UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LMNA-LMNB2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LMNA-LMNB2
	FusionPDB ID: 45791
	FusionGDB2.0 ID: 45791
		Hgene	Tgene
	Gene symbol	LMNA	LMNB2
	Gene ID	4000	84823
	Gene name	lamin A/C	lamin B2
	Synonyms	CDCD1\|CDDC\|CMD1A\|CMT2B1\|EMD2\|FPL\|FPLD\|FPLD2\|HGPS\|IDC\|LDP1\|LFP\|LGMD1B\|LMN1\|LMNC\|LMNL1\|MADA\|PRO1	EPM9\|LAMB2\|LMN2
	Cytomap	1q22	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	lamin70 kDa laminepididymis secretory sperm binding proteinlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32	lamin-B2epididymis secretory sperm binding proteinlamin B3
	Modification date	20200329	20200313
	UniProtAcc	P02545	Q03252
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000496738, ENST00000347559, ENST00000361308, ENST00000368297, ENST00000368299, ENST00000368300, ENST00000368301, ENST00000392353, ENST00000448611, ENST00000473598,	ENST00000325327, ENST00000582871, ENST00000475819,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 16 X 9=2304	2 X 2 X 2=8
	# samples	21	2
	** MAII score	log2(21/2304*10)=-3.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: LMNA [Title/Abstract] AND LMNB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LMNA(156105912)-LMNB2(2434103), # samples:1
Anticipated loss of major functional domain due to fusion event.	LMNA-LMNB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LMNA-LMNB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LMNA-LMNB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LMNA-LMNB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LMNA	GO:0090343	positive regulation of cell aging	20458013

Fusion gene breakpoints across LMNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LMNB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	203N	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368301	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	5204	1798	512	2458	648
ENST00000368301	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	5203	1798	512	2458	648
ENST00000361308	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4812	1406	120	2066	648
ENST00000361308	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4811	1406	120	2066	648
ENST00000347559	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4812	1406	120	2066	648
ENST00000347559	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4811	1406	120	2066	648
ENST00000368300	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4775	1369	83	2029	648
ENST00000368300	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4774	1369	83	2029	648
ENST00000368299	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4760	1354	68	2014	648
ENST00000368299	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4759	1354	68	2014	648
ENST00000448611	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4271	865	8	1525	505
ENST00000448611	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4270	865	8	1525	505
ENST00000368297	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4422	1016	102	1676	524
ENST00000368297	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4421	1016	102	1676	524
ENST00000473598	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4386	980	84	1640	518
ENST00000473598	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4385	980	84	1640	518
ENST00000392353	LMNA	chr1	156105912	+	ENST00000325327	LMNB2	chr19	2434103	-	4320	914	0	1574	524
ENST00000392353	LMNA	chr1	156105912	+	ENST00000582871	LMNB2	chr19	2434103	-	4319	914	0	1574	524

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368301	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006204761	0.9937953
ENST00000368301	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.0062648	0.99373525
ENST00000361308	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006473271	0.9935267
ENST00000361308	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006541843	0.9934582
ENST00000347559	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006473271	0.9935267
ENST00000347559	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006541843	0.9934582
ENST00000368300	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006505496	0.9934946
ENST00000368300	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006572685	0.9934274
ENST00000368299	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006575665	0.9934243
ENST00000368299	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.006643224	0.99335676
ENST00000448611	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.008648699	0.99135137
ENST00000448611	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.008709515	0.99129045
ENST00000368297	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.007664692	0.99233526
ENST00000368297	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.007725648	0.99227434
ENST00000473598	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.004318137	0.9956819
ENST00000473598	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.004352785	0.99564725
ENST00000392353	ENST00000325327	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.007620236	0.9923798
ENST00000392353	ENST00000582871	LMNA	chr1	156105912	+	LMNB2	chr19	2434103	-	0.007680299	0.99231964

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>45791_45791_1_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000347559_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_2_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000347559_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_3_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000361308_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_4_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000361308_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_5_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368297_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=524AA_BP=239
MQPLLCLGNLEDARERTGTLLAQHPAWGRTRAKPGSPLNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAK
LEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKK
ELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRAR
MQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGT
GGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTL

--------------------------------------------------------------

>45791_45791_6_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368297_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=524AA_BP=239
MQPLLCLGNLEDARERTGTLLAQHPAWGRTRAKPGSPLNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAK
LEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKK
ELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRAR
MQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGT
GGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTL

--------------------------------------------------------------

>45791_45791_7_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368299_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_8_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368299_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_9_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368300_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_10_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368300_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_11_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368301_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_12_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000368301_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=648AA_BP=61
MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID
RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL
EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV
EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE
AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSS
GSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEE
IAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEED

--------------------------------------------------------------

>45791_45791_13_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000392353_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=524AA_BP=239
MQPLLCLGNLEDARERTGTLLAQHPAWGRTRAKPGSPLNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAK
LEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKK
ELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRAR
MQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGT
GGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTL

--------------------------------------------------------------

>45791_45791_14_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000392353_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=524AA_BP=239
MQPLLCLGNLEDARERTGTLLAQHPAWGRTRAKPGSPLNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAK
LEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKK
ELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRAR
MQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGT
GGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTL

--------------------------------------------------------------

>45791_45791_15_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000448611_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=505AA_BP=220
MLFCSLPVCCLAMGNSEGCNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRR
VDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAER
NSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALD
MEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVS
IEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLV

--------------------------------------------------------------

>45791_45791_16_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000448611_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=505AA_BP=220
MLFCSLPVCCLAMGNSEGCNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRR
VDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAER
NSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALD
MEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVS
IEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLV

--------------------------------------------------------------

>45791_45791_17_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000473598_LMNB2_chr19_2434103_ENST00000325327_length(amino acids)=518AA_BP=233
MGHIWRLKAGAQMDLEAWDPHLEPDAEAMVDGNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALG
EAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTY
SAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLD
EYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGF
HLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQS

--------------------------------------------------------------

>45791_45791_18_LMNA-LMNB2_LMNA_chr1_156105912_ENST00000473598_LMNB2_chr19_2434103_ENST00000582871_length(amino acids)=518AA_BP=233
MGHIWRLKAGAQMDLEAWDPHLEPDAEAMVDGNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALG
EAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTY
SAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLD
EYQELLDIKLALDMEIHAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGF
HLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:156105912/chr19:2434103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LMNA P02545	LMNB2 Q03252
FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269\|PubMed:10080180, ECO:0000269\|PubMed:10580070, ECO:0000269\|PubMed:10587585, ECO:0000269\|PubMed:10814726, ECO:0000269\|PubMed:11799477, ECO:0000269\|PubMed:12075506, ECO:0000269\|PubMed:12927431, ECO:0000269\|PubMed:15317753, ECO:0000269\|PubMed:18551513, ECO:0000269\|PubMed:18611980, ECO:0000269\|PubMed:22431096, ECO:0000269\|PubMed:23666920, ECO:0000269\|PubMed:31548606}.; FUNCTION: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.	FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

31_387

385.6666666666667

635.0

Domain

IF rod

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

31_387

385.6666666666667

573.0

Domain

IF rod

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

31_387

385.6666666666667

665.0

Domain

IF rod

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

31_387

385.6666666666667

573.0

Domain

IF rod

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

1_33

385.6666666666667

635.0

Region

Note=Head

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

219_242

385.6666666666667

635.0

Region

Note=Linker 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

243_383

385.6666666666667

635.0

Region

Note=Coil 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

34_70

385.6666666666667

635.0

Region

Note=Coil 1A

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

71_80

385.6666666666667

635.0

Region

Note=Linker 1

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

81_218

385.6666666666667

635.0

Region

Note=Coil 1B

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

1_33

385.6666666666667

573.0

Region

Note=Head

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

219_242

385.6666666666667

573.0

Region

Note=Linker 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

243_383

385.6666666666667

573.0

Region

Note=Coil 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

34_70

385.6666666666667

573.0

Region

Note=Coil 1A

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

71_80

385.6666666666667

573.0

Region

Note=Linker 1

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

81_218

385.6666666666667

573.0

Region

Note=Coil 1B

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

1_33

385.6666666666667

665.0

Region

Note=Head

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

219_242

385.6666666666667

665.0

Region

Note=Linker 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

243_383

385.6666666666667

665.0

Region

Note=Coil 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

34_70

385.6666666666667

665.0

Region

Note=Coil 1A

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

71_80

385.6666666666667

665.0

Region

Note=Linker 1

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

81_218

385.6666666666667

665.0

Region

Note=Coil 1B

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

1_33

385.6666666666667

573.0

Region

Note=Head

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

219_242

385.6666666666667

573.0

Region

Note=Linker 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

243_383

385.6666666666667

573.0

Region

Note=Coil 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

34_70

385.6666666666667

573.0

Region

Note=Coil 1A

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

71_80

385.6666666666667

573.0

Region

Note=Linker 1

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

81_218

385.6666666666667

573.0

Region

Note=Coil 1B

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

1_33

273.6666666666667

575.0

Region

Note=Head

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

219_242

273.6666666666667

575.0

Region

Note=Linker 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

34_70

273.6666666666667

575.0

Region

Note=Coil 1A

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

71_80

273.6666666666667

575.0

Region

Note=Linker 1

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

81_218

273.6666666666667

575.0

Region

Note=Coil 1B

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

590_602

380.6666666666667

601.0

Compositional bias

Note=Asp/Glu-rich (highly acidic%3B could be involved in chromatin binding)

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

462_579

380.6666666666667

601.0

Domain

LTD

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

435_440

380.6666666666667

601.0

Motif

Nuclear localization signal

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

401_620

380.6666666666667

601.0

Region

Note=Tail

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

428_545

385.6666666666667

635.0

Domain

LTD

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

428_545

385.6666666666667

573.0

Domain

LTD

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

428_545

385.6666666666667

665.0

Domain

LTD

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

428_545

385.6666666666667

573.0

Domain

LTD

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

31_387

273.6666666666667

575.0

Domain

IF rod

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

428_545

273.6666666666667

575.0

Domain

LTD

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

417_422

385.6666666666667

635.0

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

417_422

385.6666666666667

573.0

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

417_422

385.6666666666667

665.0

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

417_422

385.6666666666667

573.0

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

417_422

273.6666666666667

575.0

Motif

Nuclear localization signal

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000347559

384_664

385.6666666666667

635.0

Region

Note=Tail

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000361308

384_664

385.6666666666667

573.0

Region

Note=Tail

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368300

384_664

385.6666666666667

665.0

Region

Note=Tail

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000368301

384_664

385.6666666666667

573.0

Region

Note=Tail

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

243_383

273.6666666666667

575.0

Region

Note=Coil 2

Hgene

LMNA

chr1:156105912

chr19:2434103

ENST00000448611

384_664

273.6666666666667

575.0

Region

Note=Tail

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

46_402

380.6666666666667

601.0

Domain

IF rod

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

1_48

380.6666666666667

601.0

Region

Note=Head

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

230_256

380.6666666666667

601.0

Region

Note=Linker 2

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

257_400

380.6666666666667

601.0

Region

Note=Coil 2

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

49_83

380.6666666666667

601.0

Region

Note=Coil 1A

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

84_95

380.6666666666667

601.0

Region

Note=Linker 1

Tgene

LMNB2

chr1:156105912

chr19:2434103

ENST00000582871

96_229

380.6666666666667

601.0

Region

Note=Coil 1B

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LMNA
LMNB2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to LMNA-LMNB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LMNA-LMNB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source