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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MIER1-LEPR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MIER1-LEPR
FusionPDB ID: 53628
FusionGDB2.0 ID: 53628
HgeneTgene
Gene symbol

MIER1

LEPR

Gene ID

57708

54741

Gene nameMIER1 transcriptional regulatorleptin receptor overlapping transcript
SynonymsER1|MI-ER1LEPR|OB-RGRP|OBRGRP|VPS55
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionmesoderm induction early response protein 1mesoderm induction early response 1 homologmesoderm induction early response 1, transcriptional regulatorleptin receptor gene-related proteinDnaJ (Hsp40) homolog, subfamily C, member 6OB-R gene-related proteinendospaninendospanin-1leptin receptor overlapping transcript protein
Modification date2020031320200320
UniProtAcc

Q8N108

O95214

Ensembl transtripts involved in fusion geneENST idsENST00000479067, ENST00000355356, 
ENST00000357692, ENST00000371012, 
ENST00000371014, ENST00000371016, 
ENST00000371018, ENST00000401041, 
ENST00000401042, ENST00000355977, 
ENST00000344610, ENST00000349533, 
ENST00000371059, ENST00000371060, 
ENST00000371058, ENST00000462765, 
ENST00000406510, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 3=908 X 9 X 4=288
# samples 69
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MIER1 [Title/Abstract] AND LEPR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MIER1(67405735)-LEPR(66036156), # samples:2
Anticipated loss of major functional domain due to fusion event.MIER1-LEPR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MIER1-LEPR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MIER1-LEPR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MIER1-LEPR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIER1

GO:0016575

histone deacetylation

28046085

HgeneMIER1

GO:0031937

positive regulation of chromatin silencing

12482978

TgeneLEPR

GO:0046426

negative regulation of JAK-STAT cascade

18042720

TgeneLEPR

GO:0060400

negative regulation of growth hormone receptor signaling pathway

19907080

TgeneLEPR

GO:2000009

negative regulation of protein localization to cell surface

18042720


check buttonFusion gene breakpoints across MIER1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LEPR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GF-A2C7-01AMIER1chr1

67405735

-LEPRchr1

66036156

+
ChimerDB4SKCMTCGA-GF-A2C7-01AMIER1chr1

67405735

+LEPRchr1

66036156

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371018MIER1chr167405735+ENST00000344610LEPRchr166036156+30824012623081940
ENST00000371018MIER1chr167405735+ENST00000371059LEPRchr166036156+32554012623237991
ENST00000371018MIER1chr167405735+ENST00000371060LEPRchr166036156+53114012623051929
ENST00000371018MIER1chr167405735+ENST00000349533LEPRchr166036156+840340126238581198
ENST00000357692MIER1chr167405735+ENST00000344610LEPRchr166036156+30233422003022941
ENST00000357692MIER1chr167405735+ENST00000371059LEPRchr166036156+31963422003178992
ENST00000357692MIER1chr167405735+ENST00000371060LEPRchr166036156+52523422002992930
ENST00000357692MIER1chr167405735+ENST00000349533LEPRchr166036156+834434220037991199
ENST00000401041MIER1chr167405735+ENST00000344610LEPRchr166036156+2944263702943958
ENST00000401041MIER1chr167405735+ENST00000371059LEPRchr166036156+31172637030991009
ENST00000401041MIER1chr167405735+ENST00000371060LEPRchr166036156+5173263702913947
ENST00000401041MIER1chr167405735+ENST00000349533LEPRchr166036156+82652637037201216
ENST00000371016MIER1chr167405735+ENST00000344610LEPRchr166036156+30183371983017939
ENST00000371016MIER1chr167405735+ENST00000371059LEPRchr166036156+31913371983173991
ENST00000371016MIER1chr167405735+ENST00000371060LEPRchr166036156+52473371982987929
ENST00000371016MIER1chr167405735+ENST00000349533LEPRchr166036156+833933719837941198
ENST00000371014MIER1chr167405735+ENST00000344610LEPRchr166036156+2944263702943958
ENST00000371014MIER1chr167405735+ENST00000371059LEPRchr166036156+31172637030991009
ENST00000371014MIER1chr167405735+ENST00000371060LEPRchr166036156+5173263702913947
ENST00000371014MIER1chr167405735+ENST00000349533LEPRchr166036156+82652637037201216
ENST00000371012MIER1chr167405735+ENST00000344610LEPRchr166036156+30103291903009940
ENST00000371012MIER1chr167405735+ENST00000371059LEPRchr166036156+31833291903165991
ENST00000371012MIER1chr167405735+ENST00000371060LEPRchr166036156+52393291902979929
ENST00000371012MIER1chr167405735+ENST00000349533LEPRchr166036156+833132919037861198
ENST00000401042MIER1chr167405735+ENST00000344610LEPRchr166036156+28641831492863905
ENST00000401042MIER1chr167405735+ENST00000371059LEPRchr166036156+30371831493019956
ENST00000401042MIER1chr167405735+ENST00000371060LEPRchr166036156+50931831492833894
ENST00000401042MIER1chr167405735+ENST00000349533LEPRchr166036156+818518314936401163
ENST00000355356MIER1chr167405735+ENST00000344610LEPRchr166036156+28641831492863905
ENST00000355356MIER1chr167405735+ENST00000371059LEPRchr166036156+30371831493019956
ENST00000355356MIER1chr167405735+ENST00000371060LEPRchr166036156+50931831492833894
ENST00000355356MIER1chr167405735+ENST00000349533LEPRchr166036156+818518314936401163

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371018ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0001846930.9998153
ENST00000371018ENST00000371059MIER1chr167405735+LEPRchr166036156+0.0001418040.99985814
ENST00000371018ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001253040.9998747
ENST00000371018ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0002351840.99976486
ENST00000357692ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0001767710.9998233
ENST00000357692ENST00000371059MIER1chr167405735+LEPRchr166036156+0.000127260.9998727
ENST00000357692ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001236470.9998764
ENST00000357692ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0002158780.9997842
ENST00000401041ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0001533890.9998466
ENST00000401041ENST00000371059MIER1chr167405735+LEPRchr166036156+0.0003011750.9996989
ENST00000401041ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001027910.99989724
ENST00000401041ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0001498190.99985015
ENST00000371016ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0001762440.99982375
ENST00000371016ENST00000371059MIER1chr167405735+LEPRchr166036156+0.000126490.9998735
ENST00000371016ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001227480.9998772
ENST00000371016ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0002150680.9997849
ENST00000371014ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0001533890.9998466
ENST00000371014ENST00000371059MIER1chr167405735+LEPRchr166036156+0.0003011750.9996989
ENST00000371014ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001027910.99989724
ENST00000371014ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0001498190.99985015
ENST00000371012ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0001769560.99982303
ENST00000371012ENST00000371059MIER1chr167405735+LEPRchr166036156+0.0001253310.9998747
ENST00000371012ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001235580.9998764
ENST00000371012ENST00000349533MIER1chr167405735+LEPRchr166036156+0.000212550.9997875
ENST00000401042ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0002080770.9997919
ENST00000401042ENST00000371059MIER1chr167405735+LEPRchr166036156+0.0001500490.9998499
ENST00000401042ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001571340.9998429
ENST00000401042ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0001793490.99982065
ENST00000355356ENST00000344610MIER1chr167405735+LEPRchr166036156+0.0002080770.9997919
ENST00000355356ENST00000371059MIER1chr167405735+LEPRchr166036156+0.0001500490.9998499
ENST00000355356ENST00000371060MIER1chr167405735+LEPRchr166036156+0.0001571340.9998429
ENST00000355356ENST00000349533MIER1chr167405735+LEPRchr166036156+0.0001793490.99982065

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53628_53628_1_MIER1-LEPR_MIER1_chr1_67405735_ENST00000355356_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=905AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY
PIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKKMPGTKELLGG

--------------------------------------------------------------

>53628_53628_2_MIER1-LEPR_MIER1_chr1_67405735_ENST00000355356_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1163AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY
PIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKH
TASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISN
SKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGV

--------------------------------------------------------------

>53628_53628_3_MIER1-LEPR_MIER1_chr1_67405735_ENST00000355356_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=956AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY
PIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSH

--------------------------------------------------------------

>53628_53628_4_MIER1-LEPR_MIER1_chr1_67405735_ENST00000355356_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=894AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY

--------------------------------------------------------------

>53628_53628_5_MIER1-LEPR_MIER1_chr1_67405735_ENST00000357692_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=941AA_BP=47
MVEVQCRQDGCDAVENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKN
TSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVES
LFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVK
PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPR
VFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEH
ECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLL
SGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSV
SLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTS
CNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN
LNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQR

--------------------------------------------------------------

>53628_53628_6_MIER1-LEPR_MIER1_chr1_67405735_ENST00000357692_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1199AA_BP=47
MVEVQCRQDGCDAVENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKN
TSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVES
LFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVK
PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPR
VFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEH
ECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLL
SGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSV
SLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTS
CNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN
LNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQR
MKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCIS
DQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNI
ISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKK

--------------------------------------------------------------

>53628_53628_7_MIER1-LEPR_MIER1_chr1_67405735_ENST00000357692_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=992AA_BP=47
MVEVQCRQDGCDAVENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKN
TSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVES
LFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVK
PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPR
VFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEH
ECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLL
SGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSV
SLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTS
CNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN
LNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQR
MKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNT

--------------------------------------------------------------

>53628_53628_8_MIER1-LEPR_MIER1_chr1_67405735_ENST00000357692_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=930AA_BP=47
MVEVQCRQDGCDAVENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKN
TSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVES
LFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVK
PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPR
VFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEH
ECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLL
SGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSV
SLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTS
CNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN
LNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQR

--------------------------------------------------------------

>53628_53628_9_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371012_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=940AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM

--------------------------------------------------------------

>53628_53628_10_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371012_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1198AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM
KKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISD
QFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNII
SPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKT

--------------------------------------------------------------

>53628_53628_11_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371012_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=991AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM
KKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNTQ

--------------------------------------------------------------

>53628_53628_12_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371012_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=929AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM

--------------------------------------------------------------

>53628_53628_13_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371014_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=958AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI

--------------------------------------------------------------

>53628_53628_14_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371014_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1216AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI
ISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTV
VSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSW
EIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDS

--------------------------------------------------------------

>53628_53628_15_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371014_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=1009AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI
ISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTL

--------------------------------------------------------------

>53628_53628_16_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371014_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=947AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI

--------------------------------------------------------------

>53628_53628_17_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371016_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=939AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM

--------------------------------------------------------------

>53628_53628_18_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371016_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1198AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM
KKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISD
QFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNII
SPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKT

--------------------------------------------------------------

>53628_53628_19_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371016_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=991AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM
KKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNTQ

--------------------------------------------------------------

>53628_53628_20_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371016_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=929AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM

--------------------------------------------------------------

>53628_53628_21_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371018_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=940AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM

--------------------------------------------------------------

>53628_53628_22_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371018_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1198AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM
KKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISD
QFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNII
SPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKT

--------------------------------------------------------------

>53628_53628_23_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371018_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=991AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM
KKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNTQ

--------------------------------------------------------------

>53628_53628_24_MIER1-LEPR_MIER1_chr1_67405735_ENST00000371018_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=929AA_BP=46
MVEVQCRQDGCDAENVHQMFMFNWFTDCLWTLFLSNYQPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNT
SNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESL
FKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKP
DPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRV
FTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHE
CHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLS
GYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVS
LPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSC
NGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNL
NEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRM

--------------------------------------------------------------

>53628_53628_25_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401041_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=958AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI

--------------------------------------------------------------

>53628_53628_26_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401041_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1216AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI
ISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTV
VSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSW
EIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDS

--------------------------------------------------------------

>53628_53628_27_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401041_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=1009AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI
ISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTL

--------------------------------------------------------------

>53628_53628_28_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401041_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=947AA_BP=64
MDGASSGGGGSSEGGGGSSGSGYGVVARFSQCLAEFRTWLRTNWLRFNADKTDVMLPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMP
PNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNI
QCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGG
VIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVR
GKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNET
KPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCY
LQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGK
EVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMK
NDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWI
LSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVI

--------------------------------------------------------------

>53628_53628_29_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401042_LEPR_chr1_66036156_ENST00000344610_length(amino acids)=905AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY
PIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKKMPGTKELLGG

--------------------------------------------------------------

>53628_53628_30_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401042_LEPR_chr1_66036156_ENST00000349533_length(amino acids)=1163AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY
PIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKH
TASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISN
SKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGV

--------------------------------------------------------------

>53628_53628_31_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401042_LEPR_chr1_66036156_ENST00000371059_length(amino acids)=956AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY
PIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSH

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>53628_53628_32_MIER1-LEPR_MIER1_chr1_67405735_ENST00000401042_LEPR_chr1_66036156_ENST00000371060_length(amino acids)=894AA_BP=11
MAEPSVESSSPEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFR
SEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQ
MVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVK
YSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVP
SKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTS
TIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSS
VKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTV
VMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGA
SVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:67405735/chr1:66036156)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIER1

Q8N108

LEPR

O95214

FUNCTION: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}.FUNCTION: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:19907080}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220239_33313.333333333333334907.0DomainFibronectin type-III 1
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220331_42913.333333333333334907.0DomainNote=Ig-like
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220539_63413.333333333333334907.0DomainFibronectin type-III 2
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220639_73213.333333333333334907.0DomainFibronectin type-III 3
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220740_83313.333333333333334907.0DomainFibronectin type-III 4
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220239_33313.3333333333333341166.0DomainFibronectin type-III 1
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220331_42913.3333333333333341166.0DomainNote=Ig-like
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220539_63413.3333333333333341166.0DomainFibronectin type-III 2
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220639_73213.3333333333333341166.0DomainFibronectin type-III 3
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220740_83313.3333333333333341166.0DomainFibronectin type-III 4
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018239_33313.333333333333334907.0DomainFibronectin type-III 1
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018331_42913.333333333333334907.0DomainNote=Ig-like
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018539_63413.333333333333334907.0DomainFibronectin type-III 2
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018639_73213.333333333333334907.0DomainFibronectin type-III 3
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018740_83313.333333333333334907.0DomainFibronectin type-III 4
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220239_33313.333333333333334959.0DomainFibronectin type-III 1
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220331_42913.333333333333334959.0DomainNote=Ig-like
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220539_63413.333333333333334959.0DomainFibronectin type-III 2
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220639_73213.333333333333334959.0DomainFibronectin type-III 3
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220740_83313.333333333333334959.0DomainFibronectin type-III 4
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220239_33313.333333333333334897.0DomainFibronectin type-III 1
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220331_42913.333333333333334897.0DomainNote=Ig-like
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220539_63413.333333333333334897.0DomainFibronectin type-III 2
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220639_73213.333333333333334897.0DomainFibronectin type-III 3
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220740_83313.333333333333334897.0DomainFibronectin type-III 4
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220622_62613.333333333333334907.0MotifNote=WSXWS motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220871_87913.333333333333334907.0MotifNote=Box 1 motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220622_62613.3333333333333341166.0MotifNote=WSXWS motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220871_87913.3333333333333341166.0MotifNote=Box 1 motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018622_62613.333333333333334907.0MotifNote=WSXWS motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018871_87913.333333333333334907.0MotifNote=Box 1 motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220622_62613.333333333333334959.0MotifNote=WSXWS motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220871_87913.333333333333334959.0MotifNote=Box 1 motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220622_62613.333333333333334897.0MotifNote=WSXWS motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220871_87913.333333333333334897.0MotifNote=Box 1 motif
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220467_48413.333333333333334907.0RegionLeptin-binding
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220893_89813.333333333333334907.0RegionRequired for JAK2 activation
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220898_90613.333333333333334907.0RegionRequired for STAT3 phosphorylation
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220467_48413.3333333333333341166.0RegionLeptin-binding
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220893_89813.3333333333333341166.0RegionRequired for JAK2 activation
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220898_90613.3333333333333341166.0RegionRequired for STAT3 phosphorylation
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018467_48413.333333333333334907.0RegionLeptin-binding
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018893_89813.333333333333334907.0RegionRequired for JAK2 activation
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018898_90613.333333333333334907.0RegionRequired for STAT3 phosphorylation
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220467_48413.333333333333334959.0RegionLeptin-binding
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220893_89813.333333333333334959.0RegionRequired for JAK2 activation
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220898_90613.333333333333334959.0RegionRequired for STAT3 phosphorylation
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220467_48413.333333333333334897.0RegionLeptin-binding
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220893_89813.333333333333334897.0RegionRequired for JAK2 activation
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220898_90613.333333333333334897.0RegionRequired for STAT3 phosphorylation
TgeneLEPRchr1:67405735chr1:66036156ENST0000034461022022_83913.333333333333334907.0Topological domainExtracellular
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220863_116513.333333333333334907.0Topological domainCytoplasmic
TgeneLEPRchr1:67405735chr1:66036156ENST0000034953322022_83913.3333333333333341166.0Topological domainExtracellular
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220863_116513.3333333333333341166.0Topological domainCytoplasmic
TgeneLEPRchr1:67405735chr1:66036156ENST0000037105801822_83913.333333333333334907.0Topological domainExtracellular
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018863_116513.333333333333334907.0Topological domainCytoplasmic
TgeneLEPRchr1:67405735chr1:66036156ENST0000037105922022_83913.333333333333334959.0Topological domainExtracellular
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220863_116513.333333333333334959.0Topological domainCytoplasmic
TgeneLEPRchr1:67405735chr1:66036156ENST0000037106022022_83913.333333333333334897.0Topological domainExtracellular
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220863_116513.333333333333334897.0Topological domainCytoplasmic
TgeneLEPRchr1:67405735chr1:66036156ENST00000344610220840_86213.333333333333334907.0TransmembraneHelical
TgeneLEPRchr1:67405735chr1:66036156ENST00000349533220840_86213.3333333333333341166.0TransmembraneHelical
TgeneLEPRchr1:67405735chr1:66036156ENST00000371058018840_86213.333333333333334907.0TransmembraneHelical
TgeneLEPRchr1:67405735chr1:66036156ENST00000371059220840_86213.333333333333334959.0TransmembraneHelical
TgeneLEPRchr1:67405735chr1:66036156ENST00000371060220840_86213.333333333333334897.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIER1chr1:67405735chr1:66036156ENST00000355356+21336_18111.333333333333334513.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000355977+31436_1810371.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000357692+41536_18128.333333333333332530.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000371014+31536_18164.33333333333333487.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000371016+41636_18128.333333333333332451.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000371018+41636_18128.333333333333332471.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000401041+31436_18164.33333333333333566.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000401042+21436_18111.333333333333334434.0Compositional biasNote=Glu-rich
HgeneMIER1chr1:67405735chr1:66036156ENST00000355356+213180_27811.333333333333334513.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000355356+213283_33511.333333333333334513.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000355977+314180_2780371.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000355977+314283_3350371.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000357692+415180_27828.333333333333332530.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000357692+415283_33528.333333333333332530.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000371014+315180_27864.33333333333333487.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000371014+315283_33564.33333333333333487.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000371016+416180_27828.333333333333332451.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000371016+416283_33528.333333333333332451.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000371018+416180_27828.333333333333332471.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000371018+416283_33528.333333333333332471.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000401041+314180_27864.33333333333333566.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000401041+314283_33564.33333333333333566.0DomainSANT
HgeneMIER1chr1:67405735chr1:66036156ENST00000401042+214180_27811.333333333333334434.0DomainELM2
HgeneMIER1chr1:67405735chr1:66036156ENST00000401042+214283_33511.333333333333334434.0DomainSANT


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MIER1
LEPR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMIER1chr1:67405735chr1:66036156ENST00000355356+213180_28411.333333333333334513.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000355977+314180_2840371.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000357692+415180_28428.333333333333332530.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000371014+315180_28464.33333333333333487.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000371016+416180_28428.333333333333332451.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000371018+416180_28428.333333333333332471.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000401041+314180_28464.33333333333333566.0HDAC1
HgeneMIER1chr1:67405735chr1:66036156ENST00000401042+214180_28411.333333333333334434.0HDAC1


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Related Drugs to MIER1-LEPR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MIER1-LEPR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource