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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MFSD6-CALCRL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MFSD6-CALCRL
FusionPDB ID: 53283
FusionGDB2.0 ID: 53283
HgeneTgene
Gene symbol

MFSD6

CALCRL

Gene ID

54842

10203

Gene namemajor facilitator superfamily domain containing 6calcitonin receptor like receptor
SynonymsMMR2|hMMR2CGRPR|CRLR|LMPHM8
Cytomap

2q32.2

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionmajor facilitator superfamily domain-containing protein 6macrophage MHC class I receptor 2 homologmacrophage MHC receptor 2calcitonin gene-related peptide type 1 receptorCGRP type 1 receptorcalcitonin receptor-like
Modification date2020031320200313
UniProtAcc

Q6ZSS7

Q16602

Ensembl transtripts involved in fusion geneENST idsENST00000281416, ENST00000392328, 
ENST00000489793, ENST00000535751, 
ENST00000479784, ENST00000392370, 
ENST00000409998, ENST00000410068, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 3 X 5=1201 X 1 X 1=1
# samples 81
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: MFSD6 [Title/Abstract] AND CALCRL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MFSD6(191302287)-CALCRL(188228229), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCALCRL

GO:0001525

angiogenesis

20596610

TgeneCALCRL

GO:0006816

calcium ion transport

10882736

TgeneCALCRL

GO:0015031

protein transport

9620797

TgeneCALCRL

GO:0031623

receptor internalization

10882736|20074556

TgeneCALCRL

GO:0071329

cellular response to sucrose stimulus

10882736


check buttonFusion gene breakpoints across MFSD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CALCRL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-2561-01AMFSD6chr2

191302287

-CALCRLchr2

188228229

-
ChimerDB4GBMTCGA-06-2561-01AMFSD6chr2

191302287

+CALCRLchr2

188228229

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392328MFSD6chr2191302287+ENST00000409998CALCRLchr2188228229-579718563242741805
ENST00000392328MFSD6chr2191302287+ENST00000392370CALCRLchr2188228229-579718563242741805
ENST00000392328MFSD6chr2191302287+ENST00000410068CALCRLchr2188228229-299918563242741805
ENST00000281416MFSD6chr2191302287+ENST00000409998CALCRLchr2188228229-560816671352552805
ENST00000281416MFSD6chr2191302287+ENST00000392370CALCRLchr2188228229-560816671352552805
ENST00000281416MFSD6chr2191302287+ENST00000410068CALCRLchr2188228229-281016671352552805

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392328ENST00000409998MFSD6chr2191302287+CALCRLchr2188228229-0.00017330.9998267
ENST00000392328ENST00000392370MFSD6chr2191302287+CALCRLchr2188228229-0.00017330.9998267
ENST00000392328ENST00000410068MFSD6chr2191302287+CALCRLchr2188228229-0.0004468670.99955314
ENST00000281416ENST00000409998MFSD6chr2191302287+CALCRLchr2188228229-0.0001466990.99985325
ENST00000281416ENST00000392370MFSD6chr2191302287+CALCRLchr2188228229-0.0001466990.99985325
ENST00000281416ENST00000410068MFSD6chr2191302287+CALCRLchr2188228229-0.0002696550.9997303

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53283_53283_1_MFSD6-CALCRL_MFSD6_chr2_191302287_ENST00000281416_CALCRL_chr2_188228229_ENST00000392370_length(amino acids)=805AA_BP=510
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRSLSCQRITLHKNLFFSFVCNSVVTIIHLT
AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISS
DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ

--------------------------------------------------------------

>53283_53283_2_MFSD6-CALCRL_MFSD6_chr2_191302287_ENST00000281416_CALCRL_chr2_188228229_ENST00000409998_length(amino acids)=805AA_BP=510
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRSLSCQRITLHKNLFFSFVCNSVVTIIHLT
AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISS
DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ

--------------------------------------------------------------

>53283_53283_3_MFSD6-CALCRL_MFSD6_chr2_191302287_ENST00000281416_CALCRL_chr2_188228229_ENST00000410068_length(amino acids)=805AA_BP=510
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRSLSCQRITLHKNLFFSFVCNSVVTIIHLT
AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISS
DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ

--------------------------------------------------------------

>53283_53283_4_MFSD6-CALCRL_MFSD6_chr2_191302287_ENST00000392328_CALCRL_chr2_188228229_ENST00000392370_length(amino acids)=805AA_BP=510
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRSLSCQRITLHKNLFFSFVCNSVVTIIHLT
AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISS
DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ

--------------------------------------------------------------

>53283_53283_5_MFSD6-CALCRL_MFSD6_chr2_191302287_ENST00000392328_CALCRL_chr2_188228229_ENST00000409998_length(amino acids)=805AA_BP=510
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRSLSCQRITLHKNLFFSFVCNSVVTIIHLT
AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISS
DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ

--------------------------------------------------------------

>53283_53283_6_MFSD6-CALCRL_MFSD6_chr2_191302287_ENST00000392328_CALCRL_chr2_188228229_ENST00000410068_length(amino acids)=805AA_BP=510
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRSLSCQRITLHKNLFFSFVCNSVVTIIHLT
AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISS
DTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:191302287/chr2:188228229)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD6

Q6ZSS7

CALCRL

Q16602

FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739). {ECO:0000250, ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:30115739}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16105_125510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16132_152510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16286_306510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16335_355510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16369_389510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16450_470510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16479_499510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+1673_93510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38105_125510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38132_152510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38286_306510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38335_355510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38369_389510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38450_470510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38479_499510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+3873_93510.6666666666667792.0TransmembraneHelical
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715167_173166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715194_213166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715237_253166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715274_289166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715314_336166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715355_366166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715389_461166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816167_173166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816194_213166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816237_253166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816274_289166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816314_336166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816355_366166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816389_461166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614167_173166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614194_213166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614237_253166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614274_289166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614314_336166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614355_366166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614389_461166.66666666666666462.0Topological domainCytoplasmic
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715174_193166.66666666666666462.0TransmembraneHelical%3B Name%3D2
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715214_236166.66666666666666462.0TransmembraneHelical%3B Name%3D3
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715254_273166.66666666666666462.0TransmembraneHelical%3B Name%3D4
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715290_313166.66666666666666462.0TransmembraneHelical%3B Name%3D5
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715337_354166.66666666666666462.0TransmembraneHelical%3B Name%3D6
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715367_388166.66666666666666462.0TransmembraneHelical%3B Name%3D7
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816174_193166.66666666666666462.0TransmembraneHelical%3B Name%3D2
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816214_236166.66666666666666462.0TransmembraneHelical%3B Name%3D3
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816254_273166.66666666666666462.0TransmembraneHelical%3B Name%3D4
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816290_313166.66666666666666462.0TransmembraneHelical%3B Name%3D5
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816337_354166.66666666666666462.0TransmembraneHelical%3B Name%3D6
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816367_388166.66666666666666462.0TransmembraneHelical%3B Name%3D7
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614174_193166.66666666666666462.0TransmembraneHelical%3B Name%3D2
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614214_236166.66666666666666462.0TransmembraneHelical%3B Name%3D3
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614254_273166.66666666666666462.0TransmembraneHelical%3B Name%3D4
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614290_313166.66666666666666462.0TransmembraneHelical%3B Name%3D5
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614337_354166.66666666666666462.0TransmembraneHelical%3B Name%3D6
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614367_388166.66666666666666462.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16507_527510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16544_564510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16579_599510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000281416+16605_625510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38507_527510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38544_564510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38579_599510.6666666666667792.0TransmembraneHelical
HgeneMFSD6chr2:191302287chr2:188228229ENST00000392328+38605_625510.6666666666667792.0TransmembraneHelical
TgeneCALCRLchr2:191302287chr2:188228229ENST0000039237071523_146166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST0000040999881623_146166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST0000041006861423_146166.66666666666666462.0Topological domainExtracellular
TgeneCALCRLchr2:191302287chr2:188228229ENST00000392370715147_166166.66666666666666462.0TransmembraneHelical%3B Name%3D1
TgeneCALCRLchr2:191302287chr2:188228229ENST00000409998816147_166166.66666666666666462.0TransmembraneHelical%3B Name%3D1
TgeneCALCRLchr2:191302287chr2:188228229ENST00000410068614147_166166.66666666666666462.0TransmembraneHelical%3B Name%3D1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MFSD6
CALCRL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MFSD6-CALCRL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MFSD6-CALCRL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource