UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MRPL35-CTNNA2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MRPL35-CTNNA2
	FusionPDB ID: 55016
	FusionGDB2.0 ID: 55016
		Hgene	Tgene
	Gene symbol	MRPL35	CTNNA2
	Gene ID	51318	1496
	Gene name	mitochondrial ribosomal protein L35	catenin alpha 2
	Synonyms	L35mt\|MRP-L35	CAP-R\|CAPR\|CDCBM9\|CT114\|CTNR
	Cytomap	2p11.2	2p12
	Type of gene	protein-coding	protein-coding
	Description	39S ribosomal protein L35, mitochondrialmitochondrial large ribosomal subunit protein bL35m	catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
	Modification date	20200313	20200313
	UniProtAcc	Q9NZE8	P26232
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000254644, ENST00000337109, ENST00000409180, ENST00000605125,	ENST00000409266, ENST00000496251, ENST00000343114, ENST00000361291, ENST00000402739, ENST00000466387, ENST00000496558, ENST00000540488, ENST00000541047,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 4=320	26 X 24 X 10=6240
	# samples	10	28
	** MAII score	log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/6240*10)=-4.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MRPL35 [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MRPL35(86434450)-CTNNA2(80772107), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MRPL35 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CTNNA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-18-3414-01A	MRPL35	chr2	86434450	-	CTNNA2	chr2	80772107	+
ChimerDB4	LUSC	TCGA-18-3414-01A	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+
ChimerDB4	LUSC	TCGA-18-3414	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000466387	CTNNA2	chr2	80772107	+	2849	514	136	1941	601
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000496558	CTNNA2	chr2	80772107	+	2850	514	136	1941	601
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000361291	CTNNA2	chr2	80772107	+	1942	514	136	1941	602
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000402739	CTNNA2	chr2	80772107	+	2903	514	136	2085	649
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000540488	CTNNA2	chr2	80772107	+	1807	514	136	1806	557
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000541047	CTNNA2	chr2	80772107	+	2849	514	136	1941	601
ENST00000254644	MRPL35	chr2	86434450	+	ENST00000343114	CTNNA2	chr2	80772107	+	2850	514	136	1941	601
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000466387	CTNNA2	chr2	80772107	+	2747	412	34	1839	601
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000496558	CTNNA2	chr2	80772107	+	2748	412	34	1839	601
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000361291	CTNNA2	chr2	80772107	+	1840	412	34	1839	602
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000402739	CTNNA2	chr2	80772107	+	2801	412	34	1983	649
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000540488	CTNNA2	chr2	80772107	+	1705	412	34	1704	557
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000541047	CTNNA2	chr2	80772107	+	2747	412	34	1839	601
ENST00000337109	MRPL35	chr2	86434450	+	ENST00000343114	CTNNA2	chr2	80772107	+	2748	412	34	1839	601
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000466387	CTNNA2	chr2	80772107	+	2741	406	28	1833	601
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000496558	CTNNA2	chr2	80772107	+	2742	406	28	1833	601
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000361291	CTNNA2	chr2	80772107	+	1834	406	28	1833	602
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000402739	CTNNA2	chr2	80772107	+	2795	406	28	1977	649
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000540488	CTNNA2	chr2	80772107	+	1699	406	28	1698	557
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000541047	CTNNA2	chr2	80772107	+	2741	406	28	1833	601
ENST00000409180	MRPL35	chr2	86434450	+	ENST00000343114	CTNNA2	chr2	80772107	+	2742	406	28	1833	601

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000254644	ENST00000466387	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002261953	0.997738
ENST00000254644	ENST00000496558	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002249756	0.9977502
ENST00000254644	ENST00000361291	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.004601764	0.9953982
ENST00000254644	ENST00000402739	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.003223653	0.9967764
ENST00000254644	ENST00000540488	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.0035309	0.99646914
ENST00000254644	ENST00000541047	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002261953	0.997738
ENST00000254644	ENST00000343114	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002249756	0.9977502
ENST00000337109	ENST00000466387	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002573915	0.9974261
ENST00000337109	ENST00000496558	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002569559	0.9974304
ENST00000337109	ENST00000361291	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.005698697	0.9943013
ENST00000337109	ENST00000402739	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.0036519	0.9963481
ENST00000337109	ENST00000540488	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.004757954	0.9952421
ENST00000337109	ENST00000541047	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002573915	0.9974261
ENST00000337109	ENST00000343114	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002569559	0.9974304
ENST00000409180	ENST00000466387	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002627702	0.99737227
ENST00000409180	ENST00000496558	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002617352	0.9973826
ENST00000409180	ENST00000361291	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.005568373	0.9944317
ENST00000409180	ENST00000402739	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.003689004	0.996311
ENST00000409180	ENST00000540488	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.004625069	0.995375
ENST00000409180	ENST00000541047	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002627702	0.99737227
ENST00000409180	ENST00000343114	MRPL35	chr2	86434450	+	CTNNA2	chr2	80772107	+	0.002617352	0.9973826

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55016_55016_1_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000343114_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_2_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000361291_length(amino acids)=602AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_3_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000402739_length(amino acids)=649AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCA
EGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQ

--------------------------------------------------------------

>55016_55016_4_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000466387_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_5_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000496558_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_6_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000540488_length(amino acids)=557AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKH

--------------------------------------------------------------

>55016_55016_7_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000541047_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_8_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000343114_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_9_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000361291_length(amino acids)=602AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_10_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000402739_length(amino acids)=649AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCA
EGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQ

--------------------------------------------------------------

>55016_55016_11_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000466387_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_12_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000496558_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_13_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000540488_length(amino acids)=557AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKH

--------------------------------------------------------------

>55016_55016_14_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000541047_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_15_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000343114_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_16_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000361291_length(amino acids)=602AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_17_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000402739_length(amino acids)=649AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCA
EGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQ

--------------------------------------------------------------

>55016_55016_18_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000466387_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_19_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000496558_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

>55016_55016_20_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000540488_length(amino acids)=557AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKH

--------------------------------------------------------------

>55016_55016_21_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000541047_length(amino acids)=601AA_BP=126
MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP
VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV
FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT
KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA
GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR
MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86434450/chr2:80772107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MRPL35 Q9NZE8	CTNNA2 P26232
	FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250\|UniProtKB:Q61301, ECO:0000269\|PubMed:30013181}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MRPL35_pLDDT.png

CTNNA2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MRPL35
CTNNA2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MRPL35-CTNNA2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MRPL35-CTNNA2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source