0RepeatNote=TPR 2
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417301_337196.66666666666666756.0RepeatNote=TPR 3
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417338_378196.66666666666666756.0RepeatNote=TPR 4
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417379_418196.66666666666666756.0RepeatNote=TPR 5
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417419_466196.66666666666666756.0RepeatNote=TPR 6
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417467_500196.66666666666666756.0RepeatNote=TPR 7
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417501_540196.66666666666666756.0RepeatNote=TPR 8
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417541_580196.66666666666666756.0RepeatNote=TPR 9
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417581_620196.66666666666666756.0RepeatNote=TPR 10
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417621_660196.66666666666666756.0RepeatNote=TPR 11
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417661_696196.66666666666666756.0RepeatNote=TPR 12
HgeneANAPC5chr12:121783642chr1:155034721ENST00000261819-417697_736196.66666666666666756.0RepeatNote=TPR 13
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215209_24997.66666666666667644.0RepeatNote=TPR 1
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215250_30097.66666666666667644.0RepeatNote=TPR 2
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215301_33797.66666666666667644.0RepeatNote=TPR 3
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215338_37897.66666666666667644.0RepeatNote=TPR 4
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215379_41897.66666666666667644.0RepeatNote=TPR 5
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215419_46697.66666666666667644.0RepeatNote=TPR 6
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215467_50097.66666666666667644.0RepeatNote=TPR 7
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215501_54097.66666666666667644.0RepeatNote=TPR 8
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215541_58097.66666666666667644.0RepeatNote=TPR 9
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215581_62097.66666666666667644.0RepeatNote=TPR 10
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215621_66097.66666666666667644.0RepeatNote=TPR 11
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215661_69697.66666666666667644.0RepeatNote=TPR 12
HgeneANAPC5chr12:121783642chr1:155034721ENST00000344395-215697_73697.66666666666667644.0RepeatNote=TPR 13
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316209_24997.66666666666667644.0RepeatNote=TPR 1
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316250_30097.66666666666667644.0RepeatNote=TPR 2
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316301_33797.66666666666667644.0RepeatNote=TPR 3
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316338_37897.66666666666667644.0RepeatNote=TPR 4
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316379_41897.66666666666667644.0RepeatNote=TPR 5
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316419_46697.66666666666667644.0RepeatNote=TPR 6
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316467_50097.66666666666667644.0RepeatNote=TPR 7
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316501_54097.66666666666667644.0RepeatNote=TPR 8
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316541_58097.66666666666667644.0RepeatNote=TPR 9
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316581_62097.66666666666667644.0RepeatNote=TPR 10
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316621_66097.66666666666667644.0RepeatNote=TPR 11
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316661_69697.66666666666667644.0RepeatNote=TPR 12
HgeneANAPC5chr12:121783642chr1:155034721ENST00000441917-316697_73697.66666666666667644.0RepeatNote=TPR 13
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15209_24975.66666666666667220.0RepeatNote=TPR 1
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15250_30075.66666666666667220.0RepeatNote=TPR 2
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15301_33775.66666666666667220.0RepeatNote=TPR 3
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15338_37875.66666666666667220.0RepeatNote=TPR 4
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15379_41875.66666666666667220.0RepeatNote=TPR 5
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15419_46675.66666666666667220.0RepeatNote=TPR 6
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15467_50075.66666666666667220.0RepeatNote=TPR 7
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15501_54075.66666666666667220.0RepeatNote=TPR 8
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15541_58075.66666666666667220.0RepeatNote=TPR 9
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15581_62075.66666666666667220.0RepeatNote=TPR 10
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15621_66075.66666666666667220.0RepeatNote=TPR 11
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15661_69675.66666666666667220.0RepeatNote=TPR 12
HgeneANAPC5chr12:121783642chr1:155034721ENST00000536366-15697_73675.66666666666667220.0RepeatNote=TPR 13
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821509_656759.0815.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922509_656784.0840.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023509_656808.0864.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922509_656783.0839.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720509_656735.6666666666666812.6666666666666Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821509_656759.6666666666666836.6666666666666Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023509_656807.0863.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821509_656769.0825.0Compositional biasNote=Cys-rich
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821213_414759.0815.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821421_508759.0815.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821657_685759.0815.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922213_414784.0840.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922421_508784.0840.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922657_685784.0840.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023213_414808.0864.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023421_508808.0864.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023657_685808.0864.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922213_414783.0839.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922421_508783.0839.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922657_685783.0839.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720213_414735.6666666666666812.6666666666666DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720421_508735.6666666666666812.6666666666666DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720657_685735.6666666666666812.6666666666666DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821213_414759.6666666666666836.6666666666666DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821421_508759.6666666666666836.6666666666666DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821657_685759.6666666666666836.6666666666666DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114213_414465.0521.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114421_508465.0521.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023213_414807.0863.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023421_508807.0863.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023657_685807.0863.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821213_414769.0825.0DomainPeptidase M12B
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821421_508769.0825.0DomainDisintegrin
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821657_685769.0825.0DomainEGF-like
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821177_184759.0815.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821484_486759.0815.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922177_184784.0840.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922484_486784.0840.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023177_184808.0864.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023484_486808.0864.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922177_184783.0839.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922484_486783.0839.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720177_184735.6666666666666812.6666666666666MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720484_486735.6666666666666812.6666666666666MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821177_184759.6666666666666836.6666666666666MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821484_486759.6666666666666836.6666666666666MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114177_184465.0521.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023177_184807.0863.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023484_486807.0863.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821177_184769.0825.0MotifCysteine switch
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821484_486769.0825.0MotifCell attachment site
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821207_696759.0815.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821718_863759.0815.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922207_696784.0840.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922718_863784.0840.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023207_696808.0864.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023718_863808.0864.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922207_696783.0839.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922718_863783.0839.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720207_696735.6666666666666812.6666666666666Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720718_863735.6666666666666812.6666666666666Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821207_696759.6666666666666836.6666666666666Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821718_863759.6666666666666836.6666666666666Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000003684131114207_696465.0521.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023207_696807.0863.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023718_863807.0863.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821207_696769.0825.0Topological domainExtracellular
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821718_863769.0825.0Topological domainCytoplasmic
TgeneADAM15chr12:121783642chr1:155034721ENST000002718361821697_717759.0815.0TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000003559561922697_717784.0840.0TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000003569552023697_717808.0864.0TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000003592801922697_717783.0839.0TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000003606741720697_717735.6666666666666812.6666666666666TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000003684121821697_717759.6666666666666836.6666666666666TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000004499102023697_717807.0863.0TransmembraneHelical
TgeneADAM15chr12:121783642chr1:155034721ENST000005314551821697_717769.0825.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANAPC5
ADAM15


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ANAPC5-ADAM15


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANAPC5-ADAM15


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource