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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LPP-KMT2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LPP-KMT2A
FusionPDB ID: 49568
FusionGDB2.0 ID: 49568
HgeneTgene
Gene symbol

LPP

KMT2A

Gene ID

4026

4297

Gene nameLIM domain containing preferred translocation partner in lipomalysine methyltransferase 2A
Synonyms-ALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS
Cytomap

3q27.3-q28

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionlipoma-preferred partnerLIM proteinlipoma preferred partnerhistone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
Modification date2020031320200319
UniProtAcc

Q93052

Q03164

Ensembl transtripts involved in fusion geneENST idsENST00000312675, ENST00000543006, 
ENST00000448637, ENST00000471917, 
ENST00000354520, ENST00000389506, 
ENST00000420751, ENST00000534358, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score41 X 30 X 15=1845031 X 72 X 3=6696
# samples 5279
** MAII scorelog2(52/18450*10)=-5.14896538280667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(79/6696*10)=-3.08337496948588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LPP [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
LPP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

TgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

TgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

TgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

TgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

TgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722


check buttonFusion gene breakpoints across LPP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..LPPchr3

188478070

+KMT2Achr11

118359328

ChimerKB3..LPPchr3

188584166

+KMT2Achr11

118353210

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312675LPPchr3188478070+ENST00000534358KMT2Achr1111835932813895165612392423039
ENST00000312675LPPchr3188478070+ENST00000389506KMT2Achr1111835932810979165612392333036
ENST00000312675LPPchr3188478070+ENST00000354520KMT2Achr1111835932811758165612392333036
ENST00000543006LPPchr3188478070+ENST00000534358KMT2Achr11118359328138381599991853058
ENST00000543006LPPchr3188478070+ENST00000389506KMT2Achr11118359328109221599991763055
ENST00000543006LPPchr3188478070+ENST00000354520KMT2Achr11118359328117011599991763055

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49568_49568_1_LPP-KMT2A_LPP_chr3_188478070_ENST00000312675_KMT2A_chr11_118359328_ENST00000354520_length(amino acids)=3036AA_BP=511
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPA
DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEPFHKFCLEENERPLEDQLEN
WCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLF
AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLN
SRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGG
QPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPG
EPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHM
AVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNG
LEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFT
ESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSR
RHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGS
SSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLR
GQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPE
FMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIEST
SPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEE
DIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTAT
TRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDT
YNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSS
SISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADH
ISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQT
LPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSG
LLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGS
LNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVT
LTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQ
HVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRF
QLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPK
TVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGIL
HDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMD
LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAAR

--------------------------------------------------------------

>49568_49568_2_LPP-KMT2A_LPP_chr3_188478070_ENST00000312675_KMT2A_chr11_118359328_ENST00000389506_length(amino acids)=3036AA_BP=511
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPA
DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEPFHKFCLEENERPLEDQLEN
WCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLF
AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLN
SRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGG
QPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPG
EPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHM
AVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNG
LEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFT
ESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSR
RHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGS
SSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLR
GQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPE
FMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIEST
SPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEE
DIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTAT
TRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDT
YNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSS
SISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADH
ISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQT
LPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSG
LLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGS
LNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVT
LTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQ
HVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRF
QLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPK
TVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGIL
HDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMD
LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAAR

--------------------------------------------------------------

>49568_49568_3_LPP-KMT2A_LPP_chr3_188478070_ENST00000312675_KMT2A_chr11_118359328_ENST00000534358_length(amino acids)=3039AA_BP=511
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVV
APKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKP
RPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQ
PSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQ
QGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPA
DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEPFHKFCLEENERPLEDQLEN
WCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLF
AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA
LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPK
GPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF
LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSI
GSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHL
HLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI
ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSV
TATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS
VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYV
LQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLD
LGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY
QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESA
EPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT
SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN

--------------------------------------------------------------

>49568_49568_4_LPP-KMT2A_LPP_chr3_188478070_ENST00000543006_KMT2A_chr11_118359328_ENST00000354520_length(amino acids)=3055AA_BP=530
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE
DELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEP
FHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKG
WDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRL
ALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVL
EFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHT
EQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCA
LWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVF
RRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDIN
STVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHE
IVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSS
NLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEP
SSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSK
SFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQ
SKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARAR
SNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKI
SQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSL
ESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLF
EVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPT
PEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPA
TEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHS
FPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTL
INFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVV
SMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQT
TGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQR
SASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVL
PEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNA
RLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPN
DEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYM

--------------------------------------------------------------

>49568_49568_5_LPP-KMT2A_LPP_chr3_188478070_ENST00000543006_KMT2A_chr11_118359328_ENST00000389506_length(amino acids)=3055AA_BP=530
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE
DELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEP
FHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKG
WDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRL
ALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVL
EFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHT
EQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCA
LWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVF
RRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDIN
STVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHE
IVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSS
NLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEP
SSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSK
SFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQ
SKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARAR
SNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKI
SQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSL
ESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLF
EVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPT
PEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPA
TEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHS
FPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTL
INFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVV
SMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQT
TGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQR
SASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVL
PEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNA
RLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPN
DEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYM

--------------------------------------------------------------

>49568_49568_6_LPP-KMT2A_LPP_chr3_188478070_ENST00000543006_KMT2A_chr11_118359328_ENST00000534358_length(amino acids)=3058AA_BP=530
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIHSRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFG
NPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASY
TTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE
DELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEP
FHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKG
WDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAE
WRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYT
SVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREEN
SHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHV
NCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGF
EVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEP
DINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPT
THEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTS
TSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSF
AEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKH
SSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMEN
ESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSA
RARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDL
PKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQL
SSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDM
GLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGV
DPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHL
KPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQH
LHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSN
MTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVL
NVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPS
TQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSS
GQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQV
AVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEAR
SNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEY
NPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:/chr11:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPP

Q93052

KMT2A

Q03164

FUNCTION: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10637295}.FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811138_156470.0613.0Compositional biasPolar residues
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811185_202470.0613.0Compositional biasPro residues
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811204_219470.0613.0Compositional biasPolar residues
HgeneLPPchr3:188478070chr11:118359328ENST0000031267581126_42470.0613.0Compositional biasPolar residues
HgeneLPPchr3:188478070chr11:118359328ENST0000031267581164_78470.0613.0Compositional biasPro residues
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811138_156470.0613.0Compositional biasPolar residues
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811185_202470.0613.0Compositional biasPro residues
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811204_219470.0613.0Compositional biasPolar residues
HgeneLPPchr3:188478070chr11:118359328ENST0000054300681126_42470.0613.0Compositional biasPolar residues
HgeneLPPchr3:188478070chr11:118359328ENST0000054300681164_78470.0613.0Compositional biasPro residues
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811414_473470.0613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811414_473470.0613.0DomainLIM zinc-binding 1
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811132_219470.0613.0RegionDisordered
HgeneLPPchr3:188478070chr11:118359328ENST000003126758111_118470.0613.0RegionDisordered
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811307_387470.0613.0RegionDisordered
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811132_219470.0613.0RegionDisordered
HgeneLPPchr3:188478070chr11:118359328ENST000005430068111_118470.0613.0RegionDisordered
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811307_387470.0613.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351822_18471406.03932.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352096_21181406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352146_21741406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352189_22321406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352275_23201406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352402_24181406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352419_24451406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352526_25941406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352721_27461406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352747_27841406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352785_28211406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353011_30641406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353166_31831406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353195_32221406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353230_32441406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353464_35301406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353563_36061406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361822_18471444.03970.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362096_21181444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362146_21741444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362189_22321444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362275_23201444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362402_24181444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362419_24451444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362526_25941444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362721_27461444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362747_27841444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362785_28211444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363011_30641444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363166_31831444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363195_32221444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363230_32441444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363464_35301444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363563_36061444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361822_18471444.03973.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362096_21181444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362146_21741444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362189_22321444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362275_23201444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362402_24181444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362419_24451444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362526_25941444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362721_27461444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362747_27841444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362785_28211444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363011_30641444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363166_31831444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363195_32221444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363230_32441444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363464_35301444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363563_36061444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351703_17481406.03932.0DomainBromo%3B divergent
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352018_20741406.03932.0DomainFYR N-terminal
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353666_37471406.03932.0DomainFYR C-terminal
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353829_39451406.03932.0DomainSET
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353953_39691406.03932.0DomainPost-SET
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361703_17481444.03970.0DomainBromo%3B divergent
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362018_20741444.03970.0DomainFYR N-terminal
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363666_37471444.03970.0DomainFYR C-terminal
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363829_39451444.03970.0DomainSET
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363953_39691444.03970.0DomainPost-SET
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361703_17481444.03973.0DomainBromo%3B divergent
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362018_20741444.03973.0DomainFYR N-terminal
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363666_37471444.03973.0DomainFYR C-terminal
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363829_39451444.03973.0DomainSET
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363953_39691444.03973.0DomainPost-SET
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351663_17131406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351806_18691406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352081_21331406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352145_22321406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352275_23331406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352373_24601406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352475_26181406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352647_26751406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352713_28211406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208352961_30641406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353166_32441406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353464_36081406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353620_36431406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353785_38081406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208353906_39071406.03932.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361663_17131444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361806_18691444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362081_21331444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362145_22321444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362275_23331444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362373_24601444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362475_26181444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362647_26751444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362713_28211444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069362961_30641444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363166_32441444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363464_36081444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363620_36431444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363785_38081444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069363906_39071444.03970.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361663_17131444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361806_18691444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362081_21331444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362145_22321444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362275_23331444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362373_24601444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362475_26181444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362647_26751444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362713_28211444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589362961_30641444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363166_32441444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363464_36081444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363620_36431444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363785_38081444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589363906_39071444.03973.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351431_14821406.03932.0Zinc fingerPHD-type 1
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351479_15331406.03932.0Zinc fingerPHD-type 2
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351566_16271406.03932.0Zinc fingerPHD-type 3
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351870_19101406.03932.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351931_19781406.03932.0Zinc fingerPHD-type 4
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361479_15331444.03970.0Zinc fingerPHD-type 2
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361566_16271444.03970.0Zinc fingerPHD-type 3
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361870_19101444.03970.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361931_19781444.03970.0Zinc fingerPHD-type 4
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361479_15331444.03973.0Zinc fingerPHD-type 2
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361566_16271444.03973.0Zinc fingerPHD-type 3
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361870_19101444.03973.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361931_19781444.03973.0Zinc fingerPHD-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811474_534470.0613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188478070chr11:118359328ENST00000312675811535_603470.0613.0DomainLIM zinc-binding 3
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811474_534470.0613.0DomainLIM zinc-binding 2
HgeneLPPchr3:188478070chr11:118359328ENST00000543006811535_603470.0613.0DomainLIM zinc-binding 3
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351046_10611406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351249_12721406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351278_13021406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351303_13171406.03932.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835184_2031406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835204_2261406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835236_2531406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835325_3511406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST0000035452083537_581406.03932.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835445_4951406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835535_5561406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835557_5761406.03932.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835713_7311406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835747_7801406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835798_8451406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST0000035452083581_1031406.03932.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835846_8981406.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361046_10611444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361249_12721444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361278_13021444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361303_13171444.03970.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936184_2031444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936204_2261444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936236_2531444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936325_3511444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST0000038950693637_581444.03970.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936445_4951444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936535_5561444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936557_5761444.03970.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936713_7311444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936747_7801444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936798_8451444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST0000038950693681_1031444.03970.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936846_8981444.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361046_10611444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361249_12721444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361278_13021444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361303_13171444.03973.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936184_2031444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936204_2261444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936236_2531444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936325_3511444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST0000053435893637_581444.03973.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936445_4951444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936535_5561444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936557_5761444.03973.0Compositional biasPro residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936713_7311444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936747_7801444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936798_8451444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST0000053435893681_1031444.03973.0Compositional biasPolar residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936846_8981444.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835169_1801406.03932.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835217_2271406.03932.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835301_3091406.03932.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936169_1801444.03970.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936217_2271444.03970.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936301_3091444.03970.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936169_1801444.03973.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936217_2271444.03973.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936301_3091444.03973.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835123_1341406.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835147_1521406.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208356_251406.03932.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936123_1341444.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936147_1521444.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069366_251444.03970.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936123_1341444.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936147_1521444.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589366_251444.03973.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351038_10661406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351106_11661406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351200_13751406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835132_2531406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351_1081406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835301_3521406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835445_5851406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835713_7801406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000354520835798_9491406.03932.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361038_10661444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361106_11661444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361200_13751444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936132_2531444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361_1081444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936301_3521444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936445_5851444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936713_7801444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000389506936798_9491444.03970.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361038_10661444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361106_11661444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361200_13751444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936132_2531444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361_1081444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936301_3521444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936445_5851444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936713_7801444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST00000534358936798_9491444.03973.0RegionDisordered
TgeneKMT2Achr3:188478070chr11:118359328ENST000003545208351147_11951406.03932.0Zinc fingerCXXC-type
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361147_11951444.03970.0Zinc fingerCXXC-type
TgeneKMT2Achr3:188478070chr11:118359328ENST000003895069361431_14821444.03970.0Zinc fingerPHD-type 1
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361147_11951444.03973.0Zinc fingerCXXC-type
TgeneKMT2Achr3:188478070chr11:118359328ENST000005343589361431_14821444.03973.0Zinc fingerPHD-type 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1243)LPPchr3188478070+KMT2Achr11118359328
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPP
KSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYK
QPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKT
LEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVT
GHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPAS
YTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVS
GQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGG
RNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDP
VSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPA
DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAV
EKKAYCEPCYIFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCH
VCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRC
KSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYES
KMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWR
LALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSR
SSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKI
IQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVS
SNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPG
EPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDS
ANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRC
EFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKG
EVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGI
LNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDI
NSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGS
CYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLL
SSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTA
TDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGS
SSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAP
QVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHT
DSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSC
KETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVS
SDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENES
QSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDS
QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTP
LYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYN
FTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTAT
TRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNC
HSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDS
DNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGL
DSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSV
LTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDP
TPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQV
PVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQ
NMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTT
GLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSG
LLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKK
LAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVP
NIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSG
LASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLI
KASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQ
TTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNF
TQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGP
TKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGT
PGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPK
TVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICA
ESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQ
LSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLAS
KHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGV
YRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCY
MFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRK
3036
PDB file (1244)LPPchr3188478070+KMT2Achr11118359328
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLIPTMSHPSWLPP
KSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYK
QPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKT
LEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVT
GHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPAS
YTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVS
GQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGG
RNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDP
VSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPA
DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAV
EKKAYCEPCYIFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCH
VCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRC
KSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYES
KMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPA
EWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESI
PSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDI
VKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPN
KVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPK
GPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYG
DDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQ
LRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDL
IKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDC
LGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVE
PDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQT
SGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGD
PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTT
GTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPK
LAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRD
QHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGK
KSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCN
NVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKME
NESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSC
QDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFG
LTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLY
YYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSV
TATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKM
DNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLK
SDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEG
LGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSD
LSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPG
VDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPG
LQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIV
VNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLT
LTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRK
NKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHR
TVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGS
VSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISN
LLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLP
STQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQV
SNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSV
PGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSG
TGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESA
EPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQ
ICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFL
IEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNF
LASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEA
VGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGI
GCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFA
3039
PDB file (1246)LPPchr3188478070+KMT2Achr11118359328
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIH
SRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQ
PPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP
PPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPR
PPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGP
IPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS
GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYA
PNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQ
NPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE
DELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVD
CFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEPFHKFCLEENE
RPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNY
PTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFA
KGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLP
ESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYR
QAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRK
MDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMER
VFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHT
EQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPP
PGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDD
DGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNC
VFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGL
EPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKR
CVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTA
EIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPS
AGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMR
TGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSS
NLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSK
SSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEA
LSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSII
NEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEF
MDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQA
PRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASEN
PGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKR
RYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQ
VDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKI
SQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEK
EHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTST
PSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALG
ESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSS
ISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITE
KSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQ
GHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAV
QTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSV
METNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHS
FPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATP
SSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPN
HPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAA
GTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTL
TNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQT
PSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTG
IHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGG
SPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSS
SEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVL
PEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKK
PKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGV
NGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSA
RAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDL
PMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIR
SIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCY
SRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKC
3055
PDB file (1248)LPPchr3188478070+KMT2Achr11118359328
MRLRDRAEDRTWSSDSLCSAFFIVPLDAHQREDLFPQLHCSWLNLVSTIH
SRSQLSEIPTMSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQ
PPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPP
PPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPR
PPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGP
IPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS
GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYA
PNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQ
NPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE
DELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVD
CFTCIICNNKLRGQPFYAVEKKAYCEPCYIFVYCQVCCEPFHKFCLEENE
RPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNY
PTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFA
KGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILS
NLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLL
RYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGV
KRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQ
MERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREEN
SHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPEL
NPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVF
EDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRA
KNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFL
NGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDA
RKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQ
NTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRP
LPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMS
PMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTS
TSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVL
SSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSS
KEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRS
SIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLK
PEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKE
LQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISA
SENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGS
FKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSA
EGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDL
PKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDA
GEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVH
TSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQ
ALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSV
SSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVT
ITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGS
VEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISN
AAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSST
PSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQH
LHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTV
ATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQ
LPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAA
TAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGH
VTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGT
SQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLAS
KTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTS
PGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLR
TSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQV
AVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESIT
EKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSF
AGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPH
GSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATS
MDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGN
VIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEP
NCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA
3058


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LPP_pLDDT.png
all structure
all structure
KMT2A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LPP_KMT2A_1246_pLDDT_and_active_sites.png (AA BP:)
all structure
LPP_KMT2A_1248_pLDDT_and_active_sites.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
12461.0213031.0751138.4170.6940.6620.7830.5870.8040.7290.709Chain A: 946,947,948,949,954,955,956,957,958,960,9
65,977,978,980,981,982,983,984,1015,1084,1085,1087
,1088,1089,1090,1091,1092,1093,1096,1100,1104,1105
,1106,1107,1108,1109,1110,1111,1112,1113,1138,1139
,1140,1141,1142,1150,1152,1700,1701,1702,1703,1704
,1708,1783,1784,1785,1786,1787,2795,2796,2797,2798
,2799,2800,2811,2812,2815,2816,2833,2871
12481.0013491.0131085.5950.5660.70.9330.4021.0630.3780.848Chain A: 1662,1663,2850,2856,2857,2858,2859,2860,2
861,2862,2864,2865,2866,2867,2868,2871,2873,2875,2
876,2877,2924,2925,2926,2927,2928,2929,2930,2947,2
954,2957,2968,2969,2970,2971,2972,2973,2974,2975,2
981,2985,2986,2991,2992,2993,2994,2995,2996,3000,3
003,3004,3005,3006,3015,3031,3032,3033,3034,3045,3
046,3047,3048,3057

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KMT2APPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,
LPPATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, Sestd1, Ppp2r3a, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES, EFTUD2, ESR2, KIAA1429, HDAC2, DYRK1A, SH2D3C, DCP1A, RIN3, ACTB, EZR, GFAP, IMPDH2, KRT19, MAPRE1, PEX14, PFN1, PRPH, SQSTM1, SYNE3, TJP2, VASP, VCL, VIM, ZYX, NAA40, KIAA0408, SLC9A3R2, AJUBA, PLEKHG2, COQ3, SLU7, FHL2, FBXW7, nsp14,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LPPall structure
KMT2Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LPP-KMT2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LPP-KMT2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLPPC0087031Juvenile-Onset Still Disease1CTD_human
HgeneLPPC3495559Juvenile arthritis1CTD_human
HgeneLPPC3714758Juvenile psoriatic arthritis1CTD_human
HgeneLPPC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneLPPC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
TgeneKMT2AC0023418leukemia2CTD_human
TgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
TgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneKMT2AC0023470Myeloid Leukemia2CTD_human
TgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
TgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
TgeneKMT2AC0001418Adenocarcinoma1CTD_human
TgeneKMT2AC0004403Autosome Abnormalities1CTD_human
TgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneKMT2AC0005695Bladder Neoplasm1CTD_human
TgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
TgeneKMT2AC0008625Chromosome Aberrations1CTD_human
TgeneKMT2AC0023448Lymphoid leukemia1CTD_human
TgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
TgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
TgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
TgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
TgeneKMT2AC0036341Schizophrenia1PSYGENET
TgeneKMT2AC0038356Stomach Neoplasms1CTD_human
TgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
TgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
TgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
TgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
TgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
TgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
TgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
TgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
TgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
TgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneKMT2AC2239176Liver carcinoma1CTD_human
TgeneKMT2AC2930974Acute erythroleukemia1CTD_human
TgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human