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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MPRIP-TOM1L2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MPRIP-TOM1L2
	FusionPDB ID: 54793
	FusionGDB2.0 ID: 54793
		Hgene	Tgene
	Gene symbol	MPRIP	TOM1L2
	Gene ID	23164	146691
	Gene name	myosin phosphatase Rho interacting protein	target of myb1 like 2 membrane trafficking protein
	Synonyms	M-RIP\|MRIP\|RHOIP3\|RIP3\|p116Rip	-
	Cytomap	17p11.2	17p11.2
	Type of gene	protein-coding	protein-coding
	Description	myosin phosphatase Rho-interacting proteinRho interacting protein 3	TOM1-like protein 2target of Myb-like protein 2target of myb1-like 2
	Modification date	20200313	20200313
	UniProtAcc	Q6WCQ1	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000395807, ENST00000341712, ENST00000395804, ENST00000395806, ENST00000395811, ENST00000444976,	ENST00000318094, ENST00000379504, ENST00000395739, ENST00000478943, ENST00000535933, ENST00000540946, ENST00000542206, ENST00000581396, ENST00000577517,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	24 X 12 X 11=3168	8 X 8 X 4=256
	# samples	23	8
	** MAII score	log2(23/3168*10)=-3.78386656913523 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MPRIP [Title/Abstract] AND TOM1L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MPRIP(16946285)-TOM1L2(17766162), # samples:4
Anticipated loss of major functional domain due to fusion event.	MPRIP-TOM1L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MPRIP-TOM1L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MPRIP-TOM1L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MPRIP-TOM1L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MPRIP-TOM1L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MPRIP-TOM1L2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TOM1L2	GO:0007165	signal transduction	16479011
Tgene	TOM1L2	GO:0045839	negative regulation of mitotic nuclear division	16479011

Fusion gene breakpoints across MPRIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TOM1L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-K4-A5RH-01A	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-
ChimerDB4	BLCA	TCGA-K4-A5RH-01A	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-
ChimerDB4	BLCA	TCGA-K4-A5RH-01A	MPRIP	chr17	16946285	-	TOM1L2	chr17	17766162	-
ChimerDB4	BLCA	TCGA-K4-A5RH-01A	MPRIP	chr17	16946285	+	TOM1L2	chr17	17766162	-
ChimerDB4	BLCA	TCGA-K4-A5RH	MPRIP	chr17	16946285	+	TOM1L2	chr17	17766162	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17754266	-	4579	212	729	154	191
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17754266	-	1268	212	729	154	191
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17754266	-	1244	212	729	154	191
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17754266	-	744	212	729	154	191
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17754266	-	647	212	627	154	157
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17754266	-	4570	203	720	145	191
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17754266	-	1259	203	720	145	191
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17754266	-	1235	203	720	145	191
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17754266	-	735	203	720	145	191
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17754266	-	638	203	618	145	157
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17754266	-	4546	179	696	121	191
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17754266	-	1235	179	696	121	191
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17754266	-	1211	179	696	121	191
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17754266	-	711	179	696	121	191
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17754266	-	614	179	594	121	157
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17754266	-	4490	123	640	65	191
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17754266	-	1179	123	640	65	191
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17754266	-	1155	123	640	65	191
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17754266	-	655	123	0	368	122
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17754266	-	558	123	538	65	157
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17754266	-	4579	212	729	154	191
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17754266	-	1268	212	729	154	191
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17754266	-	1244	212	729	154	191
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17754266	-	744	212	729	154	191
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17754266	-	647	212	627	154	157
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17752173	-	4519	212	2631	3155	174
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17752173	-	1208	212	669	154	171
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17752173	-	1184	212	669	154	171
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17752173	-	684	212	669	154	171
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17752173	-	587	212	567	154	137
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000540946	TOM1L2	chr17	17752173	-	564	212	561	154	135
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000542206	TOM1L2	chr17	17752173	-	464	212	89	397	102
ENST00000395811	MPRIP	chr17	16946285	+	ENST00000478943	TOM1L2	chr17	17752173	-	1208	212	669	154	171
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17752173	-	4510	203	2622	3146	174
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17752173	-	1199	203	660	145	171
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17752173	-	1175	203	660	145	171
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17752173	-	675	203	660	145	171
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17752173	-	578	203	558	145	137
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000540946	TOM1L2	chr17	17752173	-	555	203	552	145	135
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000542206	TOM1L2	chr17	17752173	-	455	203	80	388	102
ENST00000444976	MPRIP	chr17	16946285	+	ENST00000478943	TOM1L2	chr17	17752173	-	1199	203	660	145	171
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17752173	-	4486	179	2598	3122	174
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17752173	-	1175	179	636	121	171
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17752173	-	1151	179	636	121	171
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17752173	-	651	179	636	121	171
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17752173	-	554	179	534	121	137
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000540946	TOM1L2	chr17	17752173	-	531	179	528	121	135
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000542206	TOM1L2	chr17	17752173	-	431	179	56	364	102
ENST00000395804	MPRIP	chr17	16946285	+	ENST00000478943	TOM1L2	chr17	17752173	-	1175	179	636	121	171
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17752173	-	4430	123	2542	3066	174
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17752173	-	1119	123	580	65	171
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17752173	-	1095	123	580	65	171
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17752173	-	595	123	130	462	110
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17752173	-	498	123	478	65	137
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000540946	TOM1L2	chr17	17752173	-	475	123	130	462	110
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000542206	TOM1L2	chr17	17752173	-	375	123	0	308	102
ENST00000341712	MPRIP	chr17	16946285	+	ENST00000478943	TOM1L2	chr17	17752173	-	1119	123	580	65	171
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000581396	TOM1L2	chr17	17752173	-	4519	212	2631	3155	174
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000379504	TOM1L2	chr17	17752173	-	1208	212	669	154	171
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000318094	TOM1L2	chr17	17752173	-	1184	212	669	154	171
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000395739	TOM1L2	chr17	17752173	-	684	212	669	154	171
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000535933	TOM1L2	chr17	17752173	-	587	212	567	154	137
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000540946	TOM1L2	chr17	17752173	-	564	212	561	154	135
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000542206	TOM1L2	chr17	17752173	-	464	212	89	397	102
ENST00000395806	MPRIP	chr17	16946285	+	ENST00000478943	TOM1L2	chr17	17752173	-	1208	212	669	154	171

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395811	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.32522044	0.6747796
ENST00000395811	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.007047309	0.99295264
ENST00000395811	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.006823722	0.9931763
ENST00000395811	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.004870143	0.9951298
ENST00000395811	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.003760051	0.9962399
ENST00000444976	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.32439384	0.6756062
ENST00000444976	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.007701246	0.9922988
ENST00000444976	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.008048854	0.9919511
ENST00000444976	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.004899781	0.9951002
ENST00000444976	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.00400046	0.9959996
ENST00000395804	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.32172772	0.67827225
ENST00000395804	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.007280222	0.99271977
ENST00000395804	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.007758268	0.99224174
ENST00000395804	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.00373213	0.99626786
ENST00000395804	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.002404956	0.997595
ENST00000341712	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.37206277	0.6279372
ENST00000341712	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.014856789	0.98514324
ENST00000341712	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.015430579	0.9845694
ENST00000341712	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.011058683	0.9889414
ENST00000341712	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.008266573	0.99173343
ENST00000395806	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.32522044	0.6747796
ENST00000395806	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.007047309	0.99295264
ENST00000395806	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.006823722	0.9931763
ENST00000395806	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.004870143	0.9951298
ENST00000395806	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17754266	-	0.003760051	0.9962399
ENST00000395811	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.33253974	0.66746026
ENST00000395811	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.23571065	0.7642893
ENST00000395811	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.2527377	0.7472623
ENST00000395811	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.16530368	0.83469635
ENST00000395811	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.095093444	0.9049066
ENST00000395811	ENST00000540946	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.09051138	0.9094886
ENST00000395811	ENST00000542206	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.012733986	0.98726606
ENST00000395811	ENST00000478943	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.23571065	0.7642893
ENST00000444976	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.33172712	0.6682729
ENST00000444976	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.30033788	0.69966215
ENST00000444976	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.32763627	0.67236376
ENST00000444976	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.18315978	0.8168402
ENST00000444976	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.0796148	0.9203852
ENST00000444976	ENST00000540946	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.08668317	0.91331685
ENST00000444976	ENST00000542206	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.013391672	0.9866084
ENST00000444976	ENST00000478943	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.30033788	0.69966215
ENST00000395804	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.32868153	0.6713185
ENST00000395804	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.24268414	0.7573159
ENST00000395804	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.24852704	0.751473
ENST00000395804	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.13529374	0.8647063
ENST00000395804	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.08268223	0.9173178
ENST00000395804	ENST00000540946	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.08866942	0.9113305
ENST00000395804	ENST00000542206	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.010883939	0.989116
ENST00000395804	ENST00000478943	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.24268414	0.7573159
ENST00000341712	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.3834524	0.6165476
ENST00000341712	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.40530118	0.5946988
ENST00000341712	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.43503505	0.5649649
ENST00000341712	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.25309384	0.7469062
ENST00000341712	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.26392347	0.73607653
ENST00000341712	ENST00000540946	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.23265442	0.76734555
ENST00000341712	ENST00000542206	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.023673045	0.97632694
ENST00000341712	ENST00000478943	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.40530118	0.5946988
ENST00000395806	ENST00000581396	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.33253974	0.66746026
ENST00000395806	ENST00000379504	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.23571065	0.7642893
ENST00000395806	ENST00000318094	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.2527377	0.7472623
ENST00000395806	ENST00000395739	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.16530368	0.83469635
ENST00000395806	ENST00000535933	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.095093444	0.9049066
ENST00000395806	ENST00000540946	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.09051138	0.9094886
ENST00000395806	ENST00000542206	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.012733986	0.98726606
ENST00000395806	ENST00000478943	MPRIP	chr17	16946285	+	TOM1L2	chr17	17752173	-	0.23571065	0.7642893

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54793_54793_1_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000318094_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_2_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000379504_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_3_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000395739_length(amino acids)=110AA_BP=0
MIWRRVSQVKSLINSLKKEPKLLKWFPTSPRPPWRLLPQPQTLLAGRSQSGQRMPSSPCEQLCGLPPQMAGPRSHPVDTGHWPLLHPQLH

--------------------------------------------------------------

>54793_54793_4_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000478943_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_5_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000535933_length(amino acids)=137AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_6_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000540946_length(amino acids)=110AA_BP=0
MIWRRVSQVKSLINSLKKEPKLLKWFPTSPRPPWRLLPQPQTLLAGRSQSGQRMPSSPCEQLCGLPPQMAGPRSHPVDTGHWPLLHPQLH

--------------------------------------------------------------

>54793_54793_7_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000542206_length(amino acids)=102AA_BP=38
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQKGDDLEEGVTSEEFDKFLEERAKAAEMVPDLPSPPMEAPAPASNPSGRK

--------------------------------------------------------------

>54793_54793_8_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17752173_ENST00000581396_length(amino acids)=174AA_BP=
MFFIPTPRTAPLQLQRQRQLVARHHWRGLAAPGAAGSGGPVWAGRRPLAMLTSVTCLPSLEPPLRWPACTSYPEVACPTCRQRGLLLEAC

--------------------------------------------------------------

>54793_54793_9_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17754266_ENST00000318094_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_10_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17754266_ENST00000379504_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_11_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17754266_ENST00000395739_length(amino acids)=122AA_BP=41
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQIPVAQPSVMDDIEVWLRTDLKGDDLEEGVTSEEFDKFLEERAKAAEMVP

--------------------------------------------------------------

>54793_54793_12_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17754266_ENST00000535933_length(amino acids)=157AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_13_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000341712_TOM1L2_chr17_17754266_ENST00000581396_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_14_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000318094_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_15_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000379504_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_16_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000395739_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_17_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000478943_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_18_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000535933_length(amino acids)=137AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_19_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000540946_length(amino acids)=135AA_BP=0
LVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGT

--------------------------------------------------------------

>54793_54793_20_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000542206_length(amino acids)=102AA_BP=38
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQKGDDLEEGVTSEEFDKFLEERAKAAEMVPDLPSPPMEAPAPASNPSGRK

--------------------------------------------------------------

>54793_54793_21_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17752173_ENST00000581396_length(amino acids)=174AA_BP=
MFFIPTPRTAPLQLQRQRQLVARHHWRGLAAPGAAGSGGPVWAGRRPLAMLTSVTCLPSLEPPLRWPACTSYPEVACPTCRQRGLLLEAC

--------------------------------------------------------------

>54793_54793_22_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17754266_ENST00000318094_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_23_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17754266_ENST00000379504_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_24_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17754266_ENST00000395739_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_25_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17754266_ENST00000535933_length(amino acids)=157AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_26_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395804_TOM1L2_chr17_17754266_ENST00000581396_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_27_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000318094_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_28_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000379504_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_29_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000395739_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_30_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000478943_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_31_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000535933_length(amino acids)=137AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_32_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000540946_length(amino acids)=135AA_BP=0
LVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGT

--------------------------------------------------------------

>54793_54793_33_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000542206_length(amino acids)=102AA_BP=38
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQKGDDLEEGVTSEEFDKFLEERAKAAEMVPDLPSPPMEAPAPASNPSGRK

--------------------------------------------------------------

>54793_54793_34_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17752173_ENST00000581396_length(amino acids)=174AA_BP=
MFFIPTPRTAPLQLQRQRQLVARHHWRGLAAPGAAGSGGPVWAGRRPLAMLTSVTCLPSLEPPLRWPACTSYPEVACPTCRQRGLLLEAC

--------------------------------------------------------------

>54793_54793_35_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17754266_ENST00000318094_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_36_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17754266_ENST00000379504_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_37_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17754266_ENST00000395739_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_38_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17754266_ENST00000535933_length(amino acids)=157AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_39_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395806_TOM1L2_chr17_17754266_ENST00000581396_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_40_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000318094_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_41_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000379504_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_42_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000395739_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_43_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000478943_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_44_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000535933_length(amino acids)=137AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_45_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000540946_length(amino acids)=135AA_BP=0
LVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGT

--------------------------------------------------------------

>54793_54793_46_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000542206_length(amino acids)=102AA_BP=38
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQKGDDLEEGVTSEEFDKFLEERAKAAEMVPDLPSPPMEAPAPASNPSGRK

--------------------------------------------------------------

>54793_54793_47_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17752173_ENST00000581396_length(amino acids)=174AA_BP=
MFFIPTPRTAPLQLQRQRQLVARHHWRGLAAPGAAGSGGPVWAGRRPLAMLTSVTCLPSLEPPLRWPACTSYPEVACPTCRQRGLLLEAC

--------------------------------------------------------------

>54793_54793_48_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17754266_ENST00000318094_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_49_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17754266_ENST00000379504_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_50_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17754266_ENST00000395739_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_51_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17754266_ENST00000535933_length(amino acids)=157AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_52_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000395811_TOM1L2_chr17_17754266_ENST00000581396_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_53_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000318094_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_54_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000379504_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_55_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000395739_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_56_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000478943_length(amino acids)=171AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA

--------------------------------------------------------------

>54793_54793_57_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000535933_length(amino acids)=137AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_58_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000540946_length(amino acids)=135AA_BP=0
LVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGT

--------------------------------------------------------------

>54793_54793_59_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000542206_length(amino acids)=102AA_BP=38
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQKGDDLEEGVTSEEFDKFLEERAKAAEMVPDLPSPPMEAPAPASNPSGRK

--------------------------------------------------------------

>54793_54793_60_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17752173_ENST00000581396_length(amino acids)=174AA_BP=
MFFIPTPRTAPLQLQRQRQLVARHHWRGLAAPGAAGSGGPVWAGRRPLAMLTSVTCLPSLEPPLRWPACTSYPEVACPTCRQRGLLLEAC

--------------------------------------------------------------

>54793_54793_61_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17754266_ENST00000318094_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_62_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17754266_ENST00000379504_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_63_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17754266_ENST00000395739_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

>54793_54793_64_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17754266_ENST00000535933_length(amino acids)=157AA_BP=1
MKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRAAHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRS

--------------------------------------------------------------

>54793_54793_65_MPRIP-TOM1L2_MPRIP_chr17_16946285_ENST00000444976_TOM1L2_chr17_17754266_ENST00000581396_length(amino acids)=191AA_BP=1
MPALPGRKHGQRGPWWEGRESLAAVVPPLREKKWLKLVLTSGRPGSRHGGISMETQVCRPCGAGDVGVASARCPRGASGDPPSGEANHRA
AHRAKRASSDRSGFFRPEGFEAGAGASMGGEGRSGTISAALALSSRNLSNSSLVTPSSRSSPFRSVLSHTSMSSMTDGCATGICVRSSSL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16946285/chr17:17766162)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MPRIP Q6WCQ1	.
FUNCTION: Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250\|UniProtKB:P97434, ECO:0000269\|PubMed:15545284, ECO:0000269\|PubMed:16257966}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000478943

219_307

179.0

241.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000478943

219_307

159.0

241.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000478943

329_334

179.0

241.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000478943

329_334

159.0

241.0

Motif

Note=Clathrin-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000341712

673_977

41.0

1231.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395804

673_977

41.0

1026.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395811

673_977

41.0

1039.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000444976

673_977

41.0

1001.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000341712

673_977

41.0

1231.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395804

673_977

41.0

1026.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395811

673_977

41.0

1039.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000444976

673_977

41.0

1001.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000341712

179_252

41.0

1231.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395804

179_252

41.0

1026.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395811

179_252

41.0

1039.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000444976

179_252

41.0

1001.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000341712

179_252

41.0

1231.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395804

179_252

41.0

1026.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395811

179_252

41.0

1039.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000444976

179_252

41.0

1001.0

Compositional bias

Note=Ser-rich

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000341712

387_483

41.0

1231.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000341712

43_150

41.0

1231.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395804

387_483

41.0

1026.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395804

43_150

41.0

1026.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395811

387_483

41.0

1039.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000395811

43_150

41.0

1039.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000444976

387_483

41.0

1001.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17752173

ENST00000444976

43_150

41.0

1001.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000341712

387_483

41.0

1231.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000341712

43_150

41.0

1231.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395804

387_483

41.0

1026.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395804

43_150

41.0

1026.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395811

387_483

41.0

1039.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000395811

43_150

41.0

1039.0

Domain

PH 1

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000444976

387_483

41.0

1001.0

Domain

PH 2

Hgene

MPRIP

chr17:16946285

chr17:17754266

ENST00000444976

43_150

41.0

1001.0

Domain

PH 1

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000318094

20_152

401.0

463.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000318094

219_307

401.0

463.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000379504

20_152

446.0

508.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000379504

219_307

446.0

508.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000395739

20_152

401.0

463.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000395739

219_307

401.0

463.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000478943

20_152

179.0

241.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000581396

20_152

396.0

458.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000581396

219_307

396.0

458.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000318094

20_152

381.0

463.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000318094

219_307

381.0

463.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000379504

20_152

426.0

508.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000379504

219_307

426.0

508.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000395739

20_152

381.0

463.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000395739

219_307

381.0

463.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000478943

20_152

159.0

241.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000581396

20_152

376.0

458.0

Domain

VHS

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000581396

219_307

376.0

458.0

Domain

GAT

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000318094

329_334

401.0

463.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000379504

329_334

446.0

508.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000395739

329_334

401.0

463.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17752173

ENST00000581396

329_334

396.0

458.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000318094

329_334

381.0

463.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000379504

329_334

426.0

508.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000395739

329_334

381.0

463.0

Motif

Note=Clathrin-binding

Tgene

TOM1L2

chr17:16946285

chr17:17754266

ENST00000581396

329_334

376.0

458.0

Motif

Note=Clathrin-binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MPRIP
TOM1L2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000341712	+	1	24	2_383	41.0	1231.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000395804	+	1	23	2_383	41.0	1026.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000395811	+	1	23	2_383	41.0	1039.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000444976	+	1	22	2_383	41.0	1001.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000341712	+	1	24	2_383	41.0	1231.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000395804	+	1	23	2_383	41.0	1026.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000395811	+	1	23	2_383	41.0	1039.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000444976	+	1	22	2_383	41.0	1001.0	F-actin
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000341712	+	1	24	824_879	41.0	1231.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000395804	+	1	23	824_879	41.0	1026.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000395811	+	1	23	824_879	41.0	1039.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000444976	+	1	22	824_879	41.0	1001.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000341712	+	1	24	824_879	41.0	1231.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000395804	+	1	23	824_879	41.0	1026.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000395811	+	1	23	824_879	41.0	1039.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000444976	+	1	22	824_879	41.0	1001.0	PPP1R12A
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000341712	+	1	24	546_824	41.0	1231.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000395804	+	1	23	546_824	41.0	1026.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000395811	+	1	23	546_824	41.0	1039.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17752173	ENST00000444976	+	1	22	546_824	41.0	1001.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000341712	+	1	24	546_824	41.0	1231.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000395804	+	1	23	546_824	41.0	1026.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000395811	+	1	23	546_824	41.0	1039.0	RHOA
Hgene	MPRIP	chr17:16946285	chr17:17754266	ENST00000444976	+	1	22	546_824	41.0	1001.0	RHOA

Top

Related Drugs to MPRIP-TOM1L2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MPRIP-TOM1L2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source