Fusion partner gene information | Fusion gene name: LRP1B-HNMT |
FusionPDB ID: 49731 | FusionGDB2.0 ID: 49731 | | Hgene | Tgene | Gene symbol | LRP1B | HNMT | Gene ID | 53353 | 3176 | Gene name | LDL receptor related protein 1B | histamine N-methyltransferase |
Synonyms | LRP-1B|LRP-DIT|LRPDIT | HMT|HNMT-S1|HNMT-S2|MRT51 |
Cytomap | 2q22.1-q22.2 | 2q22.1 |
Type of gene | protein-coding | protein-coding |
Description | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | histamine N-methyltransferase |
Modification date | 20200313 | 20200313 |
UniProtAcc | Q9NZR2 | P50135 |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000389484, ENST00000486364,
| ENST00000485653, ENST00000280096, ENST00000280097, ENST00000329366, ENST00000410115, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 10 X 10 X 4=400 | 1 X 1 X 1=1 |
# samples | 10 | 1 |
** MAII score | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 |
Context (manual curation of fusion genes in FusionPDB) | PubMed: LRP1B [Title/Abstract] AND HNMT [Title/Abstract] AND fusion [Title/Abstract] |
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LRP1B(142237964)-HNMT(138758487), # samples:1
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Anticipated loss of major functional domain due to fusion event. | LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP1B-HNMT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1005_1043 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 7 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1052_1089 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 8 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1094_1132 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 9 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1135_1174 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 10 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 116_154 | 114.33333333333333 | 4600.0 | Domain | EGF-like 1 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1174_1213 | 114.33333333333333 | 4600.0 | Domain | EGF-like 5 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1214_1253 | 114.33333333333333 | 4600.0 | Domain | EGF-like 6 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1527_1570 | 114.33333333333333 | 4600.0 | Domain | EGF-like 7 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 155_194 | 114.33333333333333 | 4600.0 | Domain | EGF-like 2%3B calcium-binding |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1834_1875 | 114.33333333333333 | 4600.0 | Domain | EGF-like 8 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2143_2183 | 114.33333333333333 | 4600.0 | Domain | EGF-like 9 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2464_2504 | 114.33333333333333 | 4600.0 | Domain | EGF-like 10 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2509_2548 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 11 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2551_2587 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 12 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2590_2626 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 13 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2629_2675 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 14 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2681_2717 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 15 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2719_2757 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 16 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2760_2800 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 17 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2804_2841 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 18 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2844_2885 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 19 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2890_2926 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 20 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2927_2967 | 114.33333333333333 | 4600.0 | Domain | EGF-like 11 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2968_3008 | 114.33333333333333 | 4600.0 | Domain | EGF-like 12%3B calcium-binding |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3273_3314 | 114.33333333333333 | 4600.0 | Domain | EGF-like 13 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3316_3353 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 21 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3356_3392 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 22 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3395_3432 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 23 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3435_3472 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 24 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3475_3511 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 25 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3514_3550 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 26 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3552_3588 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 27 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3593_3629 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 28 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3631_3668 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 29 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3673_3711 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 30 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3714_3752 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 31 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3761_3797 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 32 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3801_3843 | 114.33333333333333 | 4600.0 | Domain | EGF-like 14 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3844_3881 | 114.33333333333333 | 4600.0 | Domain | EGF-like 15 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4171_4208 | 114.33333333333333 | 4600.0 | Domain | EGF-like 16 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4213_4249 | 114.33333333333333 | 4600.0 | Domain | EGF-like 17 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4249_4285 | 114.33333333333333 | 4600.0 | Domain | EGF-like 18 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4285_4321 | 114.33333333333333 | 4600.0 | Domain | EGF-like 19 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4321_4357 | 114.33333333333333 | 4600.0 | Domain | EGF-like 20 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4357_4392 | 114.33333333333333 | 4600.0 | Domain | EGF-like 21 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4390_4427 | 114.33333333333333 | 4600.0 | Domain | EGF-like 22 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 471_517 | 114.33333333333333 | 4600.0 | Domain | EGF-like 3 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 794_834 | 114.33333333333333 | 4600.0 | Domain | EGF-like 4 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 844_882 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 3 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 885_923 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 4 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 926_963 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 5 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 966_1003 | 114.33333333333333 | 4600.0 | Domain | LDL-receptor class A 6 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4492_4495 | 114.33333333333333 | 4600.0 | Motif | Endocytosis signal |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4559_4562 | 114.33333333333333 | 4600.0 | Motif | Endocytosis signal |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1300_1346 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 8 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1347_1389 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 9 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1390_1436 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 10 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1437_1480 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 11 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1481_1522 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 12 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1618_1660 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 13 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1661_1704 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 14 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1705_1744 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 15 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1745_1787 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 16 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1922_1964 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 17 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 1965_2007 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 28 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2008_2051 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 19 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2052_2095 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 20 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2239_2280 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 21 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2281_2329 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 22 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2330_2374 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 23 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2375_2416 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 24 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 2417_2459 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 25 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 295_337 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 1 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3055_3098 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 26 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3099_3141 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 27 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3142_3185 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 28 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3186_3224 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 29 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3225_3268 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 30 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 338_381 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 2 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 382_425 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 3 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3933_3980 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 31 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 3981_4038 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 32 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4039_4082 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 33 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4083_4127 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 34 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 568_610 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 4 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 611_656 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 5 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 657_706 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 6 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 707_750 | 114.33333333333333 | 4600.0 | Repeat | Note=LDL-receptor class B 7 |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 25_4444 | 114.33333333333333 | 4600.0 | Topological domain | Extracellular |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4468_4599 | 114.33333333333333 | 4600.0 | Topological domain | Cytoplasmic |
Hgene | LRP1B | chr2:142237964 | chr2:138758487 | ENST00000389484 | - | 3 | 91 | 4445_4467 | 114.33333333333333 | 4600.0 | Transmembrane | Helical |