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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LSM14A-GPI

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LSM14A-GPI
FusionPDB ID: 50186
FusionGDB2.0 ID: 50186
HgeneTgene
Gene symbol

LSM14A

GPI

Gene ID

26065

10007

Gene nameLSM14A mRNA processing body assembly factorglucosamine-6-phosphate deaminase 1
SynonymsC19orf13|FAM61A|RAP55|RAP55AGNP1|GNPDA|GNPI|GPI|HLN
Cytomap

19q13.11

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionprotein LSM14 homolog ALSM14 homolog ALSM14A, SCD6 homolog ARNA-associated protein 55RNA-associated protein 55AalphaSNBPfamily with sequence similarity 61, member AhRAP55hRAP55Aprotein SCD6 homologputative alpha-synuclein-binding proteinglucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin
Modification date2020032720200313
UniProtAcc

Q8ND56

Q8IV16

Ensembl transtripts involved in fusion geneENST idsENST00000433627, ENST00000544216, 
ENST00000540746, 		ENST00000356487, 
ENST00000415930, ENST00000586425, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 10 X 10=180019 X 17 X 10=3230
# samples 2423
** MAII scorelog2(24/1800*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3230*10)=-3.81182839863691
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LSM14A [Title/Abstract] AND GPI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LSM14A(34712643)-GPI(34887205), # samples:1
LSM14A(34663668)-GPI(34884153), # samples:1
LSM14A(34663668)-GPI(34884633), # samples:1
LSM14A(34663668)-GPI(34884819), # samples:1
LSM14A(34699956)-GPI(34868408), # samples:1
Anticipated loss of major functional domain due to fusion event.LSM14A-GPI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LSM14A-GPI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LSM14A-GPI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LSM14A-GPI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LSM14A-GPI seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
LSM14A-GPI seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LSM14A-GPI seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLSM14A

GO:0033962

cytoplasmic mRNA processing body assembly

16484376


check buttonFusion gene breakpoints across LSM14A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CZ-5468-01ALSM14Achr19

34663668

+GPIchr19

34884153

+
ChimerDB4KIRCTCGA-CZ-5468-01ALSM14Achr19

34663668

+GPIchr19

34884633

+
ChimerDB4KIRCTCGA-CZ-5468-01ALSM14Achr19

34663668

+GPIchr19

34884819

+
ChimerDB4LUSCTCGA-66-2781LSM14Achr19

34712643

+GPIchr19

34887205

+
ChimerDB4OVTCGA-29-1703-01ALSM14Achr19

34699956

+GPIchr19

34868408

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540746LSM14Achr1934712643+ENST00000415930GPIchr1934887205+40981363851977630
ENST00000540746LSM14Achr1934712643+ENST00000356487GPIchr1934887205+22701363851977630
ENST00000540746LSM14Achr1934712643+ENST00000586425GPIchr1934887205+20751363851725546
ENST00000544216LSM14Achr1934712643+ENST00000415930GPIchr1934887205+41801445442059671
ENST00000544216LSM14Achr1934712643+ENST00000356487GPIchr1934887205+23521445442059671
ENST00000544216LSM14Achr1934712643+ENST00000586425GPIchr1934887205+21571445441807587
ENST00000433627LSM14Achr1934712643+ENST00000415930GPIchr1934887205+41781443422057671
ENST00000433627LSM14Achr1934712643+ENST00000356487GPIchr1934887205+23501443422057671
ENST00000433627LSM14Achr1934712643+ENST00000586425GPIchr1934887205+21551443421805587
ENST00000540746LSM14Achr1934663668+ENST00000415930GPIchr1934884633+3171239851050321
ENST00000540746LSM14Achr1934663668+ENST00000356487GPIchr1934884633+134323910681356
ENST00000540746LSM14Achr1934663668+ENST00000586425GPIchr1934884633+11482398251275
ENST00000544216LSM14Achr1934663668+ENST00000415930GPIchr1934884633+3130198441009321
ENST00000544216LSM14Achr1934663668+ENST00000356487GPIchr1934884633+130219810272342
ENST00000544216LSM14Achr1934663668+ENST00000586425GPIchr1934884633+11071987842261
ENST00000433627LSM14Achr1934663668+ENST00000415930GPIchr1934884633+3128196421007321
ENST00000433627LSM14Achr1934663668+ENST00000356487GPIchr1934884633+130019610250342
ENST00000433627LSM14Achr1934663668+ENST00000586425GPIchr1934884633+11051967820261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540746ENST00000415930LSM14Achr1934712643+GPIchr1934887205+0.0036936710.9963063
ENST00000540746ENST00000356487LSM14Achr1934712643+GPIchr1934887205+0.0044809550.99551904
ENST00000540746ENST00000586425LSM14Achr1934712643+GPIchr1934887205+0.0071619070.9928381
ENST00000544216ENST00000415930LSM14Achr1934712643+GPIchr1934887205+0.0038137730.9961862
ENST00000544216ENST00000356487LSM14Achr1934712643+GPIchr1934887205+0.0042468350.99575317
ENST00000544216ENST00000586425LSM14Achr1934712643+GPIchr1934887205+0.0066630340.99333704
ENST00000433627ENST00000415930LSM14Achr1934712643+GPIchr1934887205+0.0038065010.9961935
ENST00000433627ENST00000356487LSM14Achr1934712643+GPIchr1934887205+0.0042245490.9957755
ENST00000433627ENST00000586425LSM14Achr1934712643+GPIchr1934887205+0.0066315220.99336845
ENST00000540746ENST00000415930LSM14Achr1934663668+GPIchr1934884633+0.0053271320.99467283
ENST00000540746ENST00000356487LSM14Achr1934663668+GPIchr1934884633+0.0103078830.98969215
ENST00000540746ENST00000586425LSM14Achr1934663668+GPIchr1934884633+0.0156724580.9843276
ENST00000544216ENST00000415930LSM14Achr1934663668+GPIchr1934884633+0.0053312750.99466866
ENST00000544216ENST00000356487LSM14Achr1934663668+GPIchr1934884633+0.0105039380.98949605
ENST00000544216ENST00000586425LSM14Achr1934663668+GPIchr1934884633+0.017675310.9823247
ENST00000433627ENST00000415930LSM14Achr1934663668+GPIchr1934884633+0.0053256060.9946743
ENST00000433627ENST00000356487LSM14Achr1934663668+GPIchr1934884633+0.0103873040.98961264
ENST00000433627ENST00000586425LSM14Achr1934663668+GPIchr1934884633+0.017717840.98228216

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50186_50186_1_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000433627_GPI_chr19_34884633_ENST00000356487_length(amino acids)=342AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

--------------------------------------------------------------

>50186_50186_2_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000433627_GPI_chr19_34884633_ENST00000415930_length(amino acids)=321AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWY
INCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIR
KGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDI

--------------------------------------------------------------

>50186_50186_3_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000433627_GPI_chr19_34884633_ENST00000586425_length(amino acids)=261AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL

--------------------------------------------------------------

>50186_50186_4_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000540746_GPI_chr19_34884633_ENST00000356487_length(amino acids)=356AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

--------------------------------------------------------------

>50186_50186_5_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000540746_GPI_chr19_34884633_ENST00000415930_length(amino acids)=321AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWY
INCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIR
KGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDI

--------------------------------------------------------------

>50186_50186_6_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000540746_GPI_chr19_34884633_ENST00000586425_length(amino acids)=275AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL
VHPVSPREQLLEVVKTFGKGYGGVFGVDGVEDALVADLRLGDEADLAADVRGAPAHGAAAAAPSCSQRGRSHATVARSARPLAPSAPTAA

--------------------------------------------------------------

>50186_50186_7_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000544216_GPI_chr19_34884633_ENST00000356487_length(amino acids)=342AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

--------------------------------------------------------------

>50186_50186_8_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000544216_GPI_chr19_34884633_ENST00000415930_length(amino acids)=321AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWY
INCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIR
KGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDI

--------------------------------------------------------------

>50186_50186_9_LSM14A-GPI_LSM14A_chr19_34663668_ENST00000544216_GPI_chr19_34884633_ENST00000586425_length(amino acids)=261AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL

--------------------------------------------------------------

>50186_50186_10_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000433627_GPI_chr19_34887205_ENST00000356487_length(amino acids)=671AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEG
NADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRG
GFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLA
NFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVEL

--------------------------------------------------------------

>50186_50186_11_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000433627_GPI_chr19_34887205_ENST00000415930_length(amino acids)=671AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEG
NADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRG
GFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLA
NFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVEL

--------------------------------------------------------------

>50186_50186_12_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000433627_GPI_chr19_34887205_ENST00000586425_length(amino acids)=587AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEG
NADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRG
GFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLA

--------------------------------------------------------------

>50186_50186_13_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000540746_GPI_chr19_34887205_ENST00000356487_length(amino acids)=630AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFES
ANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERR
LNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRGGFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPI
VWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVF
EGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQREARVQ

--------------------------------------------------------------

>50186_50186_14_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000540746_GPI_chr19_34887205_ENST00000415930_length(amino acids)=630AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFES
ANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERR
LNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRGGFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPI
VWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVF
EGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQREARVQ

--------------------------------------------------------------

>50186_50186_15_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000540746_GPI_chr19_34887205_ENST00000586425_length(amino acids)=546AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFES
ANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERR
LNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRGGFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPI
VWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKSG

--------------------------------------------------------------

>50186_50186_16_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000544216_GPI_chr19_34887205_ENST00000356487_length(amino acids)=671AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEG
NADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRG
GFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLA
NFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVEL

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>50186_50186_17_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000544216_GPI_chr19_34887205_ENST00000415930_length(amino acids)=671AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEG
NADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRG
GFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLA
NFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVEL

--------------------------------------------------------------

>50186_50186_18_LSM14A-GPI_LSM14A_chr19_34712643_ENST00000544216_GPI_chr19_34887205_ENST00000586425_length(amino acids)=587AA_BP=1
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEG
NADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGFRGGRGRGGGRGGTFTAPRGFRG
GFRGGRGGREFADFEYRGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34712643/chr19:34887205)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LSM14A

Q8ND56

GPI

Q8IV16

FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753, ECO:0000269|PubMed:26339800, ECO:0000269|PubMed:29510985}.FUNCTION: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity). {ECO:0000250|UniProtKB:Q9D1N2, ECO:0000269|PubMed:17997385, ECO:0000269|PubMed:19304573, ECO:0000269|PubMed:21314738, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLSM14Achr19:34712643chr19:34887205ENST00000433627+911284_320456.01040.0DomainDFDF
HgeneLSM14Achr19:34712643chr19:34887205ENST00000544216+910284_320456.0464.0DomainDFDF
HgeneLSM14Achr19:34712643chr19:34887205ENST00000433627+911361_377456.01040.0MotifNote=FFD box
HgeneLSM14Achr19:34712643chr19:34887205ENST00000433627+911380_400456.01040.0MotifNote=TFG box
HgeneLSM14Achr19:34712643chr19:34887205ENST00000544216+910361_377456.0464.0MotifNote=FFD box
HgeneLSM14Achr19:34712643chr19:34887205ENST00000544216+910380_400456.0464.0MotifNote=TFG box

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLSM14Achr19:34663668chr19:34884633ENST00000433627+111284_32040.3333333333333361040.0DomainDFDF
HgeneLSM14Achr19:34663668chr19:34884633ENST00000544216+110284_32040.333333333333336464.0DomainDFDF
HgeneLSM14Achr19:34663668chr19:34884633ENST00000433627+111361_37740.3333333333333361040.0MotifNote=FFD box
HgeneLSM14Achr19:34663668chr19:34884633ENST00000433627+111380_40040.3333333333333361040.0MotifNote=TFG box
HgeneLSM14Achr19:34663668chr19:34884633ENST00000544216+110361_37740.333333333333336464.0MotifNote=FFD box
HgeneLSM14Achr19:34663668chr19:34884633ENST00000544216+110380_40040.333333333333336464.0MotifNote=TFG box
TgeneGPIchr19:34663668chr19:34884633ENST00000356487918159_160288.3333333333333559.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34663668chr19:34884633ENST00000356487918210_215288.3333333333333559.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34663668chr19:34884633ENST00000415930918159_160299.3333333333333570.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34663668chr19:34884633ENST00000415930918210_215299.3333333333333570.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34712643chr19:34887205ENST000003564871118159_160354.0559.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34712643chr19:34887205ENST000003564871118210_215354.0559.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34712643chr19:34887205ENST000004159301118159_160365.0570.0RegionGlucose-6-phosphate binding
TgeneGPIchr19:34712643chr19:34887205ENST000004159301118210_215365.0570.0RegionGlucose-6-phosphate binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
LSM14ALsm14a, ELAVL1, RAE1, HNRNPDL, SYNCRIP, CIRBP, HNRNPH1, DDX1, HNRNPU, HNRNPL, CSNK2A1, HECW2, TP53, PRMT8, NTRK1, XPO1, AHSA1, SORT1, EGFR, SFPQ, STRAP, G3BP1, PHACTR3, PTCH1, ESR2, HEXIM1, MEPCE, LARP7, SNAI1, RECQL4, ATG16L1, ZC3H7A, EIF4ENIF1, DDX6, C1QBP, PRMT1, EDC4, PATL1, LSM1, LSM2, LSM3, LSM4, LSM6, LSM7, DCP1A, EDC3, UBQLN2, ZBTB10, HDAC2, APEX1, ITFG1, PLEKHA4, ORF9b, ENG, ZC3H18, N, nsp9, nsp3, ESR1, CELF1, DAZL, FAM120C, FMR1, FUBP3, FXR1, IGF2BP2, AGO1, AGO2, AGO3, ALG13, ANKRD17, ATXN2, CAPRIN1, CNOT1, CNOT10, CNOT3, CNOT4, RQCD1, CPEB4, DCP1B, FAM120A, G3BP2, GIGYF1, GTPBP1, HELZ, IGF2BP1, LSM12, LSM14B, KIAA0430, MEX3A, MKRN2, OTUD4, PRRC2A, PRRC2B, PRRC2C, PUM1, R3HDM1, RC3H1, RC3H2, SECISBP2, SMG1, SMG5, SMG7, SMG8, STAU2, TDRD3, TNRC6B, TOP3B, TRIM56, UBAP2L, UPF1, USP10, YTHDF1, YTHDF2, YTHDF3, ZC3HAV1, ZCCHC11, MEX3B, MOV10, DDX3X, FXR2, ANKHD1-EIF4EBP3, CNOT2, KIAA0355, LARP1B, PUM2, RBMS1, ZCCHC3, UNK, XRN1, CEP85, LARP4B, RNF214, UBAP2, RBM47, NUFIP2, TAF15, CNOT6, NUPL2, PARP12, SPATS2L, ARHGAP11B, ARHGAP23, CIC, FBP1, INSIG1, INSIG2, NUP37, DDX58, OGT, CD274, UFL1, FBL, MAPRE1, MYCBP2, NAA40, TMEM14B, IFI27L1, COL8A1, KIF2C, TMC4, GAGE2E, PEA15, SEPT9, CPEB1, KLF15, KLF16, KLF5, KLF8, SOX15, SOX5, SOX6, TLX2, TLX3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LSM14Aall structure
GPI


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LSM14A-GPI


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LSM14A-GPI


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource