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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LDLR-ACY1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LDLR-ACY1
FusionPDB ID: 44351
FusionGDB2.0 ID: 44351
HgeneTgene
Gene symbol

LDLR

ACY1

Gene ID

3949

95

Gene namelow density lipoprotein receptoraminoacylase 1
SynonymsFH|FHC|FHCL1|LDLCQ2ACY-1|ACY1D|HEL-S-5
Cytomap

19p13.2

3p21.2

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3aminoacylase-1N-acyl-L-amino-acid amidohydrolaseacylaseepididymis secretory protein Li 5
Modification date2020032220200313
UniProtAcc

Q5SW96

Q03154

Ensembl transtripts involved in fusion geneENST idsENST00000455727, ENST00000535915, 
ENST00000545707, ENST00000557933, 
ENST00000558013, ENST00000558518, 
ENST00000560628, 		ENST00000468068, 
ENST00000404366, ENST00000476351, 
ENST00000458031, ENST00000476854, 
ENST00000494103, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 17 X 15=58653 X 6 X 3=54
# samples 334
** MAII scorelog2(33/5865*10)=-4.15159317867005
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/54*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LDLR [Title/Abstract] AND ACY1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LDLR(11222315)-ACY1(52019222), # samples:1
LDLR(11222315)-ACY1(52019223), # samples:1
Anticipated loss of major functional domain due to fusion event.LDLR-ACY1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-ACY1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-ACY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-ACY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LDLR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACY1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5730-11ALDLRchr19

11222315

+ACY1chr3

52019222

+
ChimerDB4Non-CancerTCGA-CG-5730-11ALDLRchr19

11222315

+ACY1chr3

52019223

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000558518LDLRchr1911222315+ENST00000458031ACY1chr352019222+261413731692505778
ENST00000558518LDLRchr1911222315+ENST00000494103ACY1chr352019222+241213731692289706
ENST00000558518LDLRchr1911222315+ENST00000476854ACY1chr352019222+243313731692310713
ENST00000557933LDLRchr1911222315+ENST00000458031ACY1chr352019222+25141273692405778
ENST00000557933LDLRchr1911222315+ENST00000494103ACY1chr352019222+23121273692189706
ENST00000557933LDLRchr1911222315+ENST00000476854ACY1chr352019222+23331273692210713
ENST00000455727LDLRchr1911222315+ENST00000458031ACY1chr352019222+2009768681900610
ENST00000455727LDLRchr1911222315+ENST00000494103ACY1chr352019222+1807768681684538
ENST00000455727LDLRchr1911222315+ENST00000476854ACY1chr352019222+1828768681705545
ENST00000535915LDLRchr1911222315+ENST00000458031ACY1chr352019222+23901149682281737
ENST00000535915LDLRchr1911222315+ENST00000494103ACY1chr352019222+21881149682065665
ENST00000535915LDLRchr1911222315+ENST00000476854ACY1chr352019222+22091149682086672
ENST00000545707LDLRchr1911222315+ENST00000458031ACY1chr352019222+2132891682023651
ENST00000545707LDLRchr1911222315+ENST00000494103ACY1chr352019222+1930891681807579
ENST00000545707LDLRchr1911222315+ENST00000476854ACY1chr352019222+1951891681828586
ENST00000558013LDLRchr1911222315+ENST00000458031ACY1chr352019222+24981257532389778
ENST00000558013LDLRchr1911222315+ENST00000494103ACY1chr352019222+22961257532173706
ENST00000558013LDLRchr1911222315+ENST00000476854ACY1chr352019222+23171257532194713
ENST00000558518LDLRchr1911222315+ENST00000458031ACY1chr352019223+261413731692505778
ENST00000558518LDLRchr1911222315+ENST00000494103ACY1chr352019223+241213731692289706
ENST00000558518LDLRchr1911222315+ENST00000476854ACY1chr352019223+243313731692310713
ENST00000557933LDLRchr1911222315+ENST00000458031ACY1chr352019223+25141273692405778
ENST00000557933LDLRchr1911222315+ENST00000494103ACY1chr352019223+23121273692189706
ENST00000557933LDLRchr1911222315+ENST00000476854ACY1chr352019223+23331273692210713
ENST00000455727LDLRchr1911222315+ENST00000458031ACY1chr352019223+2009768681900610
ENST00000455727LDLRchr1911222315+ENST00000494103ACY1chr352019223+1807768681684538
ENST00000455727LDLRchr1911222315+ENST00000476854ACY1chr352019223+1828768681705545
ENST00000535915LDLRchr1911222315+ENST00000458031ACY1chr352019223+23901149682281737
ENST00000535915LDLRchr1911222315+ENST00000494103ACY1chr352019223+21881149682065665
ENST00000535915LDLRchr1911222315+ENST00000476854ACY1chr352019223+22091149682086672
ENST00000545707LDLRchr1911222315+ENST00000458031ACY1chr352019223+2132891682023651
ENST00000545707LDLRchr1911222315+ENST00000494103ACY1chr352019223+1930891681807579
ENST00000545707LDLRchr1911222315+ENST00000476854ACY1chr352019223+1951891681828586
ENST00000558013LDLRchr1911222315+ENST00000458031ACY1chr352019223+24981257532389778
ENST00000558013LDLRchr1911222315+ENST00000494103ACY1chr352019223+22961257532173706
ENST00000558013LDLRchr1911222315+ENST00000476854ACY1chr352019223+23171257532194713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000558518ENST00000458031LDLRchr1911222315+ACY1chr352019222+0.0118463150.98815376
ENST00000558518ENST00000494103LDLRchr1911222315+ACY1chr352019222+0.0145079160.98549205
ENST00000558518ENST00000476854LDLRchr1911222315+ACY1chr352019222+0.0168128180.9831872
ENST00000557933ENST00000458031LDLRchr1911222315+ACY1chr352019222+0.0118800870.98811984
ENST00000557933ENST00000494103LDLRchr1911222315+ACY1chr352019222+0.0148016280.9851983
ENST00000557933ENST00000476854LDLRchr1911222315+ACY1chr352019222+0.0167384930.9832615
ENST00000455727ENST00000458031LDLRchr1911222315+ACY1chr352019222+0.0164192580.98358077
ENST00000455727ENST00000494103LDLRchr1911222315+ACY1chr352019222+0.0220355730.9779644
ENST00000455727ENST00000476854LDLRchr1911222315+ACY1chr352019222+0.0240774920.97592247
ENST00000535915ENST00000458031LDLRchr1911222315+ACY1chr352019222+0.011085780.9889142
ENST00000535915ENST00000494103LDLRchr1911222315+ACY1chr352019222+0.016021140.98397887
ENST00000535915ENST00000476854LDLRchr1911222315+ACY1chr352019222+0.0162214060.98377854
ENST00000545707ENST00000458031LDLRchr1911222315+ACY1chr352019222+0.018488950.98151106
ENST00000545707ENST00000494103LDLRchr1911222315+ACY1chr352019222+0.0208908490.97910917
ENST00000545707ENST00000476854LDLRchr1911222315+ACY1chr352019222+0.0220637680.97793627
ENST00000558013ENST00000458031LDLRchr1911222315+ACY1chr352019222+0.0119701750.9880298
ENST00000558013ENST00000494103LDLRchr1911222315+ACY1chr352019222+0.0149260880.9850739
ENST00000558013ENST00000476854LDLRchr1911222315+ACY1chr352019222+0.016978990.983021
ENST00000558518ENST00000458031LDLRchr1911222315+ACY1chr352019223+0.0118463150.98815376
ENST00000558518ENST00000494103LDLRchr1911222315+ACY1chr352019223+0.0145079160.98549205
ENST00000558518ENST00000476854LDLRchr1911222315+ACY1chr352019223+0.0168128180.9831872
ENST00000557933ENST00000458031LDLRchr1911222315+ACY1chr352019223+0.0118800870.98811984
ENST00000557933ENST00000494103LDLRchr1911222315+ACY1chr352019223+0.0148016280.9851983
ENST00000557933ENST00000476854LDLRchr1911222315+ACY1chr352019223+0.0167384930.9832615
ENST00000455727ENST00000458031LDLRchr1911222315+ACY1chr352019223+0.0164192580.98358077
ENST00000455727ENST00000494103LDLRchr1911222315+ACY1chr352019223+0.0220355730.9779644
ENST00000455727ENST00000476854LDLRchr1911222315+ACY1chr352019223+0.0240774920.97592247
ENST00000535915ENST00000458031LDLRchr1911222315+ACY1chr352019223+0.011085780.9889142
ENST00000535915ENST00000494103LDLRchr1911222315+ACY1chr352019223+0.016021140.98397887
ENST00000535915ENST00000476854LDLRchr1911222315+ACY1chr352019223+0.0162214060.98377854
ENST00000545707ENST00000458031LDLRchr1911222315+ACY1chr352019223+0.018488950.98151106
ENST00000545707ENST00000494103LDLRchr1911222315+ACY1chr352019223+0.0208908490.97910917
ENST00000545707ENST00000476854LDLRchr1911222315+ACY1chr352019223+0.0220637680.97793627
ENST00000558013ENST00000458031LDLRchr1911222315+ACY1chr352019223+0.0119701750.9880298
ENST00000558013ENST00000494103LDLRchr1911222315+ACY1chr352019223+0.0149260880.9850739
ENST00000558013ENST00000476854LDLRchr1911222315+ACY1chr352019223+0.016978990.983021

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44351_44351_1_LDLR-ACY1_LDLR_chr19_11222315_ENST00000455727_ACY1_chr3_52019222_ENST00000458031_length(amino acids)=610AA_BP=233
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGT
NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELF
VQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSV
TSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTL

--------------------------------------------------------------

>44351_44351_2_LDLR-ACY1_LDLR_chr19_11222315_ENST00000455727_ACY1_chr3_52019222_ENST00000476854_length(amino acids)=545AA_BP=233
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGT
NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELF
VQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQ
VTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPA

--------------------------------------------------------------

>44351_44351_3_LDLR-ACY1_LDLR_chr19_11222315_ENST00000455727_ACY1_chr3_52019222_ENST00000494103_length(amino acids)=538AA_BP=233
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGT
NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFR
EKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDS

--------------------------------------------------------------

>44351_44351_4_LDLR-ACY1_LDLR_chr19_11222315_ENST00000455727_ACY1_chr3_52019223_ENST00000458031_length(amino acids)=610AA_BP=233
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGT
NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELF
VQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSV
TSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTL

--------------------------------------------------------------

>44351_44351_5_LDLR-ACY1_LDLR_chr19_11222315_ENST00000455727_ACY1_chr3_52019223_ENST00000476854_length(amino acids)=545AA_BP=233
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGT
NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELF
VQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQ
VTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPA

--------------------------------------------------------------

>44351_44351_6_LDLR-ACY1_LDLR_chr19_11222315_ENST00000455727_ACY1_chr3_52019223_ENST00000494103_length(amino acids)=538AA_BP=233
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGT
NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFR
EKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDS

--------------------------------------------------------------

>44351_44351_7_LDLR-ACY1_LDLR_chr19_11222315_ENST00000535915_ACY1_chr3_52019222_ENST00000458031_length(amino acids)=737AA_BP=360
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQY
LEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFM
EDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGV
TLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIY

--------------------------------------------------------------

>44351_44351_8_LDLR-ACY1_LDLR_chr19_11222315_ENST00000535915_ACY1_chr3_52019222_ENST00000476854_length(amino acids)=672AA_BP=360
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQY
LEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFM
EDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMN

--------------------------------------------------------------

>44351_44351_9_LDLR-ACY1_LDLR_chr19_11222315_ENST00000535915_ACY1_chr3_52019222_ENST00000494103_length(amino acids)=665AA_BP=360
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSP
WWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDF
KAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLH

--------------------------------------------------------------

>44351_44351_10_LDLR-ACY1_LDLR_chr19_11222315_ENST00000535915_ACY1_chr3_52019223_ENST00000458031_length(amino acids)=737AA_BP=360
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQY
LEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFM
EDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGV
TLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIY

--------------------------------------------------------------

>44351_44351_11_LDLR-ACY1_LDLR_chr19_11222315_ENST00000535915_ACY1_chr3_52019223_ENST00000476854_length(amino acids)=672AA_BP=360
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQY
LEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFM
EDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMN

--------------------------------------------------------------

>44351_44351_12_LDLR-ACY1_LDLR_chr19_11222315_ENST00000535915_ACY1_chr3_52019223_ENST00000494103_length(amino acids)=665AA_BP=360
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSP
WWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDF
KAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLH

--------------------------------------------------------------

>44351_44351_13_LDLR-ACY1_LDLR_chr19_11222315_ENST00000545707_ACY1_chr3_52019222_ENST00000458031_length(amino acids)=651AA_BP=274
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCV
SIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHA
SRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAA
GEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRG

--------------------------------------------------------------

>44351_44351_14_LDLR-ACY1_LDLR_chr19_11222315_ENST00000545707_ACY1_chr3_52019222_ENST00000476854_length(amino acids)=586AA_BP=274
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCV
SIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHA
SRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGF

--------------------------------------------------------------

>44351_44351_15_LDLR-ACY1_LDLR_chr19_11222315_ENST00000545707_ACY1_chr3_52019222_ENST00000494103_length(amino acids)=579AA_BP=274
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYS
ERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAP
DVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTP

--------------------------------------------------------------

>44351_44351_16_LDLR-ACY1_LDLR_chr19_11222315_ENST00000545707_ACY1_chr3_52019223_ENST00000458031_length(amino acids)=651AA_BP=274
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCV
SIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHA
SRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAA
GEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRG

--------------------------------------------------------------

>44351_44351_17_LDLR-ACY1_LDLR_chr19_11222315_ENST00000545707_ACY1_chr3_52019223_ENST00000476854_length(amino acids)=586AA_BP=274
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCV
SIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHA
SRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGF

--------------------------------------------------------------

>44351_44351_18_LDLR-ACY1_LDLR_chr19_11222315_ENST00000545707_ACY1_chr3_52019223_ENST00000494103_length(amino acids)=579AA_BP=274
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYS
ERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAP
DVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTP

--------------------------------------------------------------

>44351_44351_19_LDLR-ACY1_LDLR_chr19_11222315_ENST00000557933_ACY1_chr3_52019222_ENST00000458031_length(amino acids)=778AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGV
AYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNR

--------------------------------------------------------------

>44351_44351_20_LDLR-ACY1_LDLR_chr19_11222315_ENST00000557933_ACY1_chr3_52019222_ENST00000476854_length(amino acids)=713AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWA

--------------------------------------------------------------

>44351_44351_21_LDLR-ACY1_LDLR_chr19_11222315_ENST00000557933_ACY1_chr3_52019222_ENST00000494103_length(amino acids)=706AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPH
LKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCK

--------------------------------------------------------------

>44351_44351_22_LDLR-ACY1_LDLR_chr19_11222315_ENST00000557933_ACY1_chr3_52019223_ENST00000458031_length(amino acids)=778AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGV
AYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNR

--------------------------------------------------------------

>44351_44351_23_LDLR-ACY1_LDLR_chr19_11222315_ENST00000557933_ACY1_chr3_52019223_ENST00000476854_length(amino acids)=713AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWA

--------------------------------------------------------------

>44351_44351_24_LDLR-ACY1_LDLR_chr19_11222315_ENST00000557933_ACY1_chr3_52019223_ENST00000494103_length(amino acids)=706AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPH
LKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCK

--------------------------------------------------------------

>44351_44351_25_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558013_ACY1_chr3_52019222_ENST00000458031_length(amino acids)=778AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGV
AYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNR

--------------------------------------------------------------

>44351_44351_26_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558013_ACY1_chr3_52019222_ENST00000476854_length(amino acids)=713AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWA

--------------------------------------------------------------

>44351_44351_27_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558013_ACY1_chr3_52019222_ENST00000494103_length(amino acids)=706AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPH
LKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCK

--------------------------------------------------------------

>44351_44351_28_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558013_ACY1_chr3_52019223_ENST00000458031_length(amino acids)=778AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGV
AYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNR

--------------------------------------------------------------

>44351_44351_29_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558013_ACY1_chr3_52019223_ENST00000476854_length(amino acids)=713AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWA

--------------------------------------------------------------

>44351_44351_30_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558013_ACY1_chr3_52019223_ENST00000494103_length(amino acids)=706AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPH
LKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCK

--------------------------------------------------------------

>44351_44351_31_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558518_ACY1_chr3_52019222_ENST00000458031_length(amino acids)=778AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGV
AYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNR

--------------------------------------------------------------

>44351_44351_32_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558518_ACY1_chr3_52019222_ENST00000476854_length(amino acids)=713AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWA

--------------------------------------------------------------

>44351_44351_33_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558518_ACY1_chr3_52019222_ENST00000494103_length(amino acids)=706AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPH
LKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCK

--------------------------------------------------------------

>44351_44351_34_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558518_ACY1_chr3_52019223_ENST00000458031_length(amino acids)=778AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGV
AYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNR

--------------------------------------------------------------

>44351_44351_35_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558518_ACY1_chr3_52019223_ENST00000476854_length(amino acids)=713AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAG
FALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWA

--------------------------------------------------------------

>44351_44351_36_LDLR-ACY1_LDLR_chr19_11222315_ENST00000558518_ACY1_chr3_52019223_ENST00000494103_length(amino acids)=706AA_BP=401
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSH
TDVVPVFKEHWSHDPFEAFKDSEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPH
LKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCK

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11222315/chr3:52019222)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLR

Q5SW96

ACY1

Q03154

FUNCTION: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:15728179}.FUNCTION: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). {ECO:0000269|PubMed:12933810}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616107_145227.33333333333334693.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616146_186227.33333333333334693.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+61625_65227.33333333333334693.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+61666_106227.33333333333334693.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717107_145354.3333333333333820.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717146_186354.3333333333333820.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717195_233354.3333333333333820.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717234_272354.3333333333333820.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+71725_65354.3333333333333820.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717274_313354.3333333333333820.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717314_353354.3333333333333820.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+71766_106354.3333333333333820.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716107_145268.3333333333333683.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716146_186268.3333333333333683.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716195_233268.3333333333333683.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+71625_65268.3333333333333683.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+71666_106268.3333333333333683.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818107_145395.3333333333333859.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818146_186395.3333333333333859.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818195_233395.3333333333333859.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818234_272395.3333333333333859.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+81825_65395.3333333333333859.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818274_313395.3333333333333859.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818314_353395.3333333333333859.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818354_393395.3333333333333859.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+81866_106395.3333333333333859.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818107_145395.3333333333333861.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818146_186395.3333333333333861.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818195_233395.3333333333333861.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818234_272395.3333333333333861.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+81825_65395.3333333333333861.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818274_313395.3333333333333861.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818314_353395.3333333333333861.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818354_393395.3333333333333861.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+81866_106395.3333333333333861.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616107_145227.33333333333334693.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616146_186227.33333333333334693.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+61625_65227.33333333333334693.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+61666_106227.33333333333334693.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717107_145354.3333333333333820.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717146_186354.3333333333333820.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717195_233354.3333333333333820.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717234_272354.3333333333333820.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+71725_65354.3333333333333820.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717274_313354.3333333333333820.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717314_353354.3333333333333820.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+71766_106354.3333333333333820.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716107_145268.3333333333333683.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716146_186268.3333333333333683.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716195_233268.3333333333333683.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+71625_65268.3333333333333683.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+71666_106268.3333333333333683.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818107_145395.3333333333333859.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818146_186395.3333333333333859.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818195_233395.3333333333333859.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818234_272395.3333333333333859.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+81825_65395.3333333333333859.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818274_313395.3333333333333859.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818314_353395.3333333333333859.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818354_393395.3333333333333859.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+81866_106395.3333333333333859.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818107_145395.3333333333333861.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818146_186395.3333333333333861.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818195_233395.3333333333333861.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818234_272395.3333333333333861.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+81825_65395.3333333333333861.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818274_313395.3333333333333861.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818314_353395.3333333333333861.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818354_393395.3333333333333861.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+81866_106395.3333333333333861.0DomainLDL-receptor class A 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616195_233227.33333333333334693.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616234_272227.33333333333334693.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616274_313227.33333333333334693.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616314_353227.33333333333334693.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616354_393227.33333333333334693.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616663_712227.33333333333334693.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717354_393354.3333333333333820.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717663_712354.3333333333333820.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716234_272268.3333333333333683.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716274_313268.3333333333333683.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716314_353268.3333333333333683.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716354_393268.3333333333333683.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716663_712268.3333333333333683.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818663_712395.3333333333333859.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818663_712395.3333333333333861.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616195_233227.33333333333334693.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616234_272227.33333333333334693.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616274_313227.33333333333334693.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616314_353227.33333333333334693.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616354_393227.33333333333334693.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616663_712227.33333333333334693.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717354_393354.3333333333333820.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717663_712354.3333333333333820.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716234_272268.3333333333333683.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716274_313268.3333333333333683.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716314_353268.3333333333333683.0DomainEGF-like 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716354_393268.3333333333333683.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716663_712268.3333333333333683.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818663_712395.3333333333333859.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818663_712395.3333333333333861.0DomainEGF-like 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616823_828227.33333333333334693.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717823_828354.3333333333333820.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716823_828268.3333333333333683.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818823_828395.3333333333333859.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818823_828395.3333333333333861.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616823_828227.33333333333334693.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717823_828354.3333333333333820.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716823_828268.3333333333333683.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818823_828395.3333333333333859.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818823_828395.3333333333333861.0MotifNPXY motif
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616721_768227.33333333333334693.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616811_860227.33333333333334693.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717721_768354.3333333333333820.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717811_860354.3333333333333820.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716721_768268.3333333333333683.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716811_860268.3333333333333683.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818721_768395.3333333333333859.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818811_860395.3333333333333859.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818721_768395.3333333333333861.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818811_860395.3333333333333861.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616721_768227.33333333333334693.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616811_860227.33333333333334693.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717721_768354.3333333333333820.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717811_860354.3333333333333820.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716721_768268.3333333333333683.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716811_860268.3333333333333683.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818721_768395.3333333333333859.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818811_860395.3333333333333859.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818721_768395.3333333333333861.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818811_860395.3333333333333861.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616397_438227.33333333333334693.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616439_485227.33333333333334693.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616486_528227.33333333333334693.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616529_572227.33333333333334693.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616573_615227.33333333333334693.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616616_658227.33333333333334693.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717397_438354.3333333333333820.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717439_485354.3333333333333820.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717486_528354.3333333333333820.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717529_572354.3333333333333820.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717573_615354.3333333333333820.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717616_658354.3333333333333820.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716397_438268.3333333333333683.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716439_485268.3333333333333683.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716486_528268.3333333333333683.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716529_572268.3333333333333683.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716573_615268.3333333333333683.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716616_658268.3333333333333683.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818397_438395.3333333333333859.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818439_485395.3333333333333859.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818486_528395.3333333333333859.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818529_572395.3333333333333859.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818573_615395.3333333333333859.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818616_658395.3333333333333859.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818397_438395.3333333333333861.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818439_485395.3333333333333861.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818486_528395.3333333333333861.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818529_572395.3333333333333861.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818573_615395.3333333333333861.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818616_658395.3333333333333861.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616397_438227.33333333333334693.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616439_485227.33333333333334693.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616486_528227.33333333333334693.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616529_572227.33333333333334693.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616573_615227.33333333333334693.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616616_658227.33333333333334693.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717397_438354.3333333333333820.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717439_485354.3333333333333820.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717486_528354.3333333333333820.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717529_572354.3333333333333820.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717573_615354.3333333333333820.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717616_658354.3333333333333820.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716397_438268.3333333333333683.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716439_485268.3333333333333683.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716486_528268.3333333333333683.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716529_572268.3333333333333683.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716573_615268.3333333333333683.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716616_658268.3333333333333683.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818397_438395.3333333333333859.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818439_485395.3333333333333859.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818486_528395.3333333333333859.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818529_572395.3333333333333859.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818573_615395.3333333333333859.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818616_658395.3333333333333859.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818397_438395.3333333333333861.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818439_485395.3333333333333861.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818486_528395.3333333333333861.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818529_572395.3333333333333861.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818573_615395.3333333333333861.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818616_658395.3333333333333861.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+61622_788227.33333333333334693.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+71722_788354.3333333333333820.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+71622_788268.3333333333333683.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+81822_788395.3333333333333859.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+81822_788395.3333333333333861.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+61622_788227.33333333333334693.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+71722_788354.3333333333333820.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+71622_788268.3333333333333683.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+81822_788395.3333333333333859.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+81822_788395.3333333333333861.0Topological domainExtracellular
HgeneLDLRchr19:11222315chr3:52019222ENST00000455727+616789_810227.33333333333334693.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019222ENST00000535915+717789_810354.3333333333333820.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019222ENST00000545707+716789_810268.3333333333333683.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019222ENST00000558013+818789_810395.3333333333333859.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019222ENST00000558518+818789_810395.3333333333333861.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019223ENST00000455727+616789_810227.33333333333334693.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019223ENST00000535915+717789_810354.3333333333333820.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019223ENST00000545707+716789_810268.3333333333333683.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019223ENST00000558013+818789_810395.3333333333333859.0TransmembraneHelical
HgeneLDLRchr19:11222315chr3:52019223ENST00000558518+818789_810395.3333333333333861.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LDLR
ACY1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LDLR-ACY1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LDLR-ACY1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource