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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MBNL2-MADD

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MBNL2-MADD
	FusionPDB ID: 52022
	FusionGDB2.0 ID: 52022
		Hgene	Tgene
	Gene symbol	MBNL2	MADD
	Gene ID	10150	8567
	Gene name	muscleblind like splicing regulator 2	MAP kinase activating death domain
	Synonyms	MBLL\|MBLL39\|PRO2032	DENN\|IG20\|RAB3GEP
	Cytomap	13q32.1	11p11.2
	Type of gene	protein-coding	protein-coding
	Description	muscleblind-like protein 2muscleblind-like 2muscleblind-like protein 1muscleblind-like protein-like 39	MAP kinase-activating death domain proteinRab3 GDP/GTP exchange factordifferentially expressed in normal and neoplastic cellsinsulinoma glucagonoma clone 20
	Modification date	20200313	20200313
	UniProtAcc	Q5VZF2	Q8WXG6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000343600, ENST00000345429, ENST00000376673, ENST00000397601, ENST00000445661,	ENST00000489415, ENST00000311027, ENST00000342922, ENST00000349238, ENST00000395336, ENST00000395344, ENST00000402192, ENST00000402799, ENST00000405573, ENST00000406482, ENST00000407859,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 6=540	5 X 6 X 3=90
	# samples	11	6
	** MAII score	log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MBNL2 [Title/Abstract] AND MADD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MBNL2(97928663)-MADD(47330142), # samples:3
Anticipated loss of major functional domain due to fusion event.	MBNL2-MADD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MBNL2-MADD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MBNL2-MADD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MBNL2-MADD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MBNL2	GO:0043484	regulation of RNA splicing	15257297\|16946708
Tgene	MADD	GO:0032483	regulation of Rab protein signal transduction	20937701
Tgene	MADD	GO:2001236	regulation of extrinsic apoptotic signaling pathway	11577081

Fusion gene breakpoints across MBNL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MADD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A6YS-01A	MBNL2	chr13	97928663	-	MADD	chr11	47330142	+
ChimerDB4	SARC	TCGA-DX-A6YS-01A	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+
ChimerDB4	SARC	TCGA-SI-AA8C-01A	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000342922	MADD	chr11	47330142	+	2907	904	730	2025	431
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000402799	MADD	chr11	47330142	+	2907	904	730	2025	431
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000311027	MADD	chr11	47330142	+	2970	904	730	2088	452
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000406482	MADD	chr11	47330142	+	2837	904	730	1827	365
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000407859	MADD	chr11	47330142	+	2907	904	730	2025	431
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000349238	MADD	chr11	47330142	+	2907	904	730	2025	431
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000395344	MADD	chr11	47330142	+	2233	904	730	2025	431
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000395336	MADD	chr11	47330142	+	2900	904	730	1890	386
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000402192	MADD	chr11	47330142	+	2906	904	730	2025	431
ENST00000397601	MBNL2	chr13	97928663	+	ENST00000405573	MADD	chr11	47330142	+	2325	904	730	2034	434
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000342922	MADD	chr11	47330142	+	2993	990	816	2111	431
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000402799	MADD	chr11	47330142	+	2993	990	816	2111	431
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000311027	MADD	chr11	47330142	+	3056	990	816	2174	452
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000406482	MADD	chr11	47330142	+	2923	990	816	1913	365
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000407859	MADD	chr11	47330142	+	2993	990	816	2111	431
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000349238	MADD	chr11	47330142	+	2993	990	816	2111	431
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000395344	MADD	chr11	47330142	+	2319	990	816	2111	431
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000395336	MADD	chr11	47330142	+	2986	990	816	1976	386
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000402192	MADD	chr11	47330142	+	2992	990	816	2111	431
ENST00000343600	MBNL2	chr13	97928663	+	ENST00000405573	MADD	chr11	47330142	+	2411	990	816	2120	434
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000342922	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000402799	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000311027	MADD	chr11	47330142	+	3021	955	781	2139	452
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000406482	MADD	chr11	47330142	+	2888	955	781	1878	365
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000407859	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000349238	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000395344	MADD	chr11	47330142	+	2284	955	781	2076	431
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000395336	MADD	chr11	47330142	+	2951	955	781	1941	386
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000402192	MADD	chr11	47330142	+	2957	955	781	2076	431
ENST00000345429	MBNL2	chr13	97928663	+	ENST00000405573	MADD	chr11	47330142	+	2376	955	781	2085	434
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000342922	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000402799	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000311027	MADD	chr11	47330142	+	3021	955	781	2139	452
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000406482	MADD	chr11	47330142	+	2888	955	781	1878	365
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000407859	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000349238	MADD	chr11	47330142	+	2958	955	781	2076	431
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000395344	MADD	chr11	47330142	+	2284	955	781	2076	431
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000395336	MADD	chr11	47330142	+	2951	955	781	1941	386
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000402192	MADD	chr11	47330142	+	2957	955	781	2076	431
ENST00000376673	MBNL2	chr13	97928663	+	ENST00000405573	MADD	chr11	47330142	+	2376	955	781	2085	434
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000342922	MADD	chr11	47330142	+	2209	206	32	1327	431
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000402799	MADD	chr11	47330142	+	2209	206	32	1327	431
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000311027	MADD	chr11	47330142	+	2272	206	32	1390	452
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000406482	MADD	chr11	47330142	+	2139	206	32	1129	365
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000407859	MADD	chr11	47330142	+	2209	206	32	1327	431
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000349238	MADD	chr11	47330142	+	2209	206	32	1327	431
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000395344	MADD	chr11	47330142	+	1535	206	32	1327	431
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000395336	MADD	chr11	47330142	+	2202	206	32	1192	386
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000402192	MADD	chr11	47330142	+	2208	206	32	1327	431
ENST00000445661	MBNL2	chr13	97928663	+	ENST00000405573	MADD	chr11	47330142	+	1627	206	32	1336	434

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397601	ENST00000342922	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000287071	0.9997129
ENST00000397601	ENST00000402799	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000287071	0.9997129
ENST00000397601	ENST00000311027	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000574403	0.99942565
ENST00000397601	ENST00000406482	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000340862	0.9996592
ENST00000397601	ENST00000407859	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000287071	0.9997129
ENST00000397601	ENST00000349238	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000287071	0.9997129
ENST00000397601	ENST00000395344	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000284833	0.99971515
ENST00000397601	ENST00000395336	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000791716	0.9992083
ENST00000397601	ENST00000402192	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.00028713	0.9997129
ENST00000397601	ENST00000405573	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.001237521	0.9987625
ENST00000343600	ENST00000342922	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000291924	0.999708
ENST00000343600	ENST00000402799	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000291924	0.999708
ENST00000343600	ENST00000311027	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000597893	0.99940217
ENST00000343600	ENST00000406482	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000347305	0.99965274
ENST00000343600	ENST00000407859	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000291924	0.999708
ENST00000343600	ENST00000349238	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000291924	0.999708
ENST00000343600	ENST00000395344	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000287933	0.99971205
ENST00000343600	ENST00000395336	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000826967	0.999173
ENST00000343600	ENST00000402192	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000293066	0.9997069
ENST00000343600	ENST00000405573	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.001136221	0.9988638
ENST00000345429	ENST00000342922	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000345429	ENST00000402799	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000345429	ENST00000311027	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000577163	0.9994229
ENST00000345429	ENST00000406482	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.00033802	0.99966204
ENST00000345429	ENST00000407859	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000345429	ENST00000349238	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000345429	ENST00000395344	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000280299	0.9997197
ENST00000345429	ENST00000395336	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.00081262	0.9991874
ENST00000345429	ENST00000402192	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000283023	0.99971694
ENST00000345429	ENST00000405573	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.001092366	0.9989077
ENST00000376673	ENST00000342922	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000376673	ENST00000402799	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000376673	ENST00000311027	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000577163	0.9994229
ENST00000376673	ENST00000406482	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.00033802	0.99966204
ENST00000376673	ENST00000407859	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000376673	ENST00000349238	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000282502	0.99971753
ENST00000376673	ENST00000395344	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000280299	0.9997197
ENST00000376673	ENST00000395336	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.00081262	0.9991874
ENST00000376673	ENST00000402192	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000283023	0.99971694
ENST00000376673	ENST00000405573	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.001092366	0.9989077
ENST00000445661	ENST00000342922	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000435343	0.9995646
ENST00000445661	ENST00000402799	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000435343	0.9995646
ENST00000445661	ENST00000311027	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000879627	0.9991204
ENST00000445661	ENST00000406482	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000534993	0.99946505
ENST00000445661	ENST00000407859	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000435343	0.9995646
ENST00000445661	ENST00000349238	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000435343	0.9995646
ENST00000445661	ENST00000395344	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000527365	0.9994727
ENST00000445661	ENST00000395336	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.001261768	0.9987382
ENST00000445661	ENST00000402192	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.000435766	0.99956423
ENST00000445661	ENST00000405573	MBNL2	chr13	97928663	+	MADD	chr11	47330142	+	0.002346686	0.9976533

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52022_52022_1_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000311027_length(amino acids)=452AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE
GGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPV

--------------------------------------------------------------

>52022_52022_2_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000342922_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_3_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000349238_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_4_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000395336_length(amino acids)=386AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_5_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000395344_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_6_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000402192_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_7_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000402799_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_8_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000405573_length(amino acids)=434AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_9_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000406482_length(amino acids)=365AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFL

--------------------------------------------------------------

>52022_52022_10_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000343600_MADD_chr11_47330142_ENST00000407859_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_11_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000311027_length(amino acids)=452AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE
GGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPV

--------------------------------------------------------------

>52022_52022_12_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000342922_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_13_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000349238_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_14_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000395336_length(amino acids)=386AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_15_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000395344_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_16_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000402192_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_17_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000402799_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_18_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000405573_length(amino acids)=434AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_19_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000406482_length(amino acids)=365AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFL

--------------------------------------------------------------

>52022_52022_20_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000345429_MADD_chr11_47330142_ENST00000407859_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_21_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000311027_length(amino acids)=452AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE
GGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPV

--------------------------------------------------------------

>52022_52022_22_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000342922_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_23_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000349238_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_24_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000395336_length(amino acids)=386AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_25_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000395344_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_26_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000402192_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_27_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000402799_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_28_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000405573_length(amino acids)=434AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_29_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000406482_length(amino acids)=365AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFL

--------------------------------------------------------------

>52022_52022_30_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000376673_MADD_chr11_47330142_ENST00000407859_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_31_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000311027_length(amino acids)=452AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE
GGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPV

--------------------------------------------------------------

>52022_52022_32_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000342922_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_33_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000349238_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_34_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000395336_length(amino acids)=386AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_35_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000395344_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_36_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000402192_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_37_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000402799_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_38_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000405573_length(amino acids)=434AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_39_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000406482_length(amino acids)=365AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFL

--------------------------------------------------------------

>52022_52022_40_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000397601_MADD_chr11_47330142_ENST00000407859_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_41_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000311027_length(amino acids)=452AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE
GGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPV

--------------------------------------------------------------

>52022_52022_42_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000342922_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_43_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000349238_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_44_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000395336_length(amino acids)=386AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_45_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000395344_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_46_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000402192_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_47_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000402799_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

>52022_52022_48_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000405573_length(amino acids)=434AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL
HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV
VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE

--------------------------------------------------------------

>52022_52022_49_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000406482_length(amino acids)=365AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFL

--------------------------------------------------------------

>52022_52022_50_MBNL2-MADD_MBNL2_chr13_97928663_ENST00000445661_MADD_chr11_47330142_ENST00000407859_length(amino acids)=431AA_BP=55
MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKV
RRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:97928663/chr11:47330142)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MBNL2 Q5VZF2	MADD Q8WXG6
FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). {ECO:0000269\|PubMed:15257297, ECO:0000269\|PubMed:16273094, ECO:0000269\|PubMed:16946708}.	FUNCTION: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. {ECO:0000269\|PubMed:11577081, ECO:0000269\|PubMed:14716293, ECO:0000269\|PubMed:14735464, ECO:0000269\|PubMed:15007167, ECO:0000269\|PubMed:20937701, ECO:0000269\|PubMed:9115275}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000343600

13_41

58.0

362.0

Zinc finger

C3H1-type 1

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000345429

13_41

58.0

368.0

Zinc finger

C3H1-type 1

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000376673

13_41

58.0

374.0

Zinc finger

C3H1-type 1

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000397601

13_41

58.0

362.0

Zinc finger

C3H1-type 1

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000311027

1340_1415

1253.0

1648.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000342922

1340_1415

1215.0

1589.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000349238

1340_1415

1235.0

1609.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395336

1340_1415

1253.0

1877.6666666666667

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395344

1340_1415

1168.0

1542.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402192

1340_1415

1214.0

1588.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402799

1340_1415

1172.0

1546.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000406482

1340_1415

1172.0

1783.0

Domain

Death

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000407859

1340_1415

1192.0

1566.0

Domain

Death

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000343600

176_204

58.0

362.0

Zinc finger

C3H1-type 3

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000343600

212_238

58.0

362.0

Zinc finger

C3H1-type 4

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000343600

47_73

58.0

362.0

Zinc finger

C3H1-type 2

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000345429

176_204

58.0

368.0

Zinc finger

C3H1-type 3

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000345429

212_238

58.0

368.0

Zinc finger

C3H1-type 4

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000345429

47_73

58.0

368.0

Zinc finger

C3H1-type 2

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000376673

176_204

58.0

374.0

Zinc finger

C3H1-type 3

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000376673

212_238

58.0

374.0

Zinc finger

C3H1-type 4

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000376673

47_73

58.0

374.0

Zinc finger

C3H1-type 2

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000397601

176_204

58.0

362.0

Zinc finger

C3H1-type 3

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000397601

212_238

58.0

362.0

Zinc finger

C3H1-type 4

Hgene

MBNL2

chr13:97928663

chr11:47330142

ENST00000397601

47_73

58.0

362.0

Zinc finger

C3H1-type 2

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000311027

1157_1250

1253.0

1648.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000342922

1157_1250

1215.0

1589.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000349238

1157_1250

1235.0

1609.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395336

1157_1250

1253.0

1877.6666666666667

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395344

1157_1250

1168.0

1542.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402192

1157_1250

1214.0

1588.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402799

1157_1250

1172.0

1546.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000406482

1157_1250

1172.0

1783.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000407859

1157_1250

1192.0

1566.0

Compositional bias

Ser-rich

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000311027

14_268

1253.0

1648.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000311027

289_429

1253.0

1648.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000311027

431_565

1253.0

1648.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000342922

14_268

1215.0

1589.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000342922

289_429

1215.0

1589.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000342922

431_565

1215.0

1589.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000349238

14_268

1235.0

1609.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000349238

289_429

1235.0

1609.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000349238

431_565

1235.0

1609.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395336

14_268

1253.0

1877.6666666666667

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395336

289_429

1253.0

1877.6666666666667

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395336

431_565

1253.0

1877.6666666666667

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395344

14_268

1168.0

1542.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395344

289_429

1168.0

1542.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000395344

431_565

1168.0

1542.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402192

14_268

1214.0

1588.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402192

289_429

1214.0

1588.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402192

431_565

1214.0

1588.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402799

14_268

1172.0

1546.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402799

289_429

1172.0

1546.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000402799

431_565

1172.0

1546.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000406482

14_268

1172.0

1783.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000406482

289_429

1172.0

1783.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000406482

431_565

1172.0

1783.0

Domain

dDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000407859

14_268

1192.0

1566.0

Domain

uDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000407859

289_429

1192.0

1566.0

Domain

cDENN

Tgene

MADD

chr13:97928663

chr11:47330142

ENST00000407859

431_565

1192.0

1566.0

Domain

dDENN

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>943_MBNL2_97928663_MADD_47330142_943_MBNL2_97928663_MADD_47330142_ranked_0.pdb	MBNL2	97928663	97928663	ENST00000405573	MADD	chr11	47330142	+	MALNVAPVRDTKWLTLEVCRQFQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY EGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLL HNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCV VLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGE GGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPV	452

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MBNL2_pLDDT.png

MADD_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MBNL2
MADD

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MBNL2-MADD

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MBNL2-MADD

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source