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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MFSD6-PMS1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MFSD6-PMS1
	FusionPDB ID: 53288
	FusionGDB2.0 ID: 53288
		Hgene	Tgene
	Gene symbol	MFSD6	PMS1
	Gene ID	54842	5378
	Gene name	major facilitator superfamily domain containing 6	PMS1 homolog 1, mismatch repair system component
	Synonyms	MMR2\|hMMR2	HNPCC3\|MLH2\|PMSL1\|hPMS1
	Cytomap	2q32.2	2q32.2
	Type of gene	protein-coding	protein-coding
	Description	major facilitator superfamily domain-containing protein 6macrophage MHC class I receptor 2 homologmacrophage MHC receptor 2	PMS1 protein homolog 1DNA mismatch repair protein PMS1PMS1 postmeiotic segregation increased 1human homolog of yeast mutLmismatch repair gene PMSL1rhabdomyosarcoma antigen MU-RMS-40.10Brhabdomyosarcoma antigen MU-RMS-40.10E
	Modification date	20200313	20200327
	UniProtAcc	Q6ZSS7	PMS1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000281416, ENST00000392328, ENST00000489793, ENST00000535751,	ENST00000374826, ENST00000409985, ENST00000421722, ENST00000432292, ENST00000447232, ENST00000409823, ENST00000418224, ENST00000441310,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 3 X 5=120	11 X 6 X 7=462
	# samples	8	11
	** MAII score	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MFSD6 [Title/Abstract] AND PMS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MFSD6(191334581)-PMS1(190738222), # samples:2
Anticipated loss of major functional domain due to fusion event.	MFSD6-PMS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MFSD6-PMS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MFSD6-PMS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MFSD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PMS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1417-01A	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392328	MFSD6	chr2	191334581	+	ENST00000441310	PMS1	chr2	190738222	+	2473	1954	324	2279	651
ENST00000392328	MFSD6	chr2	191334581	+	ENST00000418224	PMS1	chr2	190738222	+	2471	1954	324	2279	651
ENST00000392328	MFSD6	chr2	191334581	+	ENST00000409823	PMS1	chr2	190738222	+	2280	1954	324	2279	651
ENST00000281416	MFSD6	chr2	191334581	+	ENST00000441310	PMS1	chr2	190738222	+	2284	1765	135	2090	651
ENST00000281416	MFSD6	chr2	191334581	+	ENST00000418224	PMS1	chr2	190738222	+	2282	1765	135	2090	651
ENST00000281416	MFSD6	chr2	191334581	+	ENST00000409823	PMS1	chr2	190738222	+	2091	1765	135	2090	651
ENST00000535751	MFSD6	chr2	191334581	+	ENST00000441310	PMS1	chr2	190738222	+	751	232	138	557	139
ENST00000535751	MFSD6	chr2	191334581	+	ENST00000418224	PMS1	chr2	190738222	+	749	232	138	557	139
ENST00000535751	MFSD6	chr2	191334581	+	ENST00000409823	PMS1	chr2	190738222	+	558	232	138	557	139

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392328	ENST00000441310	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.000595692	0.9994043
ENST00000392328	ENST00000418224	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.000587439	0.99941254
ENST00000392328	ENST00000409823	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.001058201	0.99894184
ENST00000281416	ENST00000441310	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.000274782	0.99972516
ENST00000281416	ENST00000418224	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.000271981	0.999728
ENST00000281416	ENST00000409823	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.000427141	0.9995728
ENST00000535751	ENST00000441310	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.018855961	0.9811441
ENST00000535751	ENST00000418224	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.0191697	0.9808303
ENST00000535751	ENST00000409823	MFSD6	chr2	191334581	+	PMS1	chr2	190738222	+	0.014137094	0.9858629

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53288_53288_1_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000281416_PMS1_chr2_190738222_ENST00000409823_length(amino acids)=651AA_BP=541
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNE

--------------------------------------------------------------

>53288_53288_2_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000281416_PMS1_chr2_190738222_ENST00000418224_length(amino acids)=651AA_BP=541
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNE

--------------------------------------------------------------

>53288_53288_3_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000281416_PMS1_chr2_190738222_ENST00000441310_length(amino acids)=651AA_BP=541
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNE

--------------------------------------------------------------

>53288_53288_4_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000392328_PMS1_chr2_190738222_ENST00000409823_length(amino acids)=651AA_BP=541
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNE

--------------------------------------------------------------

>53288_53288_5_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000392328_PMS1_chr2_190738222_ENST00000418224_length(amino acids)=651AA_BP=541
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNE

--------------------------------------------------------------

>53288_53288_6_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000392328_PMS1_chr2_190738222_ENST00000441310_length(amino acids)=651AA_BP=541
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKHCVKINNDLLISKVFYFFFYSAYGSLYPLLP
VYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSSTATPVSPGSVTKETTTVIVTTTKSL
PSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIKLLCSVQYGSV
LFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMKHQFGNE

--------------------------------------------------------------

>53288_53288_7_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000535751_PMS1_chr2_190738222_ENST00000409823_length(amino acids)=139AA_BP=29
MYIGLACNTARYIYISYLENAWTVLPMEVLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVR

--------------------------------------------------------------

>53288_53288_8_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000535751_PMS1_chr2_190738222_ENST00000418224_length(amino acids)=139AA_BP=29
MYIGLACNTARYIYISYLENAWTVLPMEVLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVR

--------------------------------------------------------------

>53288_53288_9_MFSD6-PMS1_MFSD6_chr2_191334581_ENST00000535751_PMS1_chr2_190738222_ENST00000441310_length(amino acids)=139AA_BP=29
MYIGLACNTARYIYISYLENAWTVLPMEVLQGVSITENYLEIEGMANCLPFYGVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:191334581/chr2:190738222)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MFSD6 Q6ZSS7	PMS1 PMS1
	932

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

105_125

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

132_152

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

286_306

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

335_355

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

369_389

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

450_470

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

479_499

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

507_527

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

73_93

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

105_125

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

132_152

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

286_306

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

335_355

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

369_389

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

450_470

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

479_499

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

507_527

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

73_93

543.3333333333334

792.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

544_564

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

579_599

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000281416

605_625

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

544_564

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

579_599

543.3333333333334

792.0

Transmembrane

Helical

Hgene

MFSD6

chr2:191334581

chr2:190738222

ENST00000392328

605_625

543.3333333333334

792.0

Transmembrane

Helical

Tgene

PMS1

chr2:191334581

chr2:190738222

ENST00000409823

571_639

785.3333333333334

894.0

DNA binding

HMG box

Tgene

PMS1

chr2:191334581

chr2:190738222

ENST00000441310

571_639

824.3333333333334

933.0

DNA binding

HMG box

Tgene

PMS1

chr2:191334581

chr2:190738222

ENST00000447232

571_639

662.3333333333334

771.0

DNA binding

HMG box

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MFSD6
PMS1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MFSD6-PMS1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MFSD6-PMS1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source