UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MBOAT1-FYN

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MBOAT1-FYN
FusionPDB ID: 52038
FusionGDB2.0 ID: 52038
HgeneTgene
Gene symbol

MBOAT1

FYN

Gene ID

154141

2534

Gene namemembrane bound O-acyltransferase domain containing 1FYN proto-oncogene, Src family tyrosine kinase
SynonymsLPEAT1|LPLAT|LPLAT 1|LPSAT|OACT1|dJ434O11.1SLK|SYN|p59-FYN
Cytomap

6p22.3

6q21

Type of geneprotein-codingprotein-coding
Descriptionlysophospholipid acyltransferase 11-acylglycerophosphoserine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 1O-acyltransferase domain-containing protein 1lyso-PS acyltransferaselysophosphatidylethanolamine acyltransferase 1lystyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)
Modification date2020031320200327
UniProtAcc

Q6ZNC8

C1orf168

Ensembl transtripts involved in fusion geneENST idsENST00000324607, ENST00000536798, 
ENST00000541730, 		ENST00000476769, 
ENST00000229470, ENST00000229471, 
ENST00000354650, ENST00000356013, 
ENST00000368667, ENST00000368678, 
ENST00000368682, ENST00000538466, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 16 X 9=201619 X 14 X 12=3192
# samples 2127
** MAII scorelog2(21/2016*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3192*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MBOAT1 [Title/Abstract] AND FYN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MBOAT1(20212367)-FYN(111983150), # samples:3
Anticipated loss of major functional domain due to fusion event.MBOAT1-FYN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MBOAT1-FYN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MBOAT1-FYN seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MBOAT1-FYN seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MBOAT1-FYN seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293


check buttonFusion gene breakpoints across MBOAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FYN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A6VO-01AMBOAT1chr6

20212367

-FYNchr6

111983150

-
ChimerDB4BRCATCGA-OL-A6VOMBOAT1chr6

20212366

-FYNchr6

111983150

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324607MBOAT1chr620212367-ENST00000368682FYNchr6111983150-1880264158472104
ENST00000324607MBOAT1chr620212367-ENST00000368678FYNchr6111983150-926264158472104
ENST00000324607MBOAT1chr620212367-ENST00000229470FYNchr6111983150-918264158472104
ENST00000324607MBOAT1chr620212367-ENST00000356013FYNchr6111983150-918264158472104
ENST00000536798MBOAT1chr620212367-ENST00000368682FYNchr6111983150-1920304198512104
ENST00000536798MBOAT1chr620212367-ENST00000368678FYNchr6111983150-966304198512104
ENST00000536798MBOAT1chr620212367-ENST00000229470FYNchr6111983150-958304198512104
ENST00000536798MBOAT1chr620212367-ENST00000356013FYNchr6111983150-958304198512104
ENST00000324607MBOAT1chr620212366-ENST00000368682FYNchr6111983150-1880264158472104
ENST00000324607MBOAT1chr620212366-ENST00000368678FYNchr6111983150-926264158472104
ENST00000324607MBOAT1chr620212366-ENST00000229470FYNchr6111983150-918264158472104
ENST00000324607MBOAT1chr620212366-ENST00000356013FYNchr6111983150-918264158472104
ENST00000536798MBOAT1chr620212366-ENST00000368682FYNchr6111983150-1920304198512104
ENST00000536798MBOAT1chr620212366-ENST00000368678FYNchr6111983150-966304198512104
ENST00000536798MBOAT1chr620212366-ENST00000229470FYNchr6111983150-958304198512104
ENST00000536798MBOAT1chr620212366-ENST00000356013FYNchr6111983150-958304198512104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324607ENST00000368682MBOAT1chr620212367-FYNchr6111983150-0.0508747440.94912523
ENST00000324607ENST00000368678MBOAT1chr620212367-FYNchr6111983150-0.075687070.924313
ENST00000324607ENST00000229470MBOAT1chr620212367-FYNchr6111983150-0.071708520.9282915
ENST00000324607ENST00000356013MBOAT1chr620212367-FYNchr6111983150-0.071708520.9282915
ENST00000536798ENST00000368682MBOAT1chr620212367-FYNchr6111983150-0.0594650880.9405349
ENST00000536798ENST00000368678MBOAT1chr620212367-FYNchr6111983150-0.098442340.9015576
ENST00000536798ENST00000229470MBOAT1chr620212367-FYNchr6111983150-0.099989860.9000101
ENST00000536798ENST00000356013MBOAT1chr620212367-FYNchr6111983150-0.099989860.9000101
ENST00000324607ENST00000368682MBOAT1chr620212366-FYNchr6111983150-0.0508747440.94912523
ENST00000324607ENST00000368678MBOAT1chr620212366-FYNchr6111983150-0.075687070.924313
ENST00000324607ENST00000229470MBOAT1chr620212366-FYNchr6111983150-0.071708520.9282915
ENST00000324607ENST00000356013MBOAT1chr620212366-FYNchr6111983150-0.071708520.9282915
ENST00000536798ENST00000368682MBOAT1chr620212366-FYNchr6111983150-0.0594650880.9405349
ENST00000536798ENST00000368678MBOAT1chr620212366-FYNchr6111983150-0.098442340.9015576
ENST00000536798ENST00000229470MBOAT1chr620212366-FYNchr6111983150-0.099989860.9000101
ENST00000536798ENST00000356013MBOAT1chr620212366-FYNchr6111983150-0.099989860.9000101

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52038_52038_1_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000324607_FYN_chr6_111983150_ENST00000229470_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_2_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000324607_FYN_chr6_111983150_ENST00000356013_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_3_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000324607_FYN_chr6_111983150_ENST00000368678_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_4_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000324607_FYN_chr6_111983150_ENST00000368682_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_5_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000536798_FYN_chr6_111983150_ENST00000229470_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_6_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000536798_FYN_chr6_111983150_ENST00000356013_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_7_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000536798_FYN_chr6_111983150_ENST00000368678_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_8_MBOAT1-FYN_MBOAT1_chr6_20212366_ENST00000536798_FYN_chr6_111983150_ENST00000368682_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_9_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000324607_FYN_chr6_111983150_ENST00000229470_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_10_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000324607_FYN_chr6_111983150_ENST00000356013_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_11_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000324607_FYN_chr6_111983150_ENST00000368678_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_12_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000324607_FYN_chr6_111983150_ENST00000368682_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_13_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000536798_FYN_chr6_111983150_ENST00000229470_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_14_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000536798_FYN_chr6_111983150_ENST00000356013_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_15_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000536798_FYN_chr6_111983150_ENST00000368678_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

>52038_52038_16_MBOAT1-FYN_MBOAT1_chr6_20212367_ENST00000536798_FYN_chr6_111983150_ENST00000368682_length(amino acids)=104AA_BP=35
MQDGSRAAAVQPFLPHHGLHLPAPAQRAPGHPAGPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDY

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:20212367/chr6:111983150)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MBOAT1

Q6ZNC8

FYN

C1orf168

FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BH98, ECO:0000269|PubMed:18772128}.728

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113126_14633.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113180_20033.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113238_25833.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113297_31733.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-11334_5433.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113371_39133.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113426_44633.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-113450_47033.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000324607-11370_9033.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18126_14633.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18180_20033.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18238_25833.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18297_31733.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-1834_5433.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18371_39133.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18426_44633.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-18450_47033.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000536798-1870_9033.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112126_1460347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112180_2000347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112238_2580347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112297_3170347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-11234_540347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112371_3910347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112426_4460347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-112450_4700347.0TransmembraneHelical
HgeneMBOAT1chr6:20212366chr6:111983150ENST00000541730-11270_900347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113126_14633.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113180_20033.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113238_25833.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113297_31733.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-11334_5433.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113371_39133.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113426_44633.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-113450_47033.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000324607-11370_9033.0496.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18126_14633.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18180_20033.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18238_25833.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18297_31733.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-1834_5433.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18371_39133.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18426_44633.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-18450_47033.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000536798-1870_9033.0242.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112126_1460347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112180_2000347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112238_2580347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112297_3170347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-11234_540347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112371_3910347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112426_4460347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-112450_4700347.0TransmembraneHelical
HgeneMBOAT1chr6:20212367chr6:111983150ENST00000541730-11270_900347.0TransmembraneHelical
TgeneFYNchr6:20212366chr6:111983150ENST00000229471911149_246413.3333333333333483.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST00000229471911271_524413.3333333333333483.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST0000022947191182_143413.3333333333333483.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST000003546501214149_246468.3333333333333538.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST000003546501214271_524468.3333333333333538.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST00000354650121482_143468.3333333333333538.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST000003560131113149_246413.3333333333333483.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST000003560131113271_524413.3333333333333483.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST00000356013111382_143413.3333333333333483.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST000003686671113149_246468.3333333333333538.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST000003686671113271_524468.3333333333333538.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST00000368667111382_143468.3333333333333538.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST000003686781113149_246465.3333333333333535.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST000003686781113271_524465.3333333333333535.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST00000368678111382_143465.3333333333333535.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST000003686821214149_246465.3333333333333535.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST000003686821214271_524465.3333333333333535.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST00000368682121482_143465.3333333333333535.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST00000538466911149_246465.3333333333333535.0DomainSH2
TgeneFYNchr6:20212366chr6:111983150ENST00000538466911271_524465.3333333333333535.0DomainProtein kinase
TgeneFYNchr6:20212366chr6:111983150ENST0000053846691182_143465.3333333333333535.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST00000229471911149_246413.3333333333333483.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST00000229471911271_524413.3333333333333483.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST0000022947191182_143413.3333333333333483.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST000003546501214149_246468.3333333333333538.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST000003546501214271_524468.3333333333333538.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST00000354650121482_143468.3333333333333538.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST000003560131113149_246413.3333333333333483.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST000003560131113271_524413.3333333333333483.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST00000356013111382_143413.3333333333333483.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST000003686671113149_246468.3333333333333538.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST000003686671113271_524468.3333333333333538.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST00000368667111382_143468.3333333333333538.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST000003686781113149_246465.3333333333333535.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST000003686781113271_524465.3333333333333535.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST00000368678111382_143465.3333333333333535.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST000003686821214149_246465.3333333333333535.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST000003686821214271_524465.3333333333333535.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST00000368682121482_143465.3333333333333535.0DomainSH3
TgeneFYNchr6:20212367chr6:111983150ENST00000538466911149_246465.3333333333333535.0DomainSH2
TgeneFYNchr6:20212367chr6:111983150ENST00000538466911271_524465.3333333333333535.0DomainProtein kinase
TgeneFYNchr6:20212367chr6:111983150ENST0000053846691182_143465.3333333333333535.0DomainSH3
TgeneFYNchr6:20212366chr6:111983150ENST00000229471911277_285413.3333333333333483.0Nucleotide bindingATP
TgeneFYNchr6:20212366chr6:111983150ENST000003546501214277_285468.3333333333333538.0Nucleotide bindingATP
TgeneFYNchr6:20212366chr6:111983150ENST000003560131113277_285413.3333333333333483.0Nucleotide bindingATP
TgeneFYNchr6:20212366chr6:111983150ENST000003686671113277_285468.3333333333333538.0Nucleotide bindingATP
TgeneFYNchr6:20212366chr6:111983150ENST000003686781113277_285465.3333333333333535.0Nucleotide bindingATP
TgeneFYNchr6:20212366chr6:111983150ENST000003686821214277_285465.3333333333333535.0Nucleotide bindingATP
TgeneFYNchr6:20212366chr6:111983150ENST00000538466911277_285465.3333333333333535.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST00000229471911277_285413.3333333333333483.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST000003546501214277_285468.3333333333333538.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST000003560131113277_285413.3333333333333483.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST000003686671113277_285468.3333333333333538.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST000003686781113277_285465.3333333333333535.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST000003686821214277_285465.3333333333333535.0Nucleotide bindingATP
TgeneFYNchr6:20212367chr6:111983150ENST00000538466911277_285465.3333333333333535.0Nucleotide bindingATP


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MBOAT1
FYN


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to MBOAT1-FYN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MBOAT1-FYN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource