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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ABL1-SLC38A10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ABL1-SLC38A10
	FusionPDB ID: 497
	FusionGDB2.0 ID: 497
		Hgene	Tgene
	Gene symbol	ABL1	SLC38A10
	Gene ID	25	124565
	Gene name	ABL proto-oncogene 1, non-receptor tyrosine kinase	solute carrier family 38 member 10
	Synonyms	ABL\|BCR-ABL\|CHDSKM\|JTK7\|bcr/abl\|c-ABL\|c-ABL1\|p150\|v-abl	PP1744
	Cytomap	9q34.12	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncated	putative sodium-coupled neutral amino acid transporter 10
	Modification date	20200327	20200313
	UniProtAcc	P00519	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000318560,	ENST00000546352, ENST00000288439, ENST00000374759,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 55 X 13=15015	7 X 5 X 6=210
	# samples	68	8
	** MAII score	log2(68/15015*10)=-4.46472591830681 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ABL1 [Title/Abstract] AND SLC38A10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ABL1(133730483)-SLC38A10(79246427), # samples:1
Anticipated loss of major functional domain due to fusion event.	ABL1-SLC38A10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABL1-SLC38A10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABL1-SLC38A10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABL1-SLC38A10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABL1	GO:0006974	cellular response to DNA damage stimulus	15657060
Hgene	ABL1	GO:0006975	DNA damage induced protein phosphorylation	18280240
Hgene	ABL1	GO:0018108	peptidyl-tyrosine phosphorylation	7590236\|9144171\|10713049\|11121037
Hgene	ABL1	GO:0038083	peptidyl-tyrosine autophosphorylation	10518561
Hgene	ABL1	GO:0042770	signal transduction in response to DNA damage	9037071\|15657060
Hgene	ABL1	GO:0043065	positive regulation of apoptotic process	9037071
Hgene	ABL1	GO:0046777	protein autophosphorylation	10713049
Hgene	ABL1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	15657060
Hgene	ABL1	GO:0051353	positive regulation of oxidoreductase activity	12893824
Hgene	ABL1	GO:0051444	negative regulation of ubiquitin-protein transferase activity	20823226
Hgene	ABL1	GO:0070301	cellular response to hydrogen peroxide	10713049
Hgene	ABL1	GO:0071103	DNA conformation change	9558345
Hgene	ABL1	GO:0071901	negative regulation of protein serine/threonine kinase activity	11121037
Hgene	ABL1	GO:1990051	activation of protein kinase C activity	10713049
Hgene	ABL1	GO:2001020	regulation of response to DNA damage stimulus	9461559

Fusion gene breakpoints across ABL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC38A10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-ZG-A9LN-01A	ABL1	chr9	133730483	-	SLC38A10	chr17	79246427	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000318560	ABL1	chr9	133730483	-	ENST00000374759	SLC38A10	chr17	79246427	-	3934	930	270	3377	1035
ENST00000318560	ABL1	chr9	133730483	-	ENST00000288439	SLC38A10	chr17	79246427	-	2380	930	270	2360	696

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000318560	ENST00000374759	ABL1	chr9	133730483	-	SLC38A10	chr17	79246427	-	0.004973135	0.9950269
ENST00000318560	ENST00000288439	ABL1	chr9	133730483	-	SLC38A10	chr17	79246427	-	0.005622948	0.9943771

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>497_497_1_ABL1-SLC38A10_ABL1_chr9_133730483_ENST00000318560_SLC38A10_chr17_79246427_ENST00000288439_length(amino acids)=696AA_BP=3
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKEN
LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSS
GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMG
SLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREK
PKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGV
QGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGE
KAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEGKASALQPPASGPGSGSPLPQPWGDA

--------------------------------------------------------------

>497_497_2_ABL1-SLC38A10_ABL1_chr9_133730483_ENST00000318560_SLC38A10_chr17_79246427_ENST00000374759_length(amino acids)=1035AA_BP=3
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKEN
LLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSS
GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGGILIPNVETILGLTGATMG
SLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREK
PKLPKEREELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVVDEGQDREVPEENKPPSRHAGGKAPGV
QGQMAPPLPDSEREKQEPEQGEVGKRPGQAQALEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGE
KAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQAASQLEEAGRAEMLDHAVLLQVIKEQQVQQKR
LLDQQEKLLAVIEEQHKEIHQQRQEDEEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDLNQRSLE
HSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPEQVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKK
PGKEVAATGTSILKEANWLVAGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQQGHRLDHGGHLE
MRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQRPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133730483/chr17:79246427)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABL1 P00519	.
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250\|UniProtKB:P00520, ECO:0000269\|PubMed:10391250, ECO:0000269\|PubMed:11971963, ECO:0000269\|PubMed:12379650, ECO:0000269\|PubMed:12531427, ECO:0000269\|PubMed:12672821, ECO:0000269\|PubMed:15031292, ECO:0000269\|PubMed:15556646, ECO:0000269\|PubMed:15657060, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16424036, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:16943190, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:17623672, ECO:0000269\|PubMed:18328268, ECO:0000269\|PubMed:18945674, ECO:0000269\|PubMed:19891780, ECO:0000269\|PubMed:20357770, ECO:0000269\|PubMed:20417104, ECO:0000269\|PubMed:28428613, ECO:0000269\|PubMed:9037071, ECO:0000269\|PubMed:9144171, ECO:0000269\|PubMed:9461559}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

18_22

183.0

1131.0

Compositional bias

Note=Poly-Ser

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

61_121

183.0

1131.0

Domain

SH3

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

1_60

183.0

1131.0

Region

Note=CAP

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

323_343

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

345_365

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

378_398

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

323_343

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

345_365

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

378_398

304.0

1120.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

605_609

183.0

1131.0

Compositional bias

Note=Poly-Lys

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

782_1019

183.0

1131.0

Compositional bias

Note=Pro-rich

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

897_903

183.0

1131.0

Compositional bias

Note=Poly-Pro

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

127_217

183.0

1131.0

Domain

SH2

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

242_493

183.0

1131.0

Domain

Protein kinase

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

1090_1100

183.0

1131.0

Motif

Nuclear export signal

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

381_405

183.0

1131.0

Motif

Note=Kinase activation loop

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

709_715

183.0

1131.0

Motif

Nuclear localization signal 2

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

762_769

183.0

1131.0

Motif

Nuclear localization signal 3

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

248_256

183.0

1131.0

Nucleotide binding

Note=ATP

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

316_322

183.0

1131.0

Nucleotide binding

Note=ATP

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

869_968

183.0

1131.0

Region

DNA-binding

Hgene

ABL1

chr9:133730483

chr17:79246427

ENST00000318560

953_1130

183.0

1131.0

Region

Note=F-actin-binding

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

120_140

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

153_173

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

229_249

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

272_292

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

36_58

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

4_24

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000288439

84_104

304.0

781.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

120_140

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

153_173

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

229_249

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

272_292

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

36_58

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

4_24

304.0

1120.0

Transmembrane

Helical

Tgene

SLC38A10

chr9:133730483

chr17:79246427

ENST00000374759

84_104

304.0

1120.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ABL1
SLC38A10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ABL1-SLC38A10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ABL1-SLC38A10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ABL1	C0023473	Myeloid Leukemia, Chronic	3	CGI;CTD_human;ORPHANET
Hgene	ABL1	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Hgene	ABL1	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Hgene	ABL1	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CGI;CTD_human
Hgene	ABL1	C0001418	Adenocarcinoma	1	CTD_human
Hgene	ABL1	C0003706	Arachnodactyly	1	GENOMICS_ENGLAND
Hgene	ABL1	C0005941	Bone Diseases, Developmental	1	CTD_human
Hgene	ABL1	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	ABL1	C0006413	Burkitt Lymphoma	1	ORPHANET
Hgene	ABL1	C0014859	Esophageal Neoplasms	1	CTD_human
Hgene	ABL1	C0015544	Failure to Thrive	1	CTD_human
Hgene	ABL1	C0018798	Congenital Heart Defects	1	CTD_human
Hgene	ABL1	C0023903	Liver neoplasms	1	CTD_human
Hgene	ABL1	C0027659	Neoplasms, Experimental	1	CTD_human
Hgene	ABL1	C0032927	Precancerous Conditions	1	CTD_human
Hgene	ABL1	C0039075	Syndactyly	1	GENOMICS_ENGLAND
Hgene	ABL1	C0151491	Congenital musculoskeletal anomalies	1	CTD_human
Hgene	ABL1	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	ABL1	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	ABL1	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	ABL1	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	ABL1	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	ABL1	C0265610	Clinodactyly of fingers	1	GENOMICS_ENGLAND
Hgene	ABL1	C0282313	Condition, Preneoplastic	1	CTD_human
Hgene	ABL1	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	ABL1	C0546837	Malignant neoplasm of esophagus	1	CTD_human
Hgene	ABL1	C0596263	Carcinogenesis	1	CTD_human
Hgene	ABL1	C0678222	Breast Carcinoma	1	CTD_human
Hgene	ABL1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	ABL1	C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Hgene	ABL1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	ABL1	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1	CGI;ORPHANET
Hgene	ABL1	C4539857	CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME	1	GENOMICS_ENGLAND;UNIPROT
Hgene	ABL1	C4551485	Clinodactyly	1	GENOMICS_ENGLAND
Hgene	ABL1	C4704874	Mammary Carcinoma, Human	1	CTD_human