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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LDHB-CTNNA2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LDHB-CTNNA2
	FusionPDB ID: 44340
	FusionGDB2.0 ID: 44340
		Hgene	Tgene
	Gene symbol	LDHB	CTNNA2
	Gene ID	3945	1496
	Gene name	lactate dehydrogenase B	catenin alpha 2
	Synonyms	HEL-S-281\|LDH-B\|LDH-H\|LDHBD\|TRG-5	CAP-R\|CAPR\|CDCBM9\|CT114\|CTNR
	Cytomap	12p12.1	2p12
	Type of gene	protein-coding	protein-coding
	Description	L-lactate dehydrogenase B chainLDH heart subunitepididymis secretory protein Li 281lactate dehydrogenase H chainrenal carcinoma antigen NY-REN-46testicular secretory protein Li 25	catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
	Modification date	20200326	20200313
	UniProtAcc	P07195	P26232
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000350669, ENST00000396076, ENST00000535112,	ENST00000409266, ENST00000496251, ENST00000343114, ENST00000361291, ENST00000402739, ENST00000466387, ENST00000496558, ENST00000540488, ENST00000541047,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 6=480	26 X 24 X 10=6240
	# samples	10	28
	** MAII score	log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/6240*10)=-4.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LDHB [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LDHB(21790005)-CTNNA2(80620336), # samples:3
Anticipated loss of major functional domain due to fusion event.	LDHB-CTNNA2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. LDHB-CTNNA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. LDHB-CTNNA2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LDHB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CTNNA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AJ-A3QS-01A	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+
ChimerDB4	UCEC	TCGA-AJ-A3QS-01A	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000396076	LDHB	chr12	21790005	-	ENST00000466387	CTNNA2	chr2	80620336	+	3739	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790005	-	ENST00000496558	CTNNA2	chr2	80620336	+	3740	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790005	-	ENST00000361291	CTNNA2	chr2	80620336	+	2832	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790005	-	ENST00000402739	CTNNA2	chr2	80620336	+	3793	1170	171	2975	934
ENST00000396076	LDHB	chr12	21790005	-	ENST00000540488	CTNNA2	chr2	80620336	+	2697	1170	171	2696	841
ENST00000396076	LDHB	chr12	21790005	-	ENST00000541047	CTNNA2	chr2	80620336	+	3739	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790005	-	ENST00000343114	CTNNA2	chr2	80620336	+	3740	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790004	-	ENST00000466387	CTNNA2	chr2	80620335	+	3739	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790004	-	ENST00000496558	CTNNA2	chr2	80620335	+	3740	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790004	-	ENST00000361291	CTNNA2	chr2	80620335	+	2832	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790004	-	ENST00000402739	CTNNA2	chr2	80620335	+	3793	1170	171	2975	934
ENST00000396076	LDHB	chr12	21790004	-	ENST00000540488	CTNNA2	chr2	80620335	+	2697	1170	171	2696	841
ENST00000396076	LDHB	chr12	21790004	-	ENST00000541047	CTNNA2	chr2	80620335	+	3739	1170	171	2831	886
ENST00000396076	LDHB	chr12	21790004	-	ENST00000343114	CTNNA2	chr2	80620335	+	3740	1170	171	2831	886

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000396076	ENST00000466387	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.001759866	0.9982401
ENST00000396076	ENST00000496558	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.001761963	0.99823797
ENST00000396076	ENST00000361291	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.004647452	0.9953525
ENST00000396076	ENST00000402739	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.001832934	0.99816704
ENST00000396076	ENST00000540488	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.004300021	0.9957
ENST00000396076	ENST00000541047	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.001759866	0.9982401
ENST00000396076	ENST00000343114	LDHB	chr12	21790005	-	CTNNA2	chr2	80620336	+	0.001761963	0.99823797
ENST00000396076	ENST00000466387	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.001759866	0.9982401
ENST00000396076	ENST00000496558	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.001761963	0.99823797
ENST00000396076	ENST00000361291	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.004647452	0.9953525
ENST00000396076	ENST00000402739	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.001832934	0.99816704
ENST00000396076	ENST00000540488	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.004300021	0.9957
ENST00000396076	ENST00000541047	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.001759866	0.9982401
ENST00000396076	ENST00000343114	LDHB	chr12	21790004	-	CTNNA2	chr2	80620335	+	0.001761963	0.99823797

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44340_44340_1_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000343114_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_2_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000361291_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_3_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000402739_length(amino acids)=934AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVID
GGRASQLSTHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKR

--------------------------------------------------------------

>44340_44340_4_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000466387_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_5_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000496558_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_6_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000540488_length(amino acids)=841AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKP

--------------------------------------------------------------

>44340_44340_7_LDHB-CTNNA2_LDHB_chr12_21790004_ENST00000396076_CTNNA2_chr2_80620335_ENST00000541047_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_8_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000343114_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_9_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000361291_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_10_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000402739_length(amino acids)=934AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVID
GGRASQLSTHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKR

--------------------------------------------------------------

>44340_44340_11_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000466387_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_12_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000496558_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

>44340_44340_13_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000540488_length(amino acids)=841AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKP

--------------------------------------------------------------

>44340_44340_14_LDHB-CTNNA2_LDHB_chr12_21790005_ENST00000396076_CTNNA2_chr2_80620336_ENST00000541047_length(amino acids)=886AA_BP=333
MSIRPRALTLPLSLGRRGGRALAEEQKAEGSSCGSAERLVAFAAKTRPYLSLCKMATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMAC
AISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIV
KYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELN
PEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKTGRKEKGDPLNIAIDKMTKKTRDLRRQ
LRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL
AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEME
NYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDV
RSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
DVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:21790005/chr2:80620336)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LDHB P07195	CTNNA2 P26232
	FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250\|UniProtKB:Q61301, ECO:0000269\|PubMed:30013181}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LDHB

chr12:21790004

chr2:80620335

ENST00000350669

31_53

279.0

335.0

Nucleotide binding

NAD

Hgene

LDHB

chr12:21790004

chr2:80620335

ENST00000396076

31_53

279.0

335.0

Nucleotide binding

NAD

Hgene

LDHB

chr12:21790005

chr2:80620336

ENST00000350669

31_53

279.0

335.0

Nucleotide binding

NAD

Hgene

LDHB

chr12:21790005

chr2:80620336

ENST00000396076

31_53

279.0

335.0

Nucleotide binding

NAD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LDHB
CTNNA2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to LDHB-CTNNA2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LDHB-CTNNA2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source