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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRP5-MOGAT2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRP5-MOGAT2
FusionPDB ID: 49809
FusionGDB2.0 ID: 49809
HgeneTgene
Gene symbol

LRP5

MOGAT2

Gene ID

4041

80168

Gene nameLDL receptor related protein 5monoacylglycerol O-acyltransferase 2
SynonymsBMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP-7|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2DGAT2L5|DGAT2L5.|MGAT2|hDC5
Cytomap

11q13.2

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 72-acylglycerol O-acyltransferase 2acyl-CoA:monoacylglycerol acyltransferase 2diacylglycerol O-acyltransferase candidate 5diacylglycerol acyltransferase 2-like protein 5
Modification date2020032920200313
UniProtAcc

A4QPB2

.
Ensembl transtripts involved in fusion geneENST idsENST00000294304, ENST00000529481, 
ENST00000526712, ENST00000198801, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 25 X 12=108004 X 4 X 2=32
# samples 415
** MAII scorelog2(41/10800*10)=-4.71926359243275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRP5 [Title/Abstract] AND MOGAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRP5(68193655)-MOGAT2(75431037), # samples:3
Anticipated loss of major functional domain due to fusion event.LRP5-MOGAT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP5-MOGAT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP5-MOGAT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP5-MOGAT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP5

GO:0008284

positive regulation of cell proliferation

9790987

HgeneLRP5

GO:0045840

positive regulation of mitotic nuclear division

9790987

HgeneLRP5

GO:0045893

positive regulation of transcription, DNA-templated

15035989|17955262

HgeneLRP5

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

HgeneLRP5

GO:0060070

canonical Wnt signaling pathway

11029007|12121999|12857724|15908424|24706814|25920554


check buttonFusion gene breakpoints across LRP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MOGAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SQ-01ALRP5chr11

68193654

+MOGAT2chr11

75431036

+
ChimerDB4BRCATCGA-A1-A0SQ-01ALRP5chr11

68193655

-MOGAT2chr11

75431037

+
ChimerDB4BRCATCGA-A1-A0SQ-01ALRP5chr11

68193655

+MOGAT2chr11

75431037

+
ChimerDB4BRCATCGA-A1-A0SQLRP5chr11

68193655

+MOGAT2chr11

75431036

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294304LRP5chr1168193655+ENST00000198801MOGAT2chr1175431037+4986374310646561516
ENST00000294304LRP5chr1168193655+ENST00000198801MOGAT2chr1175431036+4986374310646561516
ENST00000294304LRP5chr1168193654+ENST00000198801MOGAT2chr1175431036+4986374310646561516

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294304ENST00000198801LRP5chr1168193655+MOGAT2chr1175431037+0.0037735830.99622643
ENST00000294304ENST00000198801LRP5chr1168193655+MOGAT2chr1175431036+0.0037735830.99622643
ENST00000294304ENST00000198801LRP5chr1168193654+MOGAT2chr1175431036+0.0037735830.99622643

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49809_49809_1_LRP5-MOGAT2_LRP5_chr11_68193654_ENST00000294304_MOGAT2_chr11_75431036_ENST00000198801_length(amino acids)=1516AA_BP=1204
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG
LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT
IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF
IYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWI
DRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWT
IWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESA
AHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISL

--------------------------------------------------------------

>49809_49809_2_LRP5-MOGAT2_LRP5_chr11_68193655_ENST00000294304_MOGAT2_chr11_75431036_ENST00000198801_length(amino acids)=1516AA_BP=1204
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG
LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT
IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF
IYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWI
DRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWT
IWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESA
AHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISL

--------------------------------------------------------------

>49809_49809_3_LRP5-MOGAT2_LRP5_chr11_68193655_ENST00000294304_MOGAT2_chr11_75431037_ENST00000198801_length(amino acids)=1516AA_BP=1204
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQT
YLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK
RKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR
KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIG
LELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLT
IDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKF
IYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWI
DRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWT
IWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESA
AHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68193655/chr11:75431037)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP5

A4QPB2

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623295_3371212.33333333333331616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623601_6411212.33333333333331616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623902_9421212.33333333333331616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623295_3371212.33333333333331616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623601_6411212.33333333333331616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623902_9421212.33333333333331616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623295_3371212.33333333333331616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623601_6411212.33333333333331616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623902_9421212.33333333333331616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+162332_2881212.33333333333331616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623341_6021212.33333333333331616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623644_9031212.33333333333331616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623945_12121212.33333333333331616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+162332_2881212.33333333333331616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623341_6021212.33333333333331616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623644_9031212.33333333333331616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623945_12121212.33333333333331616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+162332_2881212.33333333333331616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623341_6021212.33333333333331616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623644_9031212.33333333333331616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623945_12121212.33333333333331616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231036_10781212.33333333333331616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231079_11231212.33333333333331616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231124_11641212.33333333333331616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231165_12071212.33333333333331616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623120_1621212.33333333333331616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623123_1261212.33333333333331616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623163_2061212.33333333333331616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623166_1691212.33333333333331616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623207_2471212.33333333333331616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623248_2901212.33333333333331616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623251_2541212.33333333333331616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623385_4271212.33333333333331616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623388_3911212.33333333333331616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623428_4701212.33333333333331616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623431_4341212.33333333333331616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623471_5141212.33333333333331616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623474_4771212.33333333333331616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623515_5571212.33333333333331616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623558_6001212.33333333333331616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623559_5621212.33333333333331616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623687_7291212.33333333333331616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623690_6931212.33333333333331616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623730_7721212.33333333333331616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+162375_1191212.33333333333331616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623773_8151212.33333333333331616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+162378_811212.33333333333331616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623816_8551212.33333333333331616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623819_8221212.33333333333331616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623856_8981212.33333333333331616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623859_8621212.33333333333331616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+1623989_10351212.33333333333331616.0RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231036_10781212.33333333333331616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231079_11231212.33333333333331616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231124_11641212.33333333333331616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231165_12071212.33333333333331616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623120_1621212.33333333333331616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623123_1261212.33333333333331616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623163_2061212.33333333333331616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623166_1691212.33333333333331616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623207_2471212.33333333333331616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623248_2901212.33333333333331616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623251_2541212.33333333333331616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623385_4271212.33333333333331616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623388_3911212.33333333333331616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623428_4701212.33333333333331616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623431_4341212.33333333333331616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623471_5141212.33333333333331616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623474_4771212.33333333333331616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623515_5571212.33333333333331616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623558_6001212.33333333333331616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623559_5621212.33333333333331616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623687_7291212.33333333333331616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623690_6931212.33333333333331616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623730_7721212.33333333333331616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+162375_1191212.33333333333331616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623773_8151212.33333333333331616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+162378_811212.33333333333331616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623816_8551212.33333333333331616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623819_8221212.33333333333331616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623856_8981212.33333333333331616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623859_8621212.33333333333331616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+1623989_10351212.33333333333331616.0RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231036_10781212.33333333333331616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231079_11231212.33333333333331616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231124_11641212.33333333333331616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231165_12071212.33333333333331616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623120_1621212.33333333333331616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623123_1261212.33333333333331616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623163_2061212.33333333333331616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623166_1691212.33333333333331616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623207_2471212.33333333333331616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623248_2901212.33333333333331616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623251_2541212.33333333333331616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623385_4271212.33333333333331616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623388_3911212.33333333333331616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623428_4701212.33333333333331616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623431_4341212.33333333333331616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623471_5141212.33333333333331616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623474_4771212.33333333333331616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623515_5571212.33333333333331616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623558_6001212.33333333333331616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623559_5621212.33333333333331616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623687_7291212.33333333333331616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623690_6931212.33333333333331616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623730_7721212.33333333333331616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+162375_1191212.33333333333331616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623773_8151212.33333333333331616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+162378_811212.33333333333331616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623816_8551212.33333333333331616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623819_8221212.33333333333331616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623856_8981212.33333333333331616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623859_8621212.33333333333331616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+1623989_10351212.33333333333331616.0RepeatNote=LDL-receptor class B 16
TgeneMOGAT2chr11:68193654chr11:75431036ENST0000019880106103_12330.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193654chr11:75431036ENST000001988010638_5930.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193654chr11:75431036ENST0000052671205103_1230253.0TransmembraneHelical
TgeneMOGAT2chr11:68193654chr11:75431036ENST000005267120523_370253.0TransmembraneHelical
TgeneMOGAT2chr11:68193654chr11:75431036ENST000005267120538_590253.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431036ENST0000019880106103_12330.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431036ENST000001988010638_5930.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431036ENST0000052671205103_1230253.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431036ENST000005267120523_370253.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431036ENST000005267120538_590253.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431037ENST0000019880106103_12330.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431037ENST000001988010638_5930.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431037ENST0000052671205103_1230253.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431037ENST000005267120523_370253.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431037ENST000005267120538_590253.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231495_16101212.33333333333331616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231495_16101212.33333333333331616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231495_16101212.33333333333331616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231213_12541212.33333333333331616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231258_12961212.33333333333331616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231297_13331212.33333333333331616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231335_13711212.33333333333331616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231213_12541212.33333333333331616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231258_12961212.33333333333331616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231297_13331212.33333333333331616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231335_13711212.33333333333331616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231213_12541212.33333333333331616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231258_12961212.33333333333331616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231297_13331212.33333333333331616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231335_13711212.33333333333331616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231500_15061212.33333333333331616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231538_15451212.33333333333331616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231574_15811212.33333333333331616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231591_15961212.33333333333331616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231605_16121212.33333333333331616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231500_15061212.33333333333331616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231538_15451212.33333333333331616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231574_15811212.33333333333331616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231591_15961212.33333333333331616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231605_16121212.33333333333331616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231500_15061212.33333333333331616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231538_15451212.33333333333331616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231574_15811212.33333333333331616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231591_15961212.33333333333331616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231605_16121212.33333333333331616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231408_16151212.33333333333331616.0Topological domainCytoplasmic
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+162332_13841212.33333333333331616.0Topological domainExtracellular
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231408_16151212.33333333333331616.0Topological domainCytoplasmic
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+162332_13841212.33333333333331616.0Topological domainExtracellular
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231408_16151212.33333333333331616.0Topological domainCytoplasmic
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+162332_13841212.33333333333331616.0Topological domainExtracellular
HgeneLRP5chr11:68193654chr11:75431036ENST00000294304+16231385_14071212.33333333333331616.0TransmembraneHelical
HgeneLRP5chr11:68193655chr11:75431036ENST00000294304+16231385_14071212.33333333333331616.0TransmembraneHelical
HgeneLRP5chr11:68193655chr11:75431037ENST00000294304+16231385_14071212.33333333333331616.0TransmembraneHelical
TgeneMOGAT2chr11:68193654chr11:75431036ENST000001988010623_3730.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431036ENST000001988010623_3730.333333333333332335.0TransmembraneHelical
TgeneMOGAT2chr11:68193655chr11:75431037ENST000001988010623_3730.333333333333332335.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRP5
MOGAT2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRP5-MOGAT2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRP5-MOGAT2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource