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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LPP-CASR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LPP-CASR
FusionPDB ID: 49551
FusionGDB2.0 ID: 49551
HgeneTgene
Gene symbol

LPP

CASR

Gene ID

4026

846

Gene nameLIM domain containing preferred translocation partner in lipomacalcium sensing receptor
Synonyms-CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1|hCasR
Cytomap

3q27.3-q28

3q13.33-q21.1

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerextracellular calcium-sensing receptorparathyroid Ca(2+)-sensing receptor 1parathyroid cell calcium-sensing receptor 1
Modification date2020031320200313
UniProtAcc

Q93052

P41180

Ensembl transtripts involved in fusion geneENST idsENST00000312675, ENST00000448637, 
ENST00000543006, ENST00000471917, 
ENST00000490131, ENST00000498619, 
ENST00000296154, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score41 X 30 X 15=184508 X 9 X 7=504
# samples 5215
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LPP [Title/Abstract] AND CASR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LPP(188202492)-CASR(121972795), # samples:2
Anticipated loss of major functional domain due to fusion event.LPP-CASR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-CASR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-CASR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-CASR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASR

GO:0005513

detection of calcium ion

27434672

TgeneCASR

GO:0006874

cellular calcium ion homeostasis

27434672

TgeneCASR

GO:0007186

G protein-coupled receptor signaling pathway

27434672

TgeneCASR

GO:0070509

calcium ion import

20846291


check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1120-01ALPPchr3

188202492

+CASRchr3

121972795

+
ChimerDB4OVTCGA-23-1120-01ALPPchr3

188202492

-CASRchr3

121980375

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448637LPPchr3188202492-ENST00000490131CASRchr3121980375+33714529231961034
ENST00000448637LPPchr3188202492-ENST00000498619CASRchr3121980375+45314529232261044
ENST00000448637LPPchr3188202492-ENST00000296154CASRchr3121980375+32934529231961034
ENST00000312675LPPchr3188202492-ENST00000490131CASRchr3121980375+347155212332961057
ENST00000312675LPPchr3188202492-ENST00000498619CASRchr3121980375+463155212333261067
ENST00000312675LPPchr3188202492-ENST00000296154CASRchr3121980375+339355212332961057
ENST00000543006LPPchr3188202492-ENST00000490131CASRchr3121980375+3414495932391076
ENST00000543006LPPchr3188202492-ENST00000498619CASRchr3121980375+4574495932691086
ENST00000543006LPPchr3188202492-ENST00000296154CASRchr3121980375+3336495932391076

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448637ENST00000490131LPPchr3188202492-CASRchr3121980375+0.003157470.9968425
ENST00000448637ENST00000498619LPPchr3188202492-CASRchr3121980375+0.0016881070.9983119
ENST00000448637ENST00000296154LPPchr3188202492-CASRchr3121980375+0.0037869970.9962131
ENST00000312675ENST00000490131LPPchr3188202492-CASRchr3121980375+0.0023192890.99768066
ENST00000312675ENST00000498619LPPchr3188202492-CASRchr3121980375+0.0014267060.9985733
ENST00000312675ENST00000296154LPPchr3188202492-CASRchr3121980375+0.0028363240.9971637
ENST00000543006ENST00000490131LPPchr3188202492-CASRchr3121980375+0.0031974050.99680257
ENST00000543006ENST00000498619LPPchr3188202492-CASRchr3121980375+0.0017181650.99828184
ENST00000543006ENST00000296154LPPchr3188202492-CASRchr3121980375+0.0038531450.9961468

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49551_49551_1_LPP-CASR_LPP_chr3_188202492_ENST00000312675_CASR_chr3_121980375_ENST00000296154_length(amino acids)=1057AA_BP=142
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADII
EYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK
IWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESG
DRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTN
NMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTC
CFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELS
YLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVI
WLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGK
FVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSE
DPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHE

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>49551_49551_2_LPP-CASR_LPP_chr3_188202492_ENST00000312675_CASR_chr3_121980375_ENST00000490131_length(amino acids)=1057AA_BP=142
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADII
EYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK
IWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESG
DRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTN
NMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTC
CFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELS
YLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVI
WLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGK
FVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSE
DPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHE

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>49551_49551_3_LPP-CASR_LPP_chr3_188202492_ENST00000312675_CASR_chr3_121980375_ENST00000498619_length(amino acids)=1067AA_BP=142
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADII
EYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK
IWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESG
DRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTN
NMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTFVLSVLQVPFSNCSRDCLAGTR
KGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTP
IVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLC
TFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISF
IPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPS
SSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQ

--------------------------------------------------------------

>49551_49551_4_LPP-CASR_LPP_chr3_188202492_ENST00000448637_CASR_chr3_121980375_ENST00000296154_length(amino acids)=1034AA_BP=119
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIE
KFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVV
GGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSV
ETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINW
HLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNK
CPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQD
WTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFIT
CHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFF
NKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQ
QQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQG

--------------------------------------------------------------

>49551_49551_5_LPP-CASR_LPP_chr3_188202492_ENST00000448637_CASR_chr3_121980375_ENST00000490131_length(amino acids)=1034AA_BP=119
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIE
KFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVV
GGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSV
ETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINW
HLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNK
CPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQD
WTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFIT
CHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFF
NKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQ
QQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQG

--------------------------------------------------------------

>49551_49551_6_LPP-CASR_LPP_chr3_188202492_ENST00000448637_CASR_chr3_121980375_ENST00000498619_length(amino acids)=1044AA_BP=119
MNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPP
PPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIE
KFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVV
GGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSV
ETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINW
HLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTFVLSVLQVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYS
DETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSS
SLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQ
ELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAA
SFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQ
PLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLD

--------------------------------------------------------------

>49551_49551_7_LPP-CASR_LPP_chr3_188202492_ENST00000543006_CASR_chr3_121980375_ENST00000296154_length(amino acids)=1076AA_BP=161
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKS
FLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSS
GPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQE
GAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADI
KKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNC
SRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLG
VFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLN
LQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSML
IFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSL
GGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNS

--------------------------------------------------------------

>49551_49551_8_LPP-CASR_LPP_chr3_188202492_ENST00000543006_CASR_chr3_121980375_ENST00000490131_length(amino acids)=1076AA_BP=161
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKS
FLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSS
GPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQE
GAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADI
KKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNC
SRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLG
VFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLN
LQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSML
IFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSL
GGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNS

--------------------------------------------------------------

>49551_49551_9_LPP-CASR_LPP_chr3_188202492_ENST00000543006_CASR_chr3_121980375_ENST00000498619_length(amino acids)=1086AA_BP=161
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQVSYASSSRLLSNKNQFKS
FLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSS
GPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQE
GAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADI
KKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREPLTFVL
SVLQVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVL
GIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPT
SFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFN
EAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRS
NVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEP
QKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:188202492/chr3:121972795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPP

Q93052

CASR

P41180

FUNCTION: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.FUNCTION: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). {ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416189_324164.01079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416415_417164.01079.0RegionAnion binding
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416542_612164.01079.0RegionCysteine-rich (CR)
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127189_324164.01079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127415_417164.01079.0RegionAnion binding
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127542_612164.01079.0RegionCysteine-rich (CR)
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416636_649164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416671_681164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416701_724164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416746_769164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416793_805164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416829_836164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416863_1078164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127636_649164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127671_681164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127701_724164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127746_769164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127793_805164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127829_836164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127863_1078164.01079.0Topological domainCytoplasmic
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416613_635164.01079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416650_670164.01079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416682_700164.01079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416725_745164.01079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416770_792164.01079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416806_828164.01079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:188202492chr3:121980375ENST0000029615416837_862164.01079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127613_635164.01079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127650_670164.01079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127682_700164.01079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127725_745164.01079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127770_792164.01079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127806_828164.01079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr3:188202492chr3:121980375ENST0000049013127837_862164.01079.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188202492chr3:121980375ENST00000312675-41141_370102.0613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188202492chr3:121980375ENST00000543006-41141_370102.0613.0Compositional biasNote=Pro-rich
HgeneLPPchr3:188202492chr3:121980375ENST00000312675-411414_473102.0613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188202492chr3:121980375ENST00000312675-411474_534102.0613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188202492chr3:121980375ENST00000312675-411535_603102.0613.0DomainLIM zinc-binding 3
HgeneLPPchr3:188202492chr3:121980375ENST00000543006-411414_473102.0613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188202492chr3:121980375ENST00000543006-411474_534102.0613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188202492chr3:121980375ENST00000543006-411535_603102.0613.0DomainLIM zinc-binding 3
TgeneCASRchr3:188202492chr3:121980375ENST000002961541622_188164.01079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:188202492chr3:121980375ENST000002961541666_70164.01079.0RegionAnion binding
TgeneCASRchr3:188202492chr3:121980375ENST000004901312722_188164.01079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr3:188202492chr3:121980375ENST000004901312766_70164.01079.0RegionAnion binding
TgeneCASRchr3:188202492chr3:121980375ENST000002961541620_612164.01079.0Topological domainExtracellular
TgeneCASRchr3:188202492chr3:121980375ENST000004901312720_612164.01079.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
LPPATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, Sestd1, Ppp2r3a, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES, EFTUD2, ESR2, KIAA1429, HDAC2, DYRK1A, SH2D3C, DCP1A, RIN3, ACTB, EZR, GFAP, IMPDH2, KRT19, MAPRE1, PEX14, PFN1, PRPH, SQSTM1, SYNE3, TJP2, VASP, VCL, VIM, ZYX, NAA40, KIAA0408, SLC9A3R2, AJUBA, PLEKHG2, COQ3, SLU7, FHL2, FBXW7, nsp14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LPPall structure
CASR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LPP-CASR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LPP-CASR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPPC0087031Juvenile-Onset Still Disease1CTD_human
HgeneLPPC3495559Juvenile arthritis1CTD_human
HgeneLPPC3714758Juvenile psoriatic arthritis1CTD_human
HgeneLPPC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneLPPC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human