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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MPPED2-AMOTL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MPPED2-AMOTL1
	FusionPDB ID: 54771
	FusionGDB2.0 ID: 54771
		Hgene	Tgene
	Gene symbol	MPPED2	AMOTL1
	Gene ID	744	154810
	Gene name	metallophosphoesterase domain containing 2	angiomotin like 1
	Synonyms	239FB\|C11orf8	JEAP
	Cytomap	11p14.1	11q21
	Type of gene	protein-coding	protein-coding
	Description	metallophosphoesterase MPPED2fetal brain protein 239metallophosphoesterase domain-containing protein 2	angiomotin-like protein 1junction-enriched and associated protein
	Modification date	20200313	20200313
	UniProtAcc	Q15777	Q8IY63
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358117, ENST00000448418, ENST00000524667,	ENST00000539727, ENST00000317829, ENST00000317837, ENST00000433060,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 3 X 2=12	5 X 6 X 2=60
	# samples	3	6
	** MAII score	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/60*10)=0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MPPED2 [Title/Abstract] AND AMOTL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MPPED2(30601793)-AMOTL1(94554696), # samples:4
Anticipated loss of major functional domain due to fusion event.	MPPED2-AMOTL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MPPED2-AMOTL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MPPED2-AMOTL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MPPED2-AMOTL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MPPED2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AMOTL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-FG-5963-01A	MPPED2	chr11	30601793	-	AMOTL1	chr11	94554696	+
ChimerDB4	LGG	TCGA-FG-5963-02A	MPPED2	chr11	30601793	-	AMOTL1	chr11	94554696	+
ChimerDB4	LGG	TCGA-FG-5963	MPPED2	chr11	30601792	-	AMOTL1	chr11	94554695	+
ChimerDB4	LGG	TCGA-FG-5963	MPPED2	chr11	30601793	-	AMOTL1	chr11	94554696	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000448418	MPPED2	chr11	30601793	-	ENST00000317829	AMOTL1	chr11	94554696	+	8192	489	361	2238	625
ENST00000448418	MPPED2	chr11	30601793	-	ENST00000317837	AMOTL1	chr11	94554696	+	6958	489	361	999	212
ENST00000448418	MPPED2	chr11	30601793	-	ENST00000433060	AMOTL1	chr11	94554696	+	8197	489	361	2238	625
ENST00000448418	MPPED2	chr11	30601792	-	ENST00000317829	AMOTL1	chr11	94554695	+	8192	489	361	2238	625
ENST00000448418	MPPED2	chr11	30601792	-	ENST00000317837	AMOTL1	chr11	94554695	+	6958	489	361	999	212
ENST00000448418	MPPED2	chr11	30601792	-	ENST00000433060	AMOTL1	chr11	94554695	+	8197	489	361	2238	625

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000448418	ENST00000317829	MPPED2	chr11	30601793	-	AMOTL1	chr11	94554696	+	0.002435688	0.9975643
ENST00000448418	ENST00000317837	MPPED2	chr11	30601793	-	AMOTL1	chr11	94554696	+	0.093420334	0.9065797
ENST00000448418	ENST00000433060	MPPED2	chr11	30601793	-	AMOTL1	chr11	94554696	+	0.002409392	0.99759066
ENST00000448418	ENST00000317829	MPPED2	chr11	30601792	-	AMOTL1	chr11	94554695	+	0.002435688	0.9975643
ENST00000448418	ENST00000317837	MPPED2	chr11	30601792	-	AMOTL1	chr11	94554695	+	0.093420334	0.9065797
ENST00000448418	ENST00000433060	MPPED2	chr11	30601792	-	AMOTL1	chr11	94554695	+	0.002409392	0.99759066

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54771_54771_1_MPPED2-AMOTL1_MPPED2_chr11_30601792_ENST00000448418_AMOTL1_chr11_94554695_ENST00000317829_length(amino acids)=625AA_BP=43
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPP
PAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRL
HDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELRE
KQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEADMTKWEQKY
LEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAG
KTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTG

--------------------------------------------------------------

>54771_54771_2_MPPED2-AMOTL1_MPPED2_chr11_30601792_ENST00000448418_AMOTL1_chr11_94554695_ENST00000317837_length(amino acids)=212AA_BP=43
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMNFRTSLTSSQLAEEKKEEKTWKGSIGLLLG
KEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTGSKDSSTQTDKSAELFWPSMASLPSRGRLSTTPAHSPVLKHPAAKGTAEKLENS

--------------------------------------------------------------

>54771_54771_3_MPPED2-AMOTL1_MPPED2_chr11_30601792_ENST00000448418_AMOTL1_chr11_94554695_ENST00000433060_length(amino acids)=625AA_BP=43
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPP
PAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRL
HDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELRE
KQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEADMTKWEQKY
LEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAG
KTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTG

--------------------------------------------------------------

>54771_54771_4_MPPED2-AMOTL1_MPPED2_chr11_30601793_ENST00000448418_AMOTL1_chr11_94554696_ENST00000317829_length(amino acids)=625AA_BP=43
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPP
PAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRL
HDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELRE
KQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEADMTKWEQKY
LEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAG
KTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTG

--------------------------------------------------------------

>54771_54771_5_MPPED2-AMOTL1_MPPED2_chr11_30601793_ENST00000448418_AMOTL1_chr11_94554696_ENST00000317837_length(amino acids)=212AA_BP=43
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMNFRTSLTSSQLAEEKKEEKTWKGSIGLLLG
KEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTGSKDSSTQTDKSAELFWPSMASLPSRGRLSTTPAHSPVLKHPAAKGTAEKLENS

--------------------------------------------------------------

>54771_54771_6_MPPED2-AMOTL1_MPPED2_chr11_30601793_ENST00000448418_AMOTL1_chr11_94554696_ENST00000433060_length(amino acids)=625AA_BP=43
MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPP
PAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRL
HDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELRE
KQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEADMTKWEQKY
LEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAG
KTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:30601793/chr11:94554696)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MPPED2 Q15777	AMOTL1 Q8IY63
FUNCTION: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. {ECO:0000250\|UniProtKB:B1WBP0}.	FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269\|PubMed:22362771}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000317829

438_639

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000317829

665_694

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000317829

729_762

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000433060

438_639

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000433060

665_694

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000433060

729_762

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000317829

438_639

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000317829

665_694

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000317829

729_762

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000433060

438_639

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000433060

665_694

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000433060

729_762

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000317829

953_956

323.6666666666667

907.0

Motif

Note=PDZ-binding

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000433060

953_956

373.6666666666667

957.0

Motif

Note=PDZ-binding

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000317829

953_956

323.6666666666667

907.0

Motif

Note=PDZ-binding

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000433060

953_956

373.6666666666667

957.0

Motif

Note=PDZ-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPPED2

chr11:30601792

chr11:94554695

ENST00000358117

117_118

42.666666666666664

295.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601792

chr11:94554695

ENST00000358117

252_255

42.666666666666664

295.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601792

chr11:94554695

ENST00000448418

117_118

42.666666666666664

278.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601792

chr11:94554695

ENST00000448418

252_255

42.666666666666664

278.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601793

chr11:94554696

ENST00000358117

117_118

42.666666666666664

295.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601793

chr11:94554696

ENST00000358117

252_255

42.666666666666664

295.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601793

chr11:94554696

ENST00000448418

117_118

42.666666666666664

278.0

Nucleotide binding

AMP or GMP

Hgene

MPPED2

chr11:30601793

chr11:94554696

ENST00000448418

252_255

42.666666666666664

278.0

Nucleotide binding

AMP or GMP

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000317829

259_279

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601792

chr11:94554695

ENST00000433060

259_279

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000317829

259_279

323.6666666666667

907.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

AMOTL1

chr11:30601793

chr11:94554696

ENST00000433060

259_279

373.6666666666667

957.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1315_MPPED2_30601793_AMOTL1_94554696_1315_MPPED2_30601793_AMOTL1_94554696_ranked_0.pdb	MPPED2	30601792	30601793	ENST00000433060	AMOTL1	chr11	94554696	+	MAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHIRPCQLPFPSTMQQHSPMSSQTSSASGPLHSVSLPLPLPMALGAPQPP PAASPSQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEIRRL HDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELRE KQAYVEKVEKLQQALTQLQSACEKREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEADMTKWEQKY LEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAG KTDSSSLRPARSVPSIAAATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSSIASTTAASSAHAKTG	625

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MPPED2_pLDDT.png

AMOTL1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MPPED2
AMOTL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MPPED2-AMOTL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MPPED2-AMOTL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source