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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:AP1M1-CYP4F11

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: AP1M1-CYP4F11
	FusionPDB ID: 5189
	FusionGDB2.0 ID: 5189
		Hgene	Tgene
	Gene symbol	AP1M1	CYP4F11
	Gene ID	8907	57834
	Gene name	adaptor related protein complex 1 subunit mu 1	cytochrome P450 family 4 subfamily F member 11
	Synonyms	AP47\|CLAPM2\|CLTNM\|MU-1A	CYPIVF11
	Cytomap	19p13.11	19p13.12
	Type of gene	protein-coding	protein-coding
	Description	AP-1 complex subunit mu-1AP-mu chain family member mu1AHA1 47 kDa subunitadapter-related protein complex 1 subunit mu-1adaptor protein complex AP-1 mu-1 subunitadaptor protein complex AP-1 subunit mu-1adaptor related protein complex 1 mu 1 subunitc	cytochrome P450 4F113-hydroxy fatty acids omega-hydroxylase CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 11cytochrome P450, subfamily IVF, polypeptide 11docosahexaenoic acid omega-hydroxylaselong-chain fatty acid omega-monooxygenasephy
	Modification date	20200313	20200313
	UniProtAcc	Q9BXS5	Q9HBI6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000291439, ENST00000429941, ENST00000444449, ENST00000541844, ENST00000590756,	ENST00000248041, ENST00000326742, ENST00000402119, ENST00000591841,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 6 X 5=210	2 X 3 X 2=12
	# samples	8	2
	** MAII score	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: AP1M1 [Title/Abstract] AND CYP4F11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	AP1M1(16319988)-CYP4F11(16040411), # samples:1 AP1M1(16319988)-CYP4F11(16045219), # samples:1
Anticipated loss of major functional domain due to fusion event.	AP1M1-CYP4F11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP1M1-CYP4F11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CYP4F11	GO:0006631	fatty acid metabolic process	18065749
Tgene	CYP4F11	GO:0042361	menaquinone catabolic process	24138531
Tgene	CYP4F11	GO:0042376	phylloquinone catabolic process	24138531
Tgene	CYP4F11	GO:0042377	vitamin K catabolic process	24138531

Fusion gene breakpoints across AP1M1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CYP4F11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-05-4426-01A	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-
ChimerDB4	LUAD	TCGA-05-4426-01A	AP1M1	chr19	16319988	-	CYP4F11	chr19	16045219	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000291439	AP1M1	chr19	16319988	+	ENST00000248041	CYP4F11	chr19	16040411	-	3737	995	425	2371	648
ENST00000291439	AP1M1	chr19	16319988	+	ENST00000326742	CYP4F11	chr19	16040411	-	3668	995	425	2161	578
ENST00000291439	AP1M1	chr19	16319988	+	ENST00000402119	CYP4F11	chr19	16040411	-	3531	995	425	2371	648
ENST00000541844	AP1M1	chr19	16319988	+	ENST00000248041	CYP4F11	chr19	16040411	-	3245	503	149	1879	576
ENST00000541844	AP1M1	chr19	16319988	+	ENST00000326742	CYP4F11	chr19	16040411	-	3176	503	149	1669	506
ENST00000541844	AP1M1	chr19	16319988	+	ENST00000402119	CYP4F11	chr19	16040411	-	3039	503	149	1879	576
ENST00000590756	AP1M1	chr19	16319988	+	ENST00000248041	CYP4F11	chr19	16040411	-	3245	503	149	1879	576
ENST00000590756	AP1M1	chr19	16319988	+	ENST00000326742	CYP4F11	chr19	16040411	-	3176	503	149	1669	506
ENST00000590756	AP1M1	chr19	16319988	+	ENST00000402119	CYP4F11	chr19	16040411	-	3039	503	149	1879	576
ENST00000429941	AP1M1	chr19	16319988	+	ENST00000248041	CYP4F11	chr19	16040411	-	3404	662	92	2038	648
ENST00000429941	AP1M1	chr19	16319988	+	ENST00000326742	CYP4F11	chr19	16040411	-	3335	662	92	1828	578
ENST00000429941	AP1M1	chr19	16319988	+	ENST00000402119	CYP4F11	chr19	16040411	-	3198	662	92	2038	648
ENST00000444449	AP1M1	chr19	16319988	+	ENST00000248041	CYP4F11	chr19	16040411	-	3381	639	69	2015	648
ENST00000444449	AP1M1	chr19	16319988	+	ENST00000326742	CYP4F11	chr19	16040411	-	3312	639	69	1805	578
ENST00000444449	AP1M1	chr19	16319988	+	ENST00000402119	CYP4F11	chr19	16040411	-	3175	639	69	2015	648

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000291439	ENST00000248041	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004448861	0.9955511
ENST00000291439	ENST00000326742	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004990292	0.99500966
ENST00000291439	ENST00000402119	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004868871	0.99513113
ENST00000541844	ENST00000248041	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004523263	0.9954768
ENST00000541844	ENST00000326742	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.003838235	0.9961617
ENST00000541844	ENST00000402119	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.00505863	0.99494135
ENST00000590756	ENST00000248041	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004277614	0.9957224
ENST00000590756	ENST00000326742	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.003703669	0.99629635
ENST00000590756	ENST00000402119	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004864224	0.9951357
ENST00000429941	ENST00000248041	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004379835	0.9956202
ENST00000429941	ENST00000326742	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004961109	0.9950389
ENST00000429941	ENST00000402119	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004750955	0.99524903
ENST00000444449	ENST00000248041	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.00450716	0.9954928
ENST00000444449	ENST00000326742	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.005104592	0.9948954
ENST00000444449	ENST00000402119	AP1M1	chr19	16319988	+	CYP4F11	chr19	16040411	-	0.004903553	0.9950964

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5189_5189_1_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000291439_CYP4F11_chr19_16040411_ENST00000248041_length(amino acids)=648AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK
GIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELIL

--------------------------------------------------------------

>5189_5189_2_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000291439_CYP4F11_chr19_16040411_ENST00000326742_length(amino acids)=578AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK

--------------------------------------------------------------

>5189_5189_3_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000291439_CYP4F11_chr19_16040411_ENST00000402119_length(amino acids)=648AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK
GIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELIL

--------------------------------------------------------------

>5189_5189_4_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000429941_CYP4F11_chr19_16040411_ENST00000248041_length(amino acids)=648AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK
GIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELIL

--------------------------------------------------------------

>5189_5189_5_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000429941_CYP4F11_chr19_16040411_ENST00000326742_length(amino acids)=578AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK

--------------------------------------------------------------

>5189_5189_6_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000429941_CYP4F11_chr19_16040411_ENST00000402119_length(amino acids)=648AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK
GIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELIL

--------------------------------------------------------------

>5189_5189_7_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000444449_CYP4F11_chr19_16040411_ENST00000248041_length(amino acids)=648AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK
GIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELIL

--------------------------------------------------------------

>5189_5189_8_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000444449_CYP4F11_chr19_16040411_ENST00000326742_length(amino acids)=578AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK

--------------------------------------------------------------

>5189_5189_9_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000444449_CYP4F11_chr19_16040411_ENST00000402119_length(amino acids)=648AA_BP=195
MPRPPAAIMSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFS
FLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVF
LDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSR
HRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRN
QQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM
FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPK
GIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELIL

--------------------------------------------------------------

>5189_5189_10_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000541844_CYP4F11_chr19_16040411_ENST00000248041_length(amino acids)=576AA_BP=123
MPRPPAAIMSASAVYVLDLKGKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVT
NAVSWRSEGIKYRKNEVFLDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL
KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE
DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI
SRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLH

--------------------------------------------------------------

>5189_5189_11_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000541844_CYP4F11_chr19_16040411_ENST00000326742_length(amino acids)=506AA_BP=123
MPRPPAAIMSASAVYVLDLKGKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVT
NAVSWRSEGIKYRKNEVFLDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL
KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE
DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI

--------------------------------------------------------------

>5189_5189_12_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000541844_CYP4F11_chr19_16040411_ENST00000402119_length(amino acids)=576AA_BP=123
MPRPPAAIMSASAVYVLDLKGKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVT
NAVSWRSEGIKYRKNEVFLDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL
KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE
DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI
SRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLH

--------------------------------------------------------------

>5189_5189_13_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000590756_CYP4F11_chr19_16040411_ENST00000248041_length(amino acids)=576AA_BP=123
MPRPPAAIMSASAVYVLDLKGKVLRVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVT
NAVSWRSEGIKYRKNEVFLDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL
KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE
DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI
SRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLH

--------------------------------------------------------------

>5189_5189_14_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000590756_CYP4F11_chr19_16040411_ENST00000326742_length(amino acids)=506AA_BP=123
MPRPPAAIMSASAVYVLDLKGKVLRVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVT
NAVSWRSEGIKYRKNEVFLDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL
KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE
DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI

--------------------------------------------------------------

>5189_5189_15_AP1M1-CYP4F11_AP1M1_chr19_16319988_ENST00000590756_CYP4F11_chr19_16040411_ENST00000402119_length(amino acids)=576AA_BP=123
MPRPPAAIMSASAVYVLDLKGKVLRVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVT
NAVSWRSEGIKYRKNEVFLDVIESVNLLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFL
KPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP
SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDE
DGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVI
SRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16319988/chr19:16040411)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AP1M1 Q9BXS5	CYP4F11 Q9HBI6
FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545). {ECO:0000269\|PubMed:15364545, ECO:0000269\|PubMed:18065749, ECO:0000269\|PubMed:19932081, ECO:0000269\|PubMed:24138531}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AP1M1

chr19:16319988

chr19:16040411

ENST00000291439

168_421

182.0

424.0

Domain

MHD

Hgene

AP1M1

chr19:16319988

chr19:16040411

ENST00000444449

168_421

182.0

436.0

Domain

MHD

Tgene

CYP4F11

chr19:16319988

chr19:16040411

ENST00000248041

15_37

66.0

525.0

Transmembrane

Helical

Tgene

CYP4F11

chr19:16319988

chr19:16040411

ENST00000402119

15_37

66.0

525.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
AP1M1
CYP4F11

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to AP1M1-CYP4F11

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to AP1M1-CYP4F11

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source