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Fusion Protein:MYLK-FLNA |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MYLK-FLNA | FusionPDB ID: 56515 | FusionGDB2.0 ID: 56515 | Hgene | Tgene | Gene symbol | MYLK | FLNA | Gene ID | 4638 | 2316 |
| Gene name | myosin light chain kinase | filamin A | |
| Synonyms | AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCK | ABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD | |
| Cytomap | 3q21.1 | Xq28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin | filamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filamin | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | Q86YV6 | P21333 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000346322, ENST00000354792, ENST00000359169, ENST00000360304, ENST00000360772, ENST00000418370, ENST00000475616, ENST00000578202, ENST00000583087, ENST00000510775, | ENST00000498491, ENST00000344736, ENST00000360319, ENST00000369850, ENST00000369856, ENST00000422373, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 17 X 15 X 7=1785 | 25 X 31 X 6=4650 |
| # samples | 18 | 31 | |
| ** MAII score | log2(18/1785*10)=-3.30985526258679 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/4650*10)=-3.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MYLK [Title/Abstract] AND FLNA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MYLK(123339054)-FLNA(153578575), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | MYLK-FLNA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYLK-FLNA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYLK-FLNA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYLK-FLNA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYLK-FLNA seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MYLK-FLNA seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. MYLK-FLNA seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. MYLK-FLNA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. MYLK-FLNA seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYLK | GO:0030335 | positive regulation of cell migration | 19826488 |
| Hgene | MYLK | GO:0051928 | positive regulation of calcium ion transport | 16284075 |
| Hgene | MYLK | GO:0071476 | cellular hypotonic response | 11976941 |
| Hgene | MYLK | GO:0090303 | positive regulation of wound healing | 15825080 |
| Tgene | FLNA | GO:0016479 | negative regulation of transcription by RNA polymerase I | 22307607 |
| Tgene | FLNA | GO:0030334 | regulation of cell migration | 16291724 |
| Tgene | FLNA | GO:0031532 | actin cytoskeleton reorganization | 10051605 |
| Tgene | FLNA | GO:0034394 | protein localization to cell surface | 18322202 |
| Tgene | FLNA | GO:0043113 | receptor clustering | 10692483 |
| Tgene | FLNA | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 15684392 |
| Tgene | FLNA | GO:0044319 | wound healing, spreading of cells | 16291724 |
| Tgene | FLNA | GO:0045184 | establishment of protein localization | 18322202 |
| Tgene | FLNA | GO:0051764 | actin crosslink formation | 10051605 |
| Tgene | FLNA | GO:0072659 | protein localization to plasma membrane | 24951510 |
| Tgene | FLNA | GO:0090307 | mitotic spindle assembly | 18548008 |
| Tgene | FLNA | GO:1901381 | positive regulation of potassium ion transmembrane transport | 24951510 |
| Fusion gene breakpoints across MYLK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FLNA (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-3B-A9HR-01A | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000360772 | MYLK | chr3 | 123339054 | - | ENST00000360319 | FLNA | chrX | 153578575 | - | 6705 | 5594 | 55 | 6381 | 2108 |
| ENST00000360772 | MYLK | chr3 | 123339054 | - | ENST00000422373 | FLNA | chrX | 153578575 | - | 6699 | 5594 | 55 | 6381 | 2108 |
| ENST00000360772 | MYLK | chr3 | 123339054 | - | ENST00000369850 | FLNA | chrX | 153578575 | - | 6583 | 5594 | 55 | 6381 | 2108 |
| ENST00000360772 | MYLK | chr3 | 123339054 | - | ENST00000369856 | FLNA | chrX | 153578575 | - | 6575 | 5594 | 55 | 6381 | 2108 |
| ENST00000360772 | MYLK | chr3 | 123339054 | - | ENST00000344736 | FLNA | chrX | 153578575 | - | 6447 | 5594 | 55 | 6381 | 2108 |
| ENST00000354792 | MYLK | chr3 | 123339054 | - | ENST00000360319 | FLNA | chrX | 153578575 | - | 3011 | 1900 | 18 | 2687 | 889 |
| ENST00000354792 | MYLK | chr3 | 123339054 | - | ENST00000422373 | FLNA | chrX | 153578575 | - | 3005 | 1900 | 18 | 2687 | 889 |
| ENST00000354792 | MYLK | chr3 | 123339054 | - | ENST00000369850 | FLNA | chrX | 153578575 | - | 2889 | 1900 | 18 | 2687 | 889 |
| ENST00000354792 | MYLK | chr3 | 123339054 | - | ENST00000369856 | FLNA | chrX | 153578575 | - | 2881 | 1900 | 18 | 2687 | 889 |
| ENST00000354792 | MYLK | chr3 | 123339054 | - | ENST00000344736 | FLNA | chrX | 153578575 | - | 2753 | 1900 | 18 | 2687 | 889 |
| ENST00000475616 | MYLK | chr3 | 123339054 | - | ENST00000360319 | FLNA | chrX | 153578575 | - | 6479 | 5368 | 0 | 6155 | 2051 |
| ENST00000475616 | MYLK | chr3 | 123339054 | - | ENST00000422373 | FLNA | chrX | 153578575 | - | 6473 | 5368 | 0 | 6155 | 2051 |
| ENST00000475616 | MYLK | chr3 | 123339054 | - | ENST00000369850 | FLNA | chrX | 153578575 | - | 6357 | 5368 | 0 | 6155 | 2051 |
| ENST00000475616 | MYLK | chr3 | 123339054 | - | ENST00000369856 | FLNA | chrX | 153578575 | - | 6349 | 5368 | 0 | 6155 | 2051 |
| ENST00000475616 | MYLK | chr3 | 123339054 | - | ENST00000344736 | FLNA | chrX | 153578575 | - | 6221 | 5368 | 0 | 6155 | 2051 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000360772 | ENST00000360319 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.006098833 | 0.99390113 |
| ENST00000360772 | ENST00000422373 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.006080914 | 0.99391913 |
| ENST00000360772 | ENST00000369850 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.00700489 | 0.9929951 |
| ENST00000360772 | ENST00000369856 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.007061428 | 0.9929386 |
| ENST00000360772 | ENST00000344736 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.006946436 | 0.9930535 |
| ENST00000354792 | ENST00000360319 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.008429964 | 0.99157 |
| ENST00000354792 | ENST00000422373 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.008404819 | 0.9915952 |
| ENST00000354792 | ENST00000369850 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.011025409 | 0.9889746 |
| ENST00000354792 | ENST00000369856 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.011130696 | 0.9888693 |
| ENST00000354792 | ENST00000344736 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.011213521 | 0.98878646 |
| ENST00000475616 | ENST00000360319 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.003886012 | 0.996114 |
| ENST00000475616 | ENST00000422373 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.003869288 | 0.9961307 |
| ENST00000475616 | ENST00000369850 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.004510523 | 0.99548954 |
| ENST00000475616 | ENST00000369856 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.004541893 | 0.9954581 |
| ENST00000475616 | ENST00000344736 | MYLK | chr3 | 123339054 | - | FLNA | chrX | 153578575 | - | 0.004437254 | 0.9955628 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >56515_56515_1_MYLK-FLNA_MYLK_chr3_123339054_ENST00000354792_FLNA_chrX_153578575_ENST00000344736_length(amino acids)=889AA_BP=625 MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKY AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQE CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLS -------------------------------------------------------------- >56515_56515_2_MYLK-FLNA_MYLK_chr3_123339054_ENST00000354792_FLNA_chrX_153578575_ENST00000360319_length(amino acids)=889AA_BP=625 MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKY AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQE CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLS -------------------------------------------------------------- >56515_56515_3_MYLK-FLNA_MYLK_chr3_123339054_ENST00000354792_FLNA_chrX_153578575_ENST00000369850_length(amino acids)=889AA_BP=625 MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKY AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQE CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLS -------------------------------------------------------------- >56515_56515_4_MYLK-FLNA_MYLK_chr3_123339054_ENST00000354792_FLNA_chrX_153578575_ENST00000369856_length(amino acids)=889AA_BP=625 MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKY AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQE CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLS -------------------------------------------------------------- >56515_56515_5_MYLK-FLNA_MYLK_chr3_123339054_ENST00000354792_FLNA_chrX_153578575_ENST00000422373_length(amino acids)=889AA_BP=625 MAGRPSRVSREEEGAERGPCGRLPRGDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAG ESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASD IRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPK DEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLV QCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRL ENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKK DMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKY AVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQE CPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLS -------------------------------------------------------------- >56515_56515_6_MYLK-FLNA_MYLK_chr3_123339054_ENST00000360772_FLNA_chrX_153578575_ENST00000344736_length(amino acids)=2108AA_BP=1844 MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV -------------------------------------------------------------- >56515_56515_7_MYLK-FLNA_MYLK_chr3_123339054_ENST00000360772_FLNA_chrX_153578575_ENST00000360319_length(amino acids)=2108AA_BP=1844 MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV -------------------------------------------------------------- >56515_56515_8_MYLK-FLNA_MYLK_chr3_123339054_ENST00000360772_FLNA_chrX_153578575_ENST00000369850_length(amino acids)=2108AA_BP=1844 MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV -------------------------------------------------------------- >56515_56515_9_MYLK-FLNA_MYLK_chr3_123339054_ENST00000360772_FLNA_chrX_153578575_ENST00000369856_length(amino acids)=2108AA_BP=1844 MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV -------------------------------------------------------------- >56515_56515_10_MYLK-FLNA_MYLK_chr3_123339054_ENST00000360772_FLNA_chrX_153578575_ENST00000422373_length(amino acids)=2108AA_BP=1844 MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV -------------------------------------------------------------- >56515_56515_11_MYLK-FLNA_MYLK_chr3_123339054_ENST00000475616_FLNA_chrX_153578575_ENST00000344736_length(amino acids)=2051AA_BP=1787 MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRE NGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT YTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKS -------------------------------------------------------------- >56515_56515_12_MYLK-FLNA_MYLK_chr3_123339054_ENST00000475616_FLNA_chrX_153578575_ENST00000360319_length(amino acids)=2051AA_BP=1787 MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRE NGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT YTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKS -------------------------------------------------------------- >56515_56515_13_MYLK-FLNA_MYLK_chr3_123339054_ENST00000475616_FLNA_chrX_153578575_ENST00000369850_length(amino acids)=2051AA_BP=1787 MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRE NGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT YTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKS -------------------------------------------------------------- >56515_56515_14_MYLK-FLNA_MYLK_chr3_123339054_ENST00000475616_FLNA_chrX_153578575_ENST00000369856_length(amino acids)=2051AA_BP=1787 MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRE NGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT YTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKS -------------------------------------------------------------- >56515_56515_15_MYLK-FLNA_MYLK_chr3_123339054_ENST00000475616_FLNA_chrX_153578575_ENST00000422373_length(amino acids)=2051AA_BP=1787 MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFS LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSD VRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLE GTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLS DLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLM LQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKK LPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKC VAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTL SWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEE KANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC TQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRE NGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT YTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:123339054/chrX:153578575) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYLK | FLNA |
| FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1098_1186 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1238_1326 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1334_1426 | 1720.3333333333333 | 1846.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1464_1719 | 1720.3333333333333 | 1846.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 161_249 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 33_122 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 414_503 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 514_599 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 620_711 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 721_821 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1098_1186 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1238_1326 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1334_1426 | 1738.3333333333333 | 1864.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1464_1719 | 1738.3333333333333 | 1864.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 161_249 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 33_122 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 414_503 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 514_599 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 620_711 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 721_821 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1098_1186 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1238_1326 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1334_1426 | 1789.3333333333333 | 1915.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1464_1719 | 1789.3333333333333 | 1915.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 161_249 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 33_122 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 414_503 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 514_599 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 620_711 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 721_821 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1098_1186 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1238_1326 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1334_1426 | 1738.3333333333333 | 1864.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1464_1719 | 1738.3333333333333 | 1864.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 161_249 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 33_122 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 414_503 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 514_599 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 620_711 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 721_821 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1098_1186 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1238_1326 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1334_1426 | 1789.3333333333333 | 1915.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1464_1719 | 1789.3333333333333 | 1915.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 161_249 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 33_122 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 414_503 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 514_599 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 620_711 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 721_821 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1470_1478 | 1720.3333333333333 | 1846.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1470_1478 | 1738.3333333333333 | 1864.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1470_1478 | 1789.3333333333333 | 1915.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1470_1478 | 1738.3333333333333 | 1864.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1470_1478 | 1789.3333333333333 | 1915.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1061_1460 | 1720.3333333333333 | 1846.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 868_998 | 1720.3333333333333 | 1846.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 923_963 | 1720.3333333333333 | 1846.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 948_963 | 1720.3333333333333 | 1846.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 999_1063 | 1720.3333333333333 | 1846.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1061_1460 | 1738.3333333333333 | 1864.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 868_998 | 1738.3333333333333 | 1864.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 923_963 | 1738.3333333333333 | 1864.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 948_963 | 1738.3333333333333 | 1864.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 999_1063 | 1738.3333333333333 | 1864.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1061_1460 | 1789.3333333333333 | 1915.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1711_1774 | 1789.3333333333333 | 1915.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 868_998 | 1789.3333333333333 | 1915.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 923_963 | 1789.3333333333333 | 1915.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 948_963 | 1789.3333333333333 | 1915.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 999_1063 | 1789.3333333333333 | 1915.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1061_1460 | 1738.3333333333333 | 1864.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 868_998 | 1738.3333333333333 | 1864.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 923_963 | 1738.3333333333333 | 1864.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 948_963 | 1738.3333333333333 | 1864.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 999_1063 | 1738.3333333333333 | 1864.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1061_1460 | 1789.3333333333333 | 1915.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1711_1774 | 1789.3333333333333 | 1915.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 868_998 | 1789.3333333333333 | 1915.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 923_963 | 1789.3333333333333 | 1915.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 948_963 | 1789.3333333333333 | 1915.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 999_1063 | 1789.3333333333333 | 1915.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1004_1015 | 1720.3333333333333 | 1846.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1016_1027 | 1720.3333333333333 | 1846.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1028_1039 | 1720.3333333333333 | 1846.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1040_1051 | 1720.3333333333333 | 1846.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1052_1063 | 1720.3333333333333 | 1846.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 868_895 | 1720.3333333333333 | 1846.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 896_923 | 1720.3333333333333 | 1846.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 924_951 | 1720.3333333333333 | 1846.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 952_979 | 1720.3333333333333 | 1846.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 980_998 | 1720.3333333333333 | 1846.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 999_1003 | 1720.3333333333333 | 1846.0 | Repeat | Note=2-1%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1004_1015 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1016_1027 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1028_1039 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1040_1051 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1052_1063 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 868_895 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 896_923 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 924_951 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 952_979 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 980_998 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 999_1003 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-1%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1004_1015 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1016_1027 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1028_1039 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1040_1051 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1052_1063 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 868_895 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 896_923 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 924_951 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 952_979 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 980_998 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 999_1003 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-1%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1004_1015 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1016_1027 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1028_1039 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1040_1051 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1052_1063 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 868_895 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 896_923 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 924_951 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 952_979 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 980_998 | 1738.3333333333333 | 1864.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 999_1003 | 1738.3333333333333 | 1864.0 | Repeat | Note=2-1%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1004_1015 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1016_1027 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1028_1039 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1040_1051 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1052_1063 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 868_895 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 896_923 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 924_951 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 952_979 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 980_998 | 1789.3333333333333 | 1915.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 999_1003 | 1789.3333333333333 | 1915.0 | Repeat | Note=2-1%3B truncated |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2517_2551 | 2377.3333333333335 | 2640.0 | Region | Note=Hinge 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2517_2647 | 2377.3333333333335 | 2640.0 | Region | Note=Self-association site%2C tail | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2517_2551 | 2385.3333333333335 | 2648.0 | Region | Note=Hinge 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2517_2647 | 2385.3333333333335 | 2648.0 | Region | Note=Self-association site%2C tail | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2517_2551 | 2377.3333333333335 | 2640.0 | Region | Note=Hinge 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2517_2647 | 2377.3333333333335 | 2640.0 | Region | Note=Self-association site%2C tail | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2424_2516 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 23 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2552_2646 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 24 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2424_2516 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 23 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2552_2646 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 24 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2424_2516 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 23 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2552_2646 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 24 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1906_1914 | 1720.3333333333333 | 1846.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1906_1914 | 1738.3333333333333 | 1864.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1906_1914 | 1789.3333333333333 | 1915.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1906_1914 | 1738.3333333333333 | 1864.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1906_1914 | 29.333333333333332 | 155.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1906_1914 | 1789.3333333333333 | 1915.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1906_1914 | 29.333333333333332 | 155.0 | Compositional bias | Note=Poly-Glu |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1809_1898 | 1720.3333333333333 | 1846.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1809_1898 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360304 | - | 32 | 34 | 1809_1898 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1809_1898 | 1738.3333333333333 | 1864.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1098_1186 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1238_1326 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1334_1426 | 29.333333333333332 | 155.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1464_1719 | 29.333333333333332 | 155.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 161_249 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1809_1898 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 33_122 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 414_503 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 514_599 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 620_711 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 721_821 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000475616 | - | 29 | 31 | 1809_1898 | 1789.3333333333333 | 1915.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1098_1186 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 7 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1238_1326 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 8 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1334_1426 | 29.333333333333332 | 155.0 | Domain | Fibronectin type-III |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1464_1719 | 29.333333333333332 | 155.0 | Domain | Protein kinase |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 161_249 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1809_1898 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 9 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 33_122 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 414_503 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 514_599 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 620_711 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 721_821 | 29.333333333333332 | 155.0 | Domain | Note=Ig-like C2-type 6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1470_1478 | 29.333333333333332 | 155.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1470_1478 | 29.333333333333332 | 155.0 | Nucleotide binding | ATP |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000346322 | - | 31 | 33 | 1711_1774 | 1720.3333333333333 | 1846.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000359169 | - | 31 | 33 | 1711_1774 | 1738.3333333333333 | 1864.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000360772 | - | 32 | 34 | 1711_1774 | 1738.3333333333333 | 1864.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1061_1460 | 29.333333333333332 | 155.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1711_1774 | 29.333333333333332 | 155.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 868_998 | 29.333333333333332 | 155.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 923_963 | 29.333333333333332 | 155.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 948_963 | 29.333333333333332 | 155.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 999_1063 | 29.333333333333332 | 155.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1061_1460 | 29.333333333333332 | 155.0 | Region | Actin-binding (calcium/calmodulin-insensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1711_1774 | 29.333333333333332 | 155.0 | Region | Note=Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 868_998 | 29.333333333333332 | 155.0 | Region | Note=5 X 28 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 923_963 | 29.333333333333332 | 155.0 | Region | Actin-binding (calcium/calmodulin-sensitive) |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 948_963 | 29.333333333333332 | 155.0 | Region | Calmodulin-binding |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 999_1063 | 29.333333333333332 | 155.0 | Region | Note=6 X 12 AA approximate tandem repeats |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1004_1015 | 29.333333333333332 | 155.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1016_1027 | 29.333333333333332 | 155.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1028_1039 | 29.333333333333332 | 155.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1040_1051 | 29.333333333333332 | 155.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 1052_1063 | 29.333333333333332 | 155.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 868_895 | 29.333333333333332 | 155.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 896_923 | 29.333333333333332 | 155.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 924_951 | 29.333333333333332 | 155.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 952_979 | 29.333333333333332 | 155.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 980_998 | 29.333333333333332 | 155.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000418370 | - | 1 | 3 | 999_1003 | 29.333333333333332 | 155.0 | Repeat | Note=2-1%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1004_1015 | 29.333333333333332 | 155.0 | Repeat | Note=2-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1016_1027 | 29.333333333333332 | 155.0 | Repeat | Note=2-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1028_1039 | 29.333333333333332 | 155.0 | Repeat | Note=2-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1040_1051 | 29.333333333333332 | 155.0 | Repeat | Note=2-5 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 1052_1063 | 29.333333333333332 | 155.0 | Repeat | Note=2-6 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 868_895 | 29.333333333333332 | 155.0 | Repeat | Note=1-1 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 896_923 | 29.333333333333332 | 155.0 | Repeat | Note=1-2 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 924_951 | 29.333333333333332 | 155.0 | Repeat | Note=1-3 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 952_979 | 29.333333333333332 | 155.0 | Repeat | Note=1-4 |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 980_998 | 29.333333333333332 | 155.0 | Repeat | Note=1-5%3B truncated |
| Hgene | MYLK | chr3:123339054 | chrX:153578575 | ENST00000583087 | - | 2 | 4 | 999_1003 | 29.333333333333332 | 155.0 | Repeat | Note=2-1%3B truncated |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 166_269 | 2377.3333333333335 | 2640.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 43_149 | 2377.3333333333335 | 2640.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 166_269 | 2385.3333333333335 | 2648.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 43_149 | 2385.3333333333335 | 2648.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 166_269 | 2377.3333333333335 | 2640.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 43_149 | 2377.3333333333335 | 2640.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1741_1778 | 2377.3333333333335 | 2640.0 | Region | Note=Hinge 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2_274 | 2377.3333333333335 | 2640.0 | Region | Note=Actin-binding | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1741_1778 | 2385.3333333333335 | 2648.0 | Region | Note=Hinge 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2_274 | 2385.3333333333335 | 2648.0 | Region | Note=Actin-binding | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1741_1778 | 2377.3333333333335 | 2640.0 | Region | Note=Hinge 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2_274 | 2377.3333333333335 | 2640.0 | Region | Note=Actin-binding | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1062_1154 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 9 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1155_1249 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 10 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1250_1349 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 11 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1350_1442 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 12 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1443_1539 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 13 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1540_1636 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 14 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1649_1740 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 15 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1779_1860 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 16 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1861_1950 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 17 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1951_2039 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 18 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2042_2131 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 19 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2132_2230 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 20 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2233_2325 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 21 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 2327_2420 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 22 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 276_374 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 376_474 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 475_570 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 3 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 571_663 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 4 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 667_763 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 5 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 764_866 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 6 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 867_965 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 7 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 966_1061 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 8 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1062_1154 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 9 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1155_1249 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 10 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1250_1349 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 11 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1350_1442 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 12 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1443_1539 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 13 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1540_1636 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 14 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1649_1740 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 15 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1779_1860 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 16 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1861_1950 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 17 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1951_2039 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 18 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2042_2131 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 19 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2132_2230 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 20 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2233_2325 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 21 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 2327_2420 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 22 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 276_374 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 376_474 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 475_570 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 3 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 571_663 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 4 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 667_763 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 5 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 764_866 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 6 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 867_965 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 7 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 966_1061 | 2385.3333333333335 | 2648.0 | Repeat | Note=Filamin 8 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1062_1154 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 9 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1155_1249 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 10 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1250_1349 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 11 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1350_1442 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 12 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1443_1539 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 13 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1540_1636 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 14 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1649_1740 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 15 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1779_1860 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 16 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1861_1950 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 17 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1951_2039 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 18 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2042_2131 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 19 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2132_2230 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 20 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2233_2325 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 21 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 2327_2420 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 22 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 276_374 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 1 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 376_474 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 2 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 475_570 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 3 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 571_663 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 4 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 667_763 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 5 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 764_866 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 6 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 867_965 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 7 | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 966_1061 | 2377.3333333333335 | 2640.0 | Repeat | Note=Filamin 8 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MYLK | |
| FLNA |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000360319 | 41 | 46 | 1490_1607 | 2377.3333333333335 | 2640.0 | furin | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000369850 | 43 | 48 | 1490_1607 | 2385.3333333333335 | 2648.0 | furin | |
| Tgene | FLNA | chr3:123339054 | chrX:153578575 | ENST00000422373 | 42 | 47 | 1490_1607 | 2377.3333333333335 | 2640.0 | furin |
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Related Drugs to MYLK-FLNA |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MYLK-FLNA |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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