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Fusion Protein:LRP10-MSL1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: LRP10-MSL1 | FusionPDB ID: 49708 | FusionGDB2.0 ID: 49708 | Hgene | Tgene | Gene symbol | LRP10 | MSL1 | Gene ID | 26020 | 339287 |
Gene name | LDL receptor related protein 10 | MSL complex subunit 1 | |
Synonyms | LRP-10|LRP9|MST087|MSTP087 | MSL-1 | |
Cytomap | 14q11.2 | 17q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | low-density lipoprotein receptor-related protein 10 | male-specific lethal 1 homologMSL1-like 1male specific lethal 1 homologmale-specific lethal 1-like 1male-specific lethal-1 homolog 1 | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | Q7Z4F1 | Q68DK7 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000470660, ENST00000359591, ENST00000546834, | ENST00000398532, ENST00000577454, ENST00000578648, ENST00000579565, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 8 X 3=216 | 14 X 13 X 6=1092 |
# samples | 9 | 14 | |
** MAII score | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1092*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: LRP10 [Title/Abstract] AND MSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LRP10(23346262)-MSL1(38282436), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-60-2715-01A | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + |
ChimerDB4 | LUSC | TCGA-60-2715 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000359591 | LRP10 | chr14 | 23346262 | + | ENST00000398532 | MSL1 | chr17 | 38282436 | + | 10269 | 6772 | 541 | 2718 | 725 |
ENST00000359591 | LRP10 | chr14 | 23346262 | + | ENST00000577454 | MSL1 | chr17 | 38282436 | + | 8045 | 6772 | 541 | 2718 | 725 |
ENST00000359591 | LRP10 | chr14 | 23346262 | + | ENST00000578648 | MSL1 | chr17 | 38282436 | + | 8242 | 6772 | 541 | 2718 | 725 |
ENST00000546834 | LRP10 | chr14 | 23346262 | + | ENST00000398532 | MSL1 | chr17 | 38282436 | + | 5165 | 1668 | 0 | 2744 | 914 |
ENST00000546834 | LRP10 | chr14 | 23346262 | + | ENST00000577454 | MSL1 | chr17 | 38282436 | + | 2941 | 1668 | 0 | 2285 | 761 |
ENST00000546834 | LRP10 | chr14 | 23346262 | + | ENST00000578648 | MSL1 | chr17 | 38282436 | + | 3138 | 1668 | 0 | 2696 | 898 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000359591 | ENST00000398532 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + | 0.00581477 | 0.99418527 |
ENST00000359591 | ENST00000577454 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + | 0.012513159 | 0.98748684 |
ENST00000359591 | ENST00000578648 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + | 0.014195816 | 0.9858042 |
ENST00000546834 | ENST00000398532 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + | 0.000502888 | 0.99949706 |
ENST00000546834 | ENST00000577454 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + | 0.004530012 | 0.99547005 |
ENST00000546834 | ENST00000578648 | LRP10 | chr14 | 23346262 | + | MSL1 | chr17 | 38282436 | + | 0.002995234 | 0.9970048 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >49708_49708_1_LRP10-MSL1_LRP10_chr14_23346262_ENST00000359591_MSL1_chr17_38282436_ENST00000398532_length(amino acids)=725AA_BP= MASRVRVEPGPWSPPGEAAPGSLGARGSAATPSGRPQKLRDPSGTSGQPRMLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQG TLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFL LSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSC HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQ PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ QAPPSYGQLIAQGAIPPVEDFPTENPNDVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPI KAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAED -------------------------------------------------------------- >49708_49708_2_LRP10-MSL1_LRP10_chr14_23346262_ENST00000359591_MSL1_chr17_38282436_ENST00000577454_length(amino acids)=725AA_BP= MASRVRVEPGPWSPPGEAAPGSLGARGSAATPSGRPQKLRDPSGTSGQPRMLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQG TLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFL LSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSC HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQ PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ QAPPSYGQLIAQGAIPPVEDFPTENPNDVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPI KAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAED -------------------------------------------------------------- >49708_49708_3_LRP10-MSL1_LRP10_chr14_23346262_ENST00000359591_MSL1_chr17_38282436_ENST00000578648_length(amino acids)=725AA_BP= MASRVRVEPGPWSPPGEAAPGSLGARGSAATPSGRPQKLRDPSGTSGQPRMLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQG TLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFL LSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSC HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQ PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ QAPPSYGQLIAQGAIPPVEDFPTENPNDVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPI KAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAED -------------------------------------------------------------- >49708_49708_4_LRP10-MSL1_LRP10_chr14_23346262_ENST00000546834_MSL1_chr17_38282436_ENST00000398532_length(amino acids)=914AA_BP=542 MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI EDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKL ELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRL -------------------------------------------------------------- >49708_49708_5_LRP10-MSL1_LRP10_chr14_23346262_ENST00000546834_MSL1_chr17_38282436_ENST00000577454_length(amino acids)=761AA_BP=542 MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI -------------------------------------------------------------- >49708_49708_6_LRP10-MSL1_LRP10_chr14_23346262_ENST00000546834_MSL1_chr17_38282436_ENST00000578648_length(amino acids)=898AA_BP=542 MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI EDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVAIPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKLELDEKRRKRWDIQRIR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23346262/chr17:38282436) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
LRP10 | MSL1 |
FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}. | FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 139_175 | 556.0 | 557.0 | Domain | LDL-receptor class A 1 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 192_305 | 556.0 | 557.0 | Domain | CUB 2 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 28_136 | 556.0 | 557.0 | Domain | CUB 1 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 307_354 | 556.0 | 557.0 | Domain | LDL-receptor class A 2 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 355_397 | 556.0 | 557.0 | Domain | LDL-receptor class A 3 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 398_434 | 556.0 | 557.0 | Domain | LDL-receptor class A 4 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 17_440 | 556.0 | 557.0 | Topological domain | Extracellular |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 441_461 | 556.0 | 557.0 | Transmembrane | Helical |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000579565 | 1 | 10 | 213_282 | 0 | 352.0 | Coiled coil | Ontology_term=ECO:0000269 | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000579565 | 1 | 10 | 10_15 | 0 | 352.0 | Compositional bias | Note=Poly-Ala | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000579565 | 1 | 10 | 208_214 | 0 | 352.0 | Compositional bias | Note=Poly-Gly | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000579565 | 1 | 10 | 55_185 | 0 | 352.0 | Compositional bias | Note=Pro-rich | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 317_346 | 256.0 | 615.0 | Motif | Nuclear localization signal | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 505_519 | 256.0 | 615.0 | Motif | Bipartite nuclear localization signal | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000579565 | 1 | 10 | 317_346 | 0 | 352.0 | Motif | Nuclear localization signal | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000579565 | 1 | 10 | 505_519 | 0 | 352.0 | Motif | Bipartite nuclear localization signal |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 545_579 | 0 | 714.0 | Compositional bias | Note=Arg-rich |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 614_678 | 0 | 714.0 | Compositional bias | Note=Pro-rich |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 545_579 | 556.0 | 557.0 | Compositional bias | Note=Arg-rich |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 614_678 | 556.0 | 557.0 | Compositional bias | Note=Pro-rich |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 139_175 | 0 | 714.0 | Domain | LDL-receptor class A 1 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 192_305 | 0 | 714.0 | Domain | CUB 2 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 28_136 | 0 | 714.0 | Domain | CUB 1 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 307_354 | 0 | 714.0 | Domain | LDL-receptor class A 2 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 355_397 | 0 | 714.0 | Domain | LDL-receptor class A 3 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 398_434 | 0 | 714.0 | Domain | LDL-receptor class A 4 |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 17_440 | 0 | 714.0 | Topological domain | Extracellular |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 462_713 | 0 | 714.0 | Topological domain | Cytoplasmic |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000546834 | + | 7 | 8 | 462_713 | 556.0 | 557.0 | Topological domain | Cytoplasmic |
Hgene | LRP10 | chr14:23346262 | chr17:38282436 | ENST00000359591 | + | 1 | 7 | 441_461 | 0 | 714.0 | Transmembrane | Helical |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 213_282 | 256.0 | 615.0 | Coiled coil | Ontology_term=ECO:0000269 | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 10_15 | 256.0 | 615.0 | Compositional bias | Note=Poly-Ala | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 208_214 | 256.0 | 615.0 | Compositional bias | Note=Poly-Gly | |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 55_185 | 256.0 | 615.0 | Compositional bias | Note=Pro-rich |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>1710_LRP10_23346262_MSL1_38282436_ranked_0.pdb | LRP10 | 23346262 | 23346262 | ENST00000578648 | MSL1 | chr17 | 38282436 | + | MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI EDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKL ELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRL | 914 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
LRP10_pLDDT.png![]() |
MSL1_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
LRP10 | |
MSL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | MSL1 | chr14:23346262 | chr17:38282436 | ENST00000398532 | 0 | 9 | 223_237 | 256.0 | 615.0 | MSL2 |
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Related Drugs to LRP10-MSL1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LRP10-MSL1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |