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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRP1B-HNMT

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRP1B-HNMT
FusionPDB ID: 49731
FusionGDB2.0 ID: 49731
HgeneTgene
Gene symbol

LRP1B

HNMT

Gene ID

53353

3176

Gene nameLDL receptor related protein 1Bhistamine N-methyltransferase
SynonymsLRP-1B|LRP-DIT|LRPDITHMT|HNMT-S1|HNMT-S2|MRT51
Cytomap

2q22.1-q22.2

2q22.1

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors)histamine N-methyltransferase
Modification date2020031320200313
UniProtAcc

Q9NZR2

P50135

Ensembl transtripts involved in fusion geneENST idsENST00000389484, ENST00000486364, 
ENST00000485653, ENST00000280096, 
ENST00000280097, ENST00000329366, 
ENST00000410115, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 10 X 4=4001 X 1 X 1=1
# samples 101
** MAII scorelog2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRP1B [Title/Abstract] AND HNMT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRP1B(142237964)-HNMT(138758487), # samples:1
Anticipated loss of major functional domain due to fusion event.LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHNMT

GO:0001695

histamine catabolic process

26206890

TgeneHNMT

GO:0032259

methylation

26206890


check buttonFusion gene breakpoints across LRP1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HNMT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8364LRP1Bchr2

142237964

-HNMTchr2

138758487

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000389484LRP1Bchr2142237964-ENST00000410115HNMTchr2138758487+212713158612003380

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389484ENST00000410115LRP1Bchr2142237964-HNMTchr2138758487+0.0011209330.998879

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49731_49731_1_LRP1B-HNMT_LRP1B_chr2_142237964_ENST00000389484_HNMT_chr2_138758487_ENST00000410115_length(amino acids)=380AA_BP=151
MTPLDSRLQAAPAAAAAAGPKVPPSSLQRRLPYRATTMSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCD
GDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQGEIDLQILSKVQAQYPGVCINNEVVEPSA
EQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKL
WKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:142237964/chr2:138758487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP1B

Q9NZR2

HNMT

P50135

FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.FUNCTION: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. {ECO:0000269|PubMed:26206890}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-39131_70114.333333333333334600.0DomainLDL-receptor class A 1
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-39176_114114.333333333333334600.0DomainLDL-receptor class A 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911005_1043114.333333333333334600.0DomainLDL-receptor class A 7
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911052_1089114.333333333333334600.0DomainLDL-receptor class A 8
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911094_1132114.333333333333334600.0DomainLDL-receptor class A 9
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911135_1174114.333333333333334600.0DomainLDL-receptor class A 10
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391116_154114.333333333333334600.0DomainEGF-like 1
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911174_1213114.333333333333334600.0DomainEGF-like 5
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911214_1253114.333333333333334600.0DomainEGF-like 6
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911527_1570114.333333333333334600.0DomainEGF-like 7
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391155_194114.333333333333334600.0DomainEGF-like 2%3B calcium-binding
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911834_1875114.333333333333334600.0DomainEGF-like 8
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912143_2183114.333333333333334600.0DomainEGF-like 9
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912464_2504114.333333333333334600.0DomainEGF-like 10
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912509_2548114.333333333333334600.0DomainLDL-receptor class A 11
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912551_2587114.333333333333334600.0DomainLDL-receptor class A 12
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912590_2626114.333333333333334600.0DomainLDL-receptor class A 13
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912629_2675114.333333333333334600.0DomainLDL-receptor class A 14
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912681_2717114.333333333333334600.0DomainLDL-receptor class A 15
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912719_2757114.333333333333334600.0DomainLDL-receptor class A 16
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912760_2800114.333333333333334600.0DomainLDL-receptor class A 17
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912804_2841114.333333333333334600.0DomainLDL-receptor class A 18
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912844_2885114.333333333333334600.0DomainLDL-receptor class A 19
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912890_2926114.333333333333334600.0DomainLDL-receptor class A 20
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912927_2967114.333333333333334600.0DomainEGF-like 11
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912968_3008114.333333333333334600.0DomainEGF-like 12%3B calcium-binding
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913273_3314114.333333333333334600.0DomainEGF-like 13
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913316_3353114.333333333333334600.0DomainLDL-receptor class A 21
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913356_3392114.333333333333334600.0DomainLDL-receptor class A 22
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913395_3432114.333333333333334600.0DomainLDL-receptor class A 23
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913435_3472114.333333333333334600.0DomainLDL-receptor class A 24
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913475_3511114.333333333333334600.0DomainLDL-receptor class A 25
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913514_3550114.333333333333334600.0DomainLDL-receptor class A 26
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913552_3588114.333333333333334600.0DomainLDL-receptor class A 27
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913593_3629114.333333333333334600.0DomainLDL-receptor class A 28
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913631_3668114.333333333333334600.0DomainLDL-receptor class A 29
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913673_3711114.333333333333334600.0DomainLDL-receptor class A 30
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913714_3752114.333333333333334600.0DomainLDL-receptor class A 31
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913761_3797114.333333333333334600.0DomainLDL-receptor class A 32
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913801_3843114.333333333333334600.0DomainEGF-like 14
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913844_3881114.333333333333334600.0DomainEGF-like 15
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914171_4208114.333333333333334600.0DomainEGF-like 16
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914213_4249114.333333333333334600.0DomainEGF-like 17
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914249_4285114.333333333333334600.0DomainEGF-like 18
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914285_4321114.333333333333334600.0DomainEGF-like 19
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914321_4357114.333333333333334600.0DomainEGF-like 20
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914357_4392114.333333333333334600.0DomainEGF-like 21
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914390_4427114.333333333333334600.0DomainEGF-like 22
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391471_517114.333333333333334600.0DomainEGF-like 3
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391794_834114.333333333333334600.0DomainEGF-like 4
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391844_882114.333333333333334600.0DomainLDL-receptor class A 3
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391885_923114.333333333333334600.0DomainLDL-receptor class A 4
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391926_963114.333333333333334600.0DomainLDL-receptor class A 5
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391966_1003114.333333333333334600.0DomainLDL-receptor class A 6
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914492_4495114.333333333333334600.0MotifEndocytosis signal
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914559_4562114.333333333333334600.0MotifEndocytosis signal
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911300_1346114.333333333333334600.0RepeatNote=LDL-receptor class B 8
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911347_1389114.333333333333334600.0RepeatNote=LDL-receptor class B 9
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911390_1436114.333333333333334600.0RepeatNote=LDL-receptor class B 10
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911437_1480114.333333333333334600.0RepeatNote=LDL-receptor class B 11
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911481_1522114.333333333333334600.0RepeatNote=LDL-receptor class B 12
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911618_1660114.333333333333334600.0RepeatNote=LDL-receptor class B 13
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911661_1704114.333333333333334600.0RepeatNote=LDL-receptor class B 14
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911705_1744114.333333333333334600.0RepeatNote=LDL-receptor class B 15
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911745_1787114.333333333333334600.0RepeatNote=LDL-receptor class B 16
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911922_1964114.333333333333334600.0RepeatNote=LDL-receptor class B 17
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3911965_2007114.333333333333334600.0RepeatNote=LDL-receptor class B 28
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912008_2051114.333333333333334600.0RepeatNote=LDL-receptor class B 19
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912052_2095114.333333333333334600.0RepeatNote=LDL-receptor class B 20
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912239_2280114.333333333333334600.0RepeatNote=LDL-receptor class B 21
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912281_2329114.333333333333334600.0RepeatNote=LDL-receptor class B 22
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912330_2374114.333333333333334600.0RepeatNote=LDL-receptor class B 23
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912375_2416114.333333333333334600.0RepeatNote=LDL-receptor class B 24
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3912417_2459114.333333333333334600.0RepeatNote=LDL-receptor class B 25
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391295_337114.333333333333334600.0RepeatNote=LDL-receptor class B 1
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913055_3098114.333333333333334600.0RepeatNote=LDL-receptor class B 26
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913099_3141114.333333333333334600.0RepeatNote=LDL-receptor class B 27
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913142_3185114.333333333333334600.0RepeatNote=LDL-receptor class B 28
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913186_3224114.333333333333334600.0RepeatNote=LDL-receptor class B 29
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913225_3268114.333333333333334600.0RepeatNote=LDL-receptor class B 30
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391338_381114.333333333333334600.0RepeatNote=LDL-receptor class B 2
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391382_425114.333333333333334600.0RepeatNote=LDL-receptor class B 3
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913933_3980114.333333333333334600.0RepeatNote=LDL-receptor class B 31
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3913981_4038114.333333333333334600.0RepeatNote=LDL-receptor class B 32
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914039_4082114.333333333333334600.0RepeatNote=LDL-receptor class B 33
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914083_4127114.333333333333334600.0RepeatNote=LDL-receptor class B 34
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391568_610114.333333333333334600.0RepeatNote=LDL-receptor class B 4
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391611_656114.333333333333334600.0RepeatNote=LDL-receptor class B 5
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391657_706114.333333333333334600.0RepeatNote=LDL-receptor class B 6
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-391707_750114.333333333333334600.0RepeatNote=LDL-receptor class B 7
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-39125_4444114.333333333333334600.0Topological domainExtracellular
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914468_4599114.333333333333334600.0Topological domainCytoplasmic
HgeneLRP1Bchr2:142237964chr2:138758487ENST00000389484-3914445_4467114.333333333333334600.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRP1B
HNMT


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRP1B-HNMT


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRP1B-HNMT


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource