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Fusion Protein:MACROD2-DCLK2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MACROD2-DCLK2 | FusionPDB ID: 50654 | FusionGDB2.0 ID: 50654 | Hgene | Tgene | Gene symbol | MACROD2 | DCLK2 | Gene ID | 140733 | 166614 |
| Gene name | mono-ADP ribosylhydrolase 2 | doublecortin like kinase 2 | |
| Synonyms | C20orf133|C2orf133 | CL2|CLICK-II|CLICK2|CLIK2|DCAMKL2|DCDC3|DCDC3B|DCK2 | |
| Cytomap | 20p12.1 | 4q31.23-q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate] | serine/threonine-protein kinase DCLK2CaMK-like CREB regulatory kinase 2doublecortin and CaM kinase-like 2doublecortin domain-containing protein 3Bdoublecortin-like and CAM kinase-like 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | A1Z1Q3 | Q8N568 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000217246, ENST00000310348, ENST00000378058, ENST00000402914, ENST00000407045, ENST00000464883, | ENST00000507694, ENST00000296550, ENST00000302176, ENST00000506325, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 22 X 20 X 10=4400 | 2 X 1 X 2=4 |
| # samples | 25 | 2 | |
| ** MAII score | log2(25/4400*10)=-4.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MACROD2 [Title/Abstract] AND DCLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MACROD2(13983050)-DCLK2(151023630), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MACROD2-DCLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MACROD2 | GO:0042278 | purine nucleoside metabolic process | 21257746 |
| Hgene | MACROD2 | GO:0051725 | protein de-ADP-ribosylation | 23474712 |
| Fusion gene breakpoints across MACROD2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DCLK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-C8-A1HN-01A | MACROD2 | chr20 | 13983050 | - | DCLK2 | chr4 | 151023630 | + |
| ChimerDB4 | BRCA | TCGA-C8-A1HN-01A | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000217246 | MACROD2 | chr20 | 13983050 | + | ENST00000296550 | DCLK2 | chr4 | 151023630 | + | 3648 | 558 | 341 | 2437 | 698 |
| ENST00000217246 | MACROD2 | chr20 | 13983050 | + | ENST00000506325 | DCLK2 | chr4 | 151023630 | + | 2435 | 558 | 341 | 2434 | 698 |
| ENST00000217246 | MACROD2 | chr20 | 13983050 | + | ENST00000302176 | DCLK2 | chr4 | 151023630 | + | 3680 | 558 | 341 | 2488 | 715 |
| ENST00000310348 | MACROD2 | chr20 | 13983050 | + | ENST00000296550 | DCLK2 | chr4 | 151023630 | + | 3253 | 163 | 0 | 2042 | 680 |
| ENST00000310348 | MACROD2 | chr20 | 13983050 | + | ENST00000506325 | DCLK2 | chr4 | 151023630 | + | 2040 | 163 | 0 | 2039 | 679 |
| ENST00000310348 | MACROD2 | chr20 | 13983050 | + | ENST00000302176 | DCLK2 | chr4 | 151023630 | + | 3285 | 163 | 0 | 2093 | 697 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000217246 | ENST00000296550 | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + | 0.001801767 | 0.9981982 |
| ENST00000217246 | ENST00000506325 | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + | 0.001240203 | 0.99875987 |
| ENST00000217246 | ENST00000302176 | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + | 0.00200263 | 0.99799734 |
| ENST00000310348 | ENST00000296550 | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + | 0.001444894 | 0.9985551 |
| ENST00000310348 | ENST00000506325 | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + | 0.000770032 | 0.99923 |
| ENST00000310348 | ENST00000302176 | MACROD2 | chr20 | 13983050 | + | DCLK2 | chr4 | 151023630 | + | 0.001686718 | 0.9983133 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >50654_50654_1_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000296550_length(amino acids)=698AA_BP=72 MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYT KNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTL DGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSS SSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKA KCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKP ENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAG KLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKE -------------------------------------------------------------- >50654_50654_2_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000302176_length(amino acids)=715AA_BP=72 MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYT KNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTL DGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVKRGGHYSSAYSTAKSPV NGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKEC IDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLAN ALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPF RSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQN -------------------------------------------------------------- >50654_50654_3_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000217246_DCLK2_chr4_151023630_ENST00000506325_length(amino acids)=698AA_BP=72 MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYT KNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTL DGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSS SSSPTSPGSFRGLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPE NLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGK LEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEG -------------------------------------------------------------- >50654_50654_4_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000296550_length(amino acids)=680AA_BP=54 MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRA LAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVF IACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISA HGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRR VKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLG DFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKE LISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGME -------------------------------------------------------------- >50654_50654_5_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000302176_length(amino acids)=697AA_BP=54 MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRA LAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVF IACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVKRGGHYSSAYSTAKSPVNGTPSSQLSTPKSTKSSS SSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPE NLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGK LEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEG -------------------------------------------------------------- >50654_50654_6_MACROD2-DCLK2_MACROD2_chr20_13983050_ENST00000310348_DCLK2_chr4_151023630_ENST00000506325_length(amino acids)=679AA_BP=54 MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRA LAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVF IACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKISAH GRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRV KHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGD FGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:13983050/chr4:151023630) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MACROD2 | DCLK2 |
| FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}. | FUNCTION: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 6_9 | 54.333333333333336 | 426.0 | Compositional bias | Note=Poly-Lys |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 6_9 | 54.333333333333336 | 449.0 | Compositional bias | Note=Poly-Lys |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000296550 | 0 | 16 | 293_362 | 140.33333333333334 | 767.0 | Compositional bias | Note=Ser-rich | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000296550 | 0 | 16 | 713_753 | 140.33333333333334 | 767.0 | Compositional bias | Note=Pro-rich | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000302176 | 0 | 17 | 293_362 | 140.33333333333334 | 784.0 | Compositional bias | Note=Ser-rich | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000302176 | 0 | 17 | 713_753 | 140.33333333333334 | 784.0 | Compositional bias | Note=Pro-rich | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000506325 | 0 | 16 | 293_362 | 140.33333333333334 | 766.0 | Compositional bias | Note=Ser-rich | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000506325 | 0 | 16 | 713_753 | 140.33333333333334 | 766.0 | Compositional bias | Note=Pro-rich | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000296550 | 0 | 16 | 197_280 | 140.33333333333334 | 767.0 | Domain | Doublecortin 2 | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000296550 | 0 | 16 | 394_651 | 140.33333333333334 | 767.0 | Domain | Protein kinase | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000302176 | 0 | 17 | 197_280 | 140.33333333333334 | 784.0 | Domain | Doublecortin 2 | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000302176 | 0 | 17 | 394_651 | 140.33333333333334 | 784.0 | Domain | Protein kinase | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000506325 | 0 | 16 | 197_280 | 140.33333333333334 | 766.0 | Domain | Doublecortin 2 | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000506325 | 0 | 16 | 394_651 | 140.33333333333334 | 766.0 | Domain | Protein kinase | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000296550 | 0 | 16 | 400_408 | 140.33333333333334 | 767.0 | Nucleotide binding | ATP | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000302176 | 0 | 17 | 400_408 | 140.33333333333334 | 784.0 | Nucleotide binding | ATP | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000506325 | 0 | 16 | 400_408 | 140.33333333333334 | 766.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 247_388 | 54.333333333333336 | 426.0 | Compositional bias | Note=Glu-rich |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 247_388 | 54.333333333333336 | 449.0 | Compositional bias | Note=Glu-rich |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 247_388 | 0.0 | 214.0 | Compositional bias | Note=Glu-rich |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 6_9 | 0.0 | 214.0 | Compositional bias | Note=Poly-Lys |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 247_388 | 0 | 214.0 | Compositional bias | Note=Glu-rich |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 6_9 | 0 | 214.0 | Compositional bias | Note=Poly-Lys |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 247_388 | 0 | 99.0 | Compositional bias | Note=Glu-rich |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 6_9 | 0 | 99.0 | Compositional bias | Note=Poly-Lys |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 59_240 | 54.333333333333336 | 426.0 | Domain | Macro |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 59_240 | 54.333333333333336 | 449.0 | Domain | Macro |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 59_240 | 0.0 | 214.0 | Domain | Macro |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 59_240 | 0 | 214.0 | Domain | Macro |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 59_240 | 0 | 99.0 | Domain | Macro |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 185_191 | 54.333333333333336 | 426.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 77_79 | 54.333333333333336 | 426.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 90_92 | 54.333333333333336 | 426.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000217246 | + | 2 | 17 | 97_102 | 54.333333333333336 | 426.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 185_191 | 54.333333333333336 | 449.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 77_79 | 54.333333333333336 | 449.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 90_92 | 54.333333333333336 | 449.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000310348 | + | 2 | 18 | 97_102 | 54.333333333333336 | 449.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 185_191 | 0.0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 77_79 | 0.0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 90_92 | 0.0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000378058 | + | 1 | 10 | 97_102 | 0.0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 185_191 | 0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 77_79 | 0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 90_92 | 0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000402914 | + | 1 | 14 | 97_102 | 0 | 214.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 185_191 | 0 | 99.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 77_79 | 0 | 99.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 90_92 | 0 | 99.0 | Region | Substrate binding |
| Hgene | MACROD2 | chr20:13983050 | chr4:151023630 | ENST00000407045 | + | 1 | 6 | 97_102 | 0 | 99.0 | Region | Substrate binding |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000296550 | 0 | 16 | 72_158 | 140.33333333333334 | 767.0 | Domain | Doublecortin 1 | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000302176 | 0 | 17 | 72_158 | 140.33333333333334 | 784.0 | Domain | Doublecortin 1 | |
| Tgene | DCLK2 | chr20:13983050 | chr4:151023630 | ENST00000506325 | 0 | 16 | 72_158 | 140.33333333333334 | 766.0 | Domain | Doublecortin 1 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MACROD2 | |
| DCLK2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to MACROD2-DCLK2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MACROD2-DCLK2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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