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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LRP10-MSL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LRP10-MSL1
	FusionPDB ID: 49708
	FusionGDB2.0 ID: 49708
		Hgene	Tgene
	Gene symbol	LRP10	MSL1
	Gene ID	26020	339287
	Gene name	LDL receptor related protein 10	MSL complex subunit 1
	Synonyms	LRP-10\|LRP9\|MST087\|MSTP087	MSL-1
	Cytomap	14q11.2	17q21.1
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 10	male-specific lethal 1 homologMSL1-like 1male specific lethal 1 homologmale-specific lethal 1-like 1male-specific lethal-1 homolog 1
	Modification date	20200315	20200313
	UniProtAcc	Q7Z4F1	Q68DK7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000470660, ENST00000359591, ENST00000546834,	ENST00000398532, ENST00000577454, ENST00000578648, ENST00000579565,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 8 X 3=216	14 X 13 X 6=1092
	# samples	9	14
	** MAII score	log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1092*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LRP10 [Title/Abstract] AND MSL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LRP10(23346262)-MSL1(38282436), # samples:2
Anticipated loss of major functional domain due to fusion event.	LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP10-MSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MSL1	GO:0043984	histone H4-K16 acetylation	20018852

Fusion gene breakpoints across LRP10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MSL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-60-2715-01A	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
ChimerDB4	LUSC	TCGA-60-2715	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000359591	LRP10	chr14	23346262	+	ENST00000398532	MSL1	chr17	38282436	+	10269	6772	541	2718	725
ENST00000359591	LRP10	chr14	23346262	+	ENST00000577454	MSL1	chr17	38282436	+	8045	6772	541	2718	725
ENST00000359591	LRP10	chr14	23346262	+	ENST00000578648	MSL1	chr17	38282436	+	8242	6772	541	2718	725
ENST00000546834	LRP10	chr14	23346262	+	ENST00000398532	MSL1	chr17	38282436	+	5165	1668	0	2744	914
ENST00000546834	LRP10	chr14	23346262	+	ENST00000577454	MSL1	chr17	38282436	+	2941	1668	0	2285	761
ENST00000546834	LRP10	chr14	23346262	+	ENST00000578648	MSL1	chr17	38282436	+	3138	1668	0	2696	898

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000359591	ENST00000398532	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+	0.00581477	0.99418527
ENST00000359591	ENST00000577454	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+	0.012513159	0.98748684
ENST00000359591	ENST00000578648	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+	0.014195816	0.9858042
ENST00000546834	ENST00000398532	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+	0.000502888	0.99949706
ENST00000546834	ENST00000577454	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+	0.004530012	0.99547005
ENST00000546834	ENST00000578648	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+	0.002995234	0.9970048

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49708_49708_1_LRP10-MSL1_LRP10_chr14_23346262_ENST00000359591_MSL1_chr17_38282436_ENST00000398532_length(amino acids)=725AA_BP=
MASRVRVEPGPWSPPGEAAPGSLGARGSAATPSGRPQKLRDPSGTSGQPRMLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQG
TLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFL
LSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSC
HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP
WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQ
PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ
QAPPSYGQLIAQGAIPPVEDFPTENPNDVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPI
KAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAED

--------------------------------------------------------------

>49708_49708_2_LRP10-MSL1_LRP10_chr14_23346262_ENST00000359591_MSL1_chr17_38282436_ENST00000577454_length(amino acids)=725AA_BP=
MASRVRVEPGPWSPPGEAAPGSLGARGSAATPSGRPQKLRDPSGTSGQPRMLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQG
TLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFL
LSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSC
HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP
WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQ
PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ
QAPPSYGQLIAQGAIPPVEDFPTENPNDVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPI
KAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAED

--------------------------------------------------------------

>49708_49708_3_LRP10-MSL1_LRP10_chr14_23346262_ENST00000359591_MSL1_chr17_38282436_ENST00000578648_length(amino acids)=725AA_BP=
MASRVRVEPGPWSPPGEAAPGSLGARGSAATPSGRPQKLRDPSGTSGQPRMLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQG
TLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFL
LSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSC
HWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP
WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQ
PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ
QAPPSYGQLIAQGAIPPVEDFPTENPNDVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPI
KAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAED

--------------------------------------------------------------

>49708_49708_4_LRP10-MSL1_LRP10_chr14_23346262_ENST00000546834_MSL1_chr17_38282436_ENST00000398532_length(amino acids)=914AA_BP=542
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP
LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP
GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN
GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH
FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL
VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG
GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK
RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI
EDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKL
ELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRL

--------------------------------------------------------------

>49708_49708_5_LRP10-MSL1_LRP10_chr14_23346262_ENST00000546834_MSL1_chr17_38282436_ENST00000577454_length(amino acids)=761AA_BP=542
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP
LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP
GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN
GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH
FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL
VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG
GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK
RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI

--------------------------------------------------------------

>49708_49708_6_LRP10-MSL1_LRP10_chr14_23346262_ENST00000546834_MSL1_chr17_38282436_ENST00000578648_length(amino acids)=898AA_BP=542
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP
LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP
GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN
GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH
FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL
VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG
GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK
RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI
EDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVAIPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKLELDEKRRKRWDIQRIR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23346262/chr17:38282436)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP10 Q7Z4F1	MSL1 Q68DK7
FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}.	FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). {ECO:0000269\|PubMed:16227571, ECO:0000269\|PubMed:21726816, ECO:0000269\|PubMed:22547026}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

139_175

556.0

557.0

Domain

LDL-receptor class A 1

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

192_305

556.0

557.0

Domain

CUB 2

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

28_136

556.0

557.0

Domain

CUB 1

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

307_354

556.0

557.0

Domain

LDL-receptor class A 2

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

355_397

556.0

557.0

Domain

LDL-receptor class A 3

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

398_434

556.0

557.0

Domain

LDL-receptor class A 4

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

17_440

556.0

557.0

Topological domain

Extracellular

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

441_461

556.0

557.0

Transmembrane

Helical

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000579565

213_282

352.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000579565

10_15

352.0

Compositional bias

Note=Poly-Ala

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000579565

208_214

352.0

Compositional bias

Note=Poly-Gly

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000579565

55_185

352.0

Compositional bias

Note=Pro-rich

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000398532

317_346

256.0

615.0

Motif

Nuclear localization signal

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000398532

505_519

256.0

615.0

Motif

Bipartite nuclear localization signal

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000579565

317_346

352.0

Motif

Nuclear localization signal

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000579565

505_519

352.0

Motif

Bipartite nuclear localization signal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

545_579

714.0

Compositional bias

Note=Arg-rich

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

614_678

714.0

Compositional bias

Note=Pro-rich

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

545_579

556.0

557.0

Compositional bias

Note=Arg-rich

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

614_678

556.0

557.0

Compositional bias

Note=Pro-rich

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

139_175

714.0

Domain

LDL-receptor class A 1

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

192_305

714.0

Domain

CUB 2

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

28_136

714.0

Domain

CUB 1

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

307_354

714.0

Domain

LDL-receptor class A 2

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

355_397

714.0

Domain

LDL-receptor class A 3

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

398_434

714.0

Domain

LDL-receptor class A 4

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

17_440

714.0

Topological domain

Extracellular

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

462_713

714.0

Topological domain

Cytoplasmic

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000546834

462_713

556.0

557.0

Topological domain

Cytoplasmic

Hgene

LRP10

chr14:23346262

chr17:38282436

ENST00000359591

441_461

714.0

Transmembrane

Helical

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000398532

213_282

256.0

615.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000398532

10_15

256.0

615.0

Compositional bias

Note=Poly-Ala

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000398532

208_214

256.0

615.0

Compositional bias

Note=Poly-Gly

Tgene

MSL1

chr14:23346262

chr17:38282436

ENST00000398532

55_185

256.0

615.0

Compositional bias

Note=Pro-rich

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1710_LRP10_23346262_MSL1_38282436_ranked_0.pdb	LRP10	23346262	23346262	ENST00000578648	MSL1	chr17	38282436	+	MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSP LQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSN GKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSL VCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG GPGARRRQRGRLMRRLLLARIERMERRMQLVKKDNEKERHKLFQGYETEEREETELSEKIKLECQPELSETSQTLPPKPFSCGRSGKGHK RKSPFGSTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEI EDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDLLENLDDSVFSKRHAKL ELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLMITPFLPVVAFGRPLPKLTPQNFELPWLDERSRCRL	914

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

LRP10_pLDDT.png

MSL1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LRP10
MSL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	MSL1	chr14:23346262	chr17:38282436	ENST00000398532		0	9	223_237	256.0	615.0	MSL2

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Related Drugs to LRP10-MSL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to LRP10-MSL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source