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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LGR6-NAV1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LGR6-NAV1
FusionPDB ID: 44597
FusionGDB2.0 ID: 44597
HgeneTgene
Gene symbol

LGR6

NAV1

Gene ID

59352

89796

Gene nameleucine rich repeat containing G protein-coupled receptor 6neuron navigator 1
SynonymsGPCR|VTS20631POMFIL3|STEERIN1|UNC53H1
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing G-protein coupled receptor 6gonadotropin receptorneuron navigator 1pore membrane and/or filament interacting like protein 3unc-53 homolog 1
Modification date2020031320200313
UniProtAcc

Q9HBX8

Q8NEY1

Ensembl transtripts involved in fusion geneENST idsENST00000255432, ENST00000367278, 
ENST00000439764, ENST00000308543, 
ENST00000469130, ENST00000295624, 
ENST00000367295, ENST00000367296, 
ENST00000367297, ENST00000367300, 
ENST00000367302, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 2 X 3=2410 X 10 X 4=400
# samples 812
** MAII scorelog2(8/24*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LGR6 [Title/Abstract] AND NAV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LGR6(202205121)-NAV1(201749549), # samples:3
Anticipated loss of major functional domain due to fusion event.LGR6-NAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-NAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-NAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-NAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLGR6

GO:0030177

positive regulation of Wnt signaling pathway

22615920

HgeneLGR6

GO:0030335

positive regulation of cell migration

22615920


check buttonFusion gene breakpoints across LGR6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NAV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3BF-01ALGR6chr1

202205121

-NAV1chr1

201749549

+
ChimerDB4UCECTCGA-AJ-A3BF-01ALGR6chr1

202205121

+NAV1chr1

201749549

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367278LGR6chr1202205121+ENST00000367302NAV1chr1201749549+81575178947441551
ENST00000367278LGR6chr1202205121+ENST00000367296NAV1chr1201749549+119625178949241611
ENST00000367278LGR6chr1202205121+ENST00000295624NAV1chr1201749549+119585178949151608
ENST00000367278LGR6chr1202205121+ENST00000367297NAV1chr1201749549+119435178949001603
ENST00000367278LGR6chr1202205121+ENST00000367300NAV1chr1201749549+117875178947441551
ENST00000367278LGR6chr1202205121+ENST00000367295NAV1chr1201749549+119535178949151608
ENST00000255432LGR6chr1202205121+ENST00000367302NAV1chr1201749549+7996356645831525
ENST00000255432LGR6chr1202205121+ENST00000367296NAV1chr1201749549+11801356647631585
ENST00000255432LGR6chr1202205121+ENST00000295624NAV1chr1201749549+11797356647541582
ENST00000255432LGR6chr1202205121+ENST00000367297NAV1chr1201749549+11782356647391577
ENST00000255432LGR6chr1202205121+ENST00000367300NAV1chr1201749549+11626356645831525
ENST00000255432LGR6chr1202205121+ENST00000367295NAV1chr1201749549+11792356647541582
ENST00000439764LGR6chr1202205121+ENST00000367302NAV1chr1201749549+7939299045261508
ENST00000439764LGR6chr1202205121+ENST00000367296NAV1chr1201749549+11744299047061568
ENST00000439764LGR6chr1202205121+ENST00000295624NAV1chr1201749549+11740299046971565
ENST00000439764LGR6chr1202205121+ENST00000367297NAV1chr1201749549+11725299046821560
ENST00000439764LGR6chr1202205121+ENST00000367300NAV1chr1201749549+11569299045261508
ENST00000439764LGR6chr1202205121+ENST00000367295NAV1chr1201749549+11735299046971565

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367278ENST00000367302LGR6chr1202205121+NAV1chr1201749549+0.0020004240.9979996
ENST00000367278ENST00000367296LGR6chr1202205121+NAV1chr1201749549+0.0008106870.9991893
ENST00000367278ENST00000295624LGR6chr1202205121+NAV1chr1201749549+0.000719530.9992805
ENST00000367278ENST00000367297LGR6chr1202205121+NAV1chr1201749549+0.000842640.9991573
ENST00000367278ENST00000367300LGR6chr1202205121+NAV1chr1201749549+0.0006980430.9993019
ENST00000367278ENST00000367295LGR6chr1202205121+NAV1chr1201749549+0.0007190980.99928087
ENST00000255432ENST00000367302LGR6chr1202205121+NAV1chr1201749549+0.0016379810.998362
ENST00000255432ENST00000367296LGR6chr1202205121+NAV1chr1201749549+0.0006795840.9993204
ENST00000255432ENST00000295624LGR6chr1202205121+NAV1chr1201749549+0.0005966070.99940336
ENST00000255432ENST00000367297LGR6chr1202205121+NAV1chr1201749549+0.0007020190.999298
ENST00000255432ENST00000367300LGR6chr1202205121+NAV1chr1201749549+0.0005814460.9994186
ENST00000255432ENST00000367295LGR6chr1202205121+NAV1chr1201749549+0.0005967720.99940324
ENST00000439764ENST00000367302LGR6chr1202205121+NAV1chr1201749549+0.0015548270.9984452
ENST00000439764ENST00000367296LGR6chr1202205121+NAV1chr1201749549+0.0006380310.99936193
ENST00000439764ENST00000295624LGR6chr1202205121+NAV1chr1201749549+0.0005602780.99943966
ENST00000439764ENST00000367297LGR6chr1202205121+NAV1chr1201749549+0.0006596080.99934036
ENST00000439764ENST00000367300LGR6chr1202205121+NAV1chr1201749549+0.0005449270.99945503
ENST00000439764ENST00000367295LGR6chr1202205121+NAV1chr1201749549+0.0005605530.9994394

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44597_44597_1_LGR6-NAV1_LGR6_chr1_202205121_ENST00000255432_NAV1_chr1_201749549_ENST00000295624_length(amino acids)=1582AA_BP=117
MCLTDAPNAEAPERRLWCKGKPTGQGMGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL
KILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSW
FSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKAT
DKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVS
NSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAK
AKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSA
SGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEEL
TWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRS
NSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTS
QLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSIT
SHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPA
HPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVP
GSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQV
FKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLV
LSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALT
CKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHST
SDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIA

--------------------------------------------------------------

>44597_44597_2_LGR6-NAV1_LGR6_chr1_202205121_ENST00000255432_NAV1_chr1_201749549_ENST00000367295_length(amino acids)=1582AA_BP=117
MCLTDAPNAEAPERRLWCKGKPTGQGMGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL
KILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSW
FSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKAT
DKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVS
NSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAK
AKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSA
SGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEEL
TWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRS
NSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTS
QLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSIT
SHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPA
HPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVP
GSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQV
FKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLV
LSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALT
CKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHST
SDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIA

--------------------------------------------------------------

>44597_44597_3_LGR6-NAV1_LGR6_chr1_202205121_ENST00000255432_NAV1_chr1_201749549_ENST00000367296_length(amino acids)=1585AA_BP=117
MCLTDAPNAEAPERRLWCKGKPTGQGMGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL
KILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSW
FSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKAT
DKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVS
NSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAK
AKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSA
SGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEEL
TWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRS
NSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTS
QLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSIT
SHSSIGSSKDADAKKKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTE
GPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPG
QVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAV
FQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHR
RLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNG
ALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEK
HSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPH

--------------------------------------------------------------

>44597_44597_4_LGR6-NAV1_LGR6_chr1_202205121_ENST00000255432_NAV1_chr1_201749549_ENST00000367297_length(amino acids)=1577AA_BP=117
MCLTDAPNAEAPERRLWCKGKPTGQGMGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL
KILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSW
FSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKAT
DKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVS
NSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAK
AKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSA
SGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEEL
TWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRS
NSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSQIRKLRRELESSQEKVATLTSQLSANANL
VAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSS
KDADAKKKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPH
TRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSAL
SSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYI
SKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPS
GTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHK
CPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLI
GPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPED

--------------------------------------------------------------

>44597_44597_5_LGR6-NAV1_LGR6_chr1_202205121_ENST00000255432_NAV1_chr1_201749549_ENST00000367300_length(amino acids)=1525AA_BP=117
MCLTDAPNAEAPERRLWCKGKPTGQGMGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL
KILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSW
FSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKAT
DKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVS
NSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAK
AKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSA
SGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEEL
TWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVHGSVLSLASSASS
TYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAV
IQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPS
SPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETM
HNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHI
IKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGL
KEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQI
DRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESD
SDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPV

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>44597_44597_6_LGR6-NAV1_LGR6_chr1_202205121_ENST00000255432_NAV1_chr1_201749549_ENST00000367302_length(amino acids)=1525AA_BP=117
MCLTDAPNAEAPERRLWCKGKPTGQGMGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL
KILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSW
FSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKAT
DKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVS
NSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAK
AKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSA
SGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEEL
TWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVHGSVLSLASSASS
TYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAV
IQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPS
SPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETM
HNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHI
IKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGL
KEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQI
DRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESD
SDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPV

--------------------------------------------------------------

>44597_44597_7_LGR6-NAV1_LGR6_chr1_202205121_ENST00000367278_NAV1_chr1_201749549_ENST00000295624_length(amino acids)=1608AA_BP=143
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR
FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPT
ASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPP
VAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSA
TLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLK
EPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNS
NSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPS
AFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALP
MSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEE
RMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNA
SETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHG
STETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEV
DLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQ
QEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDS
LVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIG
DVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANK
EELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTL

--------------------------------------------------------------

>44597_44597_8_LGR6-NAV1_LGR6_chr1_202205121_ENST00000367278_NAV1_chr1_201749549_ENST00000367295_length(amino acids)=1608AA_BP=143
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR
FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPT
ASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPP
VAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSA
TLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLK
EPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNS
NSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPS
AFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALP
MSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEE
RMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNA
SETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHG
STETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEV
DLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQ
QEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDS
LVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIG
DVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANK
EELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTL

--------------------------------------------------------------

>44597_44597_9_LGR6-NAV1_LGR6_chr1_202205121_ENST00000367278_NAV1_chr1_201749549_ENST00000367296_length(amino acids)=1611AA_BP=143
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR
FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPT
ASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPP
VAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSA
TLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLK
EPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNS
NSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPS
AFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALP
MSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEE
RMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNA
SETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKL
QHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQ
LEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGD
LKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKC
VDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRET
GIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDIN
ANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVR

--------------------------------------------------------------

>44597_44597_10_LGR6-NAV1_LGR6_chr1_202205121_ENST00000367278_NAV1_chr1_201749549_ENST00000367297_length(amino acids)=1603AA_BP=143
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR
FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPT
ASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPP
VAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSA
TLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLK
EPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNS
NSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPS
AFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALP
MSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSQIR
KLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKEL
RIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETA
SPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKA
ENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFL
GCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFET
LIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLV
ILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLR
VLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSA

--------------------------------------------------------------

>44597_44597_11_LGR6-NAV1_LGR6_chr1_202205121_ENST00000367278_NAV1_chr1_201749549_ENST00000367300_length(amino acids)=1551AA_BP=143
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR
FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPT
ASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPP
VAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSA
TLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLK
EPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNS
NSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPS
AFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALP
MSLSAKGQLTNIVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAE
EKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFS
IKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWE
KEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSP
MDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKR
VLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEG
IVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRM
LTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNS
IIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLDSDPLMAMLLKLQEA

--------------------------------------------------------------

>44597_44597_12_LGR6-NAV1_LGR6_chr1_202205121_ENST00000367278_NAV1_chr1_201749549_ENST00000367302_length(amino acids)=1551AA_BP=143
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR
FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPT
ASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPP
VAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSA
TLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLK
EPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNS
NSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPS
AFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALP
MSLSAKGQLTNIVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAE
EKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFS
IKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWE
KEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSP
MDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKR
VLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEG
IVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRM
LTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNS
IIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLDSDPLMAMLLKLQEA

--------------------------------------------------------------

>44597_44597_13_LGR6-NAV1_LGR6_chr1_202205121_ENST00000439764_NAV1_chr1_201749549_ENST00000295624_length(amino acids)=1565AA_BP=100
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA
LWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSG
SLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSS
DAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQ
YRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIG
SPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPIL
NINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRD
RNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQ
MGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLV
NMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKK
KKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEP
EKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALT
HSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLS
TESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLA
EYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPV
KMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGI
EDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLD

--------------------------------------------------------------

>44597_44597_14_LGR6-NAV1_LGR6_chr1_202205121_ENST00000439764_NAV1_chr1_201749549_ENST00000367295_length(amino acids)=1565AA_BP=100
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA
LWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSG
SLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSS
DAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQ
YRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIG
SPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPIL
NINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRD
RNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQ
MGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLV
NMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKK
KKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEP
EKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALT
HSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLS
TESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLA
EYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPV
KMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGI
EDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLD

--------------------------------------------------------------

>44597_44597_15_LGR6-NAV1_LGR6_chr1_202205121_ENST00000439764_NAV1_chr1_201749549_ENST00000367296_length(amino acids)=1568AA_BP=100
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA
LWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSG
SLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSS
DAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQ
YRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIG
SPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPIL
NINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRD
RNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQ
MGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLV
NMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKK
KKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEE
EEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGL
ALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTL
GLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTN
RLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTN
QPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCP
IGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPS

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>44597_44597_16_LGR6-NAV1_LGR6_chr1_202205121_ENST00000439764_NAV1_chr1_201749549_ENST00000367297_length(amino acids)=1560AA_BP=100
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA
LWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSG
SLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSS
DAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQ
YRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIG
SPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPIL
NINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRD
RNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQ
MGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRH
LAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWVYEL
RSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEV
SELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGP
SLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIH
GYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVE
RSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPN
HGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRT
WFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLDSDPLM

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>44597_44597_17_LGR6-NAV1_LGR6_chr1_202205121_ENST00000439764_NAV1_chr1_201749549_ENST00000367300_length(amino acids)=1508AA_BP=100
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA
LWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSG
SLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSS
DAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQ
YRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIG
SPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPIL
NINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRD
RNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVHGSVLSLASSASSTYSSAEERMQSEQIRKL
RRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRI
KRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIK
SSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRL
KVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKV
SGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKP
MMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDD
LSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWV
PKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQS

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>44597_44597_18_LGR6-NAV1_LGR6_chr1_202205121_ENST00000439764_NAV1_chr1_201749549_ENST00000367302_length(amino acids)=1508AA_BP=100
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEA
LWELPSLQSLWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSG
SLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSS
DAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQ
YRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIG
SPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPIL
NINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRD
RNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVHGSVLSLASSASSTYSSAEERMQSEQIRKL
RRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRI
KRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWLRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIK
SSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRL
KVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKV
SGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKP
MMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDD
LSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWV
PKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202205121/chr1:201749549)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LGR6

Q9HBX8

NAV1

Q8NEY1

FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.FUNCTION: May be involved in neuronal migration. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+41826_6690.66666666666667916.0DomainNote=LRRNT
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+41826_66142.66666666666666968.0DomainNote=LRRNT
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+41626_6699.66666666666667829.0DomainNote=LRRNT
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418115_136142.66666666666666968.0RepeatNote=LRR 2
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+41891_112142.66666666666666968.0RepeatNote=LRR 1
TgeneNAV1chr1:202205121chr1:201749549ENST000002956242291072_1163408.66666666666671875.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000002956242291303_1362408.66666666666671875.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000295624229731_756408.66666666666671875.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003672950271072_116317.6666666666666681484.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003672950271303_136217.6666666666666681484.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367295027255_28017.6666666666666681484.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367295027731_75617.6666666666666681484.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003672962301072_1163408.66666666666671878.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003672962301303_1362408.66666666666671878.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367296230731_756408.66666666666671878.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003672972291072_1163408.66666666666671870.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003672972291303_1362408.66666666666671870.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367297229731_756408.66666666666671870.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003673002281072_1163408.66666666666671818.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST000003673002281303_1362408.66666666666671818.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367300228731_756408.66666666666671818.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418952_95590.66666666666667916.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418952_955142.66666666666666968.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416952_95599.66666666666667829.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418115_13690.66666666666667916.0RepeatNote=LRR 2
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418139_16090.66666666666667916.0RepeatNote=LRR 3
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418163_18690.66666666666667916.0RepeatNote=LRR 4
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418187_20890.66666666666667916.0RepeatNote=LRR 5
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418211_23290.66666666666667916.0RepeatNote=LRR 6
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418235_25690.66666666666667916.0RepeatNote=LRR 7
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418258_27990.66666666666667916.0RepeatNote=LRR 8
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418282_30390.66666666666667916.0RepeatNote=LRR 9
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418306_32890.66666666666667916.0RepeatNote=LRR 10
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418329_35090.66666666666667916.0RepeatNote=LRR 11
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418353_37490.66666666666667916.0RepeatNote=LRR 12
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418375_39690.66666666666667916.0RepeatNote=LRR 13
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418399_42090.66666666666667916.0RepeatNote=LRR 14
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418423_44390.66666666666667916.0RepeatNote=LRR 15
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+41891_11290.66666666666667916.0RepeatNote=LRR 1
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418139_160142.66666666666666968.0RepeatNote=LRR 3
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418163_186142.66666666666666968.0RepeatNote=LRR 4
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418187_208142.66666666666666968.0RepeatNote=LRR 5
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418211_232142.66666666666666968.0RepeatNote=LRR 6
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418235_256142.66666666666666968.0RepeatNote=LRR 7
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418258_279142.66666666666666968.0RepeatNote=LRR 8
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418282_303142.66666666666666968.0RepeatNote=LRR 9
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418306_328142.66666666666666968.0RepeatNote=LRR 10
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418329_350142.66666666666666968.0RepeatNote=LRR 11
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418353_374142.66666666666666968.0RepeatNote=LRR 12
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418375_396142.66666666666666968.0RepeatNote=LRR 13
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418399_420142.66666666666666968.0RepeatNote=LRR 14
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418423_443142.66666666666666968.0RepeatNote=LRR 15
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416115_13699.66666666666667829.0RepeatNote=LRR 2
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416139_16099.66666666666667829.0RepeatNote=LRR 3
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416163_18699.66666666666667829.0RepeatNote=LRR 4
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416187_20899.66666666666667829.0RepeatNote=LRR 5
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416211_23299.66666666666667829.0RepeatNote=LRR 6
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416235_25699.66666666666667829.0RepeatNote=LRR 7
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416258_27999.66666666666667829.0RepeatNote=LRR 8
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416282_30399.66666666666667829.0RepeatNote=LRR 9
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416306_32899.66666666666667829.0RepeatNote=LRR 10
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416329_35099.66666666666667829.0RepeatNote=LRR 11
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416353_37499.66666666666667829.0RepeatNote=LRR 12
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416375_39699.66666666666667829.0RepeatNote=LRR 13
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416399_42099.66666666666667829.0RepeatNote=LRR 14
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416423_44399.66666666666667829.0RepeatNote=LRR 15
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+41691_11299.66666666666667829.0RepeatNote=LRR 1
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+41825_56790.66666666666667916.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418589_59890.66666666666667916.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418620_64490.66666666666667916.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418666_68790.66666666666667916.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418709_72790.66666666666667916.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418749_77490.66666666666667916.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418796_80990.66666666666667916.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418831_96790.66666666666667916.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+41825_567142.66666666666666968.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418589_598142.66666666666666968.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418620_644142.66666666666666968.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418666_687142.66666666666666968.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418709_727142.66666666666666968.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418749_774142.66666666666666968.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418796_809142.66666666666666968.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418831_967142.66666666666666968.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+41625_56799.66666666666667829.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416589_59899.66666666666667829.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416620_64499.66666666666667829.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416666_68799.66666666666667829.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416709_72799.66666666666667829.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416749_77499.66666666666667829.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416796_80999.66666666666667829.0Topological domainExtracellular
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416831_96799.66666666666667829.0Topological domainCytoplasmic
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418568_58890.66666666666667916.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418599_61990.66666666666667916.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418645_66590.66666666666667916.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418688_70890.66666666666667916.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418728_74890.66666666666667916.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418775_79590.66666666666667916.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202205121chr1:201749549ENST00000255432+418810_83090.66666666666667916.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418568_588142.66666666666666968.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418599_619142.66666666666666968.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418645_665142.66666666666666968.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418688_708142.66666666666666968.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418728_748142.66666666666666968.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418775_795142.66666666666666968.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202205121chr1:201749549ENST00000367278+418810_830142.66666666666666968.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416568_58899.66666666666667829.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416599_61999.66666666666667829.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416645_66599.66666666666667829.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416688_70899.66666666666667829.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416728_74899.66666666666667829.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416775_79599.66666666666667829.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202205121chr1:201749549ENST00000439764+416810_83099.66666666666667829.0TransmembraneHelical%3B Name%3D7
TgeneNAV1chr1:202205121chr1:201749549ENST00000295624229255_280408.66666666666671875.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367296230255_280408.66666666666671878.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367297229255_280408.66666666666671870.0Coiled coilOntology_term=ECO:0000255
TgeneNAV1chr1:202205121chr1:201749549ENST00000367300228255_280408.66666666666671818.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LGR6
NAV1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LGR6-NAV1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LGR6-NAV1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource