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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LASP1-KMT2A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LASP1-KMT2A
	FusionPDB ID: 44183
	FusionGDB2.0 ID: 44183
		Hgene	Tgene
	Gene symbol	LASP1	KMT2A
	Gene ID	3927	4297
	Gene name	LIM and SH3 protein 1	lysine methyltransferase 2A
	Synonyms	Lasp-1\|MLN50	ALL-1\|CXXC7\|HRX\|HTRX1\|MLL\|MLL1\|MLL1A\|TRX1\|WDSTS
	Cytomap	17q12	11q23.3
	Type of gene	protein-coding	protein-coding
	Description	LIM and SH3 domain protein 1metastatic lymph node gene 50 protein	histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
	Modification date	20200313	20200319
	UniProtAcc	Q14847	Q03164
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000318008, ENST00000433206, ENST00000435347,	ENST00000354520, ENST00000389506, ENST00000420751, ENST00000534358,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 17 X 8=2448	31 X 72 X 3=6696
	# samples	21	79
	** MAII score	log2(21/2448*10)=-3.54314232502653 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(79/6696*10)=-3.08337496948588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LASP1 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF. LASP1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-LASP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KMT2A-LASP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KMT2A-LASP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KMT2A-LASP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KMT2A-LASP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. KMT2A-LASP1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KMT2A	GO:0044648	histone H3-K4 dimethylation	25561738
Tgene	KMT2A	GO:0045944	positive regulation of transcription by RNA polymerase II	20861184
Tgene	KMT2A	GO:0051568	histone H3-K4 methylation	19556245
Tgene	KMT2A	GO:0065003	protein-containing complex assembly	15199122
Tgene	KMT2A	GO:0080182	histone H3-K4 trimethylation	20861184
Tgene	KMT2A	GO:0097692	histone H3-K4 monomethylation	25561738\|26324722

Fusion gene breakpoints across LASP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	LASP1	chr17	37071399	+	KMT2A	chr11	118355576
ChimerKB3	.	.	LASP1	chr17	37074857	+	KMT2A	chr11	118359328	+
ChimerKB3	.	.	LASP1	chr17	37078023	+	KMT2A	chr11	118355690	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000318008	LASP1	chr17	37071399	+	ENST00000534358	KMT2A	chr11	118355576		13296	943	331	8643	2770
ENST00000318008	LASP1	chr17	37071399	+	ENST00000389506	KMT2A	chr11	118355576		10380	943	331	8634	2767
ENST00000433206	LASP1	chr17	37071399	+	ENST00000534358	KMT2A	chr11	118355576		13039	686	242	8386	2714
ENST00000433206	LASP1	chr17	37071399	+	ENST00000389506	KMT2A	chr11	118355576		10123	686	242	8377	2711
ENST00000435347	LASP1	chr17	37071399	+	ENST00000534358	KMT2A	chr11	118355576		13012	659	47	8359	2770
ENST00000435347	LASP1	chr17	37071399	+	ENST00000389506	KMT2A	chr11	118355576		10096	659	47	8350	2767

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44183_44183_1_LASP1-KMT2A_LASP1_chr17_37071399_ENST00000318008_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2767AA_BP=204
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEF
EKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVA
QSYGGYKEPAAPVSIQRSAPGGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLE
NWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKL
FAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALL
NSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDG
GQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGP
GEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVH
MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLN
GLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSF
TESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGS
RRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDG
SSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHL
RGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKP
EFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIES
TSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGE
EDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTA
TTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLD
TYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVS
SSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDAD
HISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQ
TLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPS
GLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLG
SLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHV
TLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQL
QHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKR
FQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEP
KTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGI
LHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSM
DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAA

--------------------------------------------------------------

>44183_44183_2_LASP1-KMT2A_LASP1_chr17_37071399_ENST00000318008_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2770AA_BP=204
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEF
EKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVA
QSYGGYKEPAAPVSIQRSAPGGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLE
NWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKL
FAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLT
ALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAIN
SDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKP
KGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLK
NVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRK
FLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSP
TSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRS
IGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSH
LDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPH
LHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGN
LKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQ
IESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRS
YGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTS
VTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKN
LLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDS
SVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHM
DADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLY
VLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISN
PPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLL
DLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVP
GHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEH
YQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPK
TKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQES
AEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRM
LGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRA
TSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHG

--------------------------------------------------------------

>44183_44183_3_LASP1-KMT2A_LASP1_chr17_37071399_ENST00000433206_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2711AA_BP=148
MLPLRDLQDDTEHEELQGLREEALLQRVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDS
QDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCA
SSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICT
KCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVA
YTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDL
EGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSL
DHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAG
RLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHR
DLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYT
CKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPG
CRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLG
PLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNT
TSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQK
GKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKR
TVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQE
DGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLA
SHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSR
VKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLG
EGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVA
SSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQ
ISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPS
ASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSS
TPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTS
GSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTA
AITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQAS
PTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQ
SSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIED
AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMF
NFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQT
DKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCN

--------------------------------------------------------------

>44183_44183_4_LASP1-KMT2A_LASP1_chr17_37071399_ENST00000433206_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2714AA_BP=148
MLPLRDLQDDTEHEELQGLREEALLQRVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDS
QDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCA
SSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICT
KCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPE
SVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQP
LDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLP
PSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSAN
DAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQ
RHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRC
VYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQR
SPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDH
VLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQV
HNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDR
RQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAP
RKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPK
PQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEE
RLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHS
VSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELL
NLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEK
SVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPG
PSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSL
FPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLA
PSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSH
LTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTP
STAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAV
QASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTAS
VEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAES
IEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAF
DMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRS
IQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKL

--------------------------------------------------------------

>44183_44183_5_LASP1-KMT2A_LASP1_chr17_37071399_ENST00000435347_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2767AA_BP=204
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEF
EKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVA
QSYGGYKEPAAPVSIQRSAPGGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLE
NWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKL
FAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALL
NSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDG
GQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGP
GEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVH
MAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLN
GLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSF
TESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGS
RRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDG
SSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHL
RGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKP
EFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIES
TSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGE
EDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTA
TTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLD
TYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVS
SSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDAD
HISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQ
TLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPS
GLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLG
SLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHV
TLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQL
QHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKR
FQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEP
KTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGI
LHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSM
DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAA

--------------------------------------------------------------

>44183_44183_6_LASP1-KMT2A_LASP1_chr17_37071399_ENST00000435347_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2770AA_BP=204
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEF
EKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVA
QSYGGYKEPAAPVSIQRSAPGGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLE
NWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKL
FAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLT
ALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAIN
SDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKP
KGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLK
NVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRK
FLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSP
TSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRS
IGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSH
LDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPH
LHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGN
LKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQ
IESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRS
YGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTS
VTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKN
LLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDS
SVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHM
DADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLY
VLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISN
PPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLL
DLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVP
GHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEH
YQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPK
TKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQES
AEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRM
LGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRA
TSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:/chr11:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LASP1 Q14847	KMT2A Q03164
FUNCTION: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.	FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

116_151

204.0

262.0

Compositional bias

Basic and acidic residues

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

152_182

204.0

262.0

Compositional bias

Polar residues

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

116_151

204.0

708.3333333333334

Compositional bias

Basic and acidic residues

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

152_182

204.0

708.3333333333334

Compositional bias

Polar residues

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

5_56

204.0

262.0

Domain

LIM zinc-binding

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

5_56

204.0

708.3333333333334

Domain

LIM zinc-binding

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

111_186

204.0

262.0

Region

Disordered

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

111_186

204.0

708.3333333333334

Region

Disordered

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

61_95

204.0

262.0

Repeat

Note=Nebulin 1

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

97_131

204.0

262.0

Repeat

Note=Nebulin 2

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

61_95

204.0

708.3333333333334

Repeat

Note=Nebulin 1

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

97_131

204.0

708.3333333333334

Repeat

Note=Nebulin 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1046_1061

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1249_1272

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1278_1302

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1303_1317

0.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1822_1847

0.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

184_203

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

204_226

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2096_2118

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2146_2174

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2189_2232

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2275_2320

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

236_253

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2402_2418

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2419_2445

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2526_2594

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2721_2746

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2747_2784

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2785_2821

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3011_3064

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3166_3183

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3195_3222

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3230_3244

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

325_351

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3464_3530

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3563_3606

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

37_58

0.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

445_495

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

535_556

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

557_576

0.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

713_731

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

747_780

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

798_845

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

81_103

0.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

846_898

0.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1822_1847

1406.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2096_2118

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2146_2174

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2189_2232

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2275_2320

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2402_2418

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2419_2445

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2526_2594

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2721_2746

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2747_2784

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2785_2821

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3011_3064

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3166_3183

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3195_3222

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3230_3244

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3464_3530

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3563_3606

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1822_1847

1406.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2096_2118

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2146_2174

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2189_2232

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2275_2320

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2402_2418

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2419_2445

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2526_2594

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2721_2746

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2747_2784

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2785_2821

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3011_3064

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3166_3183

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3195_3222

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3230_3244

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3464_3530

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3563_3606

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

169_180

0.0

3932.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

217_227

0.0

3932.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

301_309

0.0

3932.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1703_1748

0.0

3932.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2018_2074

0.0

3932.0

Domain

FYR N-terminal

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3666_3747

0.0

3932.0

Domain

FYR C-terminal

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3829_3945

0.0

3932.0

Domain

SET

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3953_3969

0.0

3932.0

Domain

Post-SET

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1703_1748

1406.0

3970.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2018_2074

1406.0

3970.0

Domain

FYR N-terminal

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3666_3747

1406.0

3970.0

Domain

FYR C-terminal

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3829_3945

1406.0

3970.0

Domain

SET

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3953_3969

1406.0

3970.0

Domain

Post-SET

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1703_1748

1406.0

3973.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2018_2074

1406.0

3973.0

Domain

FYR N-terminal

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3666_3747

1406.0

3973.0

Domain

FYR C-terminal

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3829_3945

1406.0

3973.0

Domain

SET

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3953_3969

1406.0

3973.0

Domain

Post-SET

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

123_134

0.0

3932.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

147_152

0.0

3932.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

6_25

0.0

3932.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1038_1066

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1106_1166

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1200_1375

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

132_253

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1663_1713

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1806_1869

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1_108

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2081_2133

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2145_2232

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2275_2333

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2373_2460

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2475_2618

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2647_2675

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2713_2821

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

2961_3064

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

301_352

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3166_3244

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3464_3608

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3620_3643

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3785_3808

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

3906_3907

0.0

3932.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

445_585

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

713_780

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

798_949

0.0

3932.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1663_1713

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1806_1869

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2081_2133

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2145_2232

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2275_2333

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2373_2460

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2475_2618

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2647_2675

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2713_2821

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

2961_3064

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3166_3244

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3464_3608

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3620_3643

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3785_3808

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

3906_3907

1406.0

3970.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1663_1713

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1806_1869

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2081_2133

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2145_2232

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2275_2333

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2373_2460

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2475_2618

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2647_2675

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2713_2821

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

2961_3064

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3166_3244

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3464_3608

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3620_3643

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3785_3808

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

3906_3907

1406.0

3973.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1147_1195

0.0

3932.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1431_1482

0.0

3932.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1479_1533

0.0

3932.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1566_1627

0.0

3932.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1870_1910

0.0

3932.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000354520

1931_1978

0.0

3932.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1431_1482

1406.0

3970.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1479_1533

1406.0

3970.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1566_1627

1406.0

3970.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1870_1910

1406.0

3970.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1931_1978

1406.0

3970.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1431_1482

1406.0

3973.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1479_1533

1406.0

3973.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1566_1627

1406.0

3973.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1870_1910

1406.0

3973.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1931_1978

1406.0

3973.0

Zinc finger

PHD-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000318008

202_261

204.0

262.0

Domain

SH3

Hgene

LASP1

chr17:37071399

chr11:118355576

ENST00000435347

202_261

204.0

708.3333333333334

Domain

SH3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1046_1061

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1249_1272

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1278_1302

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1303_1317

1406.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

184_203

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

204_226

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

236_253

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

325_351

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

37_58

1406.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

445_495

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

535_556

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

557_576

1406.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

713_731

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

747_780

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

798_845

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

81_103

1406.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

846_898

1406.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1046_1061

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1249_1272

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1278_1302

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1303_1317

1406.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

184_203

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

204_226

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

236_253

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

325_351

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

37_58

1406.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

445_495

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

535_556

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

557_576

1406.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

713_731

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

747_780

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

798_845

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

81_103

1406.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

846_898

1406.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

169_180

1406.0

3970.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

217_227

1406.0

3970.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

301_309

1406.0

3970.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

169_180

1406.0

3973.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

217_227

1406.0

3973.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

301_309

1406.0

3973.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

123_134

1406.0

3970.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

147_152

1406.0

3970.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

6_25

1406.0

3970.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

123_134

1406.0

3973.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

147_152

1406.0

3973.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

6_25

1406.0

3973.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1038_1066

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1106_1166

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1200_1375

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

132_253

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1_108

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

301_352

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

445_585

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

713_780

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

798_949

1406.0

3970.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1038_1066

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1106_1166

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1200_1375

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

132_253

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1_108

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

301_352

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

445_585

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

713_780

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

798_949

1406.0

3973.0

Region

Disordered

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000389506

1147_1195

1406.0

3970.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr17:37071399

chr11:118355576

ENST00000534358

1147_1195

1406.0

3973.0

Zinc finger

CXXC-type

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (1190)	LASP1	chr17	37071399	+	KMT2A	chr11	118355576		MLPLRDLQDDTEHEELQGLREEALLQRVRYKEEFEKNKGKGFSVVADTPE LQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPL EQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGED CEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKF CLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPE CLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHD CAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYE ILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTS HLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDL EGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFF IRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQER EENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDS PELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSA EVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMC SRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRR KFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWST TDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSK ESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPG CRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLR IMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQ NTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKT KVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVS FSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMS NRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEG NLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGS AKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEP ISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQE DGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGK RSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQ CDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRP EDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSR RVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTP SMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVD SSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEK RVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPP CGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQ ISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSV SSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSH HQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLS TTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFT PSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGG TAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASV PGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQ LGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQL LASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQAS PTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVS HLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPA GQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKE SITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQ LSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPL NPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARR ATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEY AGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHS CEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCN	2711

PDB file (1191)	LASP1	chr17	37071399	+	KMT2A	chr11	118355576		MLPLRDLQDDTEHEELQGLREEALLQRVRYKEEFEKNKGKGFSVVADTPE LQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPL EQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGED CEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKF CLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPE CLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHD CAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDE MYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSR TTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQP LDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVK SFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQW QEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSR EDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCAL WSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYH FMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGIS LRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVY WSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTES SSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQR SPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRS KLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTS LGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKG EKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPS SVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLS GMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTG EEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQV EGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSP TEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPK PQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKK RGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFRE EEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKI DRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLE SSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLK NTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTE PVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDS GEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHIS SPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPG PSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLT SSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLP MSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRT DLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLI NFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQS VGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSS ASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGM FPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHV NQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAV QASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKH KVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECG QPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQK RKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNAR LKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANE PPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKS ARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMV IEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFI NHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKL	2714

PDB file (1198)	LASP1	chr17	37071399	+	KMT2A	chr11	118355576		MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKK PYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSV VADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGS SYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAP GGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCC EPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCR NSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHD FSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENL SDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALL NSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDD QQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANS MVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNY AQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTD RSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVN CALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTS NYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFE GISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCS RVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSF TESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSP TQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSP QRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNS STSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSS LKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFA EPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTL KLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQV TTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPP MQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIES TSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPD GPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSST GKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNL FREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTEN LKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLS SLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDF VLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLP TTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVI SDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDAD HISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTD SPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKI QLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKG LLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESS QRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNM TLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLL PQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTP TSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPS SGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQL QHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALS SAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNG KKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQK ECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQ EQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARS NARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEE ANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQ LKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAG EMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAA RFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDAS	2767

PDB file (1200) >>>1200.pdbFusion protein BP residue: 204 CIF file (1200) >>>1200.cif	LASP1	chr17	37071399	+	KMT2A	chr11	118355576		MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKK PYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSV VADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGS SYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAP GGGGEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCC EPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCR NSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHD FSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENL SGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLT ALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSK QDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKK ANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLD HNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPIL STDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWT HVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTS CTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFV DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGY QCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSP TSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPS YSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSS LSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGP LNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSK SSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIG SFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEV KTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEP GQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPK APPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQ IESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLM LPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYS SSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLAS HNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENG TENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEA QLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDI MDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQ QLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRL AVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHM DADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPN STDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVT QKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSA SKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVS ESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVV SNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPA PLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTT TTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVAL PPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEH YQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNK ALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDK GNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQS SQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLW LQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQE ARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHK PEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEE EVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNI DAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHG NAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIE	2770
3D view using mol* of 1200 (AA BP:204)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

LASP1_pLDDT.png

KMT2A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

LASP1_KMT2A_1200_pLDDT.png (AA BP:204)

LASP1_KMT2A_1200_pLDDT_and_active_sites.png (AA BP:204)

LASP1_KMT2A_1200_violinplot.png (AA BP:204)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

LASP1_KMT2A_1200.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
1200	1.0051	416	1.0481	1214.906	0.6539	0.6603	0.8209	0.4865	0.8837	0.5505	1.0979	Chain A: 259,261,262,263,264,265,268,271,272,273,2 75,276,278,279,281,287,290,291,292,293,294,295,297 ,298,299,300,301,302,305,306,308,309,310,311,312,3 13,314,315,316,317,318,319,321,322,323,326,329,337 ,338,339,340,342,343,344,345,346,347,348,349,1734, 1735,1736,1737,1738,1739,1740,2101,2102,2103,2104, 2508,2509,2510,2511

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
KMT2A	PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,
LASP1	TRIP13, PLSCR1, FHL3, MDFI, ZYX, Fancc, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, Prkg1, Prkaca, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, Prkcz, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TES, PPP6C, EFTUD2, TNIP2, RBPMS, DPF2, COPS5, SFN, MYC, CDK9, CANX, ATG16L1, DCAF15, BICD1, BICD2, BMH1, BMH2, TRIM28, FAM168A, POLD1, DMRT3, POU1F1, ANKS1A, PITX1, CAMK2A, RBFOX1, CHERP, DTX2, NUTF2, VAC14, MED25, HOXA1, CRYBA1, TENC1, TFG, OTX1, GCM2, TEKT3, CPSF3L, ARHGEF16, BHLHE40, ZC3H10, VEZF1, RNF38, SPAG8, GUCD1, BAHD1, GAS8, LMO4, YTHDF1, FAM168B, TEKT5, BAG4, FOXH1, PRR35, PPP1R32, OXER1, TEKT4, CRYBA2, TLX3, RBPMS2, CERCAM, LENG8, MGAT5B, VPS37C, HNRNPF, EVX2, CATSPER1, YES1, UFSP1, CSTF2T, MKRN3, C14orf119, CTNNA3, HGS, WWOX, KRTAP19-6, KRTAP6-2, KRTAP19-4, KRTAP10-8, UBQLN2, C19orf54, NOXA1, ARID5A, CYSRT1, KRTAP26-1, QRICH1, PRR20B, PRR20A, DOK6, VGLL3, KRTAP3-3, KRTAP3-2, KRTAP12-4, PRR20D, PRR20C, PRR20E, KRTAP19-3, FBXO17, PLEKHA4, HCVgp1, PRNP, NUPR1, BRD4, USP15, RIN3, ACTB, PFN1, PRPH, RDX, TJP2, VASP, VIM, NAA40, FAM24B, RPL35A, HSPA1A, BTF3, EP300, STAT1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LASP1
KMT2A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to LASP1-KMT2A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LASP1-KMT2A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	LASP1	C0004352	Autistic Disorder	1	CTD_human
Hgene	LASP1	C0014170	Endometrial Neoplasms	1	CTD_human
Hgene	LASP1	C0036341	Schizophrenia	1	PSYGENET
Hgene	LASP1	C0476089	Endometrial Carcinoma	1	CTD_human
Tgene	KMT2A	C2826025	Mixed phenotype acute leukemia	3	ORPHANET
Tgene	KMT2A	C0023418	leukemia	2	CTD_human
Tgene	KMT2A	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023466	Leukemia, Monocytic, Chronic	2	CTD_human
Tgene	KMT2A	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Tgene	KMT2A	C0023470	Myeloid Leukemia	2	CTD_human
Tgene	KMT2A	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Tgene	KMT2A	C1854630	Growth Deficiency and Mental Retardation with Facial Dysmorphism	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	KMT2A	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Tgene	KMT2A	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CTD_human
Tgene	KMT2A	C0001418	Adenocarcinoma	1	CTD_human
Tgene	KMT2A	C0004403	Autosome Abnormalities	1	CTD_human
Tgene	KMT2A	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Tgene	KMT2A	C0005695	Bladder Neoplasm	1	CTD_human
Tgene	KMT2A	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Tgene	KMT2A	C0008625	Chromosome Aberrations	1	CTD_human
Tgene	KMT2A	C0023448	Lymphoid leukemia	1	CTD_human
Tgene	KMT2A	C0023465	Acute monocytic leukemia	1	CTD_human
Tgene	KMT2A	C0023479	Acute myelomonocytic leukemia	1	CTD_human
Tgene	KMT2A	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	KMT2A	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	KMT2A	C0036341	Schizophrenia	1	PSYGENET
Tgene	KMT2A	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	KMT2A	C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene	KMT2A	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene	KMT2A	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene	KMT2A	C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene	KMT2A	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene	KMT2A	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene	KMT2A	C0270972	Cornelia De Lange Syndrome	1	ORPHANET
Tgene	KMT2A	C0280141	Acute Undifferentiated Leukemia	1	ORPHANET
Tgene	KMT2A	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	KMT2A	C0856823	Undifferentiated type acute leukemia	1	ORPHANET
Tgene	KMT2A	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	KMT2A	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tgene	KMT2A	C2239176	Liver carcinoma	1	CTD_human
Tgene	KMT2A	C2930974	Acute erythroleukemia	1	CTD_human
Tgene	KMT2A	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Tgene	KMT2A	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Tgene	KMT2A	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human