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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LUC7L3-CACNA1H

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LUC7L3-CACNA1H
FusionPDB ID: 50341
FusionGDB2.0 ID: 50341
HgeneTgene
Gene symbol

LUC7L3

CACNA1H

Gene ID

51747

8912

Gene nameLUC7 like 3 pre-mRNA splicing factorcalcium voltage-gated channel subunit alpha1 H
SynonymsCRA|CREAP-1|CROP|LUC7A|OA48-18|hLuc7ACACNA1HB|Cav3.2|ECA6|EIG6|HALD4
Cytomap

17q21.33

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionluc7-like protein 3CRE-associated protein 1LUC7-like 3cAMP regulatory element-associated protein 1cisplatin resistance-associated-overexpressed proteinokadaic acid-inducible phosphoprotein OA48-18voltage-dependent T-type calcium channel subunit alpha-1Hcalcium channel, voltage-dependent, T type, alpha 1H subunitcalcium channel, voltage-dependent, T type, alpha 1Hb subunitlow-voltage-activated calcium channel alpha1 3.2 subunitlow-voltage-activ
Modification date2020031320200313
UniProtAcc

O95232

O95180

Ensembl transtripts involved in fusion geneENST idsENST00000240304, ENST00000393227, 
ENST00000505658, ENST00000544170, 
ENST00000311571, ENST00000503798, 
ENST00000348261, ENST00000358590, 
ENST00000565831, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 13 X 8=18729 X 9 X 4=324
# samples 229
** MAII scorelog2(22/1872*10)=-3.08900500605875
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LUC7L3 [Title/Abstract] AND CACNA1H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LUC7L3(48819092)-CACNA1H(1251662), # samples:1
Anticipated loss of major functional domain due to fusion event.LUC7L3-CACNA1H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LUC7L3-CACNA1H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LUC7L3-CACNA1H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LUC7L3-CACNA1H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCACNA1H

GO:0042391

regulation of membrane potential

21084288

TgeneCACNA1H

GO:0070509

calcium ion import

21084288

TgeneCACNA1H

GO:0098662

inorganic cation transmembrane transport

27149520


check buttonFusion gene breakpoints across LUC7L3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNA1H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A92DLUC7L3chr17

48819092

+CACNA1Hchr16

1251662

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000505658LUC7L3chr1748819092+ENST00000348261CACNA1Hchr161251662+723961515364642103
ENST00000505658LUC7L3chr1748819092+ENST00000358590CACNA1Hchr161251662+722461515364462097
ENST00000505658LUC7L3chr1748819092+ENST00000565831CACNA1Hchr161251662+653761515364462097
ENST00000393227LUC7L3chr1748819092+ENST00000348261CACNA1Hchr161251662+71845609864092103
ENST00000393227LUC7L3chr1748819092+ENST00000358590CACNA1Hchr161251662+71695609863912097
ENST00000393227LUC7L3chr1748819092+ENST00000565831CACNA1Hchr161251662+64825609863912097
ENST00000240304LUC7L3chr1748819092+ENST00000348261CACNA1Hchr161251662+71805569464052103
ENST00000240304LUC7L3chr1748819092+ENST00000358590CACNA1Hchr161251662+71655569463872097
ENST00000240304LUC7L3chr1748819092+ENST00000565831CACNA1Hchr161251662+64785569463872097
ENST00000544170LUC7L3chr1748819092+ENST00000348261CACNA1Hchr161251662+708746326563122015
ENST00000544170LUC7L3chr1748819092+ENST00000358590CACNA1Hchr161251662+707246326562942009
ENST00000544170LUC7L3chr1748819092+ENST00000565831CACNA1Hchr161251662+638546326562942009

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000505658ENST00000348261LUC7L3chr1748819092+CACNA1Hchr161251662+0.0059129040.9940871
ENST00000505658ENST00000358590LUC7L3chr1748819092+CACNA1Hchr161251662+0.0068881860.99311185
ENST00000505658ENST00000565831LUC7L3chr1748819092+CACNA1Hchr161251662+0.0086285260.9913715
ENST00000393227ENST00000348261LUC7L3chr1748819092+CACNA1Hchr161251662+0.005717360.9942827
ENST00000393227ENST00000358590LUC7L3chr1748819092+CACNA1Hchr161251662+0.0067012790.9932987
ENST00000393227ENST00000565831LUC7L3chr1748819092+CACNA1Hchr161251662+0.0084759570.9915241
ENST00000240304ENST00000348261LUC7L3chr1748819092+CACNA1Hchr161251662+0.0057430640.9942569
ENST00000240304ENST00000358590LUC7L3chr1748819092+CACNA1Hchr161251662+0.0067317030.9932683
ENST00000240304ENST00000565831LUC7L3chr1748819092+CACNA1Hchr161251662+0.0085200110.99148
ENST00000544170ENST00000348261LUC7L3chr1748819092+CACNA1Hchr161251662+0.0077690290.99223095
ENST00000544170ENST00000358590LUC7L3chr1748819092+CACNA1Hchr161251662+0.0088926640.9911074
ENST00000544170ENST00000565831LUC7L3chr1748819092+CACNA1Hchr161251662+0.0112298170.98877025

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50341_50341_1_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000240304_CACNA1H_chr16_1251662_ENST00000348261_length(amino acids)=2103AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYY
ADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL
LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDN
PCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA
REDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGT
PLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVT
QGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDA
QGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRD
SLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEK

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>50341_50341_2_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000240304_CACNA1H_chr16_1251662_ENST00000358590_length(amino acids)=2097AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPT
RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI
TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLS
RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL
DAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQ
SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDK
PGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTE
GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYL

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>50341_50341_3_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000240304_CACNA1H_chr16_1251662_ENST00000565831_length(amino acids)=2097AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPT
RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI
TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLS
RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL
DAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQ
SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDK
PGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTE
GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYL

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>50341_50341_4_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000393227_CACNA1H_chr16_1251662_ENST00000348261_length(amino acids)=2103AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYY
ADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL
LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDN
PCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA
REDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGT
PLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVT
QGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDA
QGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRD
SLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEK

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>50341_50341_5_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000393227_CACNA1H_chr16_1251662_ENST00000358590_length(amino acids)=2097AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPT
RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI
TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLS
RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL
DAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQ
SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDK
PGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTE
GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYL

--------------------------------------------------------------

>50341_50341_6_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000393227_CACNA1H_chr16_1251662_ENST00000565831_length(amino acids)=2097AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPT
RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI
TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLS
RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL
DAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQ
SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDK
PGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTE
GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYL

--------------------------------------------------------------

>50341_50341_7_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000505658_CACNA1H_chr16_1251662_ENST00000348261_length(amino acids)=2103AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYY
ADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL
LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDN
PCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA
REDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGT
PLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVT
QGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDA
QGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRD
SLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEK

--------------------------------------------------------------

>50341_50341_8_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000505658_CACNA1H_chr16_1251662_ENST00000358590_length(amino acids)=2097AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPT
RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI
TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLS
RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL
DAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQ
SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDK
PGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTE
GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYL

--------------------------------------------------------------

>50341_50341_9_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000505658_CACNA1H_chr16_1251662_ENST00000565831_length(amino acids)=2097AA_BP=153
MGWWEQPPEGSTMISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMK
VGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQRES
QLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYH
HHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGT
MNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV
DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL
SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI
LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAV
TPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGR
APSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAA
ELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVV
ETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIM
YDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPT
RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI
TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLS
RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL
DAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQ
SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDK
PGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTE
GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYL

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>50341_50341_10_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000544170_CACNA1H_chr16_1251662_ENST00000348261_length(amino acids)=2015AA_BP=65
MKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQR
ESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLV
YHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGL
GTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELK
SCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRR
IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADG
GLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVF
QILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSL
AVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL
GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHRED
AAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFL
SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKL
VVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVN
IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRP
YYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAI
VLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSE
DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK
EAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGA
GTPLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRP
VTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSV
DAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPH
RDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPP

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>50341_50341_11_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000544170_CACNA1H_chr16_1251662_ENST00000358590_length(amino acids)=2009AA_BP=65
MKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQR
ESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLV
YHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGL
GTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELK
SCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRR
IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADG
GLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVF
QILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSL
AVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL
GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHRED
AAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFL
SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKL
VVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVN
IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYS
PTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM
GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEG
LSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDA
ELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGS
VASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGS
LQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFL
DKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEP
TEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGL

--------------------------------------------------------------

>50341_50341_12_LUC7L3-CACNA1H_LUC7L3_chr17_48819092_ENST00000544170_CACNA1H_chr16_1251662_ENST00000565831_length(amino acids)=2009AA_BP=65
MKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQVGSFFMINLCLVVIATQFSETKQR
ESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLV
YHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGL
GTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELK
SCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRR
IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADG
GLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVF
QILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSL
AVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL
GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHRED
AAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFL
SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKL
VVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVN
IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYS
PTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM
GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEG
LSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDA
ELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGS
VASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGS
LQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFL
DKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEP
TEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48819092/chr16:1251662)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LUC7L3

O95232

CACNA1H

O95180

FUNCTION: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}.FUNCTION: Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {ECO:0000269|PubMed:24277868, ECO:0000269|PubMed:25907736, ECO:0000269|PubMed:27149520, ECO:0000269|PubMed:27729216, ECO:0000269|PubMed:9670923, ECO:0000269|PubMed:9930755, ECO:0000305, ECO:0000305|PubMed:15048902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351107_1110404.02354.0Compositional biasNote=Poly-Ser
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351583_1586404.02354.0Compositional biasNote=Poly-Arg
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735520_530404.02354.0Compositional biasNote=Poly-His
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341107_1110404.02348.0Compositional biasNote=Poly-Ser
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341583_1586404.02348.0Compositional biasNote=Poly-Arg
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734520_530404.02348.0Compositional biasNote=Poly-His
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331107_1110404.02348.0Compositional biasNote=Poly-Ser
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331583_1586404.02348.0Compositional biasNote=Poly-Arg
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633520_530404.02348.0Compositional biasNote=Poly-His
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351281_1558404.02354.0RepeatNote=III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351602_1863404.02354.0RepeatNote=IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735779_1018404.02354.0RepeatNote=II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341281_1558404.02348.0RepeatNote=III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341602_1863404.02348.0RepeatNote=IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734779_1018404.02348.0RepeatNote=II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331281_1558404.02348.0RepeatNote=III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331602_1863404.02348.0RepeatNote=IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633779_1018404.02348.0RepeatNote=II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351016_1290404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351314_1331404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351353_1362404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351383_1396404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351419_1428404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351453_1529404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351556_1616404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351638_1651404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351674_1680404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351700_1713404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351738_1751404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351773_1835404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351864_2353404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735420_793404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735815_827404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735850_855404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735875_882404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735907_917404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735939_990404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341016_1290404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341314_1331404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341353_1362404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341383_1396404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341419_1428404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341453_1529404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341556_1616404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341638_1651404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341674_1680404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341700_1713404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341738_1751404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341773_1835404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341864_2353404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734420_793404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734815_827404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734850_855404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734875_882404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734907_917404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734939_990404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331016_1290404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331314_1331404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331353_1362404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331383_1396404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331419_1428404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331453_1529404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331556_1616404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331638_1651404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331674_1680404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331700_1713404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331738_1751404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331773_1835404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331864_2353404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633420_793404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633815_827404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633850_855404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633875_882404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633907_917404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633939_990404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351291_1313404.02354.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351332_1352404.02354.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351363_1382404.02354.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351397_1418404.02354.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351429_1452404.02354.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351530_1555404.02354.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351617_1637404.02354.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351652_1673404.02354.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351681_1699404.02354.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351714_1737404.02354.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351752_1772404.02354.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351836_1863404.02354.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735794_814404.02354.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735828_849404.02354.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735856_874404.02354.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735883_906404.02354.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735918_938404.02354.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735991_1015404.02354.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341291_1313404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341332_1352404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341363_1382404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341397_1418404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341429_1452404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341530_1555404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341617_1637404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341652_1673404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341681_1699404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341714_1737404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341752_1772404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341836_1863404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734794_814404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734828_849404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734856_874404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734883_906404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734918_938404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734991_1015404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331291_1313404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331332_1352404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331363_1382404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331397_1418404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331429_1452404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331530_1555404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331617_1637404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331652_1673404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331681_1699404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331714_1737404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331752_1772404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331836_1863404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633794_814404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633828_849404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633856_874404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633883_906404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633918_938404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633991_1015404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat II

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLUC7L3chr17:48819092chr16:1251662ENST00000240304+511124_181142.0526.6666666666666Coiled coilOntology_term=ECO:0000255
HgeneLUC7L3chr17:48819092chr16:1251662ENST00000505658+510124_181142.0433.0Coiled coilOntology_term=ECO:0000255
HgeneLUC7L3chr17:48819092chr16:1251662ENST00000240304+511228_282142.0526.6666666666666Compositional biasNote=Glu-rich
HgeneLUC7L3chr17:48819092chr16:1251662ENST00000240304+511235_395142.0526.6666666666666Compositional biasNote=Arg/Ser-rich
HgeneLUC7L3chr17:48819092chr16:1251662ENST00000505658+510228_282142.0433.0Compositional biasNote=Glu-rich
HgeneLUC7L3chr17:48819092chr16:1251662ENST00000505658+510235_395142.0433.0Compositional biasNote=Arg/Ser-rich
TgeneCACNA1Hchr17:48819092chr16:1251662ENST0000034826173587_422404.02354.0RepeatNote=I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST0000035859073487_422404.02348.0RepeatNote=I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST0000056583163387_422404.02348.0RepeatNote=I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735120_141404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735161_169404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735185_193404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003482617351_100404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735213_232404.02354.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735254_394404.02354.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734120_141404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734161_169404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734185_193404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000003585907341_100404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734213_232404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734254_394404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633120_141404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633161_169404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633185_193404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST000005658316331_100404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633213_232404.02348.0Topological domainCytoplasmic
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633254_394404.02348.0Topological domainExtracellular
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735101_119404.02354.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735142_160404.02354.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735170_184404.02354.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735194_212404.02354.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735233_253404.02354.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000348261735395_419404.02354.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734101_119404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734142_160404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734170_184404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734194_212404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734233_253404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000358590734395_419404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633101_119404.02348.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633142_160404.02348.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633170_184404.02348.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633194_212404.02348.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633233_253404.02348.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Hchr17:48819092chr16:1251662ENST00000565831633395_419404.02348.0TransmembraneHelical%3B Name%3DS6 of repeat I


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LUC7L3
CACNA1H


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LUC7L3-CACNA1H


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LUC7L3-CACNA1H


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource