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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AP2A2-TMEM80

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AP2A2-TMEM80
FusionPDB ID: 5233
FusionGDB2.0 ID: 5233
HgeneTgene
Gene symbol

AP2A2

TMEM80

Gene ID

161

283232

Gene nameadaptor related protein complex 2 subunit alpha 2transmembrane protein 80
SynonymsADTAB|CLAPA2|HIP-9|HIP9|HYPJ-
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin astransmembrane protein 80
Modification date2020031320200313
UniProtAcc

O94973

.
Ensembl transtripts involved in fusion geneENST idsENST00000332231, ENST00000448903, 
ENST00000534328, ENST00000525891, 
ENST00000528024, ENST00000397510, 
ENST00000397512, ENST00000608174, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 12=15604 X 9 X 5=180
# samples 226
** MAII scorelog2(22/1560*10)=-2.82597060022495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AP2A2 [Title/Abstract] AND TMEM80 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AP2A2(959505)-TMEM80(700615), # samples:2
AP2A2(926088)-TMEM80(698869), # samples:2
Anticipated loss of major functional domain due to fusion event.AP2A2-TMEM80 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-TMEM80 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-TMEM80 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-TMEM80 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-TMEM80 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP2A2

GO:0072583

clathrin-dependent endocytosis

23676497


check buttonFusion gene breakpoints across AP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM80 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07L-01AAP2A2chr11

959505

-TMEM80chr11

700615

+
ChimerDB4BRCATCGA-A8-A07L-01AAP2A2chr11

959505

+TMEM80chr11

700615

+
ChimerDB4BRCATCGA-A8-A07L-01AAP2A2chr11

959505

+TMEM80chr11

702945

+
ChimerDB4BRCATCGA-A8-A07L-01AAP2A2chr11

970223

+TMEM80chr11

700222

+
ChimerDB4BRCATCGA-A8-A07LAP2A2chr11

959505

+TMEM80chr11

700614

+
ChimerDB4UCSTCGA-N6-A4VG-01AAP2A2chr11

926088

-TMEM80chr11

698869

+
ChimerDB4UCSTCGA-N6-A4VGAP2A2chr11

926088

+TMEM80chr11

698868

+
ChimerDB4UCSTCGA-N6-A4VGAP2A2chr11

926088

+TMEM80chr11

698869

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534328AP2A2chr11959505+ENST00000397510TMEM80chr11700614+839278142576144
ENST00000534328AP2A2chr11959505+ENST00000608174TMEM80chr11700614+1554278142576144
ENST00000534328AP2A2chr11959505+ENST00000397512TMEM80chr11700614+1556278142576144
ENST00000332231AP2A2chr11959505+ENST00000397510TMEM80chr11700614+838277141575144
ENST00000332231AP2A2chr11959505+ENST00000608174TMEM80chr11700614+1553277141575144
ENST00000332231AP2A2chr11959505+ENST00000397512TMEM80chr11700614+1555277141575144
ENST00000448903AP2A2chr11959505+ENST00000397510TMEM80chr11700614+838277141575144
ENST00000448903AP2A2chr11959505+ENST00000608174TMEM80chr11700614+1553277141575144
ENST00000448903AP2A2chr11959505+ENST00000397512TMEM80chr11700614+1555277141575144
ENST00000534328AP2A2chr11926088+ENST00000397510TMEM80chr11698868+884209142621159
ENST00000534328AP2A2chr11926088+ENST00000608174TMEM80chr11698868+1599209142621159
ENST00000534328AP2A2chr11926088+ENST00000397512TMEM80chr11698868+1601209142621159
ENST00000332231AP2A2chr11926088+ENST00000397510TMEM80chr11698868+883208141620159
ENST00000332231AP2A2chr11926088+ENST00000608174TMEM80chr11698868+1598208141620159
ENST00000332231AP2A2chr11926088+ENST00000397512TMEM80chr11698868+1600208141620159
ENST00000448903AP2A2chr11926088+ENST00000397510TMEM80chr11698868+883208141620159
ENST00000448903AP2A2chr11926088+ENST00000608174TMEM80chr11698868+1598208141620159
ENST00000448903AP2A2chr11926088+ENST00000397512TMEM80chr11698868+1600208141620159
ENST00000534328AP2A2chr11970223+ENST00000397510TMEM80chr11700222+940366315677120
ENST00000534328AP2A2chr11970223+ENST00000608174TMEM80chr11700222+16553661036623137
ENST00000534328AP2A2chr11970223+ENST00000397512TMEM80chr11700222+16573661036623137
ENST00000332231AP2A2chr11970223+ENST00000397510TMEM80chr11700222+939365314676120
ENST00000332231AP2A2chr11970223+ENST00000608174TMEM80chr11700222+16543651035622137
ENST00000332231AP2A2chr11970223+ENST00000397512TMEM80chr11700222+16563651035622137
ENST00000448903AP2A2chr11970223+ENST00000397510TMEM80chr11700222+939365314676120
ENST00000448903AP2A2chr11970223+ENST00000608174TMEM80chr11700222+16543651035622137
ENST00000448903AP2A2chr11970223+ENST00000397512TMEM80chr11700222+16563651035622137
ENST00000534328AP2A2chr11959505+ENST00000397510TMEM80chr11700615+839278142576144
ENST00000534328AP2A2chr11959505+ENST00000608174TMEM80chr11700615+1554278142576144
ENST00000534328AP2A2chr11959505+ENST00000397512TMEM80chr11700615+1556278142576144
ENST00000332231AP2A2chr11959505+ENST00000397510TMEM80chr11700615+838277141575144
ENST00000332231AP2A2chr11959505+ENST00000608174TMEM80chr11700615+1553277141575144
ENST00000332231AP2A2chr11959505+ENST00000397512TMEM80chr11700615+1555277141575144
ENST00000448903AP2A2chr11959505+ENST00000397510TMEM80chr11700615+838277141575144
ENST00000448903AP2A2chr11959505+ENST00000608174TMEM80chr11700615+1553277141575144
ENST00000448903AP2A2chr11959505+ENST00000397512TMEM80chr11700615+1555277141575144
ENST00000534328AP2A2chr11959505+ENST00000608174TMEM80chr11702945+1461278842429137
ENST00000332231AP2A2chr11959505+ENST00000608174TMEM80chr11702945+1460277841428137
ENST00000448903AP2A2chr11959505+ENST00000608174TMEM80chr11702945+1460277841428137
ENST00000534328AP2A2chr11926088+ENST00000397510TMEM80chr11698869+884209142621159
ENST00000534328AP2A2chr11926088+ENST00000608174TMEM80chr11698869+1599209142621159
ENST00000534328AP2A2chr11926088+ENST00000397512TMEM80chr11698869+1601209142621159
ENST00000332231AP2A2chr11926088+ENST00000397510TMEM80chr11698869+883208141620159
ENST00000332231AP2A2chr11926088+ENST00000608174TMEM80chr11698869+1598208141620159
ENST00000332231AP2A2chr11926088+ENST00000397512TMEM80chr11698869+1600208141620159
ENST00000448903AP2A2chr11926088+ENST00000397510TMEM80chr11698869+883208141620159
ENST00000448903AP2A2chr11926088+ENST00000608174TMEM80chr11698869+1598208141620159
ENST00000448903AP2A2chr11926088+ENST00000397512TMEM80chr11698869+1600208141620159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534328ENST00000397510AP2A2chr11959505+TMEM80chr11700614+0.0057405470.9942595
ENST00000534328ENST00000608174AP2A2chr11959505+TMEM80chr11700614+0.0097658380.99023414
ENST00000534328ENST00000397512AP2A2chr11959505+TMEM80chr11700614+0.0096171140.99038285
ENST00000332231ENST00000397510AP2A2chr11959505+TMEM80chr11700614+0.0054807250.9945193
ENST00000332231ENST00000608174AP2A2chr11959505+TMEM80chr11700614+0.0092897290.9907102
ENST00000332231ENST00000397512AP2A2chr11959505+TMEM80chr11700614+0.0090697160.99093026
ENST00000448903ENST00000397510AP2A2chr11959505+TMEM80chr11700614+0.0054807250.9945193
ENST00000448903ENST00000608174AP2A2chr11959505+TMEM80chr11700614+0.0092897290.9907102
ENST00000448903ENST00000397512AP2A2chr11959505+TMEM80chr11700614+0.0090697160.99093026
ENST00000534328ENST00000397510AP2A2chr11926088+TMEM80chr11698868+0.0025977730.9974023
ENST00000534328ENST00000608174AP2A2chr11926088+TMEM80chr11698868+0.0133142930.98668563
ENST00000534328ENST00000397512AP2A2chr11926088+TMEM80chr11698868+0.0129963820.9870036
ENST00000332231ENST00000397510AP2A2chr11926088+TMEM80chr11698868+0.0024783470.9975216
ENST00000332231ENST00000608174AP2A2chr11926088+TMEM80chr11698868+0.0114710630.9885289
ENST00000332231ENST00000397512AP2A2chr11926088+TMEM80chr11698868+0.011457390.98854256
ENST00000448903ENST00000397510AP2A2chr11926088+TMEM80chr11698868+0.0024783470.9975216
ENST00000448903ENST00000608174AP2A2chr11926088+TMEM80chr11698868+0.0114710630.9885289
ENST00000448903ENST00000397512AP2A2chr11926088+TMEM80chr11698868+0.011457390.98854256
ENST00000534328ENST00000397510AP2A2chr11970223+TMEM80chr11700222+0.0113174250.98868257
ENST00000534328ENST00000608174AP2A2chr11970223+TMEM80chr11700222+0.0145116450.98548836
ENST00000534328ENST00000397512AP2A2chr11970223+TMEM80chr11700222+0.01413130.9858687
ENST00000332231ENST00000397510AP2A2chr11970223+TMEM80chr11700222+0.0107819880.989218
ENST00000332231ENST00000608174AP2A2chr11970223+TMEM80chr11700222+0.0134198180.9865802
ENST00000332231ENST00000397512AP2A2chr11970223+TMEM80chr11700222+0.0133200960.98667985
ENST00000448903ENST00000397510AP2A2chr11970223+TMEM80chr11700222+0.0107819880.989218
ENST00000448903ENST00000608174AP2A2chr11970223+TMEM80chr11700222+0.0134198180.9865802
ENST00000448903ENST00000397512AP2A2chr11970223+TMEM80chr11700222+0.0133200960.98667985
ENST00000534328ENST00000397510AP2A2chr11959505+TMEM80chr11700615+0.0057405470.9942595
ENST00000534328ENST00000608174AP2A2chr11959505+TMEM80chr11700615+0.0097658380.99023414
ENST00000534328ENST00000397512AP2A2chr11959505+TMEM80chr11700615+0.0096171140.99038285
ENST00000332231ENST00000397510AP2A2chr11959505+TMEM80chr11700615+0.0054807250.9945193
ENST00000332231ENST00000608174AP2A2chr11959505+TMEM80chr11700615+0.0092897290.9907102
ENST00000332231ENST00000397512AP2A2chr11959505+TMEM80chr11700615+0.0090697160.99093026
ENST00000448903ENST00000397510AP2A2chr11959505+TMEM80chr11700615+0.0054807250.9945193
ENST00000448903ENST00000608174AP2A2chr11959505+TMEM80chr11700615+0.0092897290.9907102
ENST00000448903ENST00000397512AP2A2chr11959505+TMEM80chr11700615+0.0090697160.99093026
ENST00000534328ENST00000608174AP2A2chr11959505+TMEM80chr11702945+0.0306154150.96938455
ENST00000332231ENST00000608174AP2A2chr11959505+TMEM80chr11702945+0.033633620.96636635
ENST00000448903ENST00000608174AP2A2chr11959505+TMEM80chr11702945+0.033633620.96636635
ENST00000534328ENST00000397510AP2A2chr11926088+TMEM80chr11698869+0.0025977730.9974023
ENST00000534328ENST00000608174AP2A2chr11926088+TMEM80chr11698869+0.0133142930.98668563
ENST00000534328ENST00000397512AP2A2chr11926088+TMEM80chr11698869+0.0129963820.9870036
ENST00000332231ENST00000397510AP2A2chr11926088+TMEM80chr11698869+0.0024783470.9975216
ENST00000332231ENST00000608174AP2A2chr11926088+TMEM80chr11698869+0.0114710630.9885289
ENST00000332231ENST00000397512AP2A2chr11926088+TMEM80chr11698869+0.011457390.98854256
ENST00000448903ENST00000397510AP2A2chr11926088+TMEM80chr11698869+0.0024783470.9975216
ENST00000448903ENST00000608174AP2A2chr11926088+TMEM80chr11698869+0.0114710630.9885289
ENST00000448903ENST00000397512AP2A2chr11926088+TMEM80chr11698869+0.011457390.98854256

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5233_5233_1_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000332231_TMEM80_chr11_698868_ENST00000397510_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_2_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000332231_TMEM80_chr11_698868_ENST00000397512_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_3_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000332231_TMEM80_chr11_698868_ENST00000608174_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_4_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000332231_TMEM80_chr11_698869_ENST00000397510_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_5_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000332231_TMEM80_chr11_698869_ENST00000397512_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_6_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000332231_TMEM80_chr11_698869_ENST00000608174_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_7_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000448903_TMEM80_chr11_698868_ENST00000397510_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_8_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000448903_TMEM80_chr11_698868_ENST00000397512_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_9_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000448903_TMEM80_chr11_698868_ENST00000608174_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_10_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000448903_TMEM80_chr11_698869_ENST00000397510_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_11_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000448903_TMEM80_chr11_698869_ENST00000397512_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_12_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000448903_TMEM80_chr11_698869_ENST00000608174_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_13_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000534328_TMEM80_chr11_698868_ENST00000397510_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_14_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000534328_TMEM80_chr11_698868_ENST00000397512_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_15_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000534328_TMEM80_chr11_698868_ENST00000608174_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_16_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000534328_TMEM80_chr11_698869_ENST00000397510_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_17_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000534328_TMEM80_chr11_698869_ENST00000397512_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_18_AP2A2-TMEM80_AP2A2_chr11_926088_ENST00000534328_TMEM80_chr11_698869_ENST00000608174_length(amino acids)=159AA_BP=
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY

--------------------------------------------------------------

>5233_5233_19_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_700614_ENST00000397510_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_20_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_700614_ENST00000397512_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_21_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_700614_ENST00000608174_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_22_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_700615_ENST00000397510_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_23_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_700615_ENST00000397512_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_24_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_700615_ENST00000608174_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_25_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000332231_TMEM80_chr11_702945_ENST00000608174_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_26_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_700614_ENST00000397510_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_27_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_700614_ENST00000397512_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_28_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_700614_ENST00000608174_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_29_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_700615_ENST00000397510_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_30_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_700615_ENST00000397512_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_31_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_700615_ENST00000608174_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_32_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000448903_TMEM80_chr11_702945_ENST00000608174_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_33_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_700614_ENST00000397510_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_34_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_700614_ENST00000397512_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_35_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_700614_ENST00000608174_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_36_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_700615_ENST00000397510_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_37_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_700615_ENST00000397512_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_38_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_700615_ENST00000608174_length(amino acids)=144AA_BP=45
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLA

--------------------------------------------------------------

>5233_5233_39_AP2A2-TMEM80_AP2A2_chr11_959505_ENST00000534328_TMEM80_chr11_702945_ENST00000608174_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_40_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000332231_TMEM80_chr11_700222_ENST00000397510_length(amino acids)=120AA_BP=
MEAVNLLSSNRYTEKQIITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLAASLALTAGTALLSAHFLLWQALVL

--------------------------------------------------------------

>5233_5233_41_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000332231_TMEM80_chr11_700222_ENST00000397512_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_42_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000332231_TMEM80_chr11_700222_ENST00000608174_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_43_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000448903_TMEM80_chr11_700222_ENST00000397510_length(amino acids)=120AA_BP=
MEAVNLLSSNRYTEKQIITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLAASLALTAGTALLSAHFLLWQALVL

--------------------------------------------------------------

>5233_5233_44_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000448903_TMEM80_chr11_700222_ENST00000397512_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_45_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000448903_TMEM80_chr11_700222_ENST00000608174_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_46_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000534328_TMEM80_chr11_700222_ENST00000397510_length(amino acids)=120AA_BP=
MEAVNLLSSNRYTEKQIITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLYLGTRGNLTEAERPLAASLALTAGTALLSAHFLLWQALVL

--------------------------------------------------------------

>5233_5233_47_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000534328_TMEM80_chr11_700222_ENST00000397512_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

>5233_5233_48_AP2A2-TMEM80_AP2A2_chr11_970223_ENST00000534328_TMEM80_chr11_700222_ENST00000608174_length(amino acids)=137AA_BP=
MKGSVLPLGPGGPWGSVEAWLLKPDPTDRAECALLGLILKAVLSGPYPPRSCSQHQGLQQFVLPWLLLPLLPEQMEPSKTIYGQSLGKVP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:959505/chr11:700615)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP2A2

O94973

.
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2A2chr11:926088chr11:698868ENST00000332231+12211_1222.333333333333332941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698868ENST00000448903+12211_1222.333333333333332940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698869ENST00000332231+12211_1222.333333333333332941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698869ENST00000448903+12211_1222.333333333333332940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700614ENST00000332231+22211_1245.333333333333336941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700614ENST00000448903+22211_1245.333333333333336940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700615ENST00000332231+22211_1245.333333333333336941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700615ENST00000448903+22211_1245.333333333333336940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:702945ENST00000332231+22211_1245.333333333333336941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:702945ENST00000448903+22211_1245.333333333333336940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
TgeneTMEM80chr11:926088chr11:698868ENST0000039751005128_14879.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST0000039751005172_19279.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST0000039751005194_21479.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST000003975100594_11479.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST0000039751205128_14823.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST0000039751205172_19223.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST0000039751205194_21423.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698868ENST000003975120594_11423.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST0000039751005128_14879.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST0000039751005172_19279.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST0000039751005194_21479.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST000003975100594_11479.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST0000039751205128_14823.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST0000039751205172_19223.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST0000039751205194_21423.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:926088chr11:698869ENST000003975120594_11423.333333333333332161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST0000039751025128_148117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST0000039751025172_192117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST0000039751025194_214117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST0000039751225128_14861.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST0000039751225172_19261.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST0000039751225194_21461.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700614ENST000003975122594_11461.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST0000039751025128_148117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST0000039751025172_192117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST0000039751025194_214117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST0000039751225128_14861.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST0000039751225172_19261.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST0000039751225194_21461.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST000003975122594_11461.333333333333336161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST0000039751035172_192148.33333333333334217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST0000039751035194_214148.33333333333334217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST0000039751235128_14892.33333333333333161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST0000039751235172_19292.33333333333333161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST0000039751235194_21492.33333333333333161.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST000003975123594_11492.33333333333333161.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST0000039751005128_1480217.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST0000039751005172_1920217.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST0000039751005194_2140217.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST000003975100594_1140217.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST0000039751205128_1480161.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST0000039751205172_1920161.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST0000039751205194_2140161.0TransmembraneHelical
TgeneTMEM80chr11:970223chr11:700222ENST000003975120594_1140161.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2A2chr11:926088chr11:698868ENST00000332231+12257_6122.333333333333332941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698868ENST00000332231+1225_8022.333333333333332941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:926088chr11:698868ENST00000448903+12257_6122.333333333333332940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698868ENST00000448903+1225_8022.333333333333332940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:926088chr11:698869ENST00000332231+12257_6122.333333333333332941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698869ENST00000332231+1225_8022.333333333333332941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:926088chr11:698869ENST00000448903+12257_6122.333333333333332940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:926088chr11:698869ENST00000448903+1225_8022.333333333333332940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:959505chr11:700614ENST00000332231+22257_6145.333333333333336941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700614ENST00000332231+2225_8045.333333333333336941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:959505chr11:700614ENST00000448903+22257_6145.333333333333336940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700614ENST00000448903+2225_8045.333333333333336940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:959505chr11:700615ENST00000332231+22257_6145.333333333333336941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700615ENST00000332231+2225_8045.333333333333336941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:959505chr11:700615ENST00000448903+22257_6145.333333333333336940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:700615ENST00000448903+2225_8045.333333333333336940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:959505chr11:702945ENST00000332231+22257_6145.333333333333336941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:702945ENST00000332231+2225_8045.333333333333336941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:959505chr11:702945ENST00000448903+22257_6145.333333333333336940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:959505chr11:702945ENST00000448903+2225_8045.333333333333336940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:970223chr11:700222ENST00000332231+12211_120941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:970223chr11:700222ENST00000332231+12257_610941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:970223chr11:700222ENST00000332231+1225_800941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:970223chr11:700222ENST00000448903+12211_120940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:970223chr11:700222ENST00000448903+12257_610940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:970223chr11:700222ENST00000448903+1225_800940.0RegionNote=Lipid-binding
TgeneTMEM80chr11:959505chr11:700614ENST000003975102594_114117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:700615ENST000003975102594_114117.33333333333333217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST0000039751035128_148148.33333333333334217.0TransmembraneHelical
TgeneTMEM80chr11:959505chr11:702945ENST000003975103594_114148.33333333333334217.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>145_AP2A2_926088_TMEM80_698869_ranked_0.pdbAP2A2926088926088ENST00000397512TMEM80chr11698869+
MPAVSKGDGMRGLAVFISDIRNWRGSSTVLSSVPLQMLFYLSGTYYALYFLATLLMITYKSQVFSYPHRYLVLDLALLFLMGILEAVRLY
159


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
AP2A2_pLDDT.png
all structure
all structure
TMEM80_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AP2A2
TMEM80


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AP2A2-TMEM80


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AP2A2-TMEM80


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource