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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAP3K10-SUPT5H

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAP3K10-SUPT5H
FusionPDB ID: 51247
FusionGDB2.0 ID: 51247
HgeneTgene
Gene symbol

MAP3K10

SUPT5H

Gene ID

4294

6829

Gene namemitogen-activated protein kinase kinase kinase 10SPT5 homolog, DSIF elongation factor subunit
SynonymsMEKK10|MLK2|MSTSPT5|SPT5H|Tat-CT1
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 10MKN28 derived nonreceptor_type serine/threonine kinaseMKN28 kinasemixed lineage kinase 2protein kinase MSTtranscription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homolog
Modification date2020031320200313
UniProtAcc

Q02779

.
Ensembl transtripts involved in fusion geneENST idsENST00000253055, ENST00000593906, 
ENST00000359191, ENST00000402194, 
ENST00000432763, ENST00000598725, 
ENST00000599117, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 8 X 5=20013 X 11 X 7=1001
# samples 713
** MAII scorelog2(7/200*10)=-1.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAP3K10 [Title/Abstract] AND SUPT5H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAP3K10(40712064)-SUPT5H(39948315), # samples:3
Anticipated loss of major functional domain due to fusion event.MAP3K10-SUPT5H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K10-SUPT5H seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K10-SUPT5H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K10-SUPT5H seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K10

GO:0018105

peptidyl-serine phosphorylation

19801649

HgeneMAP3K10

GO:0018107

peptidyl-threonine phosphorylation

19801649

TgeneSUPT5H

GO:0000122

negative regulation of transcription by RNA polymerase II

9450929

TgeneSUPT5H

GO:0006368

transcription elongation from RNA polymerase II promoter

9450929

TgeneSUPT5H

GO:0032785

negative regulation of DNA-templated transcription, elongation

9450929

TgeneSUPT5H

GO:0032786

positive regulation of DNA-templated transcription, elongation

9450929

TgeneSUPT5H

GO:0045944

positive regulation of transcription by RNA polymerase II

9450929


check buttonFusion gene breakpoints across MAP3K10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUPT5H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-S9-A6U0-01AMAP3K10chr19

40712064

-SUPT5Hchr19

39948315

+
ChimerDB4LGGTCGA-S9-A6U0-01AMAP3K10chr19

40712064

+SUPT5Hchr19

39948315

+
ChimerDB4LGGTCGA-S9-A6U0MAP3K10chr19

40712064

+SUPT5Hchr19

39948315

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253055MAP3K10chr1940712064+ENST00000599117SUPT5Hchr1939948315+5017172328847451485
ENST00000253055MAP3K10chr1940712064+ENST00000432763SUPT5Hchr1939948315+5013172328847451485
ENST00000253055MAP3K10chr1940712064+ENST00000402194SUPT5Hchr1939948315+5001172328847331481
ENST00000253055MAP3K10chr1940712064+ENST00000359191SUPT5Hchr1939948315+5005172328847331481
ENST00000253055MAP3K10chr1940712064+ENST00000598725SUPT5Hchr1939948315+5017172328847451485

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253055ENST00000599117MAP3K10chr1940712064+SUPT5Hchr1939948315+0.0033217390.99667823
ENST00000253055ENST00000432763MAP3K10chr1940712064+SUPT5Hchr1939948315+0.003391730.99660826
ENST00000253055ENST00000402194MAP3K10chr1940712064+SUPT5Hchr1939948315+0.0034694240.9965306
ENST00000253055ENST00000359191MAP3K10chr1940712064+SUPT5Hchr1939948315+0.0033977150.9966023
ENST00000253055ENST00000598725MAP3K10chr1940712064+SUPT5Hchr1939948315+0.0033217390.99667823

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51247_51247_1_MAP3K10-SUPT5H_MAP3K10_chr19_40712064_ENST00000253055_SUPT5H_chr19_39948315_ENST00000359191_length(amino acids)=1481AA_BP=457
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLP
QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWM
APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
RVRKRKGNFKRSRLLKLREGGSHISLPSDVDDEYEDEDQWEDGAEDILEKASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYA
KSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVK
QAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWF
AKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKER
EHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDL
TMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHV
KDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRGGFGS
PGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTP
MYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPS
SPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPG
APSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILG

--------------------------------------------------------------

>51247_51247_2_MAP3K10-SUPT5H_MAP3K10_chr19_40712064_ENST00000253055_SUPT5H_chr19_39948315_ENST00000402194_length(amino acids)=1481AA_BP=457
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLP
QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWM
APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
RVRKRKGNFKRSRLLKLREGGSHISLPSDVDDEYEDEDQWEDGAEDILEKASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYA
KSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVK
QAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWF
AKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKER
EHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDL
TMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHV
KDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRGGFGS
PGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTP
MYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPS
SPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPG
APSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILG

--------------------------------------------------------------

>51247_51247_3_MAP3K10-SUPT5H_MAP3K10_chr19_40712064_ENST00000253055_SUPT5H_chr19_39948315_ENST00000432763_length(amino acids)=1485AA_BP=457
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLP
QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWM
APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
RVRKRKGNFKRSRLLKLREGGSHISLPSDVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYM
KKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQ
THVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSL
KDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTEST
GKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVIL
FSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQN
NIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRG
GFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYG
SQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGY
PDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSP
MTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVK

--------------------------------------------------------------

>51247_51247_4_MAP3K10-SUPT5H_MAP3K10_chr19_40712064_ENST00000253055_SUPT5H_chr19_39948315_ENST00000598725_length(amino acids)=1485AA_BP=457
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLP
QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWM
APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
RVRKRKGNFKRSRLLKLREGGSHISLPSDVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYM
KKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQ
THVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSL
KDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTEST
GKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVIL
FSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQN
NIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRG
GFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYG
SQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGY
PDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSP
MTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVK

--------------------------------------------------------------

>51247_51247_5_MAP3K10-SUPT5H_MAP3K10_chr19_40712064_ENST00000253055_SUPT5H_chr19_39948315_ENST00000599117_length(amino acids)=1485AA_BP=457
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLP
QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWM
APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
RVRKRKGNFKRSRLLKLREGGSHISLPSDVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYM
KKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQ
THVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSL
KDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTEST
GKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVIL
FSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQN
NIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRG
GFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYG
SQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGY
PDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSP
MTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:40712064/chr19:39948315)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K10

Q02779

.
FUNCTION: Activates the JUN N-terminal pathway. {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+5102_5478.3333333333333955.0Compositional biasNote=Poly-Glu
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+510449_463478.3333333333333955.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+51016_81478.3333333333333955.0DomainSH3
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+51098_360478.3333333333333955.0DomainProtein kinase
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+510104_112478.3333333333333955.0Nucleotide bindingATP
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+510384_405478.3333333333333955.0RegionNote=Leucine-zipper 1
HgeneMAP3K10chr19:40712064chr19:39948315ENST00000253055+510419_440478.3333333333333955.0RegionNote=Leucine-zipper 2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128844_96880.333333333333331084.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229844_96880.333333333333331084.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230844_96880.333333333333331088.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129844_96880.333333333333331088.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331844_96880.333333333333331088.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128273_30680.333333333333331084.0DomainNote=KOW 1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128420_45180.333333333333331084.0DomainNote=KOW 2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128472_50380.333333333333331084.0DomainNote=KOW 3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128594_62780.333333333333331084.0DomainNote=KOW 4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128704_73780.333333333333331084.0DomainNote=KOW 5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229273_30680.333333333333331084.0DomainNote=KOW 1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229420_45180.333333333333331084.0DomainNote=KOW 2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229472_50380.333333333333331084.0DomainNote=KOW 3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229594_62780.333333333333331084.0DomainNote=KOW 4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229704_73780.333333333333331084.0DomainNote=KOW 5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230273_30680.333333333333331088.0DomainNote=KOW 1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230420_45180.333333333333331088.0DomainNote=KOW 2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230472_50380.333333333333331088.0DomainNote=KOW 3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230594_62780.333333333333331088.0DomainNote=KOW 4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230704_73780.333333333333331088.0DomainNote=KOW 5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129273_30680.333333333333331088.0DomainNote=KOW 1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129420_45180.333333333333331088.0DomainNote=KOW 2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129472_50380.333333333333331088.0DomainNote=KOW 3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129594_62780.333333333333331088.0DomainNote=KOW 4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129704_73780.333333333333331088.0DomainNote=KOW 5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331273_30680.333333333333331088.0DomainNote=KOW 1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331420_45180.333333333333331088.0DomainNote=KOW 2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331472_50380.333333333333331088.0DomainNote=KOW 3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331594_62780.333333333333331088.0DomainNote=KOW 4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331704_73780.333333333333331088.0DomainNote=KOW 5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128754_81780.333333333333331084.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128844_95080.333333333333331084.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229754_81780.333333333333331084.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229844_95080.333333333333331084.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230754_81780.333333333333331088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230844_95080.333333333333331088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129754_81780.333333333333331088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129844_95080.333333333333331088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331754_81780.333333333333331088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331844_95080.333333333333331088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128754_75980.333333333333331084.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128760_76580.333333333333331084.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128766_77180.333333333333331084.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128772_77880.333333333333331084.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128781_78780.333333333333331084.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128788_79480.333333333333331084.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128796_80280.333333333333331084.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128803_80980.333333333333331084.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128811_81780.333333333333331084.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128844_85180.333333333333331084.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128854_86280.333333333333331084.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128863_86980.333333333333331084.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128881_88580.333333333333331084.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128896_90280.333333333333331084.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128904_91180.333333333333331084.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128916_92180.333333333333331084.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128924_93080.333333333333331084.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128932_93980.333333333333331084.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000359191128943_95080.333333333333331084.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229754_75980.333333333333331084.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229760_76580.333333333333331084.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229766_77180.333333333333331084.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229772_77880.333333333333331084.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229781_78780.333333333333331084.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229788_79480.333333333333331084.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229796_80280.333333333333331084.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229803_80980.333333333333331084.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229811_81780.333333333333331084.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229844_85180.333333333333331084.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229854_86280.333333333333331084.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229863_86980.333333333333331084.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229881_88580.333333333333331084.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229896_90280.333333333333331084.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229904_91180.333333333333331084.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229916_92180.333333333333331084.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229924_93080.333333333333331084.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229932_93980.333333333333331084.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000402194229943_95080.333333333333331084.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230754_75980.333333333333331088.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230760_76580.333333333333331088.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230766_77180.333333333333331088.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230772_77880.333333333333331088.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230781_78780.333333333333331088.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230788_79480.333333333333331088.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230796_80280.333333333333331088.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230803_80980.333333333333331088.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230811_81780.333333333333331088.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230844_85180.333333333333331088.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230854_86280.333333333333331088.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230863_86980.333333333333331088.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230881_88580.333333333333331088.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230896_90280.333333333333331088.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230904_91180.333333333333331088.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230916_92180.333333333333331088.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230924_93080.333333333333331088.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230932_93980.333333333333331088.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000432763230943_95080.333333333333331088.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129754_75980.333333333333331088.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129760_76580.333333333333331088.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129766_77180.333333333333331088.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129772_77880.333333333333331088.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129781_78780.333333333333331088.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129788_79480.333333333333331088.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129796_80280.333333333333331088.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129803_80980.333333333333331088.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129811_81780.333333333333331088.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129844_85180.333333333333331088.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129854_86280.333333333333331088.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129863_86980.333333333333331088.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129881_88580.333333333333331088.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129896_90280.333333333333331088.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129904_91180.333333333333331088.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129916_92180.333333333333331088.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129924_93080.333333333333331088.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129932_93980.333333333333331088.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000598725129943_95080.333333333333331088.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331754_75980.333333333333331088.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331760_76580.333333333333331088.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331766_77180.333333333333331088.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331772_77880.333333333333331088.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331781_78780.333333333333331088.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331788_79480.333333333333331088.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331796_80280.333333333333331088.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331803_80980.333333333333331088.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331811_81780.333333333333331088.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331844_85180.333333333333331088.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331854_86280.333333333333331088.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331863_86980.333333333333331088.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331881_88580.333333333333331088.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331896_90280.333333333333331088.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331904_91180.333333333333331088.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331916_92180.333333333333331088.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331924_93080.333333333333331088.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331932_93980.333333333333331088.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:40712064chr19:39948315ENST00000599117331943_95080.333333333333331088.0RepeatNote=CTR2-10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSUPT5Hchr19:40712064chr19:39948315ENST0000035919112811_10680.333333333333331084.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST0000040219422911_10680.333333333333331084.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST0000043276323011_10680.333333333333331088.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST0000059872512911_10680.333333333333331088.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:40712064chr19:39948315ENST0000059911733111_10680.333333333333331088.0Compositional biasNote=Glu-rich


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2067_MAP3K10_40712064_SUPT5H_39948315_ranked_0.pdbMAP3K104071206440712064ENST00000598725SUPT5Hchr1939948315+
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLP
QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWM
APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
RVRKRKGNFKRSRLLKLREGGSHISLPSDVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYM
KKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQ
THVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSL
KDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTEST
GKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVIL
FSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQN
NIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRG
GFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYG
SQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGY
PDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSP
MTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVK
1485


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MAP3K10_pLDDT.png
all structure
all structure
SUPT5H_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAP3K10
SUPT5H


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MAP3K10-SUPT5H


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAP3K10-SUPT5H


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource