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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABL2-XRRA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABL2-XRRA1
FusionPDB ID: 505
FusionGDB2.0 ID: 505
HgeneTgene
Gene symbol

ABL2

XRRA1

Gene ID

27

143570

Gene nameABL proto-oncogene 2, non-receptor tyrosine kinaseX-ray radiation resistance associated 1
SynonymsABLL|ARG-
Cytomap

1q25.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2X-ray radiation resistance-associated protein 1
Modification date2020032720200313
UniProtAcc

P42684

.
Ensembl transtripts involved in fusion geneENST idsENST00000367623, ENST00000392043, 
ENST00000502732, ENST00000507173, 
ENST00000511413, ENST00000344730, 
ENST00000408940, ENST00000504405, 
ENST00000512653, 		ENST00000533598, 
ENST00000321448, ENST00000340360, 
ENST00000527087, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 6 X 6=2887 X 9 X 6=378
# samples 89
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABL2 [Title/Abstract] AND XRRA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABL2(179198376)-XRRA1(74559507), # samples:1
Anticipated loss of major functional domain due to fusion event.ABL2-XRRA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-XRRA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABL2

GO:0018108

peptidyl-tyrosine phosphorylation

15886098

HgeneABL2

GO:0051353

positive regulation of oxidoreductase activity

12893824

TgeneXRRA1

GO:0010165

response to X-ray

12908878


check buttonFusion gene breakpoints across ABL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRRA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-K4-A4AC-01AABL2chr1

179198376

-XRRA1chr11

74559507

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502732ABL2chr1179198376-ENST00000340360XRRA1chr1174559507-43543611031383426
ENST00000502732ABL2chr1179198376-ENST00000321448XRRA1chr1174559507-36743611031383426
ENST00000502732ABL2chr1179198376-ENST00000527087XRRA1chr1174559507-15103611031062319
ENST00000367623ABL2chr1179198376-ENST00000340360XRRA1chr1174559507-41501571541179341
ENST00000367623ABL2chr1179198376-ENST00000321448XRRA1chr1174559507-34701571541179341
ENST00000367623ABL2chr1179198376-ENST00000527087XRRA1chr1174559507-1306157154858234
ENST00000507173ABL2chr1179198376-ENST00000340360XRRA1chr1174559507-41501571541179341
ENST00000507173ABL2chr1179198376-ENST00000321448XRRA1chr1174559507-34701571541179341
ENST00000507173ABL2chr1179198376-ENST00000527087XRRA1chr1174559507-1306157154858234
ENST00000511413ABL2chr1179198376-ENST00000340360XRRA1chr1174559507-41501571541179341
ENST00000511413ABL2chr1179198376-ENST00000321448XRRA1chr1174559507-34701571541179341
ENST00000511413ABL2chr1179198376-ENST00000527087XRRA1chr1174559507-1306157154858234
ENST00000392043ABL2chr1179198376-ENST00000340360XRRA1chr1174559507-44374441861466426
ENST00000392043ABL2chr1179198376-ENST00000321448XRRA1chr1174559507-37574441861466426
ENST00000392043ABL2chr1179198376-ENST00000527087XRRA1chr1174559507-15934441861145319

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502732ENST00000340360ABL2chr1179198376-XRRA1chr1174559507-0.000896120.99910384
ENST00000502732ENST00000321448ABL2chr1179198376-XRRA1chr1174559507-0.0012731070.9987269
ENST00000502732ENST00000527087ABL2chr1179198376-XRRA1chr1174559507-0.0098748630.9901252
ENST00000367623ENST00000340360ABL2chr1179198376-XRRA1chr1174559507-0.0007582490.9992418
ENST00000367623ENST00000321448ABL2chr1179198376-XRRA1chr1174559507-0.0010565640.9989435
ENST00000367623ENST00000527087ABL2chr1179198376-XRRA1chr1174559507-0.0104220260.989578
ENST00000507173ENST00000340360ABL2chr1179198376-XRRA1chr1174559507-0.0007582490.9992418
ENST00000507173ENST00000321448ABL2chr1179198376-XRRA1chr1174559507-0.0010565640.9989435
ENST00000507173ENST00000527087ABL2chr1179198376-XRRA1chr1174559507-0.0104220260.989578
ENST00000511413ENST00000340360ABL2chr1179198376-XRRA1chr1174559507-0.0007582490.9992418
ENST00000511413ENST00000321448ABL2chr1179198376-XRRA1chr1174559507-0.0010565640.9989435
ENST00000511413ENST00000527087ABL2chr1179198376-XRRA1chr1174559507-0.0104220260.989578
ENST00000392043ENST00000340360ABL2chr1179198376-XRRA1chr1174559507-0.0008482180.9991518
ENST00000392043ENST00000321448ABL2chr1179198376-XRRA1chr1174559507-0.0012227030.99877733
ENST00000392043ENST00000527087ABL2chr1179198376-XRRA1chr1174559507-0.0084277010.99157226

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>505_505_1_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000367623_XRRA1_chr11_74559507_ENST00000321448_length(amino acids)=341AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI
EPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLV

--------------------------------------------------------------

>505_505_2_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000367623_XRRA1_chr11_74559507_ENST00000340360_length(amino acids)=341AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI
EPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLV

--------------------------------------------------------------

>505_505_3_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000367623_XRRA1_chr11_74559507_ENST00000527087_length(amino acids)=234AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI

--------------------------------------------------------------

>505_505_4_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000392043_XRRA1_chr11_74559507_ENST00000321448_length(amino acids)=426AA_BP=67
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMVKSE
IPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTV
RLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGI
QKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQY

--------------------------------------------------------------

>505_505_5_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000392043_XRRA1_chr11_74559507_ENST00000340360_length(amino acids)=426AA_BP=67
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMVKSE
IPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTV
RLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGI
QKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQY

--------------------------------------------------------------

>505_505_6_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000392043_XRRA1_chr11_74559507_ENST00000527087_length(amino acids)=319AA_BP=67
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMVKSE
IPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTV
RLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGI

--------------------------------------------------------------

>505_505_7_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000502732_XRRA1_chr11_74559507_ENST00000321448_length(amino acids)=426AA_BP=67
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMVKSE
IPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTV
RLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGI
QKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQY

--------------------------------------------------------------

>505_505_8_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000502732_XRRA1_chr11_74559507_ENST00000340360_length(amino acids)=426AA_BP=67
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMVKSE
IPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTV
RLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGI
QKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHKQY

--------------------------------------------------------------

>505_505_9_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000502732_XRRA1_chr11_74559507_ENST00000527087_length(amino acids)=319AA_BP=67
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMVKSE
IPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDTTV
RLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGI

--------------------------------------------------------------

>505_505_10_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000507173_XRRA1_chr11_74559507_ENST00000321448_length(amino acids)=341AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI
EPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLV

--------------------------------------------------------------

>505_505_11_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000507173_XRRA1_chr11_74559507_ENST00000340360_length(amino acids)=341AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI
EPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLV

--------------------------------------------------------------

>505_505_12_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000507173_XRRA1_chr11_74559507_ENST00000527087_length(amino acids)=234AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI

--------------------------------------------------------------

>505_505_13_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000511413_XRRA1_chr11_74559507_ENST00000321448_length(amino acids)=341AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI
EPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLV

--------------------------------------------------------------

>505_505_14_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000511413_XRRA1_chr11_74559507_ENST00000340360_length(amino acids)=341AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI
EPKGIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLV

--------------------------------------------------------------

>505_505_15_ABL2-XRRA1_ABL2_chr1_179198376_ENST00000511413_XRRA1_chr11_74559507_ENST00000527087_length(amino acids)=234AA_BP=1
MVKSEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHL
SDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:179198376/chr11:74559507)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABL2

P42684

.
FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016723_745177.0518.0Coiled coilOntology_term=ECO:0000255
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319723_745452.0793.0Coiled coilOntology_term=ECO:0000255
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015723_745365.0599.0Coiled coilOntology_term=ECO:0000255
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016188_209177.0518.0RepeatNote=LRR 4
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016229_250177.0518.0RepeatNote=LRR 5
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016254_275177.0518.0RepeatNote=LRR 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113561_56401065.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113732_73901065.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113843_105501065.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113984_98801065.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111561_56452.3333333333333361162.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111732_73952.3333333333333361162.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111843_105552.3333333333333361162.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111984_98852.3333333333333361162.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110561_56452.333333333333336543.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110732_73952.333333333333336543.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110843_105552.333333333333336543.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110984_98852.333333333333336543.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111561_5640.01147.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111732_7390.01147.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111843_10550.01147.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111984_9880.01147.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112561_56452.3333333333333361183.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112732_73952.3333333333333361183.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112843_105552.3333333333333361183.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112984_98852.3333333333333361183.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112561_5640.01044.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112732_7390.01044.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112843_10550.01044.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112984_9880.01044.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112561_56452.3333333333333361059.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112732_73952.3333333333333361059.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112843_105552.3333333333333361059.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112984_98852.3333333333333361059.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113561_56452.3333333333333361080.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113732_73952.3333333333333361080.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113843_105552.3333333333333361080.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113984_98852.3333333333333361080.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112561_56401168.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112732_73901168.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112843_105501168.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112984_98801168.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113107_16701065.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113173_26301065.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113288_53901065.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111107_16752.3333333333333361162.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111173_26352.3333333333333361162.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111288_53952.3333333333333361162.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110107_16752.333333333333336543.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110173_26352.333333333333336543.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110288_53952.333333333333336543.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111107_1670.01147.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111173_2630.01147.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111288_5390.01147.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112107_16752.3333333333333361183.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112173_26352.3333333333333361183.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112288_53952.3333333333333361183.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112107_1670.01044.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112173_2630.01044.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112288_5390.01044.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112107_16752.3333333333333361059.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112173_26352.3333333333333361059.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112288_53952.3333333333333361059.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113107_16752.3333333333333361080.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113173_26352.3333333333333361080.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113288_53952.3333333333333361080.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112107_16701168.0DomainSH3
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112173_26301168.0DomainSH2
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112288_53901168.0DomainProtein kinase
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113427_45101065.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113658_66001065.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111427_45152.3333333333333361162.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111658_66052.3333333333333361162.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110427_45152.333333333333336543.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110658_66052.333333333333336543.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111427_4510.01147.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111658_6600.01147.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112427_45152.3333333333333361183.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112658_66052.3333333333333361183.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112427_4510.01044.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112658_6600.01044.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112427_45152.3333333333333361059.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112658_66052.3333333333333361059.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113427_45152.3333333333333361080.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113658_66052.3333333333333361080.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112427_45101168.0MotifKinase activation loop
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112658_66001168.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113294_30201065.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113362_36801065.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111294_30252.3333333333333361162.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111362_36852.3333333333333361162.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110294_30252.333333333333336543.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110362_36852.333333333333336543.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111294_3020.01147.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111362_3680.01147.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112294_30252.3333333333333361183.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112362_36852.3333333333333361183.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112294_3020.01044.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112362_3680.01044.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112294_30252.3333333333333361059.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112362_36852.3333333333333361059.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113294_30252.3333333333333361080.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113362_36852.3333333333333361080.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112294_30201168.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112362_36801168.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-1131020_118201065.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-1132_10601065.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000344730-113694_93001065.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-1111020_118252.3333333333333361162.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-1112_10652.3333333333333361162.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000367623-111694_93052.3333333333333361162.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-1101020_118252.333333333333336543.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-1102_10652.333333333333336543.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000392043-110694_93052.333333333333336543.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-1111020_11820.01147.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-1112_1060.01147.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000408940-111694_9300.01147.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-1121020_118252.3333333333333361183.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-1122_10652.3333333333333361183.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000502732-112694_93052.3333333333333361183.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-1121020_11820.01044.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-1122_1060.01044.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000504405-112694_9300.01044.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-1121020_118252.3333333333333361059.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-1122_10652.3333333333333361059.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000507173-112694_93052.3333333333333361059.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-1131020_118252.3333333333333361080.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-1132_10652.3333333333333361080.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000511413-113694_93052.3333333333333361080.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-1121020_118201168.0RegionF-actin-binding
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-1122_10601168.0RegionNote=CAP
HgeneABL2chr1:179198376chr11:74559507ENST00000512653-112694_93001168.0RegionF-actin-binding
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016104_125177.0518.0RepeatNote=LRR 1
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016141_155177.0518.0RepeatNote=LRR 2
TgeneXRRA1chr1:179198376chr11:74559507ENST000003214481016164_184177.0518.0RepeatNote=LRR 3
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319104_125452.0793.0RepeatNote=LRR 1
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319141_155452.0793.0RepeatNote=LRR 2
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319164_184452.0793.0RepeatNote=LRR 3
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319188_209452.0793.0RepeatNote=LRR 4
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319229_250452.0793.0RepeatNote=LRR 5
TgeneXRRA1chr1:179198376chr11:74559507ENST000003403601319254_275452.0793.0RepeatNote=LRR 6
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015104_125365.0599.0RepeatNote=LRR 1
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015141_155365.0599.0RepeatNote=LRR 2
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015164_184365.0599.0RepeatNote=LRR 3
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015188_209365.0599.0RepeatNote=LRR 4
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015229_250365.0599.0RepeatNote=LRR 5
TgeneXRRA1chr1:179198376chr11:74559507ENST000005270871015254_275365.0599.0RepeatNote=LRR 6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABL2all structure
XRRA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABL2-XRRA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABL2-XRRA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource