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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ABR-NXN

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ABR-NXN
	FusionPDB ID: 556
	FusionGDB2.0 ID: 556
		Hgene	Tgene
	Gene symbol	ABR	NXN
	Gene ID	29	64359
	Gene name	ABR activator of RhoGEF and GTPase	nucleoredoxin
	Synonyms	MDB	NRX\|RRS2\|TRG-4
	Cytomap	17p13.3	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related	nucleoredoxinnucleoredoxin 1
	Modification date	20200313	20200327
	UniProtAcc	Q15018	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000291107, ENST00000302538, ENST00000536794, ENST00000544583, ENST00000574437, ENST00000543210, ENST00000572441, ENST00000573895,	ENST00000537628, ENST00000575801, ENST00000577098, ENST00000538650, ENST00000336868,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	23 X 15 X 14=4830	17 X 15 X 5=1275
	# samples	36	20
	** MAII score	log2(36/4830*10)=-3.74595437739346 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1275*10)=-2.6724253419715 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ABR [Title/Abstract] AND NXN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NXN(882559)-ABR(916404), # samples:5 ABR(953290)-NXN(729318), # samples:2
Anticipated loss of major functional domain due to fusion event.	ABR-NXN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-NXN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-NXN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-NXN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NXN-ABR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NXN-ABR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABR-NXN seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ABR-NXN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABR	GO:0090630	activation of GTPase activity	7479768

Fusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NXN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A66P-01A	ABR	chr17	953290	-	NXN	chr17	729318	-
ChimerDB4	LUAD	TCGA-91-6836-01A	ABR	chr17	1082961	-	NXN	chr17	729318	-
ChimerDB4	SKCM	TCGA-D3-A3CC-06A	ABR	chr17	953290	-	NXN	chr17	729318	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000302538	ABR	chr17	953290	-	ENST00000336868	NXN	chr17	729318	-	4522	1938	147	2885	912
ENST00000574437	ABR	chr17	953290	-	ENST00000336868	NXN	chr17	729318	-	4702	2118	123	3065	980
ENST00000291107	ABR	chr17	953290	-	ENST00000336868	NXN	chr17	729318	-	4296	1712	32	2659	875
ENST00000536794	ABR	chr17	953290	-	ENST00000336868	NXN	chr17	729318	-	4008	1424	140	2371	743
ENST00000302538	ABR	chr17	1082961	-	ENST00000336868	NXN	chr17	729318	-	2792	208	298	1155	285

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000302538	ENST00000336868	ABR	chr17	953290	-	NXN	chr17	729318	-	0.00139378	0.99860626
ENST00000574437	ENST00000336868	ABR	chr17	953290	-	NXN	chr17	729318	-	0.002188315	0.99781173
ENST00000291107	ENST00000336868	ABR	chr17	953290	-	NXN	chr17	729318	-	0.002950157	0.9970498
ENST00000536794	ENST00000336868	ABR	chr17	953290	-	NXN	chr17	729318	-	0.010014015	0.989986
ENST00000302538	ENST00000336868	ABR	chr17	1082961	-	NXN	chr17	729318	-	0.002810958	0.9971891

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>556_556_1_ABR-NXN_ABR_chr17_1082961_ENST00000302538_NXN_chr17_729318_ENST00000336868_length(amino acids)=285AA_BP=
MLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSE
ESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLV
LFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEA

--------------------------------------------------------------

>556_556_2_ABR-NXN_ABR_chr17_953290_ENST00000291107_NXN_chr17_729318_ENST00000336868_length(amino acids)=875AA_BP=0
MEEEEEAIGLLDKVLEDEDVFLLEECELGTPTSPGSGSPFLVAVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTS
QPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKV
KGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGF
LVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKAN
KGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHN
IPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKT
KVNKDNNEIVDKIMGKGQIQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSS
LEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIM
LDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLF

--------------------------------------------------------------

>556_556_3_ABR-NXN_ABR_chr17_953290_ENST00000302538_NXN_chr17_729318_ENST00000336868_length(amino acids)=912AA_BP=0
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE
MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA
LRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEW
REAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
RVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLV
IRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESF
KQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFV
DSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVN

--------------------------------------------------------------

>556_556_4_ABR-NXN_ABR_chr17_953290_ENST00000536794_NXN_chr17_729318_ENST00000336868_length(amino acids)=743AA_BP=1
MLEEHSGAAARCWSPCGSISKVAEWPGCWWAPGSLERWLHAPAAGTEAAMEILLIIRFCCNCTYALLYKPIDRVTRSTLVLHDLLKHTPV
DHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWY
IPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLF
LLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVD
SFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLKLWNKYRISNIPSLIFLDATT
GKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEII
FVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQ
LNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEE

--------------------------------------------------------------

>556_556_5_ABR-NXN_ABR_chr17_953290_ENST00000574437_NXN_chr17_729318_ENST00000336868_length(amino acids)=980AA_BP=1
MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF
SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA
LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCS
QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAV
TTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKM
KISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVEL
QVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGS
QSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIA
GPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSR
LNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:882559/chr17:916404)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABR Q15018	.
FUNCTION: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250\|UniProtKB:Q3TCJ1, ECO:0000269\|PubMed:19214193, ECO:0000269\|PubMed:20032457, ECO:0000269\|PubMed:20656690, ECO:0000269\|PubMed:24075985, ECO:0000269\|PubMed:25283148}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABR

chr17:953290

chr17:729318

ENST00000291107

417_420

560.0

823.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953290

chr17:729318

ENST00000302538

417_420

597.0

860.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953290

chr17:729318

ENST00000544583

417_420

551.0

814.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953290

chr17:729318

ENST00000574437

417_420

551.0

814.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953290

chr17:729318

ENST00000291107

301_459

560.0

823.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000291107

91_284

560.0

823.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000302538

301_459

597.0

860.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000302538

91_284

597.0

860.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000544583

301_459

551.0

814.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000544583

91_284

551.0

814.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000574437

301_459

551.0

814.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000574437

91_284

551.0

814.0

Domain

Tgene

NXN

chr17:1082961

chr17:729318

ENST00000336868

167_321

120.0

436.0

Domain

Thioredoxin

Tgene

NXN

chr17:1082961

chr17:729318

ENST00000537628

167_321

187.0

Domain

Thioredoxin

Tgene

NXN

chr17:1082961

chr17:729318

ENST00000575801

167_321

12.0

328.0

Domain

Thioredoxin

Tgene

NXN

chr17:953290

chr17:729318

ENST00000336868

167_321

120.0

436.0

Domain

Thioredoxin

Tgene

NXN

chr17:953290

chr17:729318

ENST00000537628

167_321

187.0

Domain

Thioredoxin

Tgene

NXN

chr17:953290

chr17:729318

ENST00000575801

167_321

12.0

328.0

Domain

Thioredoxin

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000291107

417_420

823.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000302538

417_420

20.333333333333332

860.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000543210

417_420

311.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000544583

417_420

814.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000574437

417_420

814.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953290

chr17:729318

ENST00000543210

417_420

311.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000291107

301_459

823.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000291107

484_613

823.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000291107

647_845

823.0

Domain

Rho-GAP

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000291107

91_284

823.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000302538

301_459

20.333333333333332

860.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000302538

484_613

20.333333333333332

860.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000302538

647_845

20.333333333333332

860.0

Domain

Rho-GAP

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000302538

91_284

20.333333333333332

860.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000543210

301_459

311.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000543210

484_613

311.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000543210

647_845

311.0

Domain

Rho-GAP

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000543210

91_284

311.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000544583

301_459

814.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000544583

484_613

814.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000544583

647_845

814.0

Domain

Rho-GAP

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000544583

91_284

814.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000574437

301_459

814.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000574437

484_613

814.0

Domain

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000574437

647_845

814.0

Domain

Rho-GAP

Hgene

ABR

chr17:1082961

chr17:729318

ENST00000574437

91_284

814.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000291107

484_613

560.0

823.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000291107

647_845

560.0

823.0

Domain

Rho-GAP

Hgene

ABR

chr17:953290

chr17:729318

ENST00000302538

484_613

597.0

860.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000302538

647_845

597.0

860.0

Domain

Rho-GAP

Hgene

ABR

chr17:953290

chr17:729318

ENST00000543210

301_459

311.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000543210

484_613

311.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000543210

647_845

311.0

Domain

Rho-GAP

Hgene

ABR

chr17:953290

chr17:729318

ENST00000543210

91_284

311.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000544583

484_613

551.0

814.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000544583

647_845

551.0

814.0

Domain

Rho-GAP

Hgene

ABR

chr17:953290

chr17:729318

ENST00000574437

484_613

551.0

814.0

Domain

Hgene

ABR

chr17:953290

chr17:729318

ENST00000574437

647_845

551.0

814.0

Domain

Rho-GAP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1781_ABR_953290_NXN_729318_ranked_0.pdb	ABR	1082961	953290	ENST00000336868	NXN	chr17	729318	-	MTCSSSGSNSRAAPPRLPAAPERAGPGACWLSPAPHQAQAPAQPPPGPGVDGAAGAMAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDF SYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEA LLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCS QSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAV TTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKM KISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVEL QVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGS QSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIA GPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSR LNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKI	980

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ABR_pLDDT.png

NXN_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ABR
NXN

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ABR-NXN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ABR-NXN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source