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Fusion Protein:LAMA5-CLCN7 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: LAMA5-CLCN7 | FusionPDB ID: 43901 | FusionGDB2.0 ID: 43901 | Hgene | Tgene | Gene symbol | LAMA5 | CLCN7 | Gene ID | 3911 | 1186 |
Gene name | laminin subunit alpha 5 | chloride voltage-gated channel 7 | |
Synonyms | - | CLC-7|CLC7|HOD|OPTA2|OPTB4|PPP1R63 | |
Cytomap | 20q13.33 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | laminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alpha | H(+)/Cl(-) exchange transporter 7chloride channel 7 alpha subunitchloride channel protein 7chloride channel, voltage-sensitive 7protein phosphatase 1, regulatory subunit 63 | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | O15230 | P51798 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000252999, ENST00000370677, ENST00000370692, ENST00000492698, | ENST00000566812, ENST00000262318, ENST00000382745, ENST00000448525, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 20 X 20 X 14=5600 | 8 X 5 X 6=240 |
# samples | 28 | 8 | |
** MAII score | log2(28/5600*10)=-4.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: LAMA5 [Title/Abstract] AND CLCN7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LAMA5(60900372)-CLCN7(1509188), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LAMA5 | GO:0016477 | cell migration | 11821406 |
Hgene | LAMA5 | GO:0034446 | substrate adhesion-dependent cell spreading | 16236823 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | READ | TCGA-F5-6465-01A | LAMA5 | chr20 | 60900372 | - | CLCN7 | chr16 | 1509188 | - |
ChimerDB4 | READ | TCGA-G5-6572-01A | LAMA5 | chr20 | 60900372 | - | CLCN7 | chr16 | 1509188 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000252999 | LAMA5 | chr20 | 60900372 | - | ENST00000448525 | CLCN7 | chr16 | 1509188 | - | 9117 | 5596 | 67 | 7419 | 2450 |
ENST00000252999 | LAMA5 | chr20 | 60900372 | - | ENST00000382745 | CLCN7 | chr16 | 1509188 | - | 9116 | 5596 | 67 | 7419 | 2450 |
ENST00000252999 | LAMA5 | chr20 | 60900372 | - | ENST00000262318 | CLCN7 | chr16 | 1509188 | - | 8708 | 5596 | 67 | 7779 | 2570 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000252999 | ENST00000448525 | LAMA5 | chr20 | 60900372 | - | CLCN7 | chr16 | 1509188 | - | 0.005594459 | 0.9944055 |
ENST00000252999 | ENST00000382745 | LAMA5 | chr20 | 60900372 | - | CLCN7 | chr16 | 1509188 | - | 0.005599645 | 0.9944003 |
ENST00000252999 | ENST00000262318 | LAMA5 | chr20 | 60900372 | - | CLCN7 | chr16 | 1509188 | - | 0.003618729 | 0.9963813 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >43901_43901_1_LAMA5-CLCN7_LAMA5_chr20_60900372_ENST00000252999_CLCN7_chr16_1509188_ENST00000262318_length(amino acids)=2570AA_BP=1842 MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLL GHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQP CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQ ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFV LNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQL SPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSE ASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSP AGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGC HEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNC SGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAA NPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGG TLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIST FTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFI PSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMH IQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVE RSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQACVAPTGVQAVPGPGPAAPGGGGQPQSGCRVGDQE GPRQVPPGKERLGGALAGPDVRPSPAHNGHWRWHPGPSAFPPGVTGFSAQTMLPSSGNGEHPAAGRAGGRRGTDPLAGLTLLWAVVSPLG -------------------------------------------------------------- >43901_43901_2_LAMA5-CLCN7_LAMA5_chr20_60900372_ENST00000252999_CLCN7_chr16_1509188_ENST00000382745_length(amino acids)=2450AA_BP=1842 MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLL GHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQP CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQ ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFV LNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQL SPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSE ASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSP AGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGC HEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNC SGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAA NPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGG TLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIST FTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFI PSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMH IQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVE RSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRK -------------------------------------------------------------- >43901_43901_3_LAMA5-CLCN7_LAMA5_chr20_60900372_ENST00000252999_CLCN7_chr16_1509188_ENST00000448525_length(amino acids)=2450AA_BP=1842 MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLL GHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQP CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQ ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFV LNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQL SPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSE ASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSP AGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGC HEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNC SGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAA NPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGG TLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIST FTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFI PSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMH IQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVE RSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRK -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:60900372/chr16:1509188) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
LAMA5 | CLCN7 |
FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1438_1483 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 12 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1484_1527 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 13 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1528_1576 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 14 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1577_1627 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 15 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1628_1637 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 16%3B first part |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1641_1830 | 1843.0 | 3696.0 | Domain | Laminin IV type A |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 300_358 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 1 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 359_428 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 2 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 41_299 | 1843.0 | 3696.0 | Domain | Laminin N-terminal |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 429_474 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 3 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 494_540 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 4 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 541_586 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 5 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 587_631 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 6 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 632_676 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 7 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 677_722 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 8 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 723_775 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 9 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 776_828 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 10 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 829_850 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 11%3B truncated |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1722_1724 | 1843.0 | 3696.0 | Motif | Cell attachment site |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1838_1840 | 1843.0 | 3696.0 | Motif | Cell attachment site |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 851_1437 | 1843.0 | 3696.0 | Region | Note=Domain IV 1 (domain IV B) |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 631_695 | 198.0 | 806.0 | Domain | CBS 1 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 741_799 | 198.0 | 806.0 | Domain | CBS 2 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 631_695 | 174.0 | 782.0 | Domain | CBS 1 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 741_799 | 174.0 | 782.0 | Domain | CBS 2 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 206_213 | 198.0 | 806.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 288_300 | 198.0 | 806.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 304_312 | 198.0 | 806.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 545_559 | 198.0 | 806.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 560_562 | 198.0 | 806.0 | Intramembrane | Note%3DLoop between two helices | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 563_574 | 198.0 | 806.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 575_578 | 198.0 | 806.0 | Intramembrane | Note%3DLoop between two helices | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 206_213 | 174.0 | 782.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 288_300 | 174.0 | 782.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 304_312 | 174.0 | 782.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 545_559 | 174.0 | 782.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 560_562 | 174.0 | 782.0 | Intramembrane | Note%3DLoop between two helices | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 563_574 | 174.0 | 782.0 | Intramembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 575_578 | 174.0 | 782.0 | Intramembrane | Note%3DLoop between two helices | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 203_207 | 198.0 | 806.0 | Motif | Selectivity filter part_1 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 245_249 | 198.0 | 806.0 | Motif | Selectivity filter part_2 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 512_516 | 198.0 | 806.0 | Motif | Selectivity filter part_3 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 203_207 | 174.0 | 782.0 | Motif | Selectivity filter part_1 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 245_249 | 174.0 | 782.0 | Motif | Selectivity filter part_2 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 512_516 | 174.0 | 782.0 | Motif | Selectivity filter part_3 | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 658_660 | 198.0 | 806.0 | Nucleotide binding | ATP | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 783_786 | 198.0 | 806.0 | Nucleotide binding | ATP | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 658_660 | 174.0 | 782.0 | Nucleotide binding | ATP | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 783_786 | 174.0 | 782.0 | Nucleotide binding | ATP | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 598_805 | 198.0 | 806.0 | Topological domain | Cytoplasmic | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 598_805 | 174.0 | 782.0 | Topological domain | Cytoplasmic | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 223_241 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 247_264 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 322_341 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 375_405 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 410_432 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 487_507 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 512_535 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 579_597 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 174_197 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 223_241 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 247_264 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 322_341 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 375_405 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 410_432 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 487_507 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 512_535 | 174.0 | 782.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 579_597 | 174.0 | 782.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2203_2221 | 1843.0 | 3696.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2335_2466 | 1843.0 | 3696.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2510_2670 | 1843.0 | 3696.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1831_1863 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 16%3B second part |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1864_1912 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 17 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1913_1968 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 18 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 1969_2022 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 19 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2023_2069 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 20 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2070_2116 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 21 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2117_2166 | 1843.0 | 3696.0 | Domain | Laminin EGF-like 22 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2736_2929 | 1843.0 | 3696.0 | Domain | Laminin G-like 1 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2941_3115 | 1843.0 | 3696.0 | Domain | Laminin G-like 2 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 3124_3292 | 1843.0 | 3696.0 | Domain | Laminin G-like 3 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 3340_3513 | 1843.0 | 3696.0 | Domain | Laminin G-like 4 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 3520_3692 | 1843.0 | 3696.0 | Domain | Laminin G-like 5 |
Hgene | LAMA5 | chr20:60900372 | chr16:1509188 | ENST00000252999 | - | 41 | 80 | 2167_2735 | 1843.0 | 3696.0 | Region | Note=Domain II and I |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 1_126 | 198.0 | 806.0 | Topological domain | Cytoplasmic | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 1_126 | 174.0 | 782.0 | Topological domain | Cytoplasmic | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 127_159 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000382745 | 5 | 25 | 174_197 | 198.0 | 806.0 | Transmembrane | Helical | |
Tgene | CLCN7 | chr20:60900372 | chr16:1509188 | ENST00000448525 | 4 | 24 | 127_159 | 174.0 | 782.0 | Transmembrane | Helical |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
LAMA5_pLDDT.png![]() |
CLCN7_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
![]() |
Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
![]() |
![]() |
Gene | PPI interactors |
![]() |
Gene | STRING network |
LAMA5 | |
CLCN7 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to LAMA5-CLCN7 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LAMA5-CLCN7 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |