UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MED1-ABCC3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MED1-ABCC3
FusionPDB ID: 52641
FusionGDB2.0 ID: 52641
HgeneTgene
Gene symbol

MED1

ABCC3

Gene ID

8930

8714

Gene namemethyl-CpG binding domain 4, DNA glycosylaseATP binding cassette subfamily C member 3
SynonymsMED1ABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2
Cytomap

3q21.3

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionmethyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylaseG/5-fluorouracil mismatch glycosylase with biphasic kineticsG/T mismatch glycosylaseG/U mismatch glycosylasemethyl-CpG binding domain protein 4methyl-CpG-binding endonuclease 1methcanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrug
Modification date2020031320200313
UniProtAcc

A0JLT2

O15438

Ensembl transtripts involved in fusion geneENST idsENST00000300651, ENST00000394287, 
ENST00000427699, ENST00000510891, 
ENST00000515707, ENST00000285238, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score42 X 23 X 11=106268 X 12 X 4=384
# samples 4113
** MAII scorelog2(41/10626*10)=-4.69583089796762
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/384*10)=-1.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MED1 [Title/Abstract] AND ABCC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MED1(37604051)-ABCC3(48733193), # samples:3
Anticipated loss of major functional domain due to fusion event.MED1-ABCC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MED1-ABCC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MED1-ABCC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MED1-ABCC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCC3

GO:0042908

xenobiotic transport

18698235|19334674


check buttonFusion gene breakpoints across MED1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0AW-01AMED1chr17

37604050

-ABCC3chr17

48733192

+
ChimerDB4BRCATCGA-BH-A0AW-01AMED1chr17

37604051

-ABCC3chr17

48733193

+
ChimerDB4BRCATCGA-BH-A0AWMED1chr17

37604050

-ABCC3chr17

48733192

+
ChimerDB4BRCATCGA-BH-A0AWMED1chr17

37604050

-ABCC3chr17

48734062

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394287MED1chr1737604051-ENST00000285238ABCC3chr1748733193+592933820648761556
ENST00000300651MED1chr1737604051-ENST00000285238ABCC3chr1748733193+594735622448941556
ENST00000394287MED1chr1737604050-ENST00000285238ABCC3chr1748733192+592933820648761556
ENST00000300651MED1chr1737604050-ENST00000285238ABCC3chr1748733192+594735622448941556
ENST00000394287MED1chr1737604050-ENST00000285238ABCC3chr1748734062+575233820646991497
ENST00000300651MED1chr1737604050-ENST00000285238ABCC3chr1748734062+577035622447171497

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394287ENST00000285238MED1chr1737604051-ABCC3chr1748733193+0.0013822430.99861777
ENST00000300651ENST00000285238MED1chr1737604051-ABCC3chr1748733193+0.0013864350.9986136
ENST00000394287ENST00000285238MED1chr1737604050-ABCC3chr1748733192+0.0013822430.99861777
ENST00000300651ENST00000285238MED1chr1737604050-ABCC3chr1748733192+0.0013864350.9986136
ENST00000394287ENST00000285238MED1chr1737604050-ABCC3chr1748734062+0.0013829460.99861705
ENST00000300651ENST00000285238MED1chr1737604050-ABCC3chr1748734062+0.0013864760.9986135

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52641_52641_1_MED1-ABCC3_MED1_chr17_37604050_ENST00000300651_ABCC3_chr17_48733192_ENST00000285238_length(amino acids)=1556AA_BP=44
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCR
GYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVP
FRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLW
SLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQL
LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFM
DLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFL
KQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKR
IQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSV
AYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAV
DSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGA
EDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWD
YAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN
KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLES
VSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS
YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGI
VGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ
PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVV

--------------------------------------------------------------

>52641_52641_2_MED1-ABCC3_MED1_chr17_37604050_ENST00000300651_ABCC3_chr17_48734062_ENST00000285238_length(amino acids)=1497AA_BP=44
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPET
SAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIY
RKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFV
SVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGIN
LSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSE
KVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPL
FTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVE
FRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT

--------------------------------------------------------------

>52641_52641_3_MED1-ABCC3_MED1_chr17_37604050_ENST00000394287_ABCC3_chr17_48733192_ENST00000285238_length(amino acids)=1556AA_BP=44
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCR
GYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVP
FRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLW
SLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQL
LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFM
DLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFL
KQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKR
IQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSV
AYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAV
DSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGA
EDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWD
YAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN
KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLES
VSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS
YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGI
VGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ
PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVV

--------------------------------------------------------------

>52641_52641_4_MED1-ABCC3_MED1_chr17_37604050_ENST00000394287_ABCC3_chr17_48734062_ENST00000285238_length(amino acids)=1497AA_BP=44
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPET
SAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIY
RKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFV
SVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGIN
LSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSE
KVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPL
FTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVE
FRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT

--------------------------------------------------------------

>52641_52641_5_MED1-ABCC3_MED1_chr17_37604051_ENST00000300651_ABCC3_chr17_48733193_ENST00000285238_length(amino acids)=1556AA_BP=44
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCR
GYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVP
FRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLW
SLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQL
LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFM
DLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFL
KQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKR
IQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSV
AYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAV
DSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGA
EDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWD
YAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN
KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLES
VSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS
YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGI
VGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ
PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVV

--------------------------------------------------------------

>52641_52641_6_MED1-ABCC3_MED1_chr17_37604051_ENST00000394287_ABCC3_chr17_48733193_ENST00000285238_length(amino acids)=1556AA_BP=44
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCR
GYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVP
FRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLW
SLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQL
LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFM
DLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFL
KQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKR
IQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSV
AYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAV
DSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGA
EDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWD
YAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN
KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLES
VSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS
YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGI
VGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ
PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37604051/chr17:48733193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MED1

A0JLT2

ABCC3

O15438

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311291_152315.01528.0DomainABC transporter 2
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031311_59415.01528.0DomainABC transmembrane type-1 1
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031629_85115.01528.0DomainABC transporter 1
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031971_125215.01528.0DomainABC transmembrane type-1 2
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121291_152315.0573.0DomainABC transporter 2
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012311_59415.0573.0DomainABC transmembrane type-1 1
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012629_85115.0573.0DomainABC transporter 1
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012971_125215.0573.0DomainABC transmembrane type-1 2
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311291_152374.01528.0DomainABC transporter 2
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131311_59474.01528.0DomainABC transmembrane type-1 1
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131629_85174.01528.0DomainABC transporter 1
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131971_125274.01528.0DomainABC transmembrane type-1 2
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121291_152374.0573.0DomainABC transporter 2
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112311_59474.0573.0DomainABC transmembrane type-1 1
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112629_85174.0573.0DomainABC transporter 1
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112971_125274.0573.0DomainABC transmembrane type-1 2
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311291_152315.01528.0DomainABC transporter 2
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031311_59415.01528.0DomainABC transmembrane type-1 1
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031629_85115.01528.0DomainABC transporter 1
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031971_125215.01528.0DomainABC transmembrane type-1 2
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121291_152315.0573.0DomainABC transporter 2
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012311_59415.0573.0DomainABC transmembrane type-1 1
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012629_85115.0573.0DomainABC transporter 1
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012971_125215.0573.0DomainABC transmembrane type-1 2
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311323_133015.01528.0Nucleotide bindingATP 2
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031661_66815.01528.0Nucleotide bindingATP 1
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121323_133015.0573.0Nucleotide bindingATP 2
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012661_66815.0573.0Nucleotide bindingATP 1
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311323_133074.01528.0Nucleotide bindingATP 2
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131661_66874.01528.0Nucleotide bindingATP 1
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121323_133074.0573.0Nucleotide bindingATP 2
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112661_66874.0573.0Nucleotide bindingATP 1
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311323_133015.01528.0Nucleotide bindingATP 2
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031661_66815.01528.0Nucleotide bindingATP 1
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121323_133015.0573.0Nucleotide bindingATP 2
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012661_66815.0573.0Nucleotide bindingATP 1
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311043_108515.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311107_110715.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311129_119915.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031121_13215.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311221_122215.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311244_152715.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031154_17115.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031193_30215.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031324_34915.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031371_42615.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031448_45015.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031472_53315.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST0000028523803154_7315.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031555_57615.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031598_96315.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST0000028523803195_9915.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031985_102115.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121043_108515.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121107_110715.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121129_119915.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012121_13215.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121221_122215.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121244_152715.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012154_17115.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012193_30215.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012324_34915.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012371_42615.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012448_45015.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012472_53315.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST0000042769901254_7315.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012555_57615.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012598_96315.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48733192ENST0000042769901295_9915.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012985_102115.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311043_108574.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311107_110774.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311129_119974.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131121_13274.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311221_122274.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311244_152774.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131154_17174.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131193_30274.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131324_34974.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131371_42674.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131448_45074.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131472_53374.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131555_57674.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131598_96374.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST0000028523813195_9974.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131985_102174.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121043_108574.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121107_110774.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121129_119974.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112121_13274.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121221_122274.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121244_152774.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112154_17174.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112193_30274.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112324_34974.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112371_42674.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112448_45074.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112472_53374.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112555_57674.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112598_96374.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST0000042769911295_9974.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112985_102174.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311043_108515.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311107_110715.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311129_119915.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031121_13215.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311221_122215.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311244_152715.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031154_17115.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031193_30215.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031324_34915.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031371_42615.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031448_45015.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031472_53315.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST0000028523803154_7315.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031555_57615.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031598_96315.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST0000028523803195_9915.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031985_102115.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121043_108515.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121107_110715.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121129_119915.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012121_13215.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121221_122215.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121244_152715.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012154_17115.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012193_30215.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012324_34915.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012371_42615.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012448_45015.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012472_53315.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST0000042769901254_7315.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012555_57615.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012598_96315.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST0000042769901295_9915.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012985_102115.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031100_12015.01528.0TransmembraneHelical%3B Name%3D3
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311022_104215.01528.0TransmembraneHelical%3B Name%3D13
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311086_110615.01528.0TransmembraneHelical%3B Name%3D14
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311108_112815.01528.0TransmembraneHelical%3B Name%3D15
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311200_122015.01528.0TransmembraneHelical%3B Name%3D16
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311223_124315.01528.0TransmembraneHelical%3B Name%3D17
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031133_15315.01528.0TransmembraneHelical%3B Name%3D4
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031172_19215.01528.0TransmembraneHelical%3B Name%3D5
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031303_32315.01528.0TransmembraneHelical%3B Name%3D6
TgeneABCC3chr17:37604050chr17:48733192ENST0000028523803133_5315.01528.0TransmembraneHelical%3B Name%3D1
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031350_37015.01528.0TransmembraneHelical%3B Name%3D7
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031427_44715.01528.0TransmembraneHelical%3B Name%3D8
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031451_47115.01528.0TransmembraneHelical%3B Name%3D9
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031534_55415.01528.0TransmembraneHelical%3B Name%3D10
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031577_59715.01528.0TransmembraneHelical%3B Name%3D11
TgeneABCC3chr17:37604050chr17:48733192ENST0000028523803174_9415.01528.0TransmembraneHelical%3B Name%3D2
TgeneABCC3chr17:37604050chr17:48733192ENST00000285238031964_98415.01528.0TransmembraneHelical%3B Name%3D12
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012100_12015.0573.0TransmembraneHelical%3B Name%3D3
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121022_104215.0573.0TransmembraneHelical%3B Name%3D13
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121086_110615.0573.0TransmembraneHelical%3B Name%3D14
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121108_112815.0573.0TransmembraneHelical%3B Name%3D15
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121200_122015.0573.0TransmembraneHelical%3B Name%3D16
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121223_124315.0573.0TransmembraneHelical%3B Name%3D17
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012133_15315.0573.0TransmembraneHelical%3B Name%3D4
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012172_19215.0573.0TransmembraneHelical%3B Name%3D5
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012303_32315.0573.0TransmembraneHelical%3B Name%3D6
TgeneABCC3chr17:37604050chr17:48733192ENST0000042769901233_5315.0573.0TransmembraneHelical%3B Name%3D1
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012350_37015.0573.0TransmembraneHelical%3B Name%3D7
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012427_44715.0573.0TransmembraneHelical%3B Name%3D8
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012451_47115.0573.0TransmembraneHelical%3B Name%3D9
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012534_55415.0573.0TransmembraneHelical%3B Name%3D10
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012577_59715.0573.0TransmembraneHelical%3B Name%3D11
TgeneABCC3chr17:37604050chr17:48733192ENST0000042769901274_9415.0573.0TransmembraneHelical%3B Name%3D2
TgeneABCC3chr17:37604050chr17:48733192ENST00000427699012964_98415.0573.0TransmembraneHelical%3B Name%3D12
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131100_12074.01528.0TransmembraneHelical%3B Name%3D3
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311022_104274.01528.0TransmembraneHelical%3B Name%3D13
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311086_110674.01528.0TransmembraneHelical%3B Name%3D14
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311108_112874.01528.0TransmembraneHelical%3B Name%3D15
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311200_122074.01528.0TransmembraneHelical%3B Name%3D16
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311223_124374.01528.0TransmembraneHelical%3B Name%3D17
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131133_15374.01528.0TransmembraneHelical%3B Name%3D4
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131172_19274.01528.0TransmembraneHelical%3B Name%3D5
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131303_32374.01528.0TransmembraneHelical%3B Name%3D6
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131350_37074.01528.0TransmembraneHelical%3B Name%3D7
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131427_44774.01528.0TransmembraneHelical%3B Name%3D8
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131451_47174.01528.0TransmembraneHelical%3B Name%3D9
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131534_55474.01528.0TransmembraneHelical%3B Name%3D10
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131577_59774.01528.0TransmembraneHelical%3B Name%3D11
TgeneABCC3chr17:37604050chr17:48734062ENST0000028523813174_9474.01528.0TransmembraneHelical%3B Name%3D2
TgeneABCC3chr17:37604050chr17:48734062ENST00000285238131964_98474.01528.0TransmembraneHelical%3B Name%3D12
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112100_12074.0573.0TransmembraneHelical%3B Name%3D3
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121022_104274.0573.0TransmembraneHelical%3B Name%3D13
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121086_110674.0573.0TransmembraneHelical%3B Name%3D14
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121108_112874.0573.0TransmembraneHelical%3B Name%3D15
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121200_122074.0573.0TransmembraneHelical%3B Name%3D16
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121223_124374.0573.0TransmembraneHelical%3B Name%3D17
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112133_15374.0573.0TransmembraneHelical%3B Name%3D4
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112172_19274.0573.0TransmembraneHelical%3B Name%3D5
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112303_32374.0573.0TransmembraneHelical%3B Name%3D6
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112350_37074.0573.0TransmembraneHelical%3B Name%3D7
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112427_44774.0573.0TransmembraneHelical%3B Name%3D8
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112451_47174.0573.0TransmembraneHelical%3B Name%3D9
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112534_55474.0573.0TransmembraneHelical%3B Name%3D10
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112577_59774.0573.0TransmembraneHelical%3B Name%3D11
TgeneABCC3chr17:37604050chr17:48734062ENST0000042769911274_9474.0573.0TransmembraneHelical%3B Name%3D2
TgeneABCC3chr17:37604050chr17:48734062ENST00000427699112964_98474.0573.0TransmembraneHelical%3B Name%3D12
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031100_12015.01528.0TransmembraneHelical%3B Name%3D3
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311022_104215.01528.0TransmembraneHelical%3B Name%3D13
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311086_110615.01528.0TransmembraneHelical%3B Name%3D14
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311108_112815.01528.0TransmembraneHelical%3B Name%3D15
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311200_122015.01528.0TransmembraneHelical%3B Name%3D16
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311223_124315.01528.0TransmembraneHelical%3B Name%3D17
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031133_15315.01528.0TransmembraneHelical%3B Name%3D4
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031172_19215.01528.0TransmembraneHelical%3B Name%3D5
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031303_32315.01528.0TransmembraneHelical%3B Name%3D6
TgeneABCC3chr17:37604051chr17:48733193ENST0000028523803133_5315.01528.0TransmembraneHelical%3B Name%3D1
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031350_37015.01528.0TransmembraneHelical%3B Name%3D7
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031427_44715.01528.0TransmembraneHelical%3B Name%3D8
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031451_47115.01528.0TransmembraneHelical%3B Name%3D9
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031534_55415.01528.0TransmembraneHelical%3B Name%3D10
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031577_59715.01528.0TransmembraneHelical%3B Name%3D11
TgeneABCC3chr17:37604051chr17:48733193ENST0000028523803174_9415.01528.0TransmembraneHelical%3B Name%3D2
TgeneABCC3chr17:37604051chr17:48733193ENST00000285238031964_98415.01528.0TransmembraneHelical%3B Name%3D12
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012100_12015.0573.0TransmembraneHelical%3B Name%3D3
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121022_104215.0573.0TransmembraneHelical%3B Name%3D13
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121086_110615.0573.0TransmembraneHelical%3B Name%3D14
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121108_112815.0573.0TransmembraneHelical%3B Name%3D15
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121200_122015.0573.0TransmembraneHelical%3B Name%3D16
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121223_124315.0573.0TransmembraneHelical%3B Name%3D17
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012133_15315.0573.0TransmembraneHelical%3B Name%3D4
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012172_19215.0573.0TransmembraneHelical%3B Name%3D5
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012303_32315.0573.0TransmembraneHelical%3B Name%3D6
TgeneABCC3chr17:37604051chr17:48733193ENST0000042769901233_5315.0573.0TransmembraneHelical%3B Name%3D1
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012350_37015.0573.0TransmembraneHelical%3B Name%3D7
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012427_44715.0573.0TransmembraneHelical%3B Name%3D8
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012451_47115.0573.0TransmembraneHelical%3B Name%3D9
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012534_55415.0573.0TransmembraneHelical%3B Name%3D10
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012577_59715.0573.0TransmembraneHelical%3B Name%3D11
TgeneABCC3chr17:37604051chr17:48733193ENST0000042769901274_9415.0573.0TransmembraneHelical%3B Name%3D2
TgeneABCC3chr17:37604051chr17:48733193ENST00000427699012964_98415.0573.0TransmembraneHelical%3B Name%3D12

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-2171078_148244.01582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-2171496_152944.01582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-2181078_148244.0557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-2181496_152944.0557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-2171078_148244.01582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-2171496_152944.01582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-2181078_148244.0557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-2181496_152944.0557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-2171078_148244.01582.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-2171496_152944.01582.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-2181078_148244.0557.0Compositional biasNote=Ser-rich
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-2181496_152944.0557.0Compositional biasNote=Lys-rich
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217604_60844.01582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217645_64944.01582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217875_90244.01582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218604_60844.0557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218645_64944.0557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218875_90244.0557.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217604_60844.01582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217645_64944.01582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217875_90244.01582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218604_60844.0557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218645_64944.0557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218875_90244.0557.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217604_60844.01582.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217645_64944.01582.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217875_90244.01582.0MotifIntegrase domain-binding motif (IBM)
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218604_60844.0557.0MotifNote=LXXLL motif 1
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218645_64944.0557.0MotifNote=LXXLL motif 2
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218875_90244.0557.0MotifIntegrase domain-binding motif (IBM)
TgeneABCC3chr17:37604050chr17:48733192ENST000002852380311_3215.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48733192ENST000004276990121_3215.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST000002852381311_3274.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST0000028523813154_7374.01528.0Topological domainCytoplasmic
TgeneABCC3chr17:37604050chr17:48734062ENST000004276991121_3274.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST0000042769911254_7374.0573.0Topological domainCytoplasmic
TgeneABCC3chr17:37604051chr17:48733193ENST000002852380311_3215.01528.0Topological domainExtracellular
TgeneABCC3chr17:37604051chr17:48733193ENST000004276990121_3215.0573.0Topological domainExtracellular
TgeneABCC3chr17:37604050chr17:48734062ENST0000028523813133_5374.01528.0TransmembraneHelical%3B Name%3D1
TgeneABCC3chr17:37604050chr17:48734062ENST0000042769911233_5374.0573.0TransmembraneHelical%3B Name%3D1


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2085_MED1_37604050_ABCC3_48733192_ranked_0.pdbMED13760405037604050ENST00000285238ABCC3chr1748733192+
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCR
GYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVP
FRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLW
SLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQL
LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFM
DLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFL
KQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKR
IQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSV
AYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAV
DSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGA
EDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWD
YAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN
KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLES
VSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS
YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGI
VGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ
PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVV
1556


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MED1_pLDDT.png
all structure
all structure
ABCC3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MED1
ABCC3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-21716_59044.01582.0ESR1
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217656_106644.01582.0ESR1
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-21816_59044.0557.0ESR1
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218656_106644.0557.0ESR1
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-21716_59044.01582.0ESR1
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217656_106644.01582.0ESR1
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-21816_59044.0557.0ESR1
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218656_106644.0557.0ESR1
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-21716_59044.01582.0ESR1
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217656_106644.01582.0ESR1
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-21816_59044.0557.0ESR1
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218656_106644.0557.0ESR1
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217681_71544.01582.0GATA1
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218681_71544.0557.0GATA1
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217681_71544.01582.0GATA1
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218681_71544.0557.0GATA1
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217681_71544.01582.0GATA1
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218681_71544.0557.0GATA1
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217622_70144.01582.0PPARGC1A and THRA
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218622_70144.0557.0PPARGC1A and THRA
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217622_70144.01582.0PPARGC1A and THRA
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218622_70144.0557.0PPARGC1A and THRA
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217622_70144.01582.0PPARGC1A and THRA
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218622_70144.0557.0PPARGC1A and THRA
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217108_21244.01582.0the Mediator complex
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217215_39044.01582.0the Mediator complex
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218108_21244.0557.0the Mediator complex
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218215_39044.0557.0the Mediator complex
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217108_21244.01582.0the Mediator complex
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217215_39044.01582.0the Mediator complex
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218108_21244.0557.0the Mediator complex
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218215_39044.0557.0the Mediator complex
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217108_21244.01582.0the Mediator complex
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217215_39044.01582.0the Mediator complex
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218108_21244.0557.0the Mediator complex
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218215_39044.0557.0the Mediator complex
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-2171_67044.01582.0the Mediator complex and THRA
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-2181_67044.0557.0the Mediator complex and THRA
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-2171_67044.01582.0the Mediator complex and THRA
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-2181_67044.0557.0the Mediator complex and THRA
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-2171_67044.01582.0the Mediator complex and THRA
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-2181_67044.0557.0the Mediator complex and THRA
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217405_64444.01582.0THRA
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218405_64444.0557.0THRA
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217405_64444.01582.0THRA
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218405_64444.0557.0THRA
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217405_64444.01582.0THRA
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218405_64444.0557.0THRA
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-2171249_142144.01582.0TP53
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-2181249_142144.0557.0TP53
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-2171249_142144.01582.0TP53
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-2181249_142144.0557.0TP53
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-2171249_142144.01582.0TP53
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-2181249_142144.0557.0TP53
HgeneMED1chr17:37604050chr17:48733192ENST00000300651-217542_78944.01582.0VDR
HgeneMED1chr17:37604050chr17:48733192ENST00000394287-218542_78944.0557.0VDR
HgeneMED1chr17:37604050chr17:48734062ENST00000300651-217542_78944.01582.0VDR
HgeneMED1chr17:37604050chr17:48734062ENST00000394287-218542_78944.0557.0VDR
HgeneMED1chr17:37604051chr17:48733193ENST00000300651-217542_78944.01582.0VDR
HgeneMED1chr17:37604051chr17:48733193ENST00000394287-218542_78944.0557.0VDR


Top

Related Drugs to MED1-ABCC3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MED1-ABCC3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource