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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MTSS1-ZC2HC1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MTSS1-ZC2HC1A
FusionPDB ID: 55928
FusionGDB2.0 ID: 55928
HgeneTgene
Gene symbol

MTSS1

ZC2HC1A

Gene ID

9788

51101

Gene nameMTSS I-BAR domain containing 1zinc finger C2HC-type containing 1A
SynonymsMIM|MIMA|MIMBC8orf70|CGI-62|FAM164A
Cytomap

8q24.13

8q21.13

Type of geneprotein-codingprotein-coding
Descriptionprotein MTSS 1MTSS1, I-BAR domain containingmetastasis suppressor 1metastasis suppressor YGL-1metastasis suppressor protein 1missing in metastasis proteinzinc finger C2HC domain-containing protein 1Afamily with sequence similarity 164, member Aprotein FAM164A
Modification date2020031320200313
UniProtAcc

O43312

Q96GY0

Ensembl transtripts involved in fusion geneENST idsENST00000325064, ENST00000354184, 
ENST00000378017, ENST00000395508, 
ENST00000431961, ENST00000518547, 
ENST00000524090, ENST00000523587, 
ENST00000521176, ENST00000263849, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 9=14045 X 6 X 4=120
# samples 177
** MAII scorelog2(17/1404*10)=-3.04593628416686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MTSS1 [Title/Abstract] AND ZC2HC1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MTSS1(125575023)-ZC2HC1A(79588022), # samples:1
Anticipated loss of major functional domain due to fusion event.MTSS1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTSS1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTSS1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MTSS1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MTSS1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MTSS1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MTSS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZC2HC1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TV-01AMTSS1chr8

125575023

-ZC2HC1Achr8

79588022

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000431961MTSS1chr8125575023-ENST00000263849ZC2HC1Achr879588022+38546206491581310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000431961ENST00000263849MTSS1chr8125575023-ZC2HC1Achr879588022+0.0125684110.98743165

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55928_55928_1_MTSS1-ZC2HC1A_MTSS1_chr8_125575023_ENST00000431961_ZC2HC1A_chr8_79588022_ENST00000263849_length(amino acids)=310AA_BP=
MLPCKICGRTFFPVALKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGG
KLPPPPPPSYDPDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSG
AGKTVVGVPSGKVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:125575023/chr8:79588022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTSS1

O43312

ZC2HC1A

Q96GY0

FUNCTION: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTSS1chr8:125575023chr8:79588022ENST00000378017-1014108_155345.0731.0Coiled coilOntology_term=ECO:0000255
HgeneMTSS1chr8:125575023chr8:79588022ENST00000518547-1014108_155345.0756.0Coiled coilOntology_term=ECO:0000255
HgeneMTSS1chr8:125575023chr8:79588022ENST00000378017-10141_250345.0731.0DomainIMD
HgeneMTSS1chr8:125575023chr8:79588022ENST00000518547-10141_250345.0756.0DomainIMD
TgeneZC2HC1Achr8:125575023chr8:79588022ENST000002638490915_395.333333333333333326.0Zinc fingerNote=C2HC-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTSS1chr8:125575023chr8:79588022ENST00000354184-1013108_155145.0474.0Coiled coilOntology_term=ECO:0000255
HgeneMTSS1chr8:125575023chr8:79588022ENST00000431961-58108_155145.0474.0Coiled coilOntology_term=ECO:0000255
HgeneMTSS1chr8:125575023chr8:79588022ENST00000354184-1013238_359145.0474.0Compositional biasNote=Ser-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000354184-1013608_726145.0474.0Compositional biasNote=Pro-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000378017-1014238_359345.0731.0Compositional biasNote=Ser-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000378017-1014608_726345.0731.0Compositional biasNote=Pro-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000431961-58238_359145.0474.0Compositional biasNote=Ser-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000431961-58608_726145.0474.0Compositional biasNote=Pro-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000518547-1014238_359345.0756.0Compositional biasNote=Ser-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000518547-1014608_726345.0756.0Compositional biasNote=Pro-rich
HgeneMTSS1chr8:125575023chr8:79588022ENST00000354184-10131_250145.0474.0DomainIMD
HgeneMTSS1chr8:125575023chr8:79588022ENST00000354184-1013727_744145.0474.0DomainWH2
HgeneMTSS1chr8:125575023chr8:79588022ENST00000378017-1014727_744345.0731.0DomainWH2
HgeneMTSS1chr8:125575023chr8:79588022ENST00000431961-581_250145.0474.0DomainIMD
HgeneMTSS1chr8:125575023chr8:79588022ENST00000431961-58727_744145.0474.0DomainWH2
HgeneMTSS1chr8:125575023chr8:79588022ENST00000518547-1014727_744345.0756.0DomainWH2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MTSS1
ZC2HC1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MTSS1-ZC2HC1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MTSS1-ZC2HC1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource