UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MXRA8-CDK11A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MXRA8-CDK11A
	FusionPDB ID: 56154
	FusionGDB2.0 ID: 56154
		Hgene	Tgene
	Gene symbol	MXRA8	CDK11A
	Gene ID	54587	728642
	Gene name	matrix remodeling associated 8	cyclin dependent kinase 11A
	Synonyms	ASP3	CDC2L2\|CDC2L3\|CDK11-p110\|CDK11-p46\|CDK11-p58\|PITSLRE\|p58GTA
	Cytomap	1p36.33	1p36.33
	Type of gene	protein-coding	protein-coding
	Description	matrix remodeling-associated protein 8limitrinmatrix-remodeling-associated protein 8matrix-remodelling associated 8	cyclin-dependent kinase 11APITSLRE BPITSLRE protein kinase beta SV1 isoformPITSLRE protein kinase beta SV16 isoformPITSLRE protein kinase beta SV17 isoformPITSLRE protein kinase beta SV18 isoformPITSLRE protein kinase beta SV2 isoformPITSLRE protei
	Modification date	20200315	20200313
	UniProtAcc	Q9BRK3	Q9UQ88
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000309212, ENST00000342753, ENST00000445648, ENST00000477278,	ENST00000357760, ENST00000358779, ENST00000378633, ENST00000378635, ENST00000404249, ENST00000495016, ENST00000356200, ENST00000378638,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 3=36	3 X 3 X 3=27
	# samples	4	3
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MXRA8 [Title/Abstract] AND CDK11A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MXRA8(1293836)-CDK11A(1654270), # samples:2
Anticipated loss of major functional domain due to fusion event.	MXRA8-CDK11A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MXRA8-CDK11A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MXRA8-CDK11A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MXRA8-CDK11A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CDK11A	GO:0006468	protein phosphorylation	12501247
Tgene	CDK11A	GO:0050684	regulation of mRNA processing	12501247

Fusion gene breakpoints across MXRA8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDK11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-43-5670-01A	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-
ChimerDB4	LUSC	TCGA-43-5670	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-
ChimerDB4	LUSC	TCGA-43-5670	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309212	MXRA8	chr1	1293835	-	ENST00000356200	CDK11A	chr1	1654270	-	2733	80	303	2555	750
ENST00000309212	MXRA8	chr1	1293835	-	ENST00000378638	CDK11A	chr1	1654270	-	2509	80	230	2482	750
ENST00000342753	MXRA8	chr1	1293835	-	ENST00000356200	CDK11A	chr1	1654270	-	2738	85	308	2560	750
ENST00000342753	MXRA8	chr1	1293835	-	ENST00000378638	CDK11A	chr1	1654270	-	2514	85	235	2487	750
ENST00000445648	MXRA8	chr1	1293835	-	ENST00000356200	CDK11A	chr1	1654270	-	2741	88	311	2563	750
ENST00000445648	MXRA8	chr1	1293835	-	ENST00000378638	CDK11A	chr1	1654270	-	2517	88	238	2490	750
ENST00000309212	MXRA8	chr1	1293836	-	ENST00000356200	CDK11A	chr1	1654270	-	2733	80	303	2555	750
ENST00000309212	MXRA8	chr1	1293836	-	ENST00000378638	CDK11A	chr1	1654270	-	2509	80	230	2482	750
ENST00000342753	MXRA8	chr1	1293836	-	ENST00000356200	CDK11A	chr1	1654270	-	2738	85	308	2560	750
ENST00000342753	MXRA8	chr1	1293836	-	ENST00000378638	CDK11A	chr1	1654270	-	2514	85	235	2487	750
ENST00000445648	MXRA8	chr1	1293836	-	ENST00000356200	CDK11A	chr1	1654270	-	2741	88	311	2563	750
ENST00000445648	MXRA8	chr1	1293836	-	ENST00000378638	CDK11A	chr1	1654270	-	2517	88	238	2490	750

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309212	ENST00000356200	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-	0.00548244	0.9945175
ENST00000309212	ENST00000378638	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-	0.007668618	0.9923314
ENST00000342753	ENST00000356200	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-	0.005511231	0.9944887
ENST00000342753	ENST00000378638	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-	0.007706743	0.99229324
ENST00000445648	ENST00000356200	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-	0.005476493	0.9945235
ENST00000445648	ENST00000378638	MXRA8	chr1	1293835	-	CDK11A	chr1	1654270	-	0.007650361	0.9923496
ENST00000309212	ENST00000356200	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-	0.00548244	0.9945175
ENST00000309212	ENST00000378638	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-	0.007668618	0.9923314
ENST00000342753	ENST00000356200	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-	0.005511231	0.9944887
ENST00000342753	ENST00000378638	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-	0.007706743	0.99229324
ENST00000445648	ENST00000356200	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-	0.005476493	0.9945235
ENST00000445648	ENST00000378638	MXRA8	chr1	1293836	-	CDK11A	chr1	1654270	-	0.007650361	0.9923496

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56154_56154_1_MXRA8-CDK11A_MXRA8_chr1_1293835_ENST00000309212_CDK11A_chr1_1654270_ENST00000356200_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_2_MXRA8-CDK11A_MXRA8_chr1_1293835_ENST00000309212_CDK11A_chr1_1654270_ENST00000378638_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_3_MXRA8-CDK11A_MXRA8_chr1_1293835_ENST00000342753_CDK11A_chr1_1654270_ENST00000356200_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_4_MXRA8-CDK11A_MXRA8_chr1_1293835_ENST00000342753_CDK11A_chr1_1654270_ENST00000378638_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_5_MXRA8-CDK11A_MXRA8_chr1_1293835_ENST00000445648_CDK11A_chr1_1654270_ENST00000356200_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_6_MXRA8-CDK11A_MXRA8_chr1_1293835_ENST00000445648_CDK11A_chr1_1654270_ENST00000378638_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_7_MXRA8-CDK11A_MXRA8_chr1_1293836_ENST00000309212_CDK11A_chr1_1654270_ENST00000356200_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_8_MXRA8-CDK11A_MXRA8_chr1_1293836_ENST00000309212_CDK11A_chr1_1654270_ENST00000378638_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_9_MXRA8-CDK11A_MXRA8_chr1_1293836_ENST00000342753_CDK11A_chr1_1654270_ENST00000356200_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_10_MXRA8-CDK11A_MXRA8_chr1_1293836_ENST00000342753_CDK11A_chr1_1654270_ENST00000378638_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_11_MXRA8-CDK11A_MXRA8_chr1_1293836_ENST00000445648_CDK11A_chr1_1654270_ENST00000356200_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

>56154_56154_12_MXRA8-CDK11A_MXRA8_chr1_1293836_ENST00000445648_CDK11A_chr1_1654270_ENST00000378638_length(amino acids)=750AA_BP=
MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK
HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS
AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE
EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP
NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR
EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT
FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:1293836/chr1:1654270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MXRA8 Q9BRK3	CDK11A Q9UQ88
FUNCTION: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). {ECO:0000250\|UniProtKB:Q9DBV4, ECO:0000269\|PubMed:22492581, ECO:0000269\|PubMed:23386276}.; FUNCTION: (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. {ECO:0000269\|PubMed:29769725}.	FUNCTION: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269\|PubMed:12501247, ECO:0000269\|PubMed:12624090}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000358779

15_381

771.0

Compositional bias

Note=Glu-rich

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000378633

15_381

784.0

Compositional bias

Note=Glu-rich

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000404249

15_381

781.0

Compositional bias

Note=Glu-rich

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000358779

15_381

771.0

Compositional bias

Note=Glu-rich

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000378633

15_381

784.0

Compositional bias

Note=Glu-rich

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000404249

15_381

781.0

Compositional bias

Note=Glu-rich

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000358779

427_647

771.0

Domain

Protein kinase

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000378633

427_647

784.0

Domain

Protein kinase

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000404249

427_647

781.0

Domain

Protein kinase

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000358779

427_647

771.0

Domain

Protein kinase

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000378633

427_647

784.0

Domain

Protein kinase

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000404249

427_647

781.0

Domain

Protein kinase

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000358779

432_440

771.0

Nucleotide binding

ATP

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000378633

432_440

784.0

Nucleotide binding

ATP

Tgene

CDK11A

chr1:1293835

chr1:1654270

ENST00000404249

432_440

781.0

Nucleotide binding

ATP

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000358779

432_440

771.0

Nucleotide binding

ATP

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000378633

432_440

784.0

Nucleotide binding

ATP

Tgene

CDK11A

chr1:1293836

chr1:1654270

ENST00000404249

432_440

781.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

364_367

16.333333333333332

443.0

Compositional bias

Note=Poly-Arg

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

364_367

16.333333333333332

451.0

Compositional bias

Note=Poly-Arg

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

364_367

16.333333333333332

443.0

Compositional bias

Note=Poly-Arg

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

364_367

16.333333333333332

451.0

Compositional bias

Note=Poly-Arg

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

160_288

16.333333333333332

443.0

Domain

Note=Ig-like V-type 2

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

29_157

16.333333333333332

443.0

Domain

Note=Ig-like V-type 1

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

160_288

16.333333333333332

451.0

Domain

Note=Ig-like V-type 2

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

29_157

16.333333333333332

451.0

Domain

Note=Ig-like V-type 1

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

160_288

16.333333333333332

443.0

Domain

Note=Ig-like V-type 2

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

29_157

16.333333333333332

443.0

Domain

Note=Ig-like V-type 1

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

160_288

16.333333333333332

451.0

Domain

Note=Ig-like V-type 2

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

29_157

16.333333333333332

451.0

Domain

Note=Ig-like V-type 1

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

252_254

16.333333333333332

443.0

Motif

RGD

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

252_254

16.333333333333332

451.0

Motif

RGD

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

252_254

16.333333333333332

443.0

Motif

RGD

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

252_254

16.333333333333332

451.0

Motif

RGD

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

20_341

16.333333333333332

443.0

Topological domain

Extracellular

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

363_442

16.333333333333332

443.0

Topological domain

Cytoplasmic

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

20_341

16.333333333333332

451.0

Topological domain

Extracellular

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

363_442

16.333333333333332

451.0

Topological domain

Cytoplasmic

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

20_341

16.333333333333332

443.0

Topological domain

Extracellular

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

363_442

16.333333333333332

443.0

Topological domain

Cytoplasmic

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

20_341

16.333333333333332

451.0

Topological domain

Extracellular

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

363_442

16.333333333333332

451.0

Topological domain

Cytoplasmic

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000309212

342_362

16.333333333333332

443.0

Transmembrane

Helical

Hgene

MXRA8

chr1:1293835

chr1:1654270

ENST00000445648

342_362

16.333333333333332

451.0

Transmembrane

Helical

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000309212

342_362

16.333333333333332

443.0

Transmembrane

Helical

Hgene

MXRA8

chr1:1293836

chr1:1654270

ENST00000445648

342_362

16.333333333333332

451.0

Transmembrane

Helical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1513_MXRA8_1293836_CDK11A_1654270_ranked_0.pdb	MXRA8	1293836	1293836	ENST00000378638	CDK11A	chr1	1654270	-	MYFQMSQSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK HARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVS AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD YVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAR EYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMT FSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQL	750

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MXRA8_pLDDT.png

CDK11A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MXRA8
CDK11A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MXRA8-CDK11A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MXRA8-CDK11A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source