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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAN1A2-PDE4DIP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAN1A2-PDE4DIP
FusionPDB ID: 51068
FusionGDB2.0 ID: 51068
HgeneTgene
Gene symbol

MAN1A2

PDE4DIP

Gene ID

10905

9659

Gene namemannosidase alpha class 1A member 2phosphodiesterase 4D interacting protein
SynonymsMAN1BCMYA2|MMGL
Cytomap

1p12

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionmannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IBmyomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8
Modification date2020031320200313
UniProtAcc

O60476

.
Ensembl transtripts involved in fusion geneENST idsENST00000482811, ENST00000356554, 
ENST00000313382, ENST00000313431, 
ENST00000369345, ENST00000369347, 
ENST00000369348, ENST00000369349, 
ENST00000369351, ENST00000369354, 
ENST00000369356, ENST00000369359, 
ENST00000478649, ENST00000479408, 
ENST00000493130, ENST00000524974, 
ENST00000529945, ENST00000530740, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 11 X 7=92412 X 9 X 8=864
# samples 2113
** MAII scorelog2(21/924*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAN1A2 [Title/Abstract] AND PDE4DIP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAN1A2(117911107)-PDE4DIP(145021167), # samples:2
Anticipated loss of major functional domain due to fusion event.MAN1A2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAN1A2-PDE4DIP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across MAN1A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE4DIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2GR-06AMAN1A2chr1

117911107

-PDE4DIPchr1

145021167

-
ChimerDB4SKCMTCGA-EE-A2GR-06AMAN1A2chr1

117911107

+PDE4DIPchr1

145021167

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356554MAN1A2chr1117911107+ENST00000313382PDE4DIPchr1145021167-8774103773577392334

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356554ENST00000313382MAN1A2chr1117911107+PDE4DIPchr1145021167-0.0085168290.99148315

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51068_51068_1_MAN1A2-PDE4DIP_MAN1A2_chr1_117911107_ENST00000356554_PDE4DIP_chr1_145021167_ENST00000313382_length(amino acids)=2334AA_BP=99
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHRDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENF
SLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ
LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLL
HLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETL
KSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVE
AAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEAN
EMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQW
LKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQ
SVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRS
TLGDLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERL
TQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV
LGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLR
AEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEIEEDKEKGELDNQSQPRDPGPQSAFSLP
GSTQHLRSQLSQCKQRYQDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH
NSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSS
SLERPWKLRAVGTLEGSSPHSVPDEDEGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKYDSLIQD
QARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLS
RELQEKEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHSSHSAVLSSKPSS
TSASQGAKAESNSNPISLPTPQNTPKEANQAHSGASTVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWD
VMRPQKGSVSGDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCN
ENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKL
VLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAGK
ASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSF
ANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALPST

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:117911107/chr1:145021167)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN1A2

O60476

.
FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN1A2chr1:117911107chr1:145021167ENST00000356554+1132_36100.66666666666667642.0Topological domainCytoplasmic
HgeneMAN1A2chr1:117911107chr1:145021167ENST00000356554+11337_57100.66666666666667642.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461002_10436.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461096_11246.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461212_12406.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461346_13856.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461431_14556.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313382046162_2056.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461736_17606.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461840_20776.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820462273_23126.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313382046238_3186.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313382046350_6846.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000031338204641_1326.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313382046743_9366.6666666666666672241.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191002_104301133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191096_112401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191212_124001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191346_138501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191431_145501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313431019162_20501133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191736_176001133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191840_207701133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310192273_231201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313431019238_31801133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313431019350_68401133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000031343101941_13201133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000313431019743_93601133.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041002_10430174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041096_11240174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041212_12400174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041346_13850174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041431_14550174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934704162_2050174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041736_17600174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041840_20770174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347042273_23120174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934704238_3180174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934704350_6840174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693470441_1320174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934704743_9360174.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071002_104377.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071096_112477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071212_124077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071346_138577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071431_145577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934807162_20577.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071736_176077.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071840_207777.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348072273_231277.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934807238_31877.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934807350_68477.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934807743_93677.66666666666667311.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231002_10430970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231096_11240970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231212_12400970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231346_13850970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231431_14550970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369349023162_2050970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231736_17600970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231840_20770970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490232273_23120970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369349023238_3180970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369349023350_6840970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036934902341_1320970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369349023743_9360970.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221002_10430989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221096_11240989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221212_12400989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221346_13850989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221431_14550989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369351022162_2050989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221736_17600989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221840_20770989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510222273_23120989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369351022238_3180989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369351022350_6840989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036935102241_1320989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369351022743_9360989.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441002_104302347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441096_112402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441212_124002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441346_138502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441431_145502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369354044162_20502347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441736_176002347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441840_207702347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540442273_231202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369354044238_31802347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369354044350_68402347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036935404441_13202347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369354044743_93602347.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441002_104302363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441096_112402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441212_124002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441346_138502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441431_145502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369356044162_20502363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441736_176002363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441840_207702363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560442273_231202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369356044238_31802363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369356044350_68402363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST0000036935604441_13202363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369356044743_93602363.0Coiled coilOntology_term=ECO:0000255
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003133820461551_16426.6666666666666672241.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003134310191551_164201133.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369347041551_16420174.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST00000369348071551_164277.66666666666667311.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693490231551_16420970.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693510221551_16420989.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693540441551_164202347.0DomainOlduvai
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693560441551_164202363.0DomainOlduvai

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN1A2chr1:117911107chr1:145021167ENST00000356554+11358_641100.66666666666667642.0Topological domainLumenal
TgenePDE4DIPchr1:117911107chr1:145021167ENST000003693480741_13277.66666666666667311.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAN1A2
PDE4DIP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MAN1A2-PDE4DIP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAN1A2-PDE4DIP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource