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Fusion Protein:LANCL2-TTC3 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: LANCL2-TTC3 | FusionPDB ID: 44030 | FusionGDB2.0 ID: 44030 | Hgene | Tgene | Gene symbol | LANCL2 | TTC3 | Gene ID | 55915 | 7267 |
Gene name | LanC like 2 | tetratricopeptide repeat domain 3 | |
Synonyms | GPR69B|TASP | DCRR1|RNF105|TPRDIII | |
Cytomap | 7p11.2 | 21q22.13 | |
Type of gene | protein-coding | protein-coding | |
Description | lanC-like protein 2G protein-coupled receptor 69BLanC (bacterial lantibiotic synthetase component C)-like 2LanC lantibiotic synthetase component C-like 2testis-specific adriamycin sensitivity protein | E3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3 | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | Q9NS86 | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000254770, ENST00000486376, | ENST00000479930, ENST00000399010, ENST00000540756, ENST00000354749, ENST00000355666, ENST00000399017, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 5 X 5=225 | 19 X 18 X 9=3078 |
# samples | 10 | 24 | |
** MAII score | log2(10/225*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(24/3078*10)=-3.68088692071969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: LANCL2 [Title/Abstract] AND TTC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LANCL2(55433922)-TTC3(38544897), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | LANCL2-TTC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LANCL2-TTC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LANCL2-TTC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LANCL2-TTC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LANCL2 | GO:0009789 | positive regulation of abscisic acid-activated signaling pathway | 19667068 |
Hgene | LANCL2 | GO:0045892 | negative regulation of transcription, DNA-templated | 12566319 |
Tgene | TTC3 | GO:0006511 | ubiquitin-dependent protein catabolic process | 20059950 |
Tgene | TTC3 | GO:0070936 | protein K48-linked ubiquitination | 20059950 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LGG | TCGA-E1-A7YQ-01A | LANCL2 | chr7 | 55433922 | + | TTC3 | chr21 | 38544897 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000254770 | LANCL2 | chr7 | 55433922 | + | ENST00000355666 | TTC3 | chr21 | 38544897 | + | 3922 | 782 | 545 | 2392 | 615 |
ENST00000254770 | LANCL2 | chr7 | 55433922 | + | ENST00000399017 | TTC3 | chr21 | 38544897 | + | 3931 | 782 | 545 | 2392 | 615 |
ENST00000254770 | LANCL2 | chr7 | 55433922 | + | ENST00000354749 | TTC3 | chr21 | 38544897 | + | 3931 | 782 | 545 | 2392 | 615 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000254770 | ENST00000355666 | LANCL2 | chr7 | 55433922 | + | TTC3 | chr21 | 38544897 | + | 0.000341953 | 0.9996581 |
ENST00000254770 | ENST00000399017 | LANCL2 | chr7 | 55433922 | + | TTC3 | chr21 | 38544897 | + | 0.000345692 | 0.9996543 |
ENST00000254770 | ENST00000354749 | LANCL2 | chr7 | 55433922 | + | TTC3 | chr21 | 38544897 | + | 0.000345692 | 0.9996543 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >44030_44030_1_LANCL2-TTC3_LANCL2_chr7_55433922_ENST00000254770_TTC3_chr21_38544897_ENST00000354749_length(amino acids)=615AA_BP=79 MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKGEISRIEKEHQ VLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEMYTQK NDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRDPAAY PDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGNHAAL HRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFPCYNS TELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDVPVRI -------------------------------------------------------------- >44030_44030_2_LANCL2-TTC3_LANCL2_chr7_55433922_ENST00000254770_TTC3_chr21_38544897_ENST00000355666_length(amino acids)=615AA_BP=79 MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKGEISRIEKEHQ VLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEMYTQK NDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRDPAAY PDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGNHAAL HRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFPCYNS TELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDVPVRI -------------------------------------------------------------- >44030_44030_3_LANCL2-TTC3_LANCL2_chr7_55433922_ENST00000254770_TTC3_chr21_38544897_ENST00000399017_length(amino acids)=615AA_BP=79 MSPPARRTAAEMGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKGEISRIEKEHQ VLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEMYTQK NDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRDPAAY PDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGNHAAL HRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFPCYNS TELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDVPVRI -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:55433922/chr21:38544897) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
LANCL2 | . |
FUNCTION: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1563_1579 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1899_1902 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Lys | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1563_1579 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1899_1902 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Lys | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1563_1579 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1899_1902 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Lys | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1957_1997 | 1489.0 | 2026.0 | Zinc finger | RING-type | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1957_1997 | 1489.0 | 2026.0 | Zinc finger | RING-type | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1957_1997 | 1489.0 | 2026.0 | Zinc finger | RING-type |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1018_1029 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1020_1029 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Lys | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1172_1185 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 453_456 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Ser | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1018_1029 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1020_1029 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Lys | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1172_1185 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 453_456 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Ser | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1018_1029 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1020_1029 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Lys | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1172_1185 | 1489.0 | 2026.0 | Compositional bias | Note=Arg/Lys-rich (basic) | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 453_456 | 1489.0 | 2026.0 | Compositional bias | Note=Poly-Ser | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 231_264 | 1489.0 | 2026.0 | Repeat | Note=TPR 1 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 266_298 | 1489.0 | 2026.0 | Repeat | Note=TPR 2 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 536_572 | 1489.0 | 2026.0 | Repeat | Note=TPR 3 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 576_609 | 1489.0 | 2026.0 | Repeat | Note=TPR 4 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 231_264 | 1489.0 | 2026.0 | Repeat | Note=TPR 1 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 266_298 | 1489.0 | 2026.0 | Repeat | Note=TPR 2 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 536_572 | 1489.0 | 2026.0 | Repeat | Note=TPR 3 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 576_609 | 1489.0 | 2026.0 | Repeat | Note=TPR 4 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 231_264 | 1489.0 | 2026.0 | Repeat | Note=TPR 1 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 266_298 | 1489.0 | 2026.0 | Repeat | Note=TPR 2 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 536_572 | 1489.0 | 2026.0 | Repeat | Note=TPR 3 | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 576_609 | 1489.0 | 2026.0 | Repeat | Note=TPR 4 |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
LANCL2 | |
TTC3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000354749 | 32 | 45 | 1_230 | 1489.0 | 2026.0 | POLG | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000355666 | 33 | 46 | 1_230 | 1489.0 | 2026.0 | POLG | |
Tgene | TTC3 | chr7:55433922 | chr21:38544897 | ENST00000399017 | 33 | 46 | 1_230 | 1489.0 | 2026.0 | POLG |
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Related Drugs to LANCL2-TTC3 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LANCL2-TTC3 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |