UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MAGI3-NOTCH2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAGI3-NOTCH2
FusionPDB ID: 50820
FusionGDB2.0 ID: 50820
HgeneTgene
Gene symbol

MAGI3

NOTCH2

Gene ID

260425

4853

Gene namemembrane associated guanylate kinase, WW and PDZ domain containing 3notch receptor 2
SynonymsMAGI-3|dJ730K3.2AGS2|HJCYS|hN2
Cytomap

1p13.2

1p12

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3neurogenic locus notch homolog protein 2Notch homolog 2notch 2
Modification date2020031320200329
UniProtAcc

Q5TCQ9

P0DPK3

Ensembl transtripts involved in fusion geneENST idsENST00000486456, ENST00000307546, 
ENST00000369611, ENST00000369615, 
ENST00000369617, 		ENST00000256646, 
ENST00000602566, ENST00000493703, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 8 X 5=48013 X 10 X 6=780
# samples 1214
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAGI3 [Title/Abstract] AND NOTCH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAGI3(113933971)-NOTCH2(120539955), # samples:3
Anticipated loss of major functional domain due to fusion event.MAGI3-NOTCH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAGI3-NOTCH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAGI3-NOTCH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAGI3-NOTCH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNOTCH2

GO:0007050

cell cycle arrest

11306509

TgeneNOTCH2

GO:0007219

Notch signaling pathway

11306509|25985737

TgeneNOTCH2

GO:0010629

negative regulation of gene expression

11306509

TgeneNOTCH2

GO:0010838

positive regulation of keratinocyte proliferation

18469519

TgeneNOTCH2

GO:0045967

negative regulation of growth rate

11306509

TgeneNOTCH2

GO:0046579

positive regulation of Ras protein signal transduction

11306509

TgeneNOTCH2

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

TgeneNOTCH2

GO:2000249

regulation of actin cytoskeleton reorganization

18469519


check buttonFusion gene breakpoints across MAGI3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOTCH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0W3-01AMAGI3chr1

113933971

-NOTCH2chr1

120529705

-
ChimerDB4BRCATCGA-BH-A0W3-01AMAGI3chr1

113933971

+NOTCH2chr1

120529705

-
ChimerDB4BRCATCGA-BH-A0W3-01AMAGI3chr1

113933971

+NOTCH2chr1

120539955

-
ChimerDB4BRCATCGA-BH-A0W3MAGI3chr1

113933971

+NOTCH2chr1

120539955

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369617MAGI3chr1113933971+ENST00000256646NOTCH2chr1120539955-1135560128576012438
ENST00000369617MAGI3chr1113933971+ENST00000602566NOTCH2chr1120539955-49036012851010241
ENST00000307546MAGI3chr1113933971+ENST00000256646NOTCH2chr1120539955-111453917573912438
ENST00000307546MAGI3chr1113933971+ENST00000602566NOTCH2chr1120539955-469339175800241
ENST00000369615MAGI3chr1113933971+ENST00000256646NOTCH2chr1120539955-111323786273782438
ENST00000369615MAGI3chr1113933971+ENST00000602566NOTCH2chr1120539955-468037862787241
ENST00000369611MAGI3chr1113933971+ENST00000256646NOTCH2chr1120539955-111153614573612438
ENST00000369611MAGI3chr1113933971+ENST00000602566NOTCH2chr1120539955-466336145770241
ENST00000369617MAGI3chr1113933971+ENST00000256646NOTCH2chr1120529705-1101960128572652326
ENST00000307546MAGI3chr1113933971+ENST00000256646NOTCH2chr1120529705-108093917570552326
ENST00000369615MAGI3chr1113933971+ENST00000256646NOTCH2chr1120529705-107963786270422326
ENST00000369611MAGI3chr1113933971+ENST00000256646NOTCH2chr1120529705-107793614570252326

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369617ENST00000256646MAGI3chr1113933971+NOTCH2chr1120539955-0.0009441210.9990559
ENST00000369617ENST00000602566MAGI3chr1113933971+NOTCH2chr1120539955-0.0086373890.99136263
ENST00000307546ENST00000256646MAGI3chr1113933971+NOTCH2chr1120539955-0.0007619240.99923813
ENST00000307546ENST00000602566MAGI3chr1113933971+NOTCH2chr1120539955-0.0077724170.9922276
ENST00000369615ENST00000256646MAGI3chr1113933971+NOTCH2chr1120539955-0.0007470640.99925286
ENST00000369615ENST00000602566MAGI3chr1113933971+NOTCH2chr1120539955-0.0076362170.9923638
ENST00000369611ENST00000256646MAGI3chr1113933971+NOTCH2chr1120539955-0.0007344570.9992655
ENST00000369611ENST00000602566MAGI3chr1113933971+NOTCH2chr1120539955-0.0077012640.9922988
ENST00000369617ENST00000256646MAGI3chr1113933971+NOTCH2chr1120529705-0.000955220.9990447
ENST00000307546ENST00000256646MAGI3chr1113933971+NOTCH2chr1120529705-0.0007768450.9992231
ENST00000369615ENST00000256646MAGI3chr1113933971+NOTCH2chr1120529705-0.0007620350.999238
ENST00000369611ENST00000256646MAGI3chr1113933971+NOTCH2chr1120529705-0.0007488080.9992512

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50820_50820_1_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000307546_NOTCH2_chr1_120529705_ENST00000256646_length(amino acids)=2326AA_BP=618
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCV
CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED
VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVN
NGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCIC
NPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDE
CASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNL
VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGW
QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLS
EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG
TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC
QCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEEN
IDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLN
GGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPP
FSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFE
CQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQG
ELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPER
TQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQ
PKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSS
ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGT
TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN
RDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKD
AKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGAS
TVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIV
TFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASS

--------------------------------------------------------------

>50820_50820_2_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000307546_NOTCH2_chr1_120539955_ENST00000256646_length(amino acids)=2438AA_BP=730
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAY
HPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

--------------------------------------------------------------

>50820_50820_3_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000307546_NOTCH2_chr1_120539955_ENST00000602566_length(amino acids)=241AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

--------------------------------------------------------------

>50820_50820_4_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369611_NOTCH2_chr1_120529705_ENST00000256646_length(amino acids)=2326AA_BP=618
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCV
CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED
VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVN
NGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCIC
NPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDE
CASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNL
VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGW
QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLS
EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG
TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC
QCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEEN
IDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLN
GGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPP
FSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFE
CQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQG
ELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPER
TQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQ
PKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSS
ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGT
TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN
RDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKD
AKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGAS
TVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIV
TFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASS

--------------------------------------------------------------

>50820_50820_5_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369611_NOTCH2_chr1_120539955_ENST00000256646_length(amino acids)=2438AA_BP=730
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAY
HPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

--------------------------------------------------------------

>50820_50820_6_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369611_NOTCH2_chr1_120539955_ENST00000602566_length(amino acids)=241AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

--------------------------------------------------------------

>50820_50820_7_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369615_NOTCH2_chr1_120529705_ENST00000256646_length(amino acids)=2326AA_BP=618
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCV
CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED
VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVN
NGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCIC
NPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDE
CASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNL
VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGW
QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLS
EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG
TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC
QCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEEN
IDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLN
GGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPP
FSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFE
CQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQG
ELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPER
TQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQ
PKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSS
ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGT
TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN
RDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKD
AKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGAS
TVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIV
TFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASS

--------------------------------------------------------------

>50820_50820_8_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369615_NOTCH2_chr1_120539955_ENST00000256646_length(amino acids)=2438AA_BP=730
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAY
HPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

--------------------------------------------------------------

>50820_50820_9_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369615_NOTCH2_chr1_120539955_ENST00000602566_length(amino acids)=241AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

--------------------------------------------------------------

>50820_50820_10_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369617_NOTCH2_chr1_120529705_ENST00000256646_length(amino acids)=2326AA_BP=618
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCV
CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED
VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVN
NGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCIC
NPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDE
CASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNL
VNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGW
QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLS
EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLG
TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC
QCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEEN
IDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLN
GGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPP
FSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFE
CQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQG
ELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPER
TQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQ
PKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSS
ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGT
TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN
RDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKD
AKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGAS
TVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIV
TFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASS

--------------------------------------------------------------

>50820_50820_11_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369617_NOTCH2_chr1_120539955_ENST00000256646_length(amino acids)=2438AA_BP=730
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF
TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECL
LQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTN
PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCM
PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDN
CDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGI
NRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGIN
CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCE
NAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTF
SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCL
HEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG
VLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCI
DLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCR
SAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPC
QHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW
DYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDAR
SFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASH
AIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQ
VSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLM
LASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ
GVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP
LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKS
RRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPV
HAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIA
PQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAY
HPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPP

--------------------------------------------------------------

>50820_50820_12_MAGI3-NOTCH2_MAGI3_chr1_113933971_ENST00000369617_NOTCH2_chr1_120539955_ENST00000602566_length(amino acids)=241AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGF

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:113933971/chr1:120539955)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI3

Q5TCQ9

NOTCH2

P0DPK3

FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+1216_9105.333333333333331482.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+1216_9105.333333333333331126.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+1226_9105.333333333333332009.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+1226_9105.333333333333331151.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+1216_9105.333333333333331482.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+1216_9105.333333333333331126.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+1226_9105.333333333333332009.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+1226_9105.333333333333331151.0Compositional biasNote=Poly-Lys
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341645_1648250.333333333333342472.0Compositional biasNote=Poly-Ala
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341994_1997250.333333333333342472.0Compositional biasNote=Poly-Leu
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463342426_2429250.333333333333342472.0Compositional biasNote=Poly-Ser
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341645_1648138.333333333333342472.0Compositional biasNote=Poly-Ala
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341994_1997138.333333333333342472.0Compositional biasNote=Poly-Leu
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462342426_2429138.333333333333342472.0Compositional biasNote=Poly-Ser
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341025_1061250.333333333333342472.0DomainEGF-like 27%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341063_1099250.333333333333342472.0DomainEGF-like 28
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341101_1147250.333333333333342472.0DomainEGF-like 29
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341149_1185250.333333333333342472.0DomainEGF-like 30%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341187_1223250.333333333333342472.0DomainEGF-like 31%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341225_1262250.333333333333342472.0DomainEGF-like 32%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341264_1302250.333333333333342472.0DomainEGF-like 33
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341304_1343250.333333333333342472.0DomainEGF-like 34
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341374_1412250.333333333333342472.0DomainEGF-like 35
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334260_296250.333333333333342472.0DomainEGF-like 7%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334298_336250.333333333333342472.0DomainEGF-like 8%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334338_374250.333333333333342472.0DomainEGF-like 9%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334375_413250.333333333333342472.0DomainEGF-like 10
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334415_454250.333333333333342472.0DomainEGF-like 11%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334456_492250.333333333333342472.0DomainEGF-like 12%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334494_530250.333333333333342472.0DomainEGF-like 13%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334532_568250.333333333333342472.0DomainEGF-like 14%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334570_605250.333333333333342472.0DomainEGF-like 15%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334607_643250.333333333333342472.0DomainEGF-like 16%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334645_680250.333333333333342472.0DomainEGF-like 17%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334682_718250.333333333333342472.0DomainEGF-like 18%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334720_755250.333333333333342472.0DomainEGF-like 19
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334757_793250.333333333333342472.0DomainEGF-like 20%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334795_831250.333333333333342472.0DomainEGF-like 21%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334833_871250.333333333333342472.0DomainEGF-like 22
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334873_909250.333333333333342472.0DomainEGF-like 23%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334911_947250.333333333333342472.0DomainEGF-like 24%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334949_985250.333333333333342472.0DomainEGF-like 25%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334987_1023250.333333333333342472.0DomainEGF-like 26%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341025_1061138.333333333333342472.0DomainEGF-like 27%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341063_1099138.333333333333342472.0DomainEGF-like 28
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341101_1147138.333333333333342472.0DomainEGF-like 29
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341149_1185138.333333333333342472.0DomainEGF-like 30%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341187_1223138.333333333333342472.0DomainEGF-like 31%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341225_1262138.333333333333342472.0DomainEGF-like 32%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341264_1302138.333333333333342472.0DomainEGF-like 33
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341304_1343138.333333333333342472.0DomainEGF-like 34
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341374_1412138.333333333333342472.0DomainEGF-like 35
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234144_180138.333333333333342472.0DomainEGF-like 4
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234182_219138.333333333333342472.0DomainEGF-like 5%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234221_258138.333333333333342472.0DomainEGF-like 6
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234260_296138.333333333333342472.0DomainEGF-like 7%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234298_336138.333333333333342472.0DomainEGF-like 8%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234338_374138.333333333333342472.0DomainEGF-like 9%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234375_413138.333333333333342472.0DomainEGF-like 10
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234415_454138.333333333333342472.0DomainEGF-like 11%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234456_492138.333333333333342472.0DomainEGF-like 12%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234494_530138.333333333333342472.0DomainEGF-like 13%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234532_568138.333333333333342472.0DomainEGF-like 14%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234570_605138.333333333333342472.0DomainEGF-like 15%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234607_643138.333333333333342472.0DomainEGF-like 16%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234645_680138.333333333333342472.0DomainEGF-like 17%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234682_718138.333333333333342472.0DomainEGF-like 18%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234720_755138.333333333333342472.0DomainEGF-like 19
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234757_793138.333333333333342472.0DomainEGF-like 20%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234795_831138.333333333333342472.0DomainEGF-like 21%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234833_871138.333333333333342472.0DomainEGF-like 22
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234873_909138.333333333333342472.0DomainEGF-like 23%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234911_947138.333333333333342472.0DomainEGF-like 24%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234949_985138.333333333333342472.0DomainEGF-like 25%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234987_1023138.333333333333342472.0DomainEGF-like 26%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341425_1677250.333333333333342472.0RegionNote=Negative regulatory region (NRR)
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341425_1677138.333333333333342472.0RegionNote=Negative regulatory region (NRR)
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341425_1465250.333333333333342472.0RepeatNote=LNR 1
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341466_1502250.333333333333342472.0RepeatNote=LNR 2
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341503_1544250.333333333333342472.0RepeatNote=LNR 3
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341827_1871250.333333333333342472.0RepeatNote=ANK 1
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341876_1905250.333333333333342472.0RepeatNote=ANK 2
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341909_1939250.333333333333342472.0RepeatNote=ANK 3
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341943_1972250.333333333333342472.0RepeatNote=ANK 4
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341976_2005250.333333333333342472.0RepeatNote=ANK 5
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463342009_2038250.333333333333342472.0RepeatNote=ANK 6
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341425_1465138.333333333333342472.0RepeatNote=LNR 1
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341466_1502138.333333333333342472.0RepeatNote=LNR 2
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341503_1544138.333333333333342472.0RepeatNote=LNR 3
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341827_1871138.333333333333342472.0RepeatNote=ANK 1
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341876_1905138.333333333333342472.0RepeatNote=ANK 2
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341909_1939138.333333333333342472.0RepeatNote=ANK 3
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341943_1972138.333333333333342472.0RepeatNote=ANK 4
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341976_2005138.333333333333342472.0RepeatNote=ANK 5
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462342009_2038138.333333333333342472.0RepeatNote=ANK 6
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341699_2471250.333333333333342472.0Topological domainCytoplasmic
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341699_2471138.333333333333342472.0Topological domainCytoplasmic
TgeneNOTCH2chr1:113933971chr1:120529705ENST000002566463341678_1698250.333333333333342472.0TransmembraneHelical
TgeneNOTCH2chr1:113933971chr1:120539955ENST000002566462341678_1698138.333333333333342472.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121238_243105.333333333333331482.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121238_243105.333333333333331126.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122238_243105.333333333333332009.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122238_243105.333333333333331151.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121238_243105.333333333333331482.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121238_243105.333333333333331126.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122238_243105.333333333333332009.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122238_243105.333333333333331151.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+1211021_1103105.333333333333331482.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121114_288105.333333333333331482.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121293_326105.333333333333331482.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121339_372105.333333333333331482.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121578_654105.333333333333331482.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+1211021_1103105.333333333333331126.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121114_288105.333333333333331126.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121293_326105.333333333333331126.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121339_372105.333333333333331126.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121578_654105.333333333333331126.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+1221021_1103105.333333333333332009.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122114_288105.333333333333332009.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122293_326105.333333333333332009.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122339_372105.333333333333332009.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122578_654105.333333333333332009.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+1221021_1103105.333333333333331151.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122114_288105.333333333333331151.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122293_326105.333333333333331151.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122339_372105.333333333333331151.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122578_654105.333333333333331151.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+1211021_1103105.333333333333331482.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121114_288105.333333333333331482.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121293_326105.333333333333331482.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121339_372105.333333333333331482.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121578_654105.333333333333331482.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+1211021_1103105.333333333333331126.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121114_288105.333333333333331126.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121293_326105.333333333333331126.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121339_372105.333333333333331126.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121578_654105.333333333333331126.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+1221021_1103105.333333333333332009.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122114_288105.333333333333332009.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122293_326105.333333333333332009.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122339_372105.333333333333332009.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122578_654105.333333333333332009.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+1221021_1103105.333333333333331151.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122114_288105.333333333333331151.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122293_326105.333333333333331151.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122339_372105.333333333333331151.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122578_654105.333333333333331151.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121121_128105.333333333333331482.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121121_128105.333333333333331126.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122121_128105.333333333333332009.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122121_128105.333333333333331151.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121121_128105.333333333333331482.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121121_128105.333333333333331126.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122121_128105.333333333333332009.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122121_128105.333333333333331151.0Nucleotide bindingATP
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334105_143250.333333333333342472.0DomainEGF-like 3
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334144_180250.333333333333342472.0DomainEGF-like 4
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334182_219250.333333333333342472.0DomainEGF-like 5%3B calcium-binding
TgeneNOTCH2chr1:113933971chr1:120529705ENST00000256646334221_258250.333333333333342472.0DomainEGF-like 6
TgeneNOTCH2chr1:113933971chr1:120529705ENST0000025664633426_63250.333333333333342472.0DomainEGF-like 1
TgeneNOTCH2chr1:113933971chr1:120529705ENST0000025664633464_102250.333333333333342472.0DomainEGF-like 2
TgeneNOTCH2chr1:113933971chr1:120539955ENST00000256646234105_143138.333333333333342472.0DomainEGF-like 3
TgeneNOTCH2chr1:113933971chr1:120539955ENST0000025664623426_63138.333333333333342472.0DomainEGF-like 1
TgeneNOTCH2chr1:113933971chr1:120539955ENST0000025664623464_102138.333333333333342472.0DomainEGF-like 2
TgeneNOTCH2chr1:113933971chr1:120529705ENST0000025664633426_1677250.333333333333342472.0Topological domainExtracellular
TgeneNOTCH2chr1:113933971chr1:120539955ENST0000025664623426_1677138.333333333333342472.0Topological domainExtracellular


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MAGI3_pLDDT.png
all structure
all structure
NOTCH2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAGI3
NOTCH2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121726_808105.333333333333331482.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121726_808105.333333333333331126.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122726_808105.333333333333332009.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122726_808105.333333333333331151.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121726_808105.333333333333331482.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121726_808105.333333333333331126.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122726_808105.333333333333332009.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122726_808105.333333333333331151.0ADGRB1
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121851_938105.333333333333331482.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121851_938105.333333333333331126.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122851_938105.333333333333332009.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122851_938105.333333333333331151.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121851_938105.333333333333331482.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121851_938105.333333333333331126.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122851_938105.333333333333332009.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122851_938105.333333333333331151.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:120529705ENST00000307546+121410_492105.333333333333331482.0PTEN
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369611+121410_492105.333333333333331126.0PTEN
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369615+122410_492105.333333333333332009.0PTEN
HgeneMAGI3chr1:113933971chr1:120529705ENST00000369617+122410_492105.333333333333331151.0PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000307546+121410_492105.333333333333331482.0PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369611+121410_492105.333333333333331126.0PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369615+122410_492105.333333333333332009.0PTEN
HgeneMAGI3chr1:113933971chr1:120539955ENST00000369617+122410_492105.333333333333331151.0PTEN


Top

Related Drugs to MAGI3-NOTCH2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MAGI3-NOTCH2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource