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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:METAP2-VEZT

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: METAP2-VEZT
	FusionPDB ID: 53015
	FusionGDB2.0 ID: 53015
		Hgene	Tgene
	Gene symbol	METAP2	VEZT
	Gene ID	10988	55591
	Gene name	methionyl aminopeptidase 2	vezatin, adherens junctions transmembrane protein
	Synonyms	MAP2\|MNPEP\|p67eIF2	VEZATIN
	Cytomap	12q22	12q22
	Type of gene	protein-coding	protein-coding
	Description	methionine aminopeptidase 2eIF-2-associated p67 homologinitiation factor 2-associated 67 kDa glycoproteinpeptidase M 2testicular tissue protein Li 17	vezatin
	Modification date	20200313	20200313
	UniProtAcc	P50579	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000261220, ENST00000323666, ENST00000546753, ENST00000550777, ENST00000551840,	ENST00000356859, ENST00000261219, ENST00000436874,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 7 X 5=175	5 X 6 X 6=180
	# samples	7	7
	** MAII score	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: METAP2 [Title/Abstract] AND VEZT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	METAP2(95868106)-VEZT(95663827), # samples:3
Anticipated loss of major functional domain due to fusion event.	METAP2-VEZT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. METAP2-VEZT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. METAP2-VEZT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. METAP2-VEZT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. METAP2-VEZT seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. METAP2-VEZT seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. METAP2-VEZT seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	METAP2	GO:0016485	protein processing	8858118
Hgene	METAP2	GO:0018206	peptidyl-methionine modification	8858118
Hgene	METAP2	GO:0031365	N-terminal protein amino acid modification	8858118

Fusion gene breakpoints across METAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VEZT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A13D-01A	METAP2	chr12	95868106	+	VEZT	chr12	95663827	+
ChimerDB4	BRCA	TCGA-A7-A13D-01B	METAP2	chr12	95868106	-	VEZT	chr12	95663827	+
ChimerDB4	LIHC	TCGA-G3-AAUZ-01A	METAP2	chr12	95889874	-	VEZT	chr12	95689827	+
ChimerDB4	LIHC	TCGA-G3-AAUZ-01A	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+
ChimerDB4	OV	TCGA-24-1435	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000323666	METAP2	chr12	95889874	+	ENST00000436874	VEZT	chr12	95689827	+	3930	1096	229	1812	527
ENST00000323666	METAP2	chr12	95889874	+	ENST00000261219	VEZT	chr12	95689827	+	2308	1096	229	1812	527
ENST00000546753	METAP2	chr12	95889874	+	ENST00000436874	VEZT	chr12	95689827	+	3731	897	99	1613	504
ENST00000546753	METAP2	chr12	95889874	+	ENST00000261219	VEZT	chr12	95689827	+	2109	897	99	1613	504
ENST00000261220	METAP2	chr12	95889874	+	ENST00000436874	VEZT	chr12	95689827	+	3662	828	30	1544	504
ENST00000261220	METAP2	chr12	95889874	+	ENST00000261219	VEZT	chr12	95689827	+	2040	828	30	1544	504
ENST00000550777	METAP2	chr12	95889874	+	ENST00000436874	VEZT	chr12	95689827	+	3618	784	25	1500	491
ENST00000550777	METAP2	chr12	95889874	+	ENST00000261219	VEZT	chr12	95689827	+	1996	784	25	1500	491
ENST00000551840	METAP2	chr12	95889874	+	ENST00000436874	VEZT	chr12	95689827	+	3716	882	18	1598	526
ENST00000551840	METAP2	chr12	95889874	+	ENST00000261219	VEZT	chr12	95689827	+	2094	882	18	1598	526
ENST00000323666	METAP2	chr12	95869954	+	ENST00000436874	VEZT	chr12	95688047	+	3423	488	229	1305	358
ENST00000323666	METAP2	chr12	95869954	+	ENST00000261219	VEZT	chr12	95688047	+	1801	488	229	1305	358
ENST00000546753	METAP2	chr12	95869954	+	ENST00000436874	VEZT	chr12	95688047	+	3293	358	99	1175	358
ENST00000546753	METAP2	chr12	95869954	+	ENST00000261219	VEZT	chr12	95688047	+	1671	358	99	1175	358
ENST00000261220	METAP2	chr12	95869954	+	ENST00000436874	VEZT	chr12	95688047	+	3221	286	30	1103	357
ENST00000261220	METAP2	chr12	95869954	+	ENST00000261219	VEZT	chr12	95688047	+	1599	286	30	1103	357
ENST00000551840	METAP2	chr12	95869954	+	ENST00000436874	VEZT	chr12	95688047	+	3209	274	18	1091	357
ENST00000551840	METAP2	chr12	95869954	+	ENST00000261219	VEZT	chr12	95688047	+	1587	274	18	1091	357

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000323666	ENST00000436874	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000149025	0.999851
ENST00000323666	ENST00000261219	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000661509	0.99933845
ENST00000546753	ENST00000436874	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000226985	0.99977297
ENST00000546753	ENST00000261219	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000823556	0.99917644
ENST00000261220	ENST00000436874	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000267751	0.9997322
ENST00000261220	ENST00000261219	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000888711	0.99911124
ENST00000550777	ENST00000436874	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	9.82E-05	0.9999018
ENST00000550777	ENST00000261219	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000365534	0.9996345
ENST00000551840	ENST00000436874	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000122462	0.9998776
ENST00000551840	ENST00000261219	METAP2	chr12	95889874	+	VEZT	chr12	95689827	+	0.000449995	0.9995499
ENST00000323666	ENST00000436874	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000198487	0.9998016
ENST00000323666	ENST00000261219	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.001270201	0.99872977
ENST00000546753	ENST00000436874	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000186827	0.99981314
ENST00000546753	ENST00000261219	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000902808	0.9990972
ENST00000261220	ENST00000436874	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000216632	0.99978334
ENST00000261220	ENST00000261219	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000953443	0.9990465
ENST00000551840	ENST00000436874	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000215121	0.9997849
ENST00000551840	ENST00000261219	METAP2	chr12	95869954	+	VEZT	chr12	95688047	+	0.000962914	0.99903715

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53015_53015_1_METAP2-VEZT_METAP2_chr12_95869954_ENST00000261220_VEZT_chr12_95688047_ENST00000261219_length(amino acids)=357AA_BP=85
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPEI
ACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKW
KQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCY

--------------------------------------------------------------

>53015_53015_2_METAP2-VEZT_METAP2_chr12_95869954_ENST00000261220_VEZT_chr12_95688047_ENST00000436874_length(amino acids)=357AA_BP=85
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPEI
ACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKW
KQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCY

--------------------------------------------------------------

>53015_53015_3_METAP2-VEZT_METAP2_chr12_95869954_ENST00000323666_VEZT_chr12_95688047_ENST00000261219_length(amino acids)=358AA_BP=86
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPE
IACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQK
WKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMC

--------------------------------------------------------------

>53015_53015_4_METAP2-VEZT_METAP2_chr12_95869954_ENST00000323666_VEZT_chr12_95688047_ENST00000436874_length(amino acids)=358AA_BP=86
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPE
IACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQK
WKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMC

--------------------------------------------------------------

>53015_53015_5_METAP2-VEZT_METAP2_chr12_95869954_ENST00000546753_VEZT_chr12_95688047_ENST00000261219_length(amino acids)=358AA_BP=86
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPE
IACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQK
WKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMC

--------------------------------------------------------------

>53015_53015_6_METAP2-VEZT_METAP2_chr12_95869954_ENST00000546753_VEZT_chr12_95688047_ENST00000436874_length(amino acids)=358AA_BP=86
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPE
IACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQK
WKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMC

--------------------------------------------------------------

>53015_53015_7_METAP2-VEZT_METAP2_chr12_95869954_ENST00000551840_VEZT_chr12_95688047_ENST00000261219_length(amino acids)=357AA_BP=85
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPEI
ACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKW
KQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCY

--------------------------------------------------------------

>53015_53015_8_METAP2-VEZT_METAP2_chr12_95869954_ENST00000551840_VEZT_chr12_95688047_ENST00000436874_length(amino acids)=357AA_BP=85
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEGKPEI
ACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKW
KQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCY

--------------------------------------------------------------

>53015_53015_9_METAP2-VEZT_METAP2_chr12_95889874_ENST00000261220_VEZT_chr12_95689827_ENST00000261219_length(amino acids)=504AA_BP=266
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEAKVQT
DPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDC
SRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKELEA
YVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSD
MGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQR

--------------------------------------------------------------

>53015_53015_10_METAP2-VEZT_METAP2_chr12_95889874_ENST00000261220_VEZT_chr12_95689827_ENST00000436874_length(amino acids)=504AA_BP=266
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEAKVQT
DPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDC
SRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKELEA
YVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSD
MGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQR

--------------------------------------------------------------

>53015_53015_11_METAP2-VEZT_METAP2_chr12_95889874_ENST00000323666_VEZT_chr12_95689827_ENST00000261219_length(amino acids)=527AA_BP=289
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDG
DGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFN
PKYDTLLKAVKDATNTGIKELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAV
LKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQA

--------------------------------------------------------------

>53015_53015_12_METAP2-VEZT_METAP2_chr12_95889874_ENST00000323666_VEZT_chr12_95689827_ENST00000436874_length(amino acids)=527AA_BP=289
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDG
DGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFN
PKYDTLLKAVKDATNTGIKELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAV
LKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQA

--------------------------------------------------------------

>53015_53015_13_METAP2-VEZT_METAP2_chr12_95889874_ENST00000546753_VEZT_chr12_95689827_ENST00000261219_length(amino acids)=504AA_BP=266
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDG
DGDGATGKKKKKKKKKRGRQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDC
SRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKELEA
YVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSD
MGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQR

--------------------------------------------------------------

>53015_53015_14_METAP2-VEZT_METAP2_chr12_95889874_ENST00000546753_VEZT_chr12_95689827_ENST00000436874_length(amino acids)=504AA_BP=266
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDG
DGDGATGKKKKKKKKKRGRQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDC
SRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKELEA
YVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSD
MGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQR

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>53015_53015_15_METAP2-VEZT_METAP2_chr12_95889874_ENST00000550777_VEZT_chr12_95689827_ENST00000261219_length(amino acids)=491AA_BP=253
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSADGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPN
GVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAG
LAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKELEAYVDDIDIDSDFRK
DDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEES
NKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQRLARLQLSPDFTFT

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>53015_53015_16_METAP2-VEZT_METAP2_chr12_95889874_ENST00000550777_VEZT_chr12_95689827_ENST00000436874_length(amino acids)=491AA_BP=253
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSADGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPN
GVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAG
LAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKELEAYVDDIDIDSDFRK
DDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEES
NKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQRLARLQLSPDFTFT

--------------------------------------------------------------

>53015_53015_17_METAP2-VEZT_METAP2_chr12_95889874_ENST00000551840_VEZT_chr12_95689827_ENST00000261219_length(amino acids)=526AA_BP=288
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGD
GDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRK
YVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNP
KYDTLLKAVKDATNTGIKELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVL
KSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQAD

--------------------------------------------------------------

>53015_53015_18_METAP2-VEZT_METAP2_chr12_95889874_ENST00000551840_VEZT_chr12_95689827_ENST00000436874_length(amino acids)=526AA_BP=288
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGD
GDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRK
YVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNP
KYDTLLKAVKDATNTGIKELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVL
KSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQAD

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:95868106/chr12:95663827)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
METAP2 P50579	.
FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

METAP2

chr12:95869954

chr12:95688047

ENST00000323666

41_46

86.33333333333333

479.0

Compositional bias

Note=Poly-Lys

Hgene

METAP2

chr12:95889874

chr12:95689827

ENST00000323666

41_46

289.0

479.0

Compositional bias

Note=Poly-Lys

Hgene

METAP2

chr12:95889874

chr12:95689827

ENST00000323666

98_106

289.0

479.0

Compositional bias

Note=Poly-Lys

Tgene

VEZT

chr12:95869954

chr12:95688047

ENST00000436874

763_766

507.3333333333333

780.0

Compositional bias

Note=Poly-Glu

Tgene

VEZT

chr12:95889874

chr12:95689827

ENST00000436874

763_766

541.0

780.0

Compositional bias

Note=Poly-Glu

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

METAP2

chr12:95869954

chr12:95688047

ENST00000323666

98_106

86.33333333333333

479.0

Compositional bias

Note=Poly-Lys

Tgene

VEZT

chr12:95869954

chr12:95688047

ENST00000436874

430_462

507.3333333333333

780.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

VEZT

chr12:95889874

chr12:95689827

ENST00000436874

430_462

541.0

780.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

VEZT

chr12:95869954

chr12:95688047

ENST00000436874

139_159

507.3333333333333

780.0

Transmembrane

Helical

Tgene

VEZT

chr12:95869954

chr12:95688047

ENST00000436874

162_182

507.3333333333333

780.0

Transmembrane

Helical

Tgene

VEZT

chr12:95889874

chr12:95689827

ENST00000436874

139_159

541.0

780.0

Transmembrane

Helical

Tgene

VEZT

chr12:95889874

chr12:95689827

ENST00000436874

162_182

541.0

780.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
METAP2
VEZT

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to METAP2-VEZT

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to METAP2-VEZT

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source