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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MDM2-RAP1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MDM2-RAP1B
FusionPDB ID: 52418
FusionGDB2.0 ID: 52418
HgeneTgene
Gene symbol

MDM2

RAP1B

Gene ID

4193

5908

Gene nameMDM2 proto-oncogeneRAP1B, member of RAS oncogene family
SynonymsACTFS|HDMX|LSKB|hdm2K-REV|RAL1B
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humras-related protein Rap-1bGTP-binding protein smg p21BRAS-related protein RAP1BRas family small GTP binding protein RAP1Bsmall GTP binding protein
Modification date2020032920200313
UniProtAcc

Q00987

.
Ensembl transtripts involved in fusion geneENST idsENST00000258149, ENST00000356290, 
ENST00000428863, ENST00000462284, 
ENST00000478070, ENST00000540827, 
ENST00000545204, ENST00000258148, 
ENST00000299252, ENST00000348801, 
ENST00000350057, ENST00000360430, 
ENST00000393410, ENST00000393412, 
ENST00000393413, ENST00000517852, 
ENST00000544561, ENST00000544125, 
ENST00000250559, ENST00000341355, 
ENST00000393436, ENST00000450214, 
ENST00000537460, ENST00000539091, 
ENST00000540209, ENST00000541216, 
ENST00000542145, ENST00000543697, 
ENST00000378985, ENST00000463493, 
ENST00000543393, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score39 X 20 X 11=858016 X 11 X 8=1408
# samples 4716
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1408*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MDM2 [Title/Abstract] AND RAP1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MDM2(69236158)-RAP1B(69042479), # samples:1
MDM2(69233581)-RAP1B(69042479), # samples:1
MDM2(69203072)-RAP1B(69047892), # samples:1
MDM2(69229764)-RAP1B(69042479), # samples:1
Anticipated loss of major functional domain due to fusion event.MDM2-RAP1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-RAP1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-RAP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-RAP1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922

TgeneRAP1B

GO:0071320

cellular response to cAMP

21840392


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAP1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0686-01AMDM2chr12

69203072

+RAP1Bchr12

69047892

+
ChimerDB4GBMTCGA-06-0686-01AMDM2chr12

69229764

+RAP1Bchr12

69042479

+
ChimerDB4GBMTCGA-06-0686-01AMDM2chr12

69233581

+RAP1Bchr12

69042479

+
ChimerDB4GBMTCGA-06-0686-01AMDM2chr12

69236158

+RAP1Bchr12

69042479

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+2116401266772168
ENST00000462284MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+2046401266772168
ENST00000462284MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+777401266772168
ENST00000462284MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+925401266772168
ENST00000356290MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+2101386251757168
ENST00000356290MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+2031386251757168
ENST00000356290MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+762386251757168
ENST00000356290MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+910386251757168
ENST00000540827MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+2101386251757168
ENST00000540827MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+2031386251757168
ENST00000540827MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+762386251757168
ENST00000540827MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+910386251757168
ENST00000258149MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+2101386251757168
ENST00000258149MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+2031386251757168
ENST00000258149MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+762386251757168
ENST00000258149MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+910386251757168
ENST00000428863MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+2101386251757168
ENST00000428863MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+2031386251757168
ENST00000428863MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+762386251757168
ENST00000428863MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+910386251757168
ENST00000393412MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+2070355220726168
ENST00000393412MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+2000355220726168
ENST00000393412MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+731355220726168
ENST00000393412MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+879355220726168
ENST00000258148MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+182811314484156
ENST00000258148MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+175811314484156
ENST00000258148MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+48911314484156
ENST00000258148MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+63711314484156
ENST00000544561MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000544561MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000544561MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000544561MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000393410MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000393410MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000393410MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000393410MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000393413MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000393413MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000393413MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000393413MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000517852MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000517852MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000517852MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000517852MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000545204MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1802870458152
ENST00000545204MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1732870458152
ENST00000545204MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+463870458152
ENST00000545204MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+611870458152
ENST00000350057MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000350057MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000350057MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000350057MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000360430MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000360430MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000360430MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000360430MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000299252MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1796810452150
ENST00000299252MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1726810452150
ENST00000299252MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+457810452150
ENST00000299252MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+605810452150
ENST00000348801MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1781660437145
ENST00000348801MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1711660437145
ENST00000348801MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+442660437145
ENST00000348801MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+590660437145
ENST00000478070MDM2chr1269203072+ENST00000250559RAP1Bchr1269047892+1781660437145
ENST00000478070MDM2chr1269203072+ENST00000393436RAP1Bchr1269047892+1711660437145
ENST00000478070MDM2chr1269203072+ENST00000341355RAP1Bchr1269047892+442660437145
ENST00000478070MDM2chr1269203072+ENST00000537460RAP1Bchr1269047892+590660437145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0056553540.9943447
ENST00000462284ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0056411380.99435884
ENST00000462284ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0288817770.9711183
ENST00000462284ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.018188570.98181146
ENST00000356290ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0055916590.99440837
ENST00000356290ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0062091670.9937908
ENST00000356290ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0278688150.97213113
ENST00000356290ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0154658460.98453414
ENST00000540827ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0055916590.99440837
ENST00000540827ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0062091670.9937908
ENST00000540827ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0278688150.97213113
ENST00000540827ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0154658460.98453414
ENST00000258149ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0055916590.99440837
ENST00000258149ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0062091670.9937908
ENST00000258149ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0278688150.97213113
ENST00000258149ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0154658460.98453414
ENST00000428863ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0055916590.99440837
ENST00000428863ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0062091670.9937908
ENST00000428863ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0278688150.97213113
ENST00000428863ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0154658460.98453414
ENST00000393412ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.00228150.9977186
ENST00000393412ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0022870880.99771297
ENST00000393412ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0194638330.9805362
ENST00000393412ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0112158410.9887841
ENST00000258148ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0035315290.9964684
ENST00000258148ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0035074610.99649256
ENST00000258148ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0050015970.99499846
ENST00000258148ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0038614330.9961385
ENST00000544561ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000544561ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000544561ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000544561ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000393410ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000393410ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000393410ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000393410ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000393413ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000393413ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000393413ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000393413ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000517852ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000517852ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000517852ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000517852ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000545204ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.003917290.99608266
ENST00000545204ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0034606140.99653935
ENST00000545204ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0035971180.99640286
ENST00000545204ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0023642450.9976357
ENST00000350057ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000350057ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000350057ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000350057ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000360430ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000360430ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000360430ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000360430ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000299252ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0031611940.9968388
ENST00000299252ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.002680040.99732
ENST00000299252ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0038243310.99617565
ENST00000299252ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0022806660.99771935
ENST00000348801ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0018778960.99812204
ENST00000348801ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0015890120.99841094
ENST00000348801ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0031804010.9968196
ENST00000348801ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0017249640.99827504
ENST00000478070ENST00000250559MDM2chr1269203072+RAP1Bchr1269047892+0.0018778960.99812204
ENST00000478070ENST00000393436MDM2chr1269203072+RAP1Bchr1269047892+0.0015890120.99841094
ENST00000478070ENST00000341355MDM2chr1269203072+RAP1Bchr1269047892+0.0031804010.9968196
ENST00000478070ENST00000537460MDM2chr1269203072+RAP1Bchr1269047892+0.0017249640.99827504

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52418_52418_1_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258148_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=156AA_BP=33
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKC

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>52418_52418_2_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258148_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=156AA_BP=33
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKC

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>52418_52418_3_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258148_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=156AA_BP=33
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKC

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>52418_52418_4_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258148_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=156AA_BP=33
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKC

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>52418_52418_5_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258149_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_6_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258149_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_7_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258149_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_8_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000258149_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_9_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000299252_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_10_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000299252_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_11_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000299252_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_12_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000299252_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_13_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000348801_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

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>52418_52418_14_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000348801_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

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>52418_52418_15_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000348801_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

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>52418_52418_16_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000348801_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

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>52418_52418_17_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000350057_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_18_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000350057_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_19_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000350057_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_20_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000350057_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_21_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000356290_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_22_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000356290_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_23_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000356290_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_24_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000356290_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_25_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000360430_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_26_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000360430_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_27_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000360430_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_28_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000360430_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_29_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393410_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_30_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393410_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_31_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393410_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_32_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393410_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_33_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393412_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_34_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393412_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_35_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393412_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_36_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393412_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_37_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393413_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_38_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393413_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_39_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393413_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_40_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000393413_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

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>52418_52418_41_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000428863_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_42_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000428863_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_43_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000428863_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_44_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000428863_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_45_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000462284_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_46_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000462284_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_47_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000462284_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_48_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000462284_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

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>52418_52418_49_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000478070_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

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>52418_52418_50_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000478070_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

--------------------------------------------------------------

>52418_52418_51_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000478070_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

--------------------------------------------------------------

>52418_52418_52_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000478070_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=145AA_BP=22
MSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKE

--------------------------------------------------------------

>52418_52418_53_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000517852_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_54_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000517852_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_55_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000517852_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_56_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000517852_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_57_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000540827_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_58_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000540827_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_59_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000540827_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_60_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000540827_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=168AA_BP=45
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDT

--------------------------------------------------------------

>52418_52418_61_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000544561_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_62_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000544561_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_63_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000544561_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_64_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000544561_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=150AA_BP=27
MCNTNMSVPTDGAVTTSQIPASEQETLEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDER

--------------------------------------------------------------

>52418_52418_65_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000545204_RAP1B_chr12_69047892_ENST00000250559_length(amino acids)=152AA_BP=29
MCNTNMSVPTDGAVTTSQIPASEQETLVSEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLED

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>52418_52418_66_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000545204_RAP1B_chr12_69047892_ENST00000341355_length(amino acids)=152AA_BP=29
MCNTNMSVPTDGAVTTSQIPASEQETLVSEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLED

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>52418_52418_67_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000545204_RAP1B_chr12_69047892_ENST00000393436_length(amino acids)=152AA_BP=29
MCNTNMSVPTDGAVTTSQIPASEQETLVSEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLED

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>52418_52418_68_MDM2-RAP1B_MDM2_chr12_69203072_ENST00000545204_RAP1B_chr12_69047892_ENST00000537460_length(amino acids)=152AA_BP=29
MCNTNMSVPTDGAVTTSQIPASEQETLVSEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLED

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69236158/chr12:69042479)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

.
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:30879903}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAP1Bchr12:69203072chr12:69047892ENST000004502141632_4019.0379.3333333333333MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005390911632_4019.0224.33333333333334MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005421450732_400258.0MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000025055938116_11961.0554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000025055938147_14961.0554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000034135537116_11961.0185.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000034135537147_14961.0185.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000039343638116_11961.0534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000039343638147_14961.0534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000045021416116_11919.0379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000045021416147_14919.0379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000004502141657_6119.0379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000053746049116_11961.0180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000053746049147_14961.0180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000053909116116_11919.0224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000053909116147_14919.0224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005390911657_6119.0224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000054020927116_11942.0323.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000054020927147_14942.0323.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005402092757_6142.0323.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005421450710_180258.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000054214507116_1190258.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST0000054214507147_1490258.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005421450757_610258.0Nucleotide bindingGTP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29210_21527.0437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29243_30127.0437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15210_21527.0322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15243_30127.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13210_21522.0266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13243_30122.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26210_21527.0322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26243_30127.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14210_21527.0297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23210_21527.0219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23243_30127.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12210_21527.0219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12243_30127.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24210_21527.0271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24243_30127.0271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211210_21533.0498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211243_30133.0498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25210_21527.0297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+2926_10927.0437.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+1526_10927.0322.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+1326_10922.0266.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+2626_10927.0322.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+1426_10927.0297.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+2326_10927.0219.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+1226_10927.0219.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+2426_10927.0271.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+21126_10933.0498.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+2526_10927.0297.0DomainSWIB/MDM2
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29179_18527.0437.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29190_20227.0437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29466_47327.0437.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15179_18527.0322.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15190_20227.0322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15466_47327.0322.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13179_18522.0266.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13190_20222.0266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13466_47322.0266.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26179_18527.0322.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26190_20227.0322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26466_47327.0322.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14179_18527.0297.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14190_20227.0297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14466_47327.0297.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23179_18527.0219.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23190_20227.0219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23466_47327.0219.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12179_18527.0219.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12190_20227.0219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12466_47327.0219.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24179_18527.0271.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24190_20227.0271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24466_47327.0271.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211179_18533.0498.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211190_20233.0498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211466_47333.0498.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25179_18527.0297.0MotifNuclear localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25190_20227.0297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25466_47327.0297.0MotifNucleolar localization signal
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+291_10127.0437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29210_30427.0437.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29242_33127.0437.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+151_10127.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15210_30427.0322.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15242_33127.0322.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+131_10122.0266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13210_30422.0266.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13242_33122.0266.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+261_10127.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26210_30427.0322.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26242_33127.0322.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+141_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14210_30427.0297.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14242_33127.0297.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+231_10127.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23210_30427.0219.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23242_33127.0219.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+121_10127.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12210_30427.0219.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12242_33127.0219.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+241_10127.0271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24210_30427.0271.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24242_33127.0271.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+2111_10133.0498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211210_30433.0498.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211242_33133.0498.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+251_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25210_30427.0297.0RegionNote=ARF-binding
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25242_33127.0297.0RegionNote=Region II
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29299_32827.0437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29438_47927.0437.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15299_32827.0322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15438_47927.0322.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13299_32822.0266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13438_47922.0266.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26299_32827.0322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26438_47927.0322.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14299_32827.0297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14438_47927.0297.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23299_32827.0219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23438_47927.0219.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12299_32827.0219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12438_47927.0219.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24299_32827.0271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24438_47927.0271.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211299_32833.0498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211438_47933.0498.0Zinc fingerRING-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25299_32827.0297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25438_47927.0297.0Zinc fingerRING-type
TgeneRAP1Bchr12:69203072chr12:69047892ENST000002505593832_4061.0554.3333333333334MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003413553732_4061.0185.0MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003934363832_4061.0534.3333333333334MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005374604932_4061.0180.33333333333334MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005402092732_4042.0323.3333333333333MotifEffector region
TgeneRAP1Bchr12:69203072chr12:69047892ENST000002505593810_1861.0554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000002505593857_6161.0554.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003413553710_1861.0185.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003413553757_6161.0185.0Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003934363810_1861.0534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003934363857_6161.0534.3333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000004502141610_1819.0379.3333333333333Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005374604910_1861.0180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005374604957_6161.0180.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005390911610_1819.0224.33333333333334Nucleotide bindingGTP
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005402092710_1842.0323.3333333333333Nucleotide bindingGTP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MDM2
RAP1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29170_30627.0437.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15170_30627.0322.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13170_30622.0266.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26170_30627.0322.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14170_30627.0297.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23170_30627.0219.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12170_30627.0219.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24170_30627.0271.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211170_30633.0498.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25170_30627.0297.0MTBP
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29150_23027.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15150_23027.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13150_23022.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26150_23027.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14150_23027.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23150_23027.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12150_23027.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24150_23027.0271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211150_23033.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25150_23027.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69203072chr12:69047892ENST00000258149+29223_23227.0437.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000299252+15223_23227.0322.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000348801+13223_23222.0266.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000356290+26223_23227.0322.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000360430+14223_23227.0297.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000393412+23223_23227.0219.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000393413+12223_23227.0219.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000428863+24223_23227.0271.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000462284+211223_23233.0498.0USP7
HgeneMDM2chr12:69203072chr12:69047892ENST00000540827+25223_23227.0297.0USP7
TgeneRAP1Bchr12:69203072chr12:69047892ENST000002505593825_6761.0554.3333333333334KRIT1
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003413553725_6761.0185.0KRIT1
TgeneRAP1Bchr12:69203072chr12:69047892ENST000003934363825_6761.0534.3333333333334KRIT1
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005374604925_6761.0180.33333333333334KRIT1
TgeneRAP1Bchr12:69203072chr12:69047892ENST000005402092725_6742.0323.3333333333333KRIT1


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Related Drugs to MDM2-RAP1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MDM2-RAP1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource