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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ANKRD42-PICALM

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ANKRD42-PICALM
	FusionPDB ID: 4731
	FusionGDB2.0 ID: 4731
		Hgene	Tgene
	Gene symbol	ANKRD42	PICALM
	Gene ID	338699	8301
	Gene name	ankyrin repeat domain 42	phosphatidylinositol binding clathrin assembly protein
	Synonyms	PPP1R79\|SARP	CALM\|CLTH\|LAP
	Cytomap	11q14.1	11q14.2
	Type of gene	protein-coding	protein-coding
	Description	ankyrin repeat domain-containing protein 42protein phosphatase 1, regulatory subunit 79several ankyrin repeat protein	phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
	Modification date	20200313	20200322
	UniProtAcc	Q8N9B4	Q13492
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000260047, ENST00000393389, ENST00000526731, ENST00000531895, ENST00000533342, ENST00000528722, ENST00000393392, ENST00000528190,	ENST00000528411, ENST00000356360, ENST00000393346, ENST00000526033, ENST00000528398, ENST00000532317,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 3=108	35 X 26 X 12=10920
	# samples	6	44
	** MAII score	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(44/10920*10)=-4.63332552228256 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ANKRD42 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ANKRD42(82909684)-PICALM(85670103), # samples:1
Anticipated loss of major functional domain due to fusion event.	ANKRD42-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ANKRD42-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ANKRD42-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ANKRD42-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PICALM	GO:0006897	endocytosis	22118466
Tgene	PICALM	GO:0006898	receptor-mediated endocytosis	10436022
Tgene	PICALM	GO:0032880	regulation of protein localization	10436022
Tgene	PICALM	GO:0045893	positive regulation of transcription, DNA-templated	11425879
Tgene	PICALM	GO:0048261	negative regulation of receptor-mediated endocytosis	10436022
Tgene	PICALM	GO:1905224	clathrin-coated pit assembly	16262731

Fusion gene breakpoints across ANKRD42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-7422-01A	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393389	ANKRD42	chr11	82909684	+	ENST00000532317	PICALM	chr11	85670103	-	2531	1154	32	1168	378
ENST00000393389	ANKRD42	chr11	82909684	+	ENST00000356360	PICALM	chr11	85670103	-	1228	1154	32	1168	378
ENST00000260047	ANKRD42	chr11	82909684	+	ENST00000532317	PICALM	chr11	85670103	-	2394	1017	150	1031	293
ENST00000260047	ANKRD42	chr11	82909684	+	ENST00000356360	PICALM	chr11	85670103	-	1091	1017	150	1031	293
ENST00000526731	ANKRD42	chr11	82909684	+	ENST00000532317	PICALM	chr11	85670103	-	2021	644	576	205	123
ENST00000526731	ANKRD42	chr11	82909684	+	ENST00000356360	PICALM	chr11	85670103	-	718	644	576	205	123
ENST00000531895	ANKRD42	chr11	82909684	+	ENST00000532317	PICALM	chr11	85670103	-	1872	495	427	56	123
ENST00000531895	ANKRD42	chr11	82909684	+	ENST00000356360	PICALM	chr11	85670103	-	569	495	427	56	123
ENST00000533342	ANKRD42	chr11	82909684	+	ENST00000532317	PICALM	chr11	85670103	-	1625	248	26	262	78
ENST00000533342	ANKRD42	chr11	82909684	+	ENST00000356360	PICALM	chr11	85670103	-	322	248	26	262	78

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393389	ENST00000532317	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.7582044	0.24179566
ENST00000393389	ENST00000356360	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.43496865	0.56503135
ENST00000260047	ENST00000532317	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.68972266	0.31027734
ENST00000260047	ENST00000356360	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.38373676	0.6162633
ENST00000526731	ENST00000532317	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.7190709	0.28092906
ENST00000526731	ENST00000356360	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.43616393	0.5638361
ENST00000531895	ENST00000532317	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.31233755	0.6876624
ENST00000531895	ENST00000356360	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.1829078	0.8170922
ENST00000533342	ENST00000532317	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.30648735	0.6935127
ENST00000533342	ENST00000356360	ANKRD42	chr11	82909684	+	PICALM	chr11	85670103	-	0.15115194	0.848848

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4731_4731_1_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000260047_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=293AA_BP=
MRRVSENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGD
RVSDDRSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGE
EGRCRCSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINEL

--------------------------------------------------------------

>4731_4731_2_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000260047_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=293AA_BP=
MRRVSENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGD
RVSDDRSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGE
EGRCRCSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINEL

--------------------------------------------------------------

>4731_4731_3_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000393389_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=378AA_BP=
MERDSEKVPAEGGRRYGDSQGVADEDGGRRTSHHVWRINGLHGHSGAESRERVSDDGERKCEESDRRSRVAAGSLSADAGFSRSDLRRVS
ENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGDRVSDD
RSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGEEGRCR
CSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHK

--------------------------------------------------------------

>4731_4731_4_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000393389_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=378AA_BP=
MERDSEKVPAEGGRRYGDSQGVADEDGGRRTSHHVWRINGLHGHSGAESRERVSDDGERKCEESDRRSRVAAGSLSADAGFSRSDLRRVS
ENLGHCRSVSRERVRGDSGHSHSCSWERVRGDSTFCSSDVNFSEVGGHQTTDSRGTAREDRGLRLSGPWEGVSDIRDPRTSDFGDRVSDD
RSRRFSGSWEGGSVEGGHSVGSSWEEVSGDRGYAASDSSGVSGSEDASYRFSGFWERESEDEGFRCSFWERAREDLGPRPSDDGEEGRCR
CSGSWVRASEDRRSIRGLDSTPPQSRRCCAMPGVANSGPSTSSRETANPCSRKKVHFGSIHDAVRAGDVKQLSEIVVRGASINELDVLHK

--------------------------------------------------------------

>4731_4731_5_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000526731_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------

>4731_4731_6_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000526731_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------

>4731_4731_7_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000531895_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------

>4731_4731_8_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000531895_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=123AA_BP=
MLAPRTTISESCFTSPARTASCMLPKCTFFLEQGFAVSLEEVEGPELATPGMAQHLRLWGGVESRPLMLRRSSLALTHEPLQRQRPSSPS

--------------------------------------------------------------

>4731_4731_9_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000533342_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=78AA_BP=

--------------------------------------------------------------

>4731_4731_10_ANKRD42-PICALM_ANKRD42_chr11_82909684_ENST00000533342_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=78AA_BP=

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:82909684/chr11:85670103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANKRD42 Q8N9B4	PICALM Q13492
	FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269\|PubMed:10436022, ECO:0000269\|PubMed:16262731, ECO:0000269\|PubMed:21808019, ECO:0000269\|PubMed:22118466, ECO:0000269\|PubMed:23741335, ECO:0000269\|PubMed:24067654, ECO:0000269\|PubMed:25241929, ECO:0000269\|PubMed:25898166, ECO:0000269\|PubMed:27574975}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

25_60

74.0

199.0

Repeat

Note=ANK 1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

130_159

74.0

199.0

Repeat

Note=ANK 4

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

163_192

74.0

199.0

Repeat

Note=ANK 5

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

200_232

74.0

199.0

Repeat

Note=ANK 6

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

235_265

74.0

199.0

Repeat

Note=ANK 7

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

269_298

74.0

199.0

Repeat

Note=ANK 8

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

302_332

74.0

199.0

Repeat

Note=ANK 9

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

64_93

74.0

199.0

Repeat

Note=ANK 2

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393389

97_126

74.0

199.0

Repeat

Note=ANK 3

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

130_159

390.0

Repeat

Note=ANK 4

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

163_192

390.0

Repeat

Note=ANK 5

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

200_232

390.0

Repeat

Note=ANK 6

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

235_265

390.0

Repeat

Note=ANK 7

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

25_60

390.0

Repeat

Note=ANK 1

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

269_298

390.0

Repeat

Note=ANK 8

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

302_332

390.0

Repeat

Note=ANK 9

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

64_93

390.0

Repeat

Note=ANK 2

Hgene

ANKRD42

chr11:82909684

chr11:85670103

ENST00000393392

97_126

390.0

Repeat

Note=ANK 3

Tgene

PICALM

chr11:82909684

chr11:85670103

ENST00000356360

14_145

628.0

633.0

Domain

ENTH

Tgene

PICALM

chr11:82909684

chr11:85670103

ENST00000393346

14_145

648.0

653.0

Domain

ENTH

Tgene

PICALM

chr11:82909684

chr11:85670103

ENST00000526033

14_145

641.0

646.0

Domain

ENTH

Tgene

PICALM

chr11:82909684

chr11:85670103

ENST00000528398

14_145

547.0

552.0

Domain

ENTH

Tgene

PICALM

chr11:82909684

chr11:85670103

ENST00000532317

14_145

606.0

611.0

Domain

ENTH

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

PICALM

PLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ANKRD42
PICALM

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	PICALM	chr11:82909684	chr11:85670103	ENST00000356360		17	19	221_294	628.0	633.0	PIMREG
Tgene	PICALM	chr11:82909684	chr11:85670103	ENST00000393346		18	20	221_294	648.0	653.0	PIMREG
Tgene	PICALM	chr11:82909684	chr11:85670103	ENST00000526033		18	20	221_294	641.0	646.0	PIMREG
Tgene	PICALM	chr11:82909684	chr11:85670103	ENST00000528398		17	19	221_294	547.0	552.0	PIMREG
Tgene	PICALM	chr11:82909684	chr11:85670103	ENST00000532317		18	20	221_294	606.0	611.0	PIMREG

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Related Drugs to ANKRD42-PICALM

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ANKRD42-PICALM

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PICALM	C0002395	Alzheimer's Disease	2	CTD_human
Tgene	PICALM	C0011265	Presenile dementia	2	CTD_human
Tgene	PICALM	C0276496	Familial Alzheimer Disease (FAD)	2	CTD_human
Tgene	PICALM	C0494463	Alzheimer Disease, Late Onset	2	CTD_human
Tgene	PICALM	C0546126	Acute Confusional Senile Dementia	2	CTD_human
Tgene	PICALM	C0750900	Alzheimer's Disease, Focal Onset	2	CTD_human
Tgene	PICALM	C0750901	Alzheimer Disease, Early Onset	2	CTD_human
Tgene	PICALM	C0234985	Mental deterioration	1	CTD_human
Tgene	PICALM	C0338656	Impaired cognition	1	CTD_human
Tgene	PICALM	C1270972	Mild cognitive disorder	1	CTD_human