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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KMT2A-TET1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KMT2A-TET1
FusionPDB ID: 43217
FusionGDB2.0 ID: 43217
HgeneTgene
Gene symbol

KMT2A

TET1

Gene ID

4297

80312

Gene namelysine methyltransferase 2Atet methylcytosine dioxygenase 1
SynonymsALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTSCXXC6|LCX|bA119F7.1
Cytomap

11q23.3

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-likemethylcytosine dioxygenase TET1CXXC finger 6CXXC zinc finger 6CXXC-type zinc finger protein 6TET1 splice variant VP_DE4TET1 splice variant VP_DE456leukemia-associated protein with a CXXC domainten-eleven translocation 1 gene proteinten-eleven tran
Modification date2020031920200313
UniProtAcc

Q03164

Q8NFU7

Ensembl transtripts involved in fusion geneENST idsENST00000420751, ENST00000354520, 
ENST00000389506, ENST00000534358, 
ENST00000373644, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score79 X 196 X 13=2012924 X 10 X 4=160
# samples 24110
** MAII scorelog2(241/201292*10)=-6.38411287931608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/160*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KMT2A [Title/Abstract] AND TET1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2A(118355463)-TET1(70440909), # samples:1
KMT2A(118352101)-TET1(70449334), # samples:1
KMT2A(118355030)-TET1(70441154), # samples:1
KMT2A(118352813)-TET1(70450563), # samples:1
TET1(70440903)-KMT2A(118355470), # samples:1
TET1(70449336)-KMT2A(118352127), # samples:1
TET1(70433245)-KMT2A(118355576), # samples:1
TET1(70446464)-KMT2A(118352428), # samples:1
Anticipated loss of major functional domain due to fusion event.KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
TET1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TET1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KMT2A-TET1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

HgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

HgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

HgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

HgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

HgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722


check buttonFusion gene breakpoints across KMT2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TET1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..KMT2Achr11

118350953

+TET1chr10

70441155

+
ChimerKB3..KMT2Achr11

118353210

+TET1chr10

70441155

ChimerKB3..KMT2Achr11

118353210

TET1chr10

70441155

+
ChimerKB3..KMT2Achr11

118355029

+TET1chr10

70441156

+
ChiTaRS5.0N/AFM165189KMT2Achr11

118355463

+TET1chr10

70440909

+
ChiTaRS5.0N/AFM165191KMT2Achr11

118352101

+TET1chr10

70449334

+
ChiTaRS5.0N/AFM165196KMT2Achr11

118355030

+TET1chr10

70441154

+
ChiTaRS5.0N/AFM165199KMT2Achr11

118352813

+TET1chr10

70450563

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534358KMT2Achr11118355029+ENST00000373644TET1chr1070441156+849642412358271934
ENST00000389506KMT2Achr11118355029+ENST00000373644TET1chr1070441156+84734218058041934
ENST00000354520KMT2Achr11118355029+ENST00000373644TET1chr1070441156+84734218058041934
ENST00000534358KMT2Achr11118353210+ENST00000373644TET1chr1070441155836441092356951890
ENST00000389506KMT2Achr11118353210+ENST00000373644TET1chr107044115583414086056721890
ENST00000354520KMT2Achr11118353210+ENST00000373644TET1chr107044115583414086056721890
ENST00000534358KMT2Achr11118355030+ENST00000373644TET1chr1070441154+849642412358271934
ENST00000389506KMT2Achr11118355030+ENST00000373644TET1chr1070441154+84734218058041934
ENST00000354520KMT2Achr11118355030+ENST00000373644TET1chr1070441154+84734218058041934

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534358ENST00000373644KMT2Achr11118355030+TET1chr1070441154+0.0001885940.9998115
ENST00000389506ENST00000373644KMT2Achr11118355030+TET1chr1070441154+0.0001837020.99981636
ENST00000354520ENST00000373644KMT2Achr11118355030+TET1chr1070441154+0.0001837020.99981636

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43217_43217_1_KMT2A-TET1_KMT2A_chr11_118353210_ENST00000354520_TET1_chr10_70441155_ENST00000373644_length(amino acids)=1890AA_BP=1362
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVC
TLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKK
PIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDA
TASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSP
MEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSL
VFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV

--------------------------------------------------------------

>43217_43217_2_KMT2A-TET1_KMT2A_chr11_118353210_ENST00000389506_TET1_chr10_70441155_ENST00000373644_length(amino acids)=1890AA_BP=1362
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVC
TLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKK
PIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDA
TASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSP
MEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSL
VFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV

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>43217_43217_3_KMT2A-TET1_KMT2A_chr11_118353210_ENST00000534358_TET1_chr10_70441155_ENST00000373644_length(amino acids)=1890AA_BP=1362
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVC
TLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKK
PIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDA
TASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSP
MEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSL
VFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV

--------------------------------------------------------------

>43217_43217_4_KMT2A-TET1_KMT2A_chr11_118355029_ENST00000354520_TET1_chr10_70441156_ENST00000373644_length(amino acids)=1934AA_BP=1406
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE
NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG
AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL
KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT
LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP

--------------------------------------------------------------

>43217_43217_5_KMT2A-TET1_KMT2A_chr11_118355029_ENST00000389506_TET1_chr10_70441156_ENST00000373644_length(amino acids)=1934AA_BP=1406
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE
NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG
AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL
KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT
LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP

--------------------------------------------------------------

>43217_43217_6_KMT2A-TET1_KMT2A_chr11_118355029_ENST00000534358_TET1_chr10_70441156_ENST00000373644_length(amino acids)=1934AA_BP=1406
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE
NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG
AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL
KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT
LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP

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>43217_43217_7_KMT2A-TET1_KMT2A_chr11_118355030_ENST00000354520_TET1_chr10_70441154_ENST00000373644_length(amino acids)=1934AA_BP=1406
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE
NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG
AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL
KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT
LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP

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>43217_43217_8_KMT2A-TET1_KMT2A_chr11_118355030_ENST00000389506_TET1_chr10_70441154_ENST00000373644_length(amino acids)=1934AA_BP=1406
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE
NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG
AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL
KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT
LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP

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>43217_43217_9_KMT2A-TET1_KMT2A_chr11_118355030_ENST00000534358_TET1_chr10_70441154_ENST00000373644_length(amino acids)=1934AA_BP=1406
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYE
NVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSG
AIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFIL
KSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPT
LSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:118355463/chr10:70440909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2A

Q03164

TET1

Q8NFU7

FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation (PubMed:19372391, PubMed:21496894). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC) (PubMed:21778364). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes and diseases, including stem cell maintenance, T and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Plays an essential role in the protection and maintenance of transcriptional and developmental programs together with QSER1 to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). {ECO:0000269|PubMed:12124344, ECO:0000269|PubMed:19372391, ECO:0000269|PubMed:19372393, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:31278917, ECO:0000269|PubMed:33833093}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351046_10611362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351249_12721362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351278_13021362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351303_13171362.03932.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835184_2031362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835204_2261362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835236_2531362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835325_3511362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST0000035452083537_581362.03932.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835445_4951362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835535_5561362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835557_5761362.03932.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835713_7311362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835747_7801362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835798_8451362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST0000035452083581_1031362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835846_8981362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361046_10611362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361249_12721362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361278_13021362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361303_13171362.03970.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836184_2031362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836204_2261362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836236_2531362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836325_3511362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST0000038950683637_581362.03970.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836445_4951362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836535_5561362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836557_5761362.03970.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836713_7311362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836747_7801362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836798_8451362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST0000038950683681_1031362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836846_8981362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361046_10611362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361249_12721362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361278_13021362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361303_13171362.03973.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836184_2031362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836204_2261362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836236_2531362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836325_3511362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST0000053435883637_581362.03973.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836445_4951362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836535_5561362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836557_5761362.03973.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836713_7311362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836747_7801362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836798_8451362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST0000053435883681_1031362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836846_8981362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935137_1431406.03932.0Compositional biasNote=Poly-Gly
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+93517_1021406.03932.0Compositional biasNote=Ala/Gly/Ser-rich
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935561_5641406.03932.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935568_5711406.03932.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936137_1431406.03970.0Compositional biasNote=Poly-Gly
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+93617_1021406.03970.0Compositional biasNote=Ala/Gly/Ser-rich
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936561_5641406.03970.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936568_5711406.03970.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936137_1431406.03973.0Compositional biasNote=Poly-Gly
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+93617_1021406.03973.0Compositional biasNote=Ala/Gly/Ser-rich
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936561_5641406.03973.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936568_5711406.03973.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835169_1801362.03932.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835217_2271362.03932.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835301_3091362.03932.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836169_1801362.03970.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836217_2271362.03970.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836301_3091362.03970.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836169_1801362.03973.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836217_2271362.03973.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836301_3091362.03973.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935169_1801406.03932.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935217_2271406.03932.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935301_3091406.03932.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936169_1801406.03970.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936217_2271406.03970.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936301_3091406.03970.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936169_1801406.03973.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936217_2271406.03973.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936301_3091406.03973.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835123_1341362.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835147_1521362.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208356_251362.03932.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836123_1341362.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836147_1521362.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068366_251362.03970.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836123_1341362.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836147_1521362.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588366_251362.03973.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935123_1341406.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+935147_1521406.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9356_251406.03932.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936123_1341406.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+936147_1521406.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9366_251406.03970.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936123_1341406.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+936147_1521406.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9366_251406.03973.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351038_10661362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351106_11661362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835132_2531362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351_1081362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835301_3521362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835445_5851362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835713_7801362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000354520835798_9491362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361038_10661362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361106_11661362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836132_2531362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361_1081362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836301_3521362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836445_5851362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836713_7801362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000389506836798_9491362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361038_10661362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361106_11661362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836132_2531362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361_1081362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836301_3521362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836445_5851362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836713_7801362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST00000534358836798_9491362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351147_11951362.03932.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361147_11951362.03970.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361147_11951362.03973.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351147_11951406.03932.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361147_11951406.03970.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361147_11951406.03973.0Zinc fingerCXXC-type
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121783_18111608.02137.0Compositional biasPolar residues
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121849_18851608.02137.0Compositional biasPolar residues
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121924_19551608.02137.0Compositional biasPolar residues
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121774_18971608.02137.0RegionDisordered
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121919_19841608.02137.0RegionDisordered
TgeneTET1chr11:118353210chr10:70441155ENST000003736447122043_20451608.02137.0Region2-oxoglutarate binding
TgeneTET1chr11:118353210chr10:70441155ENST000003736447122049_20511608.02137.0RegionSubstrate binding
TgeneTET1chr11:118353210chr10:70441155ENST000003736447122074_21001608.02137.0RegionDisordered
TgeneTET1chr11:118355030chr10:70441154ENST000003736447122043_20451608.02137.0Region2-oxoglutarate binding
TgeneTET1chr11:118355030chr10:70441154ENST000003736447122049_20511608.02137.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351822_18471362.03932.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352096_21181362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352146_21741362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352189_22321362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352275_23201362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352402_24181362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352419_24451362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352526_25941362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352721_27461362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352747_27841362.03932.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352785_28211362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353011_30641362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353166_31831362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353195_32221362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353230_32441362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353464_35301362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353563_36061362.03932.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361822_18471362.03970.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362096_21181362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362146_21741362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362189_22321362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362275_23201362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362402_24181362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362419_24451362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362526_25941362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362721_27461362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362747_27841362.03970.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362785_28211362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363011_30641362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363166_31831362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363195_32221362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363230_32441362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363464_35301362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363563_36061362.03970.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361822_18471362.03973.0Compositional biasPro residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362096_21181362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362146_21741362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362189_22321362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362275_23201362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362402_24181362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362419_24451362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362526_25941362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362721_27461362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362747_27841362.03973.0Compositional biasBasic and acidic residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362785_28211362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363011_30641362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363166_31831362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363195_32221362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363230_32441362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363464_35301362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363563_36061362.03973.0Compositional biasPolar residues
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351703_17481362.03932.0DomainBromo%3B divergent
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352018_20741362.03932.0DomainFYR N-terminal
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353666_37471362.03932.0DomainFYR C-terminal
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353829_39451362.03932.0DomainSET
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353953_39691362.03932.0DomainPost-SET
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361703_17481362.03970.0DomainBromo%3B divergent
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362018_20741362.03970.0DomainFYR N-terminal
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363666_37471362.03970.0DomainFYR C-terminal
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363829_39451362.03970.0DomainSET
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363953_39691362.03970.0DomainPost-SET
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361703_17481362.03973.0DomainBromo%3B divergent
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362018_20741362.03973.0DomainFYR N-terminal
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363666_37471362.03973.0DomainFYR C-terminal
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363829_39451362.03973.0DomainSET
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363953_39691362.03973.0DomainPost-SET
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351703_17481406.03932.0DomainBromo%3B divergent
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9352018_20741406.03932.0DomainFYR N-terminal
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9353666_37471406.03932.0DomainFYR C-terminal
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9353829_39451406.03932.0DomainSET
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9353953_39691406.03932.0DomainPost-SET
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361703_17481406.03970.0DomainBromo%3B divergent
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9362018_20741406.03970.0DomainFYR N-terminal
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9363666_37471406.03970.0DomainFYR C-terminal
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9363829_39451406.03970.0DomainSET
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9363953_39691406.03970.0DomainPost-SET
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361703_17481406.03973.0DomainBromo%3B divergent
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9362018_20741406.03973.0DomainFYR N-terminal
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9363666_37471406.03973.0DomainFYR C-terminal
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9363829_39451406.03973.0DomainSET
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9363953_39691406.03973.0DomainPost-SET
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351200_13751362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351663_17131362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351806_18691362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352081_21331362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352145_22321362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352275_23331362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352373_24601362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352475_26181362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352647_26751362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352713_28211362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208352961_30641362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353166_32441362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353464_36081362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353620_36431362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353785_38081362.03932.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208353906_39071362.03932.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361200_13751362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361663_17131362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361806_18691362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362081_21331362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362145_22321362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362275_23331362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362373_24601362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362475_26181362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362647_26751362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362713_28211362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068362961_30641362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363166_32441362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363464_36081362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363620_36431362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363785_38081362.03970.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068363906_39071362.03970.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361200_13751362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361663_17131362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361806_18691362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362081_21331362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362145_22321362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362275_23331362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362373_24601362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362475_26181362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362647_26751362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362713_28211362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588362961_30641362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363166_32441362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363464_36081362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363620_36431362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363785_38081362.03973.0RegionDisordered
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588363906_39071362.03973.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9353906_39071406.03932.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9363906_39071406.03970.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9363906_39071406.03973.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351431_14821362.03932.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351479_15331362.03932.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351566_16271362.03932.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351870_19101362.03932.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351931_19781362.03932.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361431_14821362.03970.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361479_15331362.03970.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361566_16271362.03970.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361870_19101362.03970.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361931_19781362.03970.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361431_14821362.03973.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361479_15331362.03973.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361566_16271362.03973.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361870_19101362.03973.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361931_19781362.03973.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351431_14821406.03932.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351479_15331406.03932.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351566_16271406.03932.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351870_19101406.03932.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351931_19781406.03932.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361431_14821406.03970.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361479_15331406.03970.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361566_16271406.03970.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361870_19101406.03970.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361931_19781406.03970.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361431_14821406.03973.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361479_15331406.03973.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361566_16271406.03973.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361870_19101406.03973.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361931_19781406.03973.0Zinc fingerPHD-type 4
TgeneTET1chr11:118353210chr10:70441155ENST0000037364471210_241608.02137.0Compositional biasBasic and acidic residues
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121119_11491608.02137.0Compositional biasPolar residues
TgeneTET1chr11:118353210chr10:70441155ENST0000037364471230_441608.02137.0Compositional biasPolar residues
TgeneTET1chr11:118353210chr10:70441155ENST00000373644712713_7461608.02137.0Compositional biasBasic and acidic residues
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121119_11691608.02137.0RegionDisordered
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121_471608.02137.0RegionDisordered
TgeneTET1chr11:118353210chr10:70441155ENST00000373644712528_6741608.02137.0RegionNote=Sufficient for binding to genomic CpG islands
TgeneTET1chr11:118353210chr10:70441155ENST00000373644712712_7461608.02137.0RegionDisordered
TgeneTET1chr11:118353210chr10:70441155ENST00000373644712849_8761608.02137.0RegionDisordered
TgeneTET1chr11:118353210chr10:70441155ENST00000373644712899_9231608.02137.0RegionDisordered
TgeneTET1chr11:118355030chr10:70441154ENST00000373644712528_6741608.02137.0RegionNote=Sufficient for binding to genomic CpG islands
TgeneTET1chr11:118353210chr10:70441155ENST00000373644712584_6251608.02137.0Zinc fingerCXXC-type
TgeneTET1chr11:118355030chr10:70441154ENST00000373644712584_6251608.02137.0Zinc fingerCXXC-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1052)CIF file (1052) >>>1052.cifKMT2Achr11118353210+TET1chr1070441155
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGG
PGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSAS
SGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLG
FGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLN
KSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKE
DSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV
RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQ
SPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVK
TQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLP
EERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQ
SAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS
TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDN
FRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAP
RFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRS
PSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPS
HSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN
KDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTL
GDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVK
HSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPK
AQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEE
REKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGR
RSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM
PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSARE
DPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQ
PALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVAR
ECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSL
GVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTC
FTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPS
SLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASP
GFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAA
DGPGISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFL
TSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSD
SEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSL
VFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSS
1890
3D view using mol* of 1052 (AA BP:)
PDB file (1069)KMT2Achr11118355029+TET1chr1070441156+
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGG
PGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSAS
SGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLG
FGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLN
KSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKE
DSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV
RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQ
SPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVK
TQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLP
EERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQ
SAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS
TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDN
FRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAP
RFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRS
PSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPS
HSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN
KDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTL
GDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVK
HSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPK
AQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEE
REKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGR
RSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM
PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSARE
DPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQ
PALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHR
IRVDFKEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGS
KEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQD
EQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQPVP
RSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPTLG
SNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSP
KTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGIS
QLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDL
ASSPMEEDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFL
DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHK
NLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNELN
1934


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KMT2A_pLDDT.png
all structure
all structure
TET1_pLDDT.png
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
10691.0494521.0961612.10.5760.7110.8780.8750.8291.0561.515Chain A: 123,126,127,129,130,133,134,412,413,414,4
16,417,419,420,421,1399,1400,1401,1403,1404,1406,1
407,1408,1410,1411,1413,1414,1415,1417,1444,1445,1
447,1448,1449,1454,1459,1460,1461,1486,1487,1488,1
489,1491,1492,1493,1494,1495,1496,1497,1498,1499,1
500,1501,1503,1510,1511,1512,1513,1520,1523,1524,1
527,1530,1531,1532,1533,1534,1535,1536,1537,1538,1
540,1542,1793,1795,1798,1799,1801,1802,1804,1805,1
806,1807,1808,1809,1810,1811,1812,1813,1814,1829,1
830,1831,1832,1833,1838,1839,1841,1842,1844

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KMT2APPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,
TET1MBD3, VPRBP, DDB1, OGT, ZFP36L2, EPAS1, HIF1A, HNRNPD, SMG7, RELN, GAD1, BDNF, GOLGA2, POLR1E, S100P,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KMT2Aall structure
TET1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKMT2Achr11:118353210chr10:70441155ENST000003545208351584_16001362.03932.0histone H3K4me3
HgeneKMT2Achr11:118353210chr10:70441155ENST000003895068361584_16001362.03970.0histone H3K4me3
HgeneKMT2Achr11:118353210chr10:70441155ENST000005343588361584_16001362.03973.0histone H3K4me3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000354520+9351584_16001406.03932.0histone H3K4me3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000389506+9361584_16001406.03970.0histone H3K4me3
HgeneKMT2Achr11:118355030chr10:70441154ENST00000534358+9361584_16001406.03973.0histone H3K4me3
TgeneTET1chr11:118353210chr10:70441155ENST000003736447121580_15931608.02137.0DNA
TgeneTET1chr11:118355030chr10:70441154ENST000003736447121580_15931608.02137.0DNA


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Related Drugs to KMT2A-TET1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KMT2A-TET1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
KMT2ATET1Lung AdenocarcinomaMyCancerGenome
KMT2ATET1Acute Myeloid LeukemiaMyCancerGenome
KMT2ATET1Bladder Urothelial CarcinomaMyCancerGenome
KMT2ATET1Breast Invasive Ductal CarcinomaMyCancerGenome
KMT2ATET1Colon AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
HgeneKMT2AC0023418leukemia2CTD_human
HgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
HgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
HgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
HgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneKMT2AC0023470Myeloid Leukemia2CTD_human
HgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
HgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
HgeneKMT2AC0001418Adenocarcinoma1CTD_human
HgeneKMT2AC0004403Autosome Abnormalities1CTD_human
HgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneKMT2AC0005695Bladder Neoplasm1CTD_human
HgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKMT2AC0008625Chromosome Aberrations1CTD_human
HgeneKMT2AC0023448Lymphoid leukemia1CTD_human
HgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
HgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
HgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
HgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
HgeneKMT2AC0036341Schizophrenia1PSYGENET
HgeneKMT2AC0038356Stomach Neoplasms1CTD_human
HgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
HgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
HgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
HgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
HgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
HgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
HgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
HgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
HgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneKMT2AC2239176Liver carcinoma1CTD_human
HgeneKMT2AC2930974Acute erythroleukemia1CTD_human
HgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
HgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
HgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human
TgeneTET1C0033975Psychotic Disorders1PSYGENET
TgeneTET1C0036341Schizophrenia1PSYGENET
TgeneTET1C0349204Nonorganic psychosis1PSYGENET
TgeneTET1C1510586Autism Spectrum Disorders1CTD_human