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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MBOAT1-DCDC2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MBOAT1-DCDC2
FusionPDB ID: 52036
FusionGDB2.0 ID: 52036
HgeneTgene
Gene symbol

MBOAT1

DCDC2

Gene ID

154141

51473

Gene namemembrane bound O-acyltransferase domain containing 1doublecortin domain containing 2
SynonymsLPEAT1|LPLAT|LPLAT 1|LPSAT|OACT1|dJ434O11.1DCDC2A|DFNB66|NPHP19|NSC|RU2|RU2S
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionlysophospholipid acyltransferase 11-acylglycerophosphoserine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 1O-acyltransferase domain-containing protein 1lyso-PS acyltransferaselysophosphatidylethanolamine acyltransferase 1lysdoublecortin domain-containing protein 2
Modification date2020031320200313
UniProtAcc

Q6ZNC8

Q9UHG0

Ensembl transtripts involved in fusion geneENST idsENST00000324607, ENST00000536798, 
ENST00000541730, 		ENST00000378450, 
ENST00000378454, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 16 X 9=201614 X 8 X 11=1232
# samples 2116
** MAII scorelog2(21/2016*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MBOAT1 [Title/Abstract] AND DCDC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MBOAT1(20126748)-DCDC2(24302272), # samples:2
Anticipated loss of major functional domain due to fusion event.MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MBOAT1-DCDC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MBOAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCDC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QH-01AMBOAT1chr6

20126748

-DCDC2chr6

24302272

-
ChimerDB4BLCATCGA-GV-A3QHMBOAT1chr6

20126747

-DCDC2chr6

24302272

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541730MBOAT1chr620126748-ENST00000378454DCDC2chr624302272-49208635961945449
ENST00000324607MBOAT1chr620126748-ENST00000378454DCDC2chr624302272-493687961961651
ENST00000536798MBOAT1chr620126748-ENST00000378454DCDC2chr624302272-4976919162001661
ENST00000541730MBOAT1chr620126747-ENST00000378454DCDC2chr624302272-49208635961945449
ENST00000324607MBOAT1chr620126747-ENST00000378454DCDC2chr624302272-493687961961651
ENST00000536798MBOAT1chr620126747-ENST00000378454DCDC2chr624302272-4976919162001661

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541730ENST00000378454MBOAT1chr620126748-DCDC2chr624302272-8.90E-050.99991095
ENST00000324607ENST00000378454MBOAT1chr620126748-DCDC2chr624302272-0.0002632970.9997367
ENST00000536798ENST00000378454MBOAT1chr620126748-DCDC2chr624302272-0.000270830.9997292
ENST00000541730ENST00000378454MBOAT1chr620126747-DCDC2chr624302272-8.90E-050.99991095
ENST00000324607ENST00000378454MBOAT1chr620126747-DCDC2chr624302272-0.0002632970.9997367
ENST00000536798ENST00000378454MBOAT1chr620126747-DCDC2chr624302272-0.000270830.9997292

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52036_52036_1_MBOAT1-DCDC2_MBOAT1_chr6_20126747_ENST00000324607_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=651AA_BP=291
MRRFAFPGLPFAPPRTRRPCASRGNHPRAPGREDAEQGVLRAGTGAATSRRCRMAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFV
VCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIY
IFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHM
KLLEVNWKRKGFHSLPEPSPTVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVH
RLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLK
RKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKED
FSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEV

--------------------------------------------------------------

>52036_52036_2_MBOAT1-DCDC2_MBOAT1_chr6_20126747_ENST00000536798_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=661AA_BP=301
MRLESLRLESLRRFAFPGLPFAPPRTRRPCASRGNHPRAPGREDAEQGVLRAGTGAATSRRCRMAAEPQPSSLSYRTTGSTYLHPLSELL
GIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGY
LTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYI
AFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTE
KITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGS
SDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK
ANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADV

--------------------------------------------------------------

>52036_52036_3_MBOAT1-DCDC2_MBOAT1_chr6_20126747_ENST00000541730_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=449AA_BP=89
MEFSLRIFLGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTV
KPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFY
VAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKL
KNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQ

--------------------------------------------------------------

>52036_52036_4_MBOAT1-DCDC2_MBOAT1_chr6_20126748_ENST00000324607_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=651AA_BP=291
MRRFAFPGLPFAPPRTRRPCASRGNHPRAPGREDAEQGVLRAGTGAATSRRCRMAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFV
VCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIY
IFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHM
KLLEVNWKRKGFHSLPEPSPTVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVH
RLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLK
RKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKED
FSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEV

--------------------------------------------------------------

>52036_52036_5_MBOAT1-DCDC2_MBOAT1_chr6_20126748_ENST00000536798_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=661AA_BP=301
MRLESLRLESLRRFAFPGLPFAPPRTRRPCASRGNHPRAPGREDAEQGVLRAGTGAATSRRCRMAAEPQPSSLSYRTTGSTYLHPLSELL
GIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGY
LTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYI
AFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTE
KITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGS
SDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK
ANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADV

--------------------------------------------------------------

>52036_52036_6_MBOAT1-DCDC2_MBOAT1_chr6_20126748_ENST00000541730_DCDC2_chr6_24302272_ENST00000378454_length(amino acids)=449AA_BP=89
MEFSLRIFLGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTV
KPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFY
VAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKL
KNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:20126748/chr6:24302272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBOAT1

Q6ZNC8

DCDC2

Q9UHG0

FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BH98, ECO:0000269|PubMed:18772128}.FUNCTION: Protein that plays a role in the inhibition of canonical Wnt signaling pathway (PubMed:25557784). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (PubMed:25601850, PubMed:27319779). {ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784, ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713126_146238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713180_200238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-71334_54238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-71370_90238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78126_146238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78180_200238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-7834_54238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-7870_90238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-61234_5489.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-61270_9089.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713126_146238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713180_200238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-71334_54238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-71370_90238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78126_146238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78180_200238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-7834_54238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-7870_90238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-61234_5489.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-61270_9089.0347.0TransmembraneHelical
TgeneDCDC2chr6:20126747chr6:24302272ENST0000037845003139_2210230.0DomainDoublecortin 2
TgeneDCDC2chr6:20126747chr6:24302272ENST000003784500317_1000230.0DomainDoublecortin 1
TgeneDCDC2chr6:20126747chr6:24302272ENST00000378454110139_221116.0477.0DomainDoublecortin 2
TgeneDCDC2chr6:20126748chr6:24302272ENST0000037845003139_2210230.0DomainDoublecortin 2
TgeneDCDC2chr6:20126748chr6:24302272ENST000003784500317_1000230.0DomainDoublecortin 1
TgeneDCDC2chr6:20126748chr6:24302272ENST00000378454110139_221116.0477.0DomainDoublecortin 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713238_258238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713297_317238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713371_391238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713426_446238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000324607-713450_470238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78238_258238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78297_317238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78371_391238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78426_446238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000536798-78450_470238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612126_14689.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612180_20089.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612238_25889.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612297_31789.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612371_39189.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612426_44689.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126747chr6:24302272ENST00000541730-612450_47089.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713238_258238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713297_317238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713371_391238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713426_446238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000324607-713450_470238.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78238_258238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78297_317238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78371_391238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78426_446238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000536798-78450_470238.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612126_14689.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612180_20089.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612238_25889.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612297_31789.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612371_39189.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612426_44689.0347.0TransmembraneHelical
HgeneMBOAT1chr6:20126748chr6:24302272ENST00000541730-612450_47089.0347.0TransmembraneHelical
TgeneDCDC2chr6:20126747chr6:24302272ENST0000037845411017_100116.0477.0DomainDoublecortin 1
TgeneDCDC2chr6:20126748chr6:24302272ENST0000037845411017_100116.0477.0DomainDoublecortin 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MBOAT1
DCDC2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MBOAT1-DCDC2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MBOAT1-DCDC2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource