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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MPP7-ZEB1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MPP7-ZEB1
FusionPDB ID: 54765
FusionGDB2.0 ID: 54765
HgeneTgene
Gene symbol

MPP7

ZEB1

Gene ID

143098

6935

Gene namemembrane palmitoylated protein 7zinc finger E-box binding homeobox 1
Synonyms-AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A
Cytomap

10p12.1

10p11.22

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 7membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)zinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding prote
Modification date2020031320200329
UniProtAcc

Q5T2T1

.
Ensembl transtripts involved in fusion geneENST idsENST00000337532, ENST00000375719, 
ENST00000375732, ENST00000540098, 
ENST00000481244, ENST00000445954, 
ENST00000446923, ENST00000542815, 
ENST00000559858, ENST00000560721, 
ENST00000320985, ENST00000361642, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 4=1687 X 8 X 3=168
# samples 88
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MPP7 [Title/Abstract] AND ZEB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MPP7(28491082)-ZEB1(31791276), # samples:2
MPP7(28491081)-ZEB1(31791275), # samples:2
Anticipated loss of major functional domain due to fusion event.MPP7-ZEB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP7-ZEB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP7-ZEB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP7-ZEB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MPP7-ZEB1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MPP7-ZEB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MPP7-ZEB1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMPP7

GO:0031334

positive regulation of protein complex assembly

17237226

HgeneMPP7

GO:0070830

bicellular tight junction assembly

17332497

TgeneZEB1

GO:0000122

negative regulation of transcription by RNA polymerase II

23765923|23814079

TgeneZEB1

GO:0045892

negative regulation of transcription, DNA-templated

20418909


check buttonFusion gene breakpoints across MPP7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZEB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A8O2-01AMPP7chr10

28491082

-ZEB1chr10

31791276

+
ChimerDB4ESCATCGA-IG-A8O2MPP7chr10

28491081

-ZEB1chr10

31791275

+
ChimerDB4ESCATCGA-IG-A8O2MPP7chr10

28491082

-ZEB1chr10

31791276

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337532MPP7chr1028491082-ENST00000320985ZEB1chr1031791276+54274336663488940
ENST00000337532MPP7chr1028491082-ENST00000361642ZEB1chr1031791276+60384336663488940
ENST00000375732MPP7chr1028491082-ENST00000320985ZEB1chr1031791276+54104166493471940
ENST00000375732MPP7chr1028491082-ENST00000361642ZEB1chr1031791276+60214166493471940
ENST00000375719MPP7chr1028491082-ENST00000320985ZEB1chr1031791276+55055117443566940
ENST00000375719MPP7chr1028491082-ENST00000361642ZEB1chr1031791276+61165117443566940
ENST00000337532MPP7chr1028491081-ENST00000320985ZEB1chr1031791275+54274336663488940
ENST00000337532MPP7chr1028491081-ENST00000361642ZEB1chr1031791275+60384336663488940
ENST00000375732MPP7chr1028491081-ENST00000320985ZEB1chr1031791275+54104166493471940
ENST00000375732MPP7chr1028491081-ENST00000361642ZEB1chr1031791275+60214166493471940
ENST00000375719MPP7chr1028491081-ENST00000320985ZEB1chr1031791275+55055117443566940
ENST00000375719MPP7chr1028491081-ENST00000361642ZEB1chr1031791275+61165117443566940

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337532ENST00000320985MPP7chr1028491082-ZEB1chr1031791276+0.0001795020.99982053
ENST00000337532ENST00000361642MPP7chr1028491082-ZEB1chr1031791276+0.0001611660.9998388
ENST00000375732ENST00000320985MPP7chr1028491082-ZEB1chr1031791276+0.000180330.9998197
ENST00000375732ENST00000361642MPP7chr1028491082-ZEB1chr1031791276+0.0001631050.9998369
ENST00000375719ENST00000320985MPP7chr1028491082-ZEB1chr1031791276+0.0001909180.9998091
ENST00000375719ENST00000361642MPP7chr1028491082-ZEB1chr1031791276+0.0001710560.99982893
ENST00000337532ENST00000320985MPP7chr1028491081-ZEB1chr1031791275+0.0001795020.99982053
ENST00000337532ENST00000361642MPP7chr1028491081-ZEB1chr1031791275+0.0001611660.9998388
ENST00000375732ENST00000320985MPP7chr1028491081-ZEB1chr1031791275+0.000180330.9998197
ENST00000375732ENST00000361642MPP7chr1028491081-ZEB1chr1031791275+0.0001631050.9998369
ENST00000375719ENST00000320985MPP7chr1028491081-ZEB1chr1031791275+0.0001909180.9998091
ENST00000375719ENST00000361642MPP7chr1028491081-ZEB1chr1031791275+0.0001710560.99982893

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54765_54765_1_MPP7-ZEB1_MPP7_chr10_28491081_ENST00000337532_ZEB1_chr10_31791275_ENST00000320985_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_2_MPP7-ZEB1_MPP7_chr10_28491081_ENST00000337532_ZEB1_chr10_31791275_ENST00000361642_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_3_MPP7-ZEB1_MPP7_chr10_28491081_ENST00000375719_ZEB1_chr10_31791275_ENST00000320985_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_4_MPP7-ZEB1_MPP7_chr10_28491081_ENST00000375719_ZEB1_chr10_31791275_ENST00000361642_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_5_MPP7-ZEB1_MPP7_chr10_28491081_ENST00000375732_ZEB1_chr10_31791275_ENST00000320985_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_6_MPP7-ZEB1_MPP7_chr10_28491081_ENST00000375732_ZEB1_chr10_31791275_ENST00000361642_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_7_MPP7-ZEB1_MPP7_chr10_28491082_ENST00000337532_ZEB1_chr10_31791276_ENST00000320985_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_8_MPP7-ZEB1_MPP7_chr10_28491082_ENST00000337532_ZEB1_chr10_31791276_ENST00000361642_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_9_MPP7-ZEB1_MPP7_chr10_28491082_ENST00000375719_ZEB1_chr10_31791276_ENST00000320985_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_10_MPP7-ZEB1_MPP7_chr10_28491082_ENST00000375719_ZEB1_chr10_31791276_ENST00000361642_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_11_MPP7-ZEB1_MPP7_chr10_28491082_ENST00000375732_ZEB1_chr10_31791276_ENST00000320985_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

>54765_54765_12_MPP7-ZEB1_MPP7_chr10_28491082_ENST00000375732_ZEB1_chr10_31791276_ENST00000361642_length(amino acids)=940AA_BP=
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:28491082/chr10:31791276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MPP7

Q5T2T1

.
FUNCTION: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269|PubMed:17332497}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529989_1124106.333333333333331125.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229989_1124107.333333333333331126.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329989_112490.333333333333331109.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518989_112439.3333333333333361058.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118989_112486.333333333333331105.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529989_1124106.333333333333331125.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229989_1124107.333333333333331126.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329989_112490.333333333333331109.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518989_112439.3333333333333361058.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118989_112486.333333333333331105.0Compositional biasNote=Glu-rich (acidic)
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529581_640106.333333333333331125.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229581_640107.333333333333331126.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329581_64090.333333333333331109.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518581_64039.3333333333333361058.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118581_64086.333333333333331105.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529581_640106.333333333333331125.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229581_640107.333333333333331126.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329581_64090.333333333333331109.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518581_64039.3333333333333361058.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118581_64086.333333333333331105.0DNA bindingNote=Homeobox%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529170_193106.333333333333331125.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529200_222106.333333333333331125.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529240_262106.333333333333331125.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529268_292106.333333333333331125.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529904_926106.333333333333331125.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529932_954106.333333333333331125.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491081chr10:31791275ENST0000032098529960_981106.333333333333331125.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229170_193107.333333333333331126.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229200_222107.333333333333331126.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229240_262107.333333333333331126.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229268_292107.333333333333331126.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229904_926107.333333333333331126.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229932_954107.333333333333331126.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491081chr10:31791275ENST0000036164229960_981107.333333333333331126.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329170_19390.333333333333331109.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329200_22290.333333333333331109.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329240_26290.333333333333331109.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329268_29290.333333333333331109.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329904_92690.333333333333331109.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329932_95490.333333333333331109.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491081chr10:31791275ENST0000044692329960_98190.333333333333331109.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518170_19339.3333333333333361058.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518200_22239.3333333333333361058.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518240_26239.3333333333333361058.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518268_29239.3333333333333361058.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518904_92639.3333333333333361058.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518932_95439.3333333333333361058.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491081chr10:31791275ENST0000054281518960_98139.3333333333333361058.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118170_19386.333333333333331105.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118200_22286.333333333333331105.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118240_26286.333333333333331105.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118268_29286.333333333333331105.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118904_92686.333333333333331105.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118932_95486.333333333333331105.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491081chr10:31791275ENST0000056072118960_98186.333333333333331105.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529170_193106.333333333333331125.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529200_222106.333333333333331125.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529240_262106.333333333333331125.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529268_292106.333333333333331125.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529904_926106.333333333333331125.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529932_954106.333333333333331125.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491082chr10:31791276ENST0000032098529960_981106.333333333333331125.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229170_193107.333333333333331126.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229200_222107.333333333333331126.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229240_262107.333333333333331126.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229268_292107.333333333333331126.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229904_926107.333333333333331126.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229932_954107.333333333333331126.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491082chr10:31791276ENST0000036164229960_981107.333333333333331126.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329170_19390.333333333333331109.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329200_22290.333333333333331109.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329240_26290.333333333333331109.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329268_29290.333333333333331109.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329904_92690.333333333333331109.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329932_95490.333333333333331109.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491082chr10:31791276ENST0000044692329960_98190.333333333333331109.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518170_19339.3333333333333361058.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518200_22239.3333333333333361058.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518240_26239.3333333333333361058.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518268_29239.3333333333333361058.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518904_92639.3333333333333361058.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518932_95439.3333333333333361058.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491082chr10:31791276ENST0000054281518960_98139.3333333333333361058.0Zinc fingerC2H2-type 7%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118170_19386.333333333333331105.0Zinc fingerC2H2-type 1
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118200_22286.333333333333331105.0Zinc fingerC2H2-type 2
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118240_26286.333333333333331105.0Zinc fingerC2H2-type 3
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118268_29286.333333333333331105.0Zinc fingerC2H2-type 4%3B atypical
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118904_92686.333333333333331105.0Zinc fingerC2H2-type 5
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118932_95486.333333333333331105.0Zinc fingerC2H2-type 6
TgeneZEB1chr10:28491082chr10:31791276ENST0000056072118960_98186.333333333333331105.0Zinc fingerC2H2-type 7%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMPP7chr10:28491081chr10:31791275ENST00000337532-41810_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491081chr10:31791275ENST00000337532-418139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491081chr10:31791275ENST00000337532-418228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491081chr10:31791275ENST00000337532-418368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491081chr10:31791275ENST00000337532-41867_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491081chr10:31791275ENST00000375719-51910_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491081chr10:31791275ENST00000375719-519139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491081chr10:31791275ENST00000375719-519228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491081chr10:31791275ENST00000375719-519368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491081chr10:31791275ENST00000375719-51967_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491081chr10:31791275ENST00000375732-31710_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491081chr10:31791275ENST00000375732-317139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491081chr10:31791275ENST00000375732-317228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491081chr10:31791275ENST00000375732-317368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491081chr10:31791275ENST00000375732-31767_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491081chr10:31791275ENST00000540098-21610_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491081chr10:31791275ENST00000540098-216139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491081chr10:31791275ENST00000540098-216228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491081chr10:31791275ENST00000540098-216368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491081chr10:31791275ENST00000540098-21667_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491082chr10:31791276ENST00000337532-41810_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491082chr10:31791276ENST00000337532-418139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491082chr10:31791276ENST00000337532-418228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491082chr10:31791276ENST00000337532-418368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491082chr10:31791276ENST00000337532-41867_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491082chr10:31791276ENST00000375719-51910_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491082chr10:31791276ENST00000375719-519139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491082chr10:31791276ENST00000375719-519228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491082chr10:31791276ENST00000375719-519368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491082chr10:31791276ENST00000375719-51967_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491082chr10:31791276ENST00000375732-31710_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491082chr10:31791276ENST00000375732-317139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491082chr10:31791276ENST00000375732-317228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491082chr10:31791276ENST00000375732-317368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491082chr10:31791276ENST00000375732-31767_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491082chr10:31791276ENST00000540098-21610_6552.0577.0DomainL27 1
HgeneMPP7chr10:28491082chr10:31791276ENST00000540098-216139_22052.0577.0DomainPDZ
HgeneMPP7chr10:28491082chr10:31791276ENST00000540098-216228_29852.0577.0DomainSH3
HgeneMPP7chr10:28491082chr10:31791276ENST00000540098-216368_56052.0577.0DomainGuanylate kinase-like
HgeneMPP7chr10:28491082chr10:31791276ENST00000540098-21667_12252.0577.0DomainL27 2
HgeneMPP7chr10:28491081chr10:31791275ENST00000337532-418289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491081chr10:31791275ENST00000375719-519289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491081chr10:31791275ENST00000375732-317289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491081chr10:31791275ENST00000540098-216289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491082chr10:31791276ENST00000337532-418289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491082chr10:31791276ENST00000375719-519289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491082chr10:31791276ENST00000375732-317289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif
HgeneMPP7chr10:28491082chr10:31791276ENST00000540098-216289_38352.0577.0RegionPhospho-regulated basic and hydrophobic (PRBH) motif


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1736_MPP7_28491082_ZEB1_31791276_ranked_0.pdbMPP72849108128491082ENST00000361642ZEB1chr1031791276+
MKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCK
KRFSHSGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVVASGI
NCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGH
SVISAISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGDINAL
PELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQA
GQISVQSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYLYTAE
GAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTI
VAIADQNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTENGMY
ACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERD
STEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEAENEG
940


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MPP7_pLDDT.png
all structure
all structure
ZEB1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MPP7
ZEB1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MPP7-ZEB1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MPP7-ZEB1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource