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Fusion Protein:MRPL35-CTNNA2 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: MRPL35-CTNNA2 | FusionPDB ID: 55016 | FusionGDB2.0 ID: 55016 | Hgene | Tgene | Gene symbol | MRPL35 | CTNNA2 | Gene ID | 51318 | 1496 |
Gene name | mitochondrial ribosomal protein L35 | catenin alpha 2 | |
Synonyms | L35mt|MRP-L35 | CAP-R|CAPR|CDCBM9|CT114|CTNR | |
Cytomap | 2p11.2 | 2p12 | |
Type of gene | protein-coding | protein-coding | |
Description | 39S ribosomal protein L35, mitochondrialmitochondrial large ribosomal subunit protein bL35m | catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9NZE8 | P26232 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000254644, ENST00000337109, ENST00000409180, ENST00000605125, | ENST00000409266, ENST00000496251, ENST00000343114, ENST00000361291, ENST00000402739, ENST00000466387, ENST00000496558, ENST00000540488, ENST00000541047, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 10 X 8 X 4=320 | 26 X 24 X 10=6240 |
# samples | 10 | 28 | |
** MAII score | log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/6240*10)=-4.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: MRPL35 [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MRPL35(86434450)-CTNNA2(80772107), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-18-3414-01A | MRPL35 | chr2 | 86434450 | - | CTNNA2 | chr2 | 80772107 | + |
ChimerDB4 | LUSC | TCGA-18-3414-01A | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + |
ChimerDB4 | LUSC | TCGA-18-3414 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000466387 | CTNNA2 | chr2 | 80772107 | + | 2849 | 514 | 136 | 1941 | 601 |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000496558 | CTNNA2 | chr2 | 80772107 | + | 2850 | 514 | 136 | 1941 | 601 |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000361291 | CTNNA2 | chr2 | 80772107 | + | 1942 | 514 | 136 | 1941 | 602 |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000402739 | CTNNA2 | chr2 | 80772107 | + | 2903 | 514 | 136 | 2085 | 649 |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000540488 | CTNNA2 | chr2 | 80772107 | + | 1807 | 514 | 136 | 1806 | 557 |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000541047 | CTNNA2 | chr2 | 80772107 | + | 2849 | 514 | 136 | 1941 | 601 |
ENST00000254644 | MRPL35 | chr2 | 86434450 | + | ENST00000343114 | CTNNA2 | chr2 | 80772107 | + | 2850 | 514 | 136 | 1941 | 601 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000466387 | CTNNA2 | chr2 | 80772107 | + | 2747 | 412 | 34 | 1839 | 601 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000496558 | CTNNA2 | chr2 | 80772107 | + | 2748 | 412 | 34 | 1839 | 601 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000361291 | CTNNA2 | chr2 | 80772107 | + | 1840 | 412 | 34 | 1839 | 602 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000402739 | CTNNA2 | chr2 | 80772107 | + | 2801 | 412 | 34 | 1983 | 649 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000540488 | CTNNA2 | chr2 | 80772107 | + | 1705 | 412 | 34 | 1704 | 557 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000541047 | CTNNA2 | chr2 | 80772107 | + | 2747 | 412 | 34 | 1839 | 601 |
ENST00000337109 | MRPL35 | chr2 | 86434450 | + | ENST00000343114 | CTNNA2 | chr2 | 80772107 | + | 2748 | 412 | 34 | 1839 | 601 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000466387 | CTNNA2 | chr2 | 80772107 | + | 2741 | 406 | 28 | 1833 | 601 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000496558 | CTNNA2 | chr2 | 80772107 | + | 2742 | 406 | 28 | 1833 | 601 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000361291 | CTNNA2 | chr2 | 80772107 | + | 1834 | 406 | 28 | 1833 | 602 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000402739 | CTNNA2 | chr2 | 80772107 | + | 2795 | 406 | 28 | 1977 | 649 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000540488 | CTNNA2 | chr2 | 80772107 | + | 1699 | 406 | 28 | 1698 | 557 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000541047 | CTNNA2 | chr2 | 80772107 | + | 2741 | 406 | 28 | 1833 | 601 |
ENST00000409180 | MRPL35 | chr2 | 86434450 | + | ENST00000343114 | CTNNA2 | chr2 | 80772107 | + | 2742 | 406 | 28 | 1833 | 601 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000254644 | ENST00000466387 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002261953 | 0.997738 |
ENST00000254644 | ENST00000496558 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002249756 | 0.9977502 |
ENST00000254644 | ENST00000361291 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.004601764 | 0.9953982 |
ENST00000254644 | ENST00000402739 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.003223653 | 0.9967764 |
ENST00000254644 | ENST00000540488 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.0035309 | 0.99646914 |
ENST00000254644 | ENST00000541047 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002261953 | 0.997738 |
ENST00000254644 | ENST00000343114 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002249756 | 0.9977502 |
ENST00000337109 | ENST00000466387 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002573915 | 0.9974261 |
ENST00000337109 | ENST00000496558 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002569559 | 0.9974304 |
ENST00000337109 | ENST00000361291 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.005698697 | 0.9943013 |
ENST00000337109 | ENST00000402739 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.0036519 | 0.9963481 |
ENST00000337109 | ENST00000540488 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.004757954 | 0.9952421 |
ENST00000337109 | ENST00000541047 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002573915 | 0.9974261 |
ENST00000337109 | ENST00000343114 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002569559 | 0.9974304 |
ENST00000409180 | ENST00000466387 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002627702 | 0.99737227 |
ENST00000409180 | ENST00000496558 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002617352 | 0.9973826 |
ENST00000409180 | ENST00000361291 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.005568373 | 0.9944317 |
ENST00000409180 | ENST00000402739 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.003689004 | 0.996311 |
ENST00000409180 | ENST00000540488 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.004625069 | 0.995375 |
ENST00000409180 | ENST00000541047 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002627702 | 0.99737227 |
ENST00000409180 | ENST00000343114 | MRPL35 | chr2 | 86434450 | + | CTNNA2 | chr2 | 80772107 | + | 0.002617352 | 0.9973826 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >55016_55016_1_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000343114_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_2_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000361291_length(amino acids)=602AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_3_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000402739_length(amino acids)=649AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCA EGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQ -------------------------------------------------------------- >55016_55016_4_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000466387_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_5_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000496558_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_6_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000540488_length(amino acids)=557AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKH -------------------------------------------------------------- >55016_55016_7_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000254644_CTNNA2_chr2_80772107_ENST00000541047_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_8_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000343114_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_9_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000361291_length(amino acids)=602AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_10_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000402739_length(amino acids)=649AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCA EGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQ -------------------------------------------------------------- >55016_55016_11_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000466387_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_12_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000496558_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_13_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000540488_length(amino acids)=557AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKH -------------------------------------------------------------- >55016_55016_14_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000337109_CTNNA2_chr2_80772107_ENST00000541047_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_15_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000343114_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_16_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000361291_length(amino acids)=602AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_17_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000402739_length(amino acids)=649AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCA EGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQ -------------------------------------------------------------- >55016_55016_18_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000466387_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_19_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000496558_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- >55016_55016_20_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000540488_length(amino acids)=557AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKH -------------------------------------------------------------- >55016_55016_21_MRPL35-CTNNA2_MRPL35_chr2_86434450_ENST00000409180_CTNNA2_chr2_80772107_ENST00000541047_length(amino acids)=601AA_BP=126 MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTGRFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLP VRSLTYFSARKGKRKTVKAVIDRFLRLHCGLWVRRKVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDV FKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEAT KLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSR MDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQK -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86434450/chr2:80772107) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
MRPL35 | CTNNA2 |
FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
MRPL35_pLDDT.png![]() |
CTNNA2_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
MRPL35 | |
CTNNA2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to MRPL35-CTNNA2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MRPL35-CTNNA2 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |