UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LANCL2-TFDP2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LANCL2-TFDP2
	FusionPDB ID: 44029
	FusionGDB2.0 ID: 44029
		Hgene	Tgene
	Gene symbol	LANCL2	TFDP2
	Gene ID	55915	7029
	Gene name	LanC like 2	transcription factor Dp-2
	Synonyms	GPR69B\|TASP	DP2
	Cytomap	7p11.2	3q23
	Type of gene	protein-coding	protein-coding
	Description	lanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity protein	transcription factor Dp-2transcription factor Dp-2 (E2F dimerization partner 2)
	Modification date	20200313	20200313
	UniProtAcc	Q9NS86	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000254770, ENST00000486376,	ENST00000464782, ENST00000310282, ENST00000317104, ENST00000397991, ENST00000467072, ENST00000477292, ENST00000479040, ENST00000486111, ENST00000489671, ENST00000495310, ENST00000499676,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 5 X 5=225	8 X 7 X 5=280
	# samples	10	9
	** MAII score	log2(10/225*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LANCL2 [Title/Abstract] AND TFDP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LANCL2(55469013)-TFDP2(141682805), # samples:4 TFDP2(141811903)-LANCL2(55466116), # samples:3
Anticipated loss of major functional domain due to fusion event.	LANCL2-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LANCL2-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LANCL2-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LANCL2-TFDP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFDP2-LANCL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TFDP2-LANCL2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. TFDP2-LANCL2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LANCL2	GO:0009789	positive regulation of abscisic acid-activated signaling pathway	19667068
Hgene	LANCL2	GO:0045892	negative regulation of transcription, DNA-templated	12566319
Tgene	TFDP2	GO:0045892	negative regulation of transcription, DNA-templated	20176812
Tgene	TFDP2	GO:0045944	positive regulation of transcription by RNA polymerase II	7739537

Fusion gene breakpoints across LANCL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFDP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A25F-01A	LANCL2	chr7	55469013	-	TFDP2	chr3	141682805	-
ChimerDB4	BRCA	TCGA-A2-A25F-01A	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-
ChimerDB4	BRCA	TCGA-A2-A25F	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000499676	TFDP2	chr3	141682805	-	10090	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000489671	TFDP2	chr3	141682805	-	3378	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000486111	TFDP2	chr3	141682805	-	3023	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000477292	TFDP2	chr3	141682805	-	2382	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000495310	TFDP2	chr3	141682805	-	2249	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000467072	TFDP2	chr3	141682805	-	2044	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000317104	TFDP2	chr3	141682805	-	2043	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000310282	TFDP2	chr3	141682805	-	2035	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000479040	TFDP2	chr3	141682805	-	2029	1403	545	2011	488
ENST00000254770	LANCL2	chr7	55469013	+	ENST00000397991	TFDP2	chr3	141682805	-	2022	1403	545	2011	488

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000254770	ENST00000499676	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.000514615	0.9994854
ENST00000254770	ENST00000489671	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.00117331	0.9988267
ENST00000254770	ENST00000486111	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.001446554	0.99855345
ENST00000254770	ENST00000477292	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.002145886	0.99785405
ENST00000254770	ENST00000495310	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.002790944	0.997209
ENST00000254770	ENST00000467072	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.003417503	0.99658257
ENST00000254770	ENST00000317104	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.003393339	0.9966067
ENST00000254770	ENST00000310282	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.003609513	0.9963905
ENST00000254770	ENST00000479040	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.003653756	0.9963463
ENST00000254770	ENST00000397991	LANCL2	chr7	55469013	+	TFDP2	chr3	141682805	-	0.003680135	0.9963199

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44029_44029_1_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000310282_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_2_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000317104_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_3_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000397991_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_4_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000467072_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_5_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000477292_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_6_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000479040_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_7_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000486111_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_8_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000489671_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_9_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000495310_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

>44029_44029_10_LANCL2-TFDP2_LANCL2_chr7_55469013_ENST00000254770_TFDP2_chr3_141682805_ENST00000499676_length(amino acids)=488AA_BP=285
MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT
KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC
ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY
VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM
GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:55469013/chr3:141682805)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LANCL2 Q9NS86	.
FUNCTION: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269\|PubMed:19667068}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000310282

432_446

184.0

387.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000397991

432_446

216.0

419.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000467072

432_446

184.0

387.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000477292

432_446

108.0

311.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000479040

432_446

183.0

386.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000486111

432_446

184.0

387.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000489671

432_446

244.0

447.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000495310

432_446

147.0

350.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000499676

432_446

184.0

387.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B NCB domain)

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000477292

129_210

108.0

311.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000477292

176_210

108.0

311.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000495310

176_210

147.0

350.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000310282

219_292

184.0

387.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000310282

229_261

184.0

387.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000310282

274_330

184.0

387.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000397991

219_292

216.0

419.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000397991

229_261

216.0

419.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000397991

274_330

216.0

419.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000467072

219_292

184.0

387.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000467072

229_261

184.0

387.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000467072

274_330

184.0

387.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000477292

219_292

108.0

311.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000477292

229_261

108.0

311.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000477292

274_330

108.0

311.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000479040

219_292

183.0

386.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000479040

229_261

183.0

386.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000479040

274_330

183.0

386.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000486111

219_292

184.0

387.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000486111

229_261

184.0

387.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000486111

274_330

184.0

387.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000489671

274_330

244.0

447.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000495310

219_292

147.0

350.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000495310

229_261

147.0

350.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000495310

274_330

147.0

350.0

Region

Note=DCB2

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000499676

219_292

184.0

387.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000499676

229_261

184.0

387.0

Region

Note=DCB1

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000499676

274_330

184.0

387.0

Region

Note=DCB2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000310282

129_210

184.0

387.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000397991

129_210

216.0

419.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000467072

129_210

184.0

387.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000479040

129_210

183.0

386.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000486111

129_210

184.0

387.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000489671

129_210

244.0

447.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000495310

129_210

147.0

350.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000499676

129_210

184.0

387.0

DNA binding

Ontology_term=ECO:0000255

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000310282

176_210

184.0

387.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000397991

176_210

216.0

419.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000467072

176_210

184.0

387.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000479040

176_210

183.0

386.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000486111

176_210

184.0

387.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000489671

176_210

244.0

447.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000499676

176_210

184.0

387.0

Motif

Note=DEF box

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000489671

219_292

244.0

447.0

Region

Dimerization

Tgene

TFDP2

chr7:55469013

chr3:141682805

ENST00000489671

229_261

244.0

447.0

Region

Note=DCB1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1027_LANCL2_55469013_TFDP2_141682805_1027_LANCL2_55469013_TFDP2_141682805_ranked_0.pdb	LANCL2	55469013	55469013	ENST00000397991	TFDP2	chr3	141682805	-	MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQT KIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDC ESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQY VGAAHGMAGIYYMLMQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRM GMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPN	488

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

LANCL2_pLDDT.png

TFDP2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LANCL2
TFDP2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000310282		5	10	60_82	184.0	387.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000397991		5	10	60_82	216.0	419.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000467072		9	14	60_82	184.0	387.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000477292		3	8	60_82	108.0	311.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000479040		5	10	60_82	183.0	386.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000486111		6	11	60_82	184.0	387.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000489671		8	13	60_82	244.0	447.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000495310		5	10	60_82	147.0	350.0	CEBPA
Tgene	TFDP2	chr7:55469013	chr3:141682805	ENST00000499676		8	13	60_82	184.0	387.0	CEBPA

Top

Related Drugs to LANCL2-TFDP2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LANCL2-TFDP2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source