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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRIG3-ROS1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRIG3-ROS1
FusionPDB ID: 49697
FusionGDB2.0 ID: 49697
HgeneTgene
Gene symbol

LRIG3

ROS1

Gene ID

121227

6098

Gene nameleucine rich repeats and immunoglobulin like domains 3ROS proto-oncogene 1, receptor tyrosine kinase
SynonymsLIG3MCF3|ROS|c-ros-1
Cytomap

12q14.1

6q22.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 3LIG-3proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
Modification date2020031320200314
UniProtAcc

Q6UXM1

P08922

Ensembl transtripts involved in fusion geneENST idsENST00000320743, ENST00000379141, 
ENST00000368507, ENST00000368508, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 8=64018 X 20 X 5=1800
# samples 1220
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1800*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRIG3 [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRIG3(59270227)-ROS1(117642558), # samples:3
Anticipated loss of major functional domain due to fusion event.LRIG3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG3-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROS1

GO:0001558

regulation of cell growth

16885344

TgeneROS1

GO:0006468

protein phosphorylation

16885344

TgeneROS1

GO:0032006

regulation of TOR signaling

16885344


check buttonFusion gene breakpoints across LRIG3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..LRIG3chr12

59270226

-ROS1chr6

117642557

-
ChiTaRS5.0N/AAB795247LRIG3chr12

59270227

-ROS1chr6

117642558

-
ChiTaRS5.0N/AAB795248LRIG3chr12

59270227

-ROS1chr6

117642558

-
ChiTaRS5.0N/AJB625499LRIG3chr12

59270227

-ROS1chr6

117642558

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379141LRIG3chr1259270226-ENST00000368508ROS1chr6117642557-41742579439811325
ENST00000379141LRIG3chr1259270226-ENST00000368507ROS1chr6117642557-41742579439811325
ENST00000320743LRIG3chr1259270226-ENST00000368508ROS1chr6117642557-4577298222143841387
ENST00000320743LRIG3chr1259270226-ENST00000368507ROS1chr6117642557-4577298222143841387
ENST00000379141LRIG3chr1259270227-ENST00000368508ROS1chr6117642558-41742579439811325
ENST00000379141LRIG3chr1259270227-ENST00000368507ROS1chr6117642558-41742579439811325
ENST00000320743LRIG3chr1259270227-ENST00000368508ROS1chr6117642558-4577298222143841387
ENST00000320743LRIG3chr1259270227-ENST00000368507ROS1chr6117642558-4577298222143841387

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379141ENST00000368508LRIG3chr1259270227-ROS1chr6117642558-0.0011242290.9988758
ENST00000379141ENST00000368507LRIG3chr1259270227-ROS1chr6117642558-0.0011242290.9988758
ENST00000320743ENST00000368508LRIG3chr1259270227-ROS1chr6117642558-0.0016580770.9983419
ENST00000320743ENST00000368507LRIG3chr1259270227-ROS1chr6117642558-0.0016580770.9983419

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49697_49697_1_LRIG3-ROS1_LRIG3_chr12_59270226_ENST00000320743_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1387AA_BP=920
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARL
PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS
ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR
NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN
TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF
ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT
PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS
FLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP
TCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLL
LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP
ESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPH

--------------------------------------------------------------

>49697_49697_2_LRIG3-ROS1_LRIG3_chr12_59270226_ENST00000320743_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1387AA_BP=920
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARL
PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS
ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR
NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN
TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF
ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT
PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS
FLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP
TCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLL
LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP
ESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPH

--------------------------------------------------------------

>49697_49697_3_LRIG3-ROS1_LRIG3_chr12_59270226_ENST00000379141_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=1325AA_BP=858
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG
NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL
ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC
QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS
ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ
CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIED
IGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS
DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNL
PADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANAC
YAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQ
LGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGD
FGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWN
LMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECG

--------------------------------------------------------------

>49697_49697_4_LRIG3-ROS1_LRIG3_chr12_59270226_ENST00000379141_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=1325AA_BP=858
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG
NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL
ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC
QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS
ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ
CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIED
IGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS
DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNL
PADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANAC
YAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQ
LGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGD
FGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWN
LMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECG

--------------------------------------------------------------

>49697_49697_5_LRIG3-ROS1_LRIG3_chr12_59270227_ENST00000320743_ROS1_chr6_117642558_ENST00000368507_length(amino acids)=1387AA_BP=920
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARL
PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS
ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR
NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN
TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF
ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT
PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS
FLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP
TCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLL
LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP
ESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPH

--------------------------------------------------------------

>49697_49697_6_LRIG3-ROS1_LRIG3_chr12_59270227_ENST00000320743_ROS1_chr6_117642558_ENST00000368508_length(amino acids)=1387AA_BP=920
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARL
PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS
ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR
NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN
TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF
ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT
PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS
FLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP
TCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLL
LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRK
ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP
ESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN
FFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPH

--------------------------------------------------------------

>49697_49697_7_LRIG3-ROS1_LRIG3_chr12_59270227_ENST00000379141_ROS1_chr6_117642558_ENST00000368507_length(amino acids)=1325AA_BP=858
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG
NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL
ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC
QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS
ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ
CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIED
IGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS
DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNL
PADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANAC
YAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQ
LGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGD
FGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWN
LMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECG

--------------------------------------------------------------

>49697_49697_8_LRIG3-ROS1_LRIG3_chr12_59270227_ENST00000379141_ROS1_chr6_117642558_ENST00000368508_length(amino acids)=1325AA_BP=858
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG
NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL
ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC
QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS
ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ
CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIED
IGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS
DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNL
PADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANAC
YAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQ
LGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGD
FGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWN
LMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:59270227/chr6:117642558)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG3

Q6UXM1

ROS1

P08922

FUNCTION: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}.FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-161938_74898.33333333333341120.0DomainNote=LRRNT
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619444_495898.33333333333341120.0DomainNote=LRRCT
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619499_598898.33333333333341120.0DomainNote=Ig-like C2-type 1
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619603_692898.33333333333341120.0DomainNote=Ig-like C2-type 2
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619697_783898.33333333333341120.0DomainNote=Ig-like C2-type 3
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-161938_74838.33333333333341060.0DomainNote=LRRNT
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619444_495838.33333333333341060.0DomainNote=LRRCT
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619499_598838.33333333333341060.0DomainNote=Ig-like C2-type 1
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619603_692838.33333333333341060.0DomainNote=Ig-like C2-type 2
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619697_783838.33333333333341060.0DomainNote=Ig-like C2-type 3
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619122_142898.33333333333341120.0RepeatNote=LRR 3
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619146_167898.33333333333341120.0RepeatNote=LRR 4
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619168_189898.33333333333341120.0RepeatNote=LRR 5
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619193_214898.33333333333341120.0RepeatNote=LRR 6
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619216_237898.33333333333341120.0RepeatNote=LRR 7
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619240_261898.33333333333341120.0RepeatNote=LRR 8
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619264_285898.33333333333341120.0RepeatNote=LRR 9
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619288_309898.33333333333341120.0RepeatNote=LRR 10
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619312_333898.33333333333341120.0RepeatNote=LRR 11
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619336_357898.33333333333341120.0RepeatNote=LRR 12
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619360_382898.33333333333341120.0RepeatNote=LRR 13
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619387_408898.33333333333341120.0RepeatNote=LRR 14
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619411_432898.33333333333341120.0RepeatNote=LRR 15
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-161975_96898.33333333333341120.0RepeatNote=LRR 1
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-161999_120898.33333333333341120.0RepeatNote=LRR 2
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619122_142838.33333333333341060.0RepeatNote=LRR 3
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619146_167838.33333333333341060.0RepeatNote=LRR 4
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619168_189838.33333333333341060.0RepeatNote=LRR 5
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619193_214838.33333333333341060.0RepeatNote=LRR 6
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619216_237838.33333333333341060.0RepeatNote=LRR 7
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619240_261838.33333333333341060.0RepeatNote=LRR 8
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619264_285838.33333333333341060.0RepeatNote=LRR 9
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619288_309838.33333333333341060.0RepeatNote=LRR 10
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619312_333838.33333333333341060.0RepeatNote=LRR 11
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619336_357838.33333333333341060.0RepeatNote=LRR 12
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619360_382838.33333333333341060.0RepeatNote=LRR 13
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619387_408838.33333333333341060.0RepeatNote=LRR 14
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619411_432838.33333333333341060.0RepeatNote=LRR 15
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-161975_96838.33333333333341060.0RepeatNote=LRR 1
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-161999_120838.33333333333341060.0RepeatNote=LRR 2
HgeneLRIG3chr12:59270227chr6:117642558ENST00000320743-1619810_830898.33333333333341120.0TransmembraneHelical
HgeneLRIG3chr12:59270227chr6:117642558ENST00000379141-1619810_830838.33333333333341060.0TransmembraneHelical
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431945_22221880.33333333333332348.0DomainProtein kinase
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431951_19591880.33333333333332348.0Nucleotide bindingATP
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431883_23471880.33333333333332348.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROS1chr12:59270227chr6:117642558ENST000003685083343101_1961880.33333333333332348.0DomainFibronectin type-III 1
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431043_11501880.33333333333332348.0DomainFibronectin type-III 5
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431450_15561880.33333333333332348.0DomainFibronectin type-III 6
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431557_16561880.33333333333332348.0DomainFibronectin type-III 7
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431658_17511880.33333333333332348.0DomainFibronectin type-III 8
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431752_18541880.33333333333332348.0DomainFibronectin type-III 9
TgeneROS1chr12:59270227chr6:117642558ENST000003685083343197_2851880.33333333333332348.0DomainFibronectin type-III 2
TgeneROS1chr12:59270227chr6:117642558ENST000003685083343557_6711880.33333333333332348.0DomainFibronectin type-III 3
TgeneROS1chr12:59270227chr6:117642558ENST000003685083343947_10421880.33333333333332348.0DomainFibronectin type-III 4
TgeneROS1chr12:59270227chr6:117642558ENST00000368508334328_18591880.33333333333332348.0Topological domainExtracellular
TgeneROS1chr12:59270227chr6:117642558ENST0000036850833431860_18821880.33333333333332348.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (887)CIF file (887) >>>887.cifLRIG3chr1259270226-ROS1chr6117642557-
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIK
ASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH
LKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNL
ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA
LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ
ELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTL
HIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRR
LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLH
LNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL
LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSS
YSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDG
GTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANAT
LTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVT
ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTC
DSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC
SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGF
FLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANAC
YAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGS
GEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQ
YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLER
MHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGL
LPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLN
YVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFF
LNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGL
NYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVA
1325
3D view using mol* of 887 (AA BP:)
PDB file (904) >>>904.pdbFusion protein BP residue: 920
CIF file (904) >>>904.cif		LRIG3chr1259270226-ROS1chr6117642557-
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSD
SGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVAR
LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL
AGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNR
VTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIK
NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI
TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDD
SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM
NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLL
KGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDS
PMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGK
YQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVG
HPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA
QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKL
NWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERG
NVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVV
IIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVWHRRLKNQKSAKEGVTVLINEDKELAELR
GLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVY
EGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL
KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC
VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY
KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQ
PYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR
IQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMP
VALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPH
1387
3D view using mol* of 904 (AA BP:920)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
ROS1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LRIG3_ROS1_887_pLDDT_and_active_sites.png (AA BP:)
all structure
LRIG3_ROS1_887_violinplot.png (AA BP:)
all structure
LRIG3_ROS1_904_pLDDT.png (AA BP:920)
all structure
LRIG3_ROS1_904_pLDDT_and_active_sites.png (AA BP:920)
all structure
LRIG3_ROS1_904_violinplot.png (AA BP:920)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
LRIG3_ROS1_904.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
8871.078931.131180.4180.350.7561.0281.740.7042.4730.525Chain A: 14,16,17,20,21,24,25,28,41,45,46,47,48,49
,50,53
9041.0594901.0981616.9020.510.7370.9561.1130.8711.2780.589Chain A: 635,636,637,640,641,643,645,680,682,684,7
16,794,795,963,964,965,966,967,969,973,984,985,986
,988,989,990,991,992,994,995,996,997,998,999,1001,
1003,1005,1014,1016,1018,1020,1021,1022,1029,1030,
1032,1033,1034,1036,1037,1039,1040,1041,1043,1050,
1066,1067,1068,1069,1070,1071,1072,1073,1075,1076,
1077,1079,1080,1082,1083,1115,1117,1118,1119,1123,
1124,1126,1141,1142,1143,1144,1145,1147,1148,1149,
1150,1151,1152,1154,1155,1156,1157,1158,1161,1162,
1163,1164

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
LRIG3CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3, EGFR, ERBB2, ERBB4, KIAA1429, MTDH, PSMD14, ORF3a, E, M, nsp4, nsp6, nsp9, ORF6, ORF7a, ORF7b, TRIM66, LMO7, LIMCH1, ELOVL5, GJA1, HSD17B11, METTL7A, STX4, PDE3A, CLEC12B, SPSB4, OR10H1, CLGN, FBXO2, TMPRSS13, NRSN1, RLN1, RARRES1, LRRC4C, CLEC4A, SPSB2, ANPEP, DPP4, TMPRSS4,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRIG3all structure
ROS1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRIG3-ROS1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRIG3-ROS1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
LRIG3ROS1Lung AdenocarcinomaMyCancerGenome
LRIG3ROS1Dedifferentiated LiposarcomaMyCancerGenome
LRIG3ROS1Breast Invasive Ductal CarcinomaMyCancerGenome
LRIG3ROS1Anaplastic GangliogliomaMyCancerGenome
LRIG3ROS1Cancer Of Unknown PrimaryMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneROS1C0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneROS1C0017638Glioma1CTD_human
TgeneROS1C0025202melanoma1CTD_human
TgeneROS1C0152013Adenocarcinoma of lung (disorder)1CGI;CTD_human
TgeneROS1C0259783mixed gliomas1CTD_human
TgeneROS1C0555198Malignant Glioma1CTD_human