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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LSM1-WHSC1L1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LSM1-WHSC1L1
FusionPDB ID: 50204
FusionGDB2.0 ID: 50204
HgeneTgene
Gene symbol

LSM1

WHSC1L1

Gene ID

27257

54904

Gene nameLSM1 homolog, mRNA degradation associatednuclear receptor binding SET domain protein 3
SynonymsCASM|YJL124CKMT3F|KMT3G|WHISTLE|WHSC1L1|pp14328
Cytomap

8p11.23

8p11.23

Type of geneprotein-codingprotein-coding
DescriptionU6 snRNA-associated Sm-like protein LSm1LSM1 homolog, U6 small nuclear RNA associatedLSM1 mRNA degradation associatedLSM1, U6 small nuclear RNA associatedLSM1-like protein U6 small nuclear RNA associatedcancer-associated Sm proteincancer-associated histone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistle
Modification date2020031320200313
UniProtAcc

Q9BX40

.
Ensembl transtripts involved in fusion geneENST idsENST00000311351, ENST00000520755, 
ENST00000522515, 		ENST00000316985, 
ENST00000317025, ENST00000433384, 
ENST00000527502, ENST00000525081, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 6 X 3=7214 X 10 X 9=1260
# samples 517
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1260*10)=-2.88981708224958
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LSM1 [Title/Abstract] AND WHSC1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LSM1(38033793)-WHSC1L1(38196125), # samples:2
WHSC1L1(38239316)-LSM1(38021358), # samples:2
WHSC1L1(38239317)-LSM1(38021358), # samples:2
Anticipated loss of major functional domain due to fusion event.LSM1-WHSC1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LSM1-WHSC1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWHSC1L1

GO:0016571

histone methylation

16682010


check buttonFusion gene breakpoints across LSM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WHSC1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0EI-01ALSM1chr8

38027320

-WHSC1L1chr8

38205733

-
ChimerDB4LUSCTCGA-33-6738-01ALSM1chr8

38033793

-WHSC1L1chr8

38196125

-
ChimerDB4LUSCTCGA-33-6738LSM1chr8

38033792

-WHSC1L1chr8

38196125

-
ChimerDB4LUSCTCGA-33-6738LSM1chr8

38033793

-WHSC1L1chr8

38196125

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311351LSM1chr838033792-ENST00000317025WHSC1L1chr838196125-1002544240940801223
ENST00000311351LSM1chr838033792-ENST00000433384WHSC1L1chr838196125-454944240939331174
ENST00000311351LSM1chr838033792-ENST00000527502WHSC1L1chr838196125-414644240940471212
ENST00000311351LSM1chr838033792-ENST00000316985WHSC1L1chr838196125-32444424091704431
ENST00000520755LSM1chr838033792-ENST00000317025WHSC1L1chr838196125-998340036740381223
ENST00000520755LSM1chr838033792-ENST00000433384WHSC1L1chr838196125-450740036738911174
ENST00000520755LSM1chr838033792-ENST00000527502WHSC1L1chr838196125-410440036740051212
ENST00000520755LSM1chr838033792-ENST00000316985WHSC1L1chr838196125-32024003671662431
ENST00000311351LSM1chr838033793-ENST00000317025WHSC1L1chr838196125-1002544240940801223
ENST00000311351LSM1chr838033793-ENST00000433384WHSC1L1chr838196125-454944240939331174
ENST00000311351LSM1chr838033793-ENST00000527502WHSC1L1chr838196125-414644240940471212
ENST00000311351LSM1chr838033793-ENST00000316985WHSC1L1chr838196125-32444424091704431
ENST00000520755LSM1chr838033793-ENST00000317025WHSC1L1chr838196125-998340036740381223
ENST00000520755LSM1chr838033793-ENST00000433384WHSC1L1chr838196125-450740036738911174
ENST00000520755LSM1chr838033793-ENST00000527502WHSC1L1chr838196125-410440036740051212
ENST00000520755LSM1chr838033793-ENST00000316985WHSC1L1chr838196125-32024003671662431

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311351ENST00000317025LSM1chr838033792-WHSC1L1chr838196125-8.74E-050.9999126
ENST00000311351ENST00000433384LSM1chr838033792-WHSC1L1chr838196125-0.0003706050.9996294
ENST00000311351ENST00000527502LSM1chr838033792-WHSC1L1chr838196125-0.0008611470.99913883
ENST00000311351ENST00000316985LSM1chr838033792-WHSC1L1chr838196125-0.0007947230.9992053
ENST00000520755ENST00000317025LSM1chr838033792-WHSC1L1chr838196125-8.35E-050.99991643
ENST00000520755ENST00000433384LSM1chr838033792-WHSC1L1chr838196125-0.0003694690.9996306
ENST00000520755ENST00000527502LSM1chr838033792-WHSC1L1chr838196125-0.0008453350.9991547
ENST00000520755ENST00000316985LSM1chr838033792-WHSC1L1chr838196125-0.0007942020.99920577
ENST00000311351ENST00000317025LSM1chr838033793-WHSC1L1chr838196125-8.74E-050.9999126
ENST00000311351ENST00000433384LSM1chr838033793-WHSC1L1chr838196125-0.0003706050.9996294
ENST00000311351ENST00000527502LSM1chr838033793-WHSC1L1chr838196125-0.0008611470.99913883
ENST00000311351ENST00000316985LSM1chr838033793-WHSC1L1chr838196125-0.0007947230.9992053
ENST00000520755ENST00000317025LSM1chr838033793-WHSC1L1chr838196125-8.35E-050.99991643
ENST00000520755ENST00000433384LSM1chr838033793-WHSC1L1chr838196125-0.0003694690.9996306
ENST00000520755ENST00000527502LSM1chr838033793-WHSC1L1chr838196125-0.0008453350.9991547
ENST00000520755ENST00000316985LSM1chr838033793-WHSC1L1chr838196125-0.0007942020.99920577

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50204_50204_1_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000316985_length(amino acids)=431AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK

--------------------------------------------------------------

>50204_50204_2_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000317025_length(amino acids)=1223AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV
TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACAS
TNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHS

--------------------------------------------------------------

>50204_50204_3_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000433384_length(amino acids)=1174AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRS
VPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPY
KHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKR
SIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPA
GMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPK
AYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGE

--------------------------------------------------------------

>50204_50204_4_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000527502_length(amino acids)=1212AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSDRIIDAGPK
GNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKL
KQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALV

--------------------------------------------------------------

>50204_50204_5_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000316985_length(amino acids)=431AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK

--------------------------------------------------------------

>50204_50204_6_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000317025_length(amino acids)=1223AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV
TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACAS
TNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHS

--------------------------------------------------------------

>50204_50204_7_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000433384_length(amino acids)=1174AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRS
VPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPY
KHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKR
SIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPA
GMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPK
AYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGE

--------------------------------------------------------------

>50204_50204_8_LSM1-WHSC1L1_LSM1_chr8_38033792_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000527502_length(amino acids)=1212AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSDRIIDAGPK
GNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKL
KQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALV

--------------------------------------------------------------

>50204_50204_9_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000316985_length(amino acids)=431AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK

--------------------------------------------------------------

>50204_50204_10_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000317025_length(amino acids)=1223AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV
TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACAS
TNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHS

--------------------------------------------------------------

>50204_50204_11_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000433384_length(amino acids)=1174AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRS
VPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPY
KHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKR
SIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPA
GMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPK
AYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGE

--------------------------------------------------------------

>50204_50204_12_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000311351_WHSC1L1_chr8_38196125_ENST00000527502_length(amino acids)=1212AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSDRIIDAGPK
GNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKL
KQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALV

--------------------------------------------------------------

>50204_50204_13_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000316985_length(amino acids)=431AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK

--------------------------------------------------------------

>50204_50204_14_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000317025_length(amino acids)=1223AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV
TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACAS
TNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHS

--------------------------------------------------------------

>50204_50204_15_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000433384_length(amino acids)=1174AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRS
VPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPY
KHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKR
SIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPA
GMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPK
AYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGE

--------------------------------------------------------------

>50204_50204_16_LSM1-WHSC1L1_LSM1_chr8_38033793_ENST00000520755_WHSC1L1_chr8_38196125_ENST00000527502_length(amino acids)=1212AA_BP=11
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSDRIIDAGPK
GNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKL
KQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38033793/chr8:38196125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LSM1

Q9BX40

.
FUNCTION: Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity). {ECO:0000250|UniProtKB:Q68FI1, ECO:0000250|UniProtKB:Q8CGC4}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003169851101033_1069225.0646.0Coiled coilOntology_term=ECO:0000255
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003170251241033_1069225.01438.0Coiled coilOntology_term=ECO:0000255
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000004333841231033_1069225.01389.0Coiled coilOntology_term=ECO:0000255
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003169851101033_1069225.0646.0Coiled coilOntology_term=ECO:0000255
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003170251241033_1069225.01438.0Coiled coilOntology_term=ECO:0000255
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000004333841231033_1069225.01389.0Coiled coilOntology_term=ECO:0000255
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003169851101093_1143225.0646.0DomainAWS
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003169851101145_1262225.0646.0DomainSET
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003169851101269_1285225.0646.0DomainPost-SET
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000316985110270_333225.0646.0DomainPWWP 1
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000316985110960_1022225.0646.0DomainPWWP 2
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003170251241093_1143225.01438.0DomainAWS
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003170251241145_1262225.01438.0DomainSET
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003170251241269_1285225.01438.0DomainPost-SET
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000317025124270_333225.01438.0DomainPWWP 1
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000317025124960_1022225.01438.0DomainPWWP 2
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000004333841231093_1143225.01389.0DomainAWS
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000004333841231145_1262225.01389.0DomainSET
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000004333841231269_1285225.01389.0DomainPost-SET
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000433384123270_333225.01389.0DomainPWWP 1
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000433384123960_1022225.01389.0DomainPWWP 2
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003169851101093_1143225.0646.0DomainAWS
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003169851101145_1262225.0646.0DomainSET
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003169851101269_1285225.0646.0DomainPost-SET
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000316985110270_333225.0646.0DomainPWWP 1
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000316985110960_1022225.0646.0DomainPWWP 2
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003170251241093_1143225.01438.0DomainAWS
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003170251241145_1262225.01438.0DomainSET
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003170251241269_1285225.01438.0DomainPost-SET
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000317025124270_333225.01438.0DomainPWWP 1
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000317025124960_1022225.01438.0DomainPWWP 2
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000004333841231093_1143225.01389.0DomainAWS
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000004333841231145_1262225.01389.0DomainSET
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000004333841231269_1285225.01389.0DomainPost-SET
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000433384123270_333225.01389.0DomainPWWP 1
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000433384123960_1022225.01389.0DomainPWWP 2
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003169851101321_1368225.0646.0Zinc fingerPHD-type 4%3B atypical
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000316985110701_748225.0646.0Zinc fingerPHD-type 1
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000316985110749_805225.0646.0Zinc fingerPHD-type 2
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000316985110862_955225.0646.0Zinc fingerPHD-type 3
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000003170251241321_1368225.01438.0Zinc fingerPHD-type 4%3B atypical
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000317025124701_748225.01438.0Zinc fingerPHD-type 1
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000317025124749_805225.01438.0Zinc fingerPHD-type 2
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000317025124862_955225.01438.0Zinc fingerPHD-type 3
TgeneWHSC1L1chr8:38033792chr8:38196125ENST000004333841231321_1368225.01389.0Zinc fingerPHD-type 4%3B atypical
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000433384123701_748225.01389.0Zinc fingerPHD-type 1
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000433384123749_805225.01389.0Zinc fingerPHD-type 2
TgeneWHSC1L1chr8:38033792chr8:38196125ENST00000433384123862_955225.01389.0Zinc fingerPHD-type 3
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003169851101321_1368225.0646.0Zinc fingerPHD-type 4%3B atypical
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000316985110701_748225.0646.0Zinc fingerPHD-type 1
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000316985110749_805225.0646.0Zinc fingerPHD-type 2
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000316985110862_955225.0646.0Zinc fingerPHD-type 3
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000003170251241321_1368225.01438.0Zinc fingerPHD-type 4%3B atypical
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000317025124701_748225.01438.0Zinc fingerPHD-type 1
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000317025124749_805225.01438.0Zinc fingerPHD-type 2
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000317025124862_955225.01438.0Zinc fingerPHD-type 3
TgeneWHSC1L1chr8:38033793chr8:38196125ENST000004333841231321_1368225.01389.0Zinc fingerPHD-type 4%3B atypical
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000433384123701_748225.01389.0Zinc fingerPHD-type 1
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000433384123749_805225.01389.0Zinc fingerPHD-type 2
TgeneWHSC1L1chr8:38033793chr8:38196125ENST00000433384123862_955225.01389.0Zinc fingerPHD-type 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1945_LSM1_38033793_WHSC1L1_38196125_ranked_0.pdbLSM13803379338033793ENST00000316985WHSC1L1chr838196125-
MAPPASSRTLTRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRG
AREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY
IDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASIT
MHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEK
KQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVG
FGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFS
CKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYI
LICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFH
PECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK
SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESEC
LNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV
TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACAS
TNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHS
1223


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LSM1_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LSM1
WHSC1L1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LSM1-WHSC1L1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LSM1-WHSC1L1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource