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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MORC2-PATZ1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MORC2-PATZ1
FusionPDB ID: 54588
FusionGDB2.0 ID: 54588
HgeneTgene
Gene symbol

MORC2

PATZ1

Gene ID

22880

23598

Gene nameMORC family CW-type zinc finger 2POZ/BTB and AT hook containing zinc finger 1
SynonymsCMT2Z|ZCW3|ZCWCC1MAZR|PATZ|RIAZ|ZBTB19|ZNF278|ZSG|dJ400N23
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionATPase MORC2zinc finger CW-type coiled-coil domain protein 1POZ-, AT hook-, and zinc finger-containing protein 1BTB-POZ domain zinc finger transcription factorMAZ-related factorPOZ-AT hook-zinc finger proteinprotein kinase A RI subunit alpha-associated proteinzinc finger and BTB domain-containing protein 19z
Modification date2020031320200313
UniProtAcc

Q9Y6X9

.
Ensembl transtripts involved in fusion geneENST idsENST00000397641, ENST00000215862, 
ENST00000469915, 		ENST00000215919, 
ENST00000351933, ENST00000266269, 
ENST00000405309, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 3 X 3=186 X 10 X 6=360
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/360*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MORC2 [Title/Abstract] AND PATZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MORC2(31352748)-PATZ1(31724845), # samples:1
MORC2(31363808)-PATZ1(31731849), # samples:1
Anticipated loss of major functional domain due to fusion event.MORC2-PATZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MORC2-PATZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MORC2-PATZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MORC2-PATZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMORC2

GO:0006338

chromatin remodeling

23260667

HgeneMORC2

GO:0006974

cellular response to DNA damage stimulus

23260667

HgeneMORC2

GO:0045814

negative regulation of gene expression, epigenetic

28581500|29211708

HgeneMORC2

GO:0090309

positive regulation of methylation-dependent chromatin silencing

28581500|29211708


check buttonFusion gene breakpoints across MORC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PATZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-L3-A524-01AMORC2chr22

31363808

-PATZ1chr22

31731849

-
ChimerDB4UCECTCGA-D1-A16SMORC2chr22

31352748

-PATZ1chr22

31724845

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397641MORC2chr2231352748-ENST00000266269PATZ1chr2231724845-2145566409984191
ENST00000397641MORC2chr2231352748-ENST00000405309PATZ1chr2231724845-21405665601057165
ENST00000397641MORC2chr2231363808-ENST00000266269PATZ1chr2231731849-22934775101205231
ENST00000397641MORC2chr2231363808-ENST00000405309PATZ1chr2231731849-22234776731140155
ENST00000397641MORC2chr2231363808-ENST00000351933PATZ1chr2231731849-21504775101067185

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397641ENST00000266269MORC2chr2231352748-PATZ1chr2231724845-0.0014759260.9985241
ENST00000397641ENST00000405309MORC2chr2231352748-PATZ1chr2231724845-0.006558070.99344194
ENST00000397641ENST00000266269MORC2chr2231363808-PATZ1chr2231731849-0.0029329790.99706703
ENST00000397641ENST00000405309MORC2chr2231363808-PATZ1chr2231731849-0.0954689760.904531
ENST00000397641ENST00000351933MORC2chr2231363808-PATZ1chr2231731849-0.0066925940.9933074

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54588_54588_1_MORC2-PATZ1_MORC2_chr22_31352748_ENST00000397641_PATZ1_chr22_31724845_ENST00000266269_length(amino acids)=191AA_BP=
MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSF
SCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPE

--------------------------------------------------------------

>54588_54588_2_MORC2-PATZ1_MORC2_chr22_31352748_ENST00000397641_PATZ1_chr22_31724845_ENST00000405309_length(amino acids)=165AA_BP=1
MQVSRHQEPILNGGAAFHCARTYGNKEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGS

--------------------------------------------------------------

>54588_54588_3_MORC2-PATZ1_MORC2_chr22_31363808_ENST00000397641_PATZ1_chr22_31731849_ENST00000266269_length(amino acids)=231AA_BP=
MRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCARTYG
NKEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPL

--------------------------------------------------------------

>54588_54588_4_MORC2-PATZ1_MORC2_chr22_31363808_ENST00000397641_PATZ1_chr22_31731849_ENST00000351933_length(amino acids)=185AA_BP=
MRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNREGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAV
PKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPEVDQQPM

--------------------------------------------------------------

>54588_54588_5_MORC2-PATZ1_MORC2_chr22_31363808_ENST00000397641_PATZ1_chr22_31731849_ENST00000405309_length(amino acids)=155AA_BP=
MNGGAAFHCARTYGNKEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:31352748/chr22:31724845)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MORC2

Q9Y6X9

.
FUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903264_2760538.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905264_2760688.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304264_2760642.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903264_2760538.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31352748chr22:31724845ENST000002159190341_1300538.0DomainBTB
TgenePATZ1chr22:31352748chr22:31724845ENST000002662690541_1300688.0DomainBTB
TgenePATZ1chr22:31352748chr22:31724845ENST000003519330441_1300642.0DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST000002159190341_1300538.0DomainBTB
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903292_3140538.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903355_3770538.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903383_4050538.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903413_4360538.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903442_4640538.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903495_5180538.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31352748chr22:31724845ENST0000021591903605_6280538.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905292_3140688.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905355_3770688.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905383_4050688.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905413_4360688.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905442_4640688.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905495_5180688.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31352748chr22:31724845ENST0000026626905605_6280688.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304292_3140642.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304355_3770642.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304383_4050642.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304413_4360642.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304442_4640642.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304495_5180642.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31352748chr22:31724845ENST0000035193304605_6280642.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925605_628502.3333333333333538.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903292_3140538.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903355_3770538.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903383_4050538.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903413_4360538.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903442_4640538.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903495_5180538.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST0000021591903605_6280538.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915442_464445.0688.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915495_518445.0688.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915605_628445.0688.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314442_464445.0642.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314495_518445.0642.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314605_628445.0642.0Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915442_464445.0538.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915495_518445.0538.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915605_628445.0538.0Zinc fingerC2H2-type 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-427282_3620971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-427547_5840971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-427741_7610971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-427966_10160971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-326282_36252.3333333333333361033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-326547_58452.3333333333333361033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-326741_76152.3333333333333361033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-326966_101652.3333333333333361033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127282_3620971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127547_5840971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127741_7610971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127966_10160971.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126282_36222.6666666666666681033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126547_58422.6666666666666681033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126741_76122.6666666666666681033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126966_101622.6666666666666681033.0Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-42787_890971.0Nucleotide bindingATP
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-42799_1050971.0Nucleotide bindingATP
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-32687_8952.3333333333333361033.0Nucleotide bindingATP
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-32699_10552.3333333333333361033.0Nucleotide bindingATP
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-12787_890971.0Nucleotide bindingATP
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-12799_1050971.0Nucleotide bindingATP
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-12687_8922.6666666666666681033.0Nucleotide bindingATP
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-12699_10522.6666666666666681033.0Nucleotide bindingATP
HgeneMORC2chr22:31352748chr22:31724845ENST00000215862-427490_5440971.0Zinc fingerCW-type
HgeneMORC2chr22:31352748chr22:31724845ENST00000397641-326490_54452.3333333333333361033.0Zinc fingerCW-type
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127490_5440971.0Zinc fingerCW-type
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126490_54422.6666666666666681033.0Zinc fingerCW-type
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925264_276502.3333333333333538.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915264_276445.0688.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314264_276445.0642.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915264_276445.0538.0DNA bindingNote=A.T hook
TgenePATZ1chr22:31352748chr22:31724845ENST000004053092541_130502.3333333333333538.0DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST000002662691541_130445.0688.0DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST000003519331441_130445.0642.0DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST000004053091541_130445.0538.0DomainBTB
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925292_314502.3333333333333538.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925355_377502.3333333333333538.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925383_405502.3333333333333538.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925413_436502.3333333333333538.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925442_464502.3333333333333538.0Zinc fingerC2H2-type 5
TgenePATZ1chr22:31352748chr22:31724845ENST0000040530925495_518502.3333333333333538.0Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915292_314445.0688.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915355_377445.0688.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915383_405445.0688.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST0000026626915413_436445.0688.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314292_314445.0642.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314355_377445.0642.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314383_405445.0642.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST0000035193314413_436445.0642.0Zinc fingerC2H2-type 4
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915292_314445.0538.0Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915355_377445.0538.0Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915383_405445.0538.0Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST0000040530915413_436445.0538.0Zinc fingerC2H2-type 4


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MORC2
PATZ1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MORC2-PATZ1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MORC2-PATZ1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource