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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MGLL-EEFSEC

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MGLL-EEFSEC
	FusionPDB ID: 53396
	FusionGDB2.0 ID: 53396
		Hgene	Tgene
	Gene symbol	MGLL	EEFSEC
	Gene ID	11343	60678
	Gene name	monoglyceride lipase	eukaryotic elongation factor, selenocysteine-tRNA specific
	Synonyms	HU-K5\|HUK5\|MAGL\|MGL	EFSEC\|SELB
	Cytomap	3q21.3	3q21.3
	Type of gene	protein-coding	protein-coding
	Description	monoglyceride lipaselysophospholipase homologmonoacylglycerol lipase	selenocysteine-specific elongation factorelongation factor for selenoprotein translationelongation factor secselenocysteine (Sec)-specific eukaryotic elongation factor
	Modification date	20200313	20200313
	UniProtAcc	Q99685	P57772
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265052, ENST00000398104, ENST00000434178, ENST00000453507, ENST00000398101, ENST00000476682,	ENST00000483569, ENST00000254730, ENST00000483457,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 4=196	7 X 5 X 8=280
	# samples	8	9
	** MAII score	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MGLL [Title/Abstract] AND EEFSEC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MGLL(127500631)-EEFSEC(127965678), # samples:2
Anticipated loss of major functional domain due to fusion event.	MGLL-EEFSEC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MGLL-EEFSEC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MGLL-EEFSEC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MGLL-EEFSEC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MGLL-EEFSEC seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MGLL-EEFSEC seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MGLL-EEFSEC seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MGLL	GO:0046464	acylglycerol catabolic process	22969151

Fusion gene breakpoints across MGLL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EEFSEC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-VR-A8Q7	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+
ChimerDB4	STAD	TCGA-BR-8058-01A	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265052	MGLL	chr3	127500631	-	ENST00000254730	EEFSEC	chr3	127965678	+	2660	802	486	2276	596
ENST00000265052	MGLL	chr3	127500631	-	ENST00000483457	EEFSEC	chr3	127965678	+	2338	802	486	1796	436
ENST00000398104	MGLL	chr3	127500631	-	ENST00000254730	EEFSEC	chr3	127965678	+	2235	377	61	1851	596
ENST00000398104	MGLL	chr3	127500631	-	ENST00000483457	EEFSEC	chr3	127965678	+	1913	377	61	1371	436
ENST00000453507	MGLL	chr3	127500631	-	ENST00000254730	EEFSEC	chr3	127965678	+	2153	295	33	1769	578
ENST00000453507	MGLL	chr3	127500631	-	ENST00000483457	EEFSEC	chr3	127965678	+	1831	295	33	1289	418
ENST00000265052	MGLL	chr3	127500632	-	ENST00000254730	EEFSEC	chr3	127965679	+	2660	802	486	2276	596
ENST00000265052	MGLL	chr3	127500632	-	ENST00000483457	EEFSEC	chr3	127965679	+	2338	802	486	1796	436
ENST00000398104	MGLL	chr3	127500632	-	ENST00000254730	EEFSEC	chr3	127965679	+	2235	377	61	1851	596
ENST00000398104	MGLL	chr3	127500632	-	ENST00000483457	EEFSEC	chr3	127965679	+	1913	377	61	1371	436
ENST00000453507	MGLL	chr3	127500632	-	ENST00000254730	EEFSEC	chr3	127965679	+	2153	295	33	1769	578
ENST00000453507	MGLL	chr3	127500632	-	ENST00000483457	EEFSEC	chr3	127965679	+	1831	295	33	1289	418

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265052	ENST00000254730	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+	0.009182658	0.9908173
ENST00000265052	ENST00000483457	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+	0.006850665	0.99314934
ENST00000398104	ENST00000254730	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+	0.011145795	0.98885417
ENST00000398104	ENST00000483457	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+	0.009200933	0.99079907
ENST00000453507	ENST00000254730	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+	0.009839686	0.9901603
ENST00000453507	ENST00000483457	MGLL	chr3	127500631	-	EEFSEC	chr3	127965678	+	0.005856598	0.9941434
ENST00000265052	ENST00000254730	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+	0.009182658	0.9908173
ENST00000265052	ENST00000483457	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+	0.006850665	0.99314934
ENST00000398104	ENST00000254730	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+	0.011145795	0.98885417
ENST00000398104	ENST00000483457	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+	0.009200933	0.99079907
ENST00000453507	ENST00000254730	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+	0.009839686	0.9901603
ENST00000453507	ENST00000483457	MGLL	chr3	127500632	-	EEFSEC	chr3	127965679	+	0.005856598	0.9941434

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53396_53396_1_MGLL-EEFSEC_MGLL_chr3_127500631_ENST00000265052_EEFSEC_chr3_127965678_ENST00000254730_length(amino acids)=596AA_BP=105
MVLILQAVVVVECKRQHIMETGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSM
QMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQ
EPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGIL
LHGLEDRNYADSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPES

--------------------------------------------------------------

>53396_53396_2_MGLL-EEFSEC_MGLL_chr3_127500631_ENST00000265052_EEFSEC_chr3_127965678_ENST00000483457_length(amino acids)=436AA_BP=105
MVLILQAVVVVECKRQHIMETGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIEVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYF
RGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVE

--------------------------------------------------------------

>53396_53396_3_MGLL-EEFSEC_MGLL_chr3_127500631_ENST00000398104_EEFSEC_chr3_127965678_ENST00000254730_length(amino acids)=596AA_BP=105
MARRKRGSAALGERDSGARGPGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSM
QMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQ
EPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGIL
LHGLEDRNYADSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPES

--------------------------------------------------------------

>53396_53396_4_MGLL-EEFSEC_MGLL_chr3_127500631_ENST00000398104_EEFSEC_chr3_127965678_ENST00000483457_length(amino acids)=436AA_BP=105
MARRKRGSAALGERDSGARGPGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIEVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYF
RGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVE

--------------------------------------------------------------

>53396_53396_5_MGLL-EEFSEC_MGLL_chr3_127500631_ENST00000453507_EEFSEC_chr3_127965678_ENST00000254730_length(amino acids)=578AA_BP=87
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHGAQ
IIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEA
PQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSMQMFHMPITSAMQGDRLGI
CVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQ
YLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGILLHGLEDRNYADSFLPRLK
VYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPESKKILTPALKKRARAGRGE

--------------------------------------------------------------

>53396_53396_6_MGLL-EEFSEC_MGLL_chr3_127500631_ENST00000453507_EEFSEC_chr3_127965678_ENST00000483457_length(amino acids)=418AA_BP=87
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHGAQ
IIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEA
PQGIPELIEVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHET
VMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRL

--------------------------------------------------------------

>53396_53396_7_MGLL-EEFSEC_MGLL_chr3_127500632_ENST00000265052_EEFSEC_chr3_127965679_ENST00000254730_length(amino acids)=596AA_BP=105
MVLILQAVVVVECKRQHIMETGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSM
QMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQ
EPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGIL
LHGLEDRNYADSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPES

--------------------------------------------------------------

>53396_53396_8_MGLL-EEFSEC_MGLL_chr3_127500632_ENST00000265052_EEFSEC_chr3_127965679_ENST00000483457_length(amino acids)=436AA_BP=105
MVLILQAVVVVECKRQHIMETGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIEVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYF
RGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVE

--------------------------------------------------------------

>53396_53396_9_MGLL-EEFSEC_MGLL_chr3_127500632_ENST00000398104_EEFSEC_chr3_127965679_ENST00000254730_length(amino acids)=596AA_BP=105
MARRKRGSAALGERDSGARGPGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSM
QMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQ
EPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGIL
LHGLEDRNYADSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPES

--------------------------------------------------------------

>53396_53396_10_MGLL-EEFSEC_MGLL_chr3_127500632_ENST00000398104_EEFSEC_chr3_127965679_ENST00000483457_length(amino acids)=436AA_BP=105
MARRKRGSAALGERDSGARGPGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELA
RMLMGLDLLVFAHDHGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAP
IIPVAAKPGGPEAPETEAPQGIPELIEVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYF
RGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVE

--------------------------------------------------------------

>53396_53396_11_MGLL-EEFSEC_MGLL_chr3_127500632_ENST00000453507_EEFSEC_chr3_127965679_ENST00000254730_length(amino acids)=578AA_BP=87
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHGAQ
IIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEA
PQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSMQMFHMPITSAMQGDRLGI
CVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQ
YLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGILLHGLEDRNYADSFLPRLK
VYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDSAFGQSGKFKIHIPGGLSPESKKILTPALKKRARAGRGE

--------------------------------------------------------------

>53396_53396_12_MGLL-EEFSEC_MGLL_chr3_127500632_ENST00000453507_EEFSEC_chr3_127965679_ENST00000483457_length(amino acids)=418AA_BP=87
METGPEDPSSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHGAQ
IIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEA
PQGIPELIEVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHET
VMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQATEGHCPRQQWALVEFEKPVTCPRLCLVIGSRL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:127500631/chr3:127965678)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MGLL Q99685	EEFSEC P57772
FUNCTION: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). {ECO:0000269\|PubMed:19029917, ECO:0000269\|PubMed:20079333, ECO:0000269\|PubMed:21049984, ECO:0000269\|PubMed:22969151, ECO:0000269\|PubMed:24368842}.	FUNCTION: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

547_553

105.33333333333333

597.0

Motif

Nuclear localization signal

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

547_553

105.33333333333333

597.0

Motif

Nuclear localization signal

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

146_150

105.33333333333333

597.0

Nucleotide binding

GTP

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

146_150

105.33333333333333

597.0

Nucleotide binding

GTP

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

146_149

105.33333333333333

597.0

Region

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

146_149

105.33333333333333

597.0

Region

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

5_217

105.33333333333333

597.0

Domain

tr-type G

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

5_217

105.33333333333333

597.0

Domain

tr-type G

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

92_96

105.33333333333333

597.0

Nucleotide binding

GTP

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

92_96

105.33333333333333

597.0

Nucleotide binding

GTP

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

14_21

105.33333333333333

597.0

Region

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

46_50

105.33333333333333

597.0

Region

Tgene

EEFSEC

chr3:127500631

chr3:127965678

ENST00000254730

92_95

105.33333333333333

597.0

Region

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

14_21

105.33333333333333

597.0

Region

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

46_50

105.33333333333333

597.0

Region

Tgene

EEFSEC

chr3:127500632

chr3:127965679

ENST00000254730

92_95

105.33333333333333

597.0

Region

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MGLL
EEFSEC

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MGLL-EEFSEC

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MGLL-EEFSEC

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source