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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MED24-PPP1R1B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MED24-PPP1R1B
	FusionPDB ID: 52718
	FusionGDB2.0 ID: 52718
		Hgene	Tgene
	Gene symbol	MED24	PPP1R1B
	Gene ID	9862	84152
	Gene name	mediator complex subunit 24	protein phosphatase 1 regulatory inhibitor subunit 1B
	Synonyms	ARC100\|CRSP100\|CRSP4\|DRIP100\|MED5\|THRAP4\|TRAP100	DARPP-32\|DARPP32
	Cytomap	17q21.1	17q12
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10	protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
	Modification date	20200313	20200313
	UniProtAcc	O75448	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356271, ENST00000394126, ENST00000394128, ENST00000501516, ENST00000394127, ENST00000479829,	ENST00000254079, ENST00000394265, ENST00000394267, ENST00000579000, ENST00000580825,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 18 X 9=3402	17 X 10 X 9=1530
	# samples	26	26
	** MAII score	log2(26/3402*10)=-3.70979961263493 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/1530*10)=-2.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MED24 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MED24(38182409)-PPP1R1B(37791860), # samples:2
Anticipated loss of major functional domain due to fusion event.	MED24-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MED24-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MED24-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MED24-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MED24-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MED24-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MED24-PPP1R1B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED24	GO:0006367	transcription initiation from RNA polymerase II promoter	12218053
Hgene	MED24	GO:0045893	positive regulation of transcription, DNA-templated	10198638
Tgene	PPP1R1B	GO:0032515	negative regulation of phosphoprotein phosphatase activity	10807923

Fusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-DQ-7589-01A	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+
ChimerDB4	HNSC	TCGA-DQ-7589	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394127	MED24	chr17	38182409	-	ENST00000580825	PPP1R1B	chr17	37791860	+	2355	2050	38	2116	692
ENST00000394127	MED24	chr17	38182409	-	ENST00000254079	PPP1R1B	chr17	37791860	+	2981	2050	38	2116	692
ENST00000394127	MED24	chr17	38182409	-	ENST00000579000	PPP1R1B	chr17	37791860	+	2977	2050	38	2116	692
ENST00000394127	MED24	chr17	38182409	-	ENST00000394265	PPP1R1B	chr17	37791860	+	2980	2050	38	2116	692
ENST00000394127	MED24	chr17	38182409	-	ENST00000394267	PPP1R1B	chr17	37791860	+	2981	2050	38	2116	692

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394127	ENST00000580825	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+	0.024559515	0.9754405
ENST00000394127	ENST00000254079	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+	0.013600248	0.98639977
ENST00000394127	ENST00000579000	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+	0.01383074	0.9861692
ENST00000394127	ENST00000394265	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+	0.01351582	0.9864842
ENST00000394127	ENST00000394267	MED24	chr17	38182409	-	PPP1R1B	chr17	37791860	+	0.013600248	0.98639977

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52718_52718_1_MED24-PPP1R1B_MED24_chr17_38182409_ENST00000394127_PPP1R1B_chr17_37791860_ENST00000254079_length(amino acids)=692AA_BP=670
MCAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAI
SSQFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSS
TKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQ
SLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKA
DQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGH
MLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQT
CMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAV

--------------------------------------------------------------

>52718_52718_2_MED24-PPP1R1B_MED24_chr17_38182409_ENST00000394127_PPP1R1B_chr17_37791860_ENST00000394265_length(amino acids)=692AA_BP=670
MCAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAI
SSQFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSS
TKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQ
SLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKA
DQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGH
MLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQT
CMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAV

--------------------------------------------------------------

>52718_52718_3_MED24-PPP1R1B_MED24_chr17_38182409_ENST00000394127_PPP1R1B_chr17_37791860_ENST00000394267_length(amino acids)=692AA_BP=670
MCAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAI
SSQFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSS
TKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQ
SLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKA
DQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGH
MLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQT
CMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAV

--------------------------------------------------------------

>52718_52718_4_MED24-PPP1R1B_MED24_chr17_38182409_ENST00000394127_PPP1R1B_chr17_37791860_ENST00000579000_length(amino acids)=692AA_BP=670
MCAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAI
SSQFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSS
TKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQ
SLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKA
DQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGH
MLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQT
CMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAV

--------------------------------------------------------------

>52718_52718_5_MED24-PPP1R1B_MED24_chr17_38182409_ENST00000394127_PPP1R1B_chr17_37791860_ENST00000580825_length(amino acids)=692AA_BP=670
MCAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAI
SSQFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSS
TKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQ
SLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKA
DQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGH
MLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQT
CMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38182409/chr17:37791860)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED24 O75448	.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:12218053, ECO:0000269\|PubMed:16595664}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000356271

128_132

648.6666666666666

977.0

Motif

Note=LXXLL motif 1

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000356271

344_348

648.6666666666666

977.0

Motif

Note=LXXLL motif 2

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000356271

448_452

648.6666666666666

977.0

Motif

Note=LXXLL motif 3

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000356271

557_561

648.6666666666666

977.0

Motif

Note=LXXLL motif 4

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394127

128_132

648.6666666666666

977.0

Motif

Note=LXXLL motif 1

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394127

344_348

648.6666666666666

977.0

Motif

Note=LXXLL motif 2

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394127

448_452

648.6666666666666

977.0

Motif

Note=LXXLL motif 3

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394127

557_561

648.6666666666666

977.0

Motif

Note=LXXLL motif 4

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394128

128_132

661.6666666666666

990.0

Motif

Note=LXXLL motif 1

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394128

344_348

661.6666666666666

990.0

Motif

Note=LXXLL motif 2

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394128

448_452

661.6666666666666

990.0

Motif

Note=LXXLL motif 3

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394128

557_561

661.6666666666666

990.0

Motif

Note=LXXLL motif 4

Tgene

PPP1R1B

chr17:38182409

chr17:37791860

ENST00000394265

119_136

112.33333333333333

169.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:38182409

chr17:37791860

ENST00000394267

119_136

112.33333333333333

169.0

Compositional bias

Note=Asp/Glu-rich (acidic)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000356271

788_792

648.6666666666666

977.0

Motif

Note=LXXLL motif 5

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000356271

857_861

648.6666666666666

977.0

Motif

Note=LXXLL motif 6

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394127

788_792

648.6666666666666

977.0

Motif

Note=LXXLL motif 5

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394127

857_861

648.6666666666666

977.0

Motif

Note=LXXLL motif 6

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394128

788_792

661.6666666666666

990.0

Motif

Note=LXXLL motif 5

Hgene

MED24

chr17:38182409

chr17:37791860

ENST00000394128

857_861

661.6666666666666

990.0

Motif

Note=LXXLL motif 6

Tgene

PPP1R1B

chr17:38182409

chr17:37791860

ENST00000254079

119_136

148.33333333333334

205.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:38182409

chr17:37791860

ENST00000580825

119_136

148.33333333333334

205.0

Compositional bias

Note=Asp/Glu-rich (acidic)

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1420_MED24_38182409_PPP1R1B_37791860_ranked_0.pdb	MED24	38182409	38182409	ENST00000394267	PPP1R1B	chr17	37791860	+	MCAPFLSPQSWPPPLPPAQSEIMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAI SSQFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSS TKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQ SLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKA DQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGH MLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQT CMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAV	692

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MED24_pLDDT.png

PPP1R1B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MED24
PPP1R1B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MED24-PPP1R1B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MED24-PPP1R1B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source