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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MYO1B-ABCC4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MYO1B-ABCC4
	FusionPDB ID: 56619
	FusionGDB2.0 ID: 56619
		Hgene	Tgene
	Gene symbol	MYO1B	ABCC4
	Gene ID	4430	10257
	Gene name	myosin IB	ATP binding cassette subfamily C member 4
	Synonyms	MMI-alpha\|MMIa\|MYH-1c\|myr1	MOAT-B\|MOATB\|MRP4
	Cytomap	2q32.3	13q32.1
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-IbMYO1B variant proteinmyosin-I alpha	multidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter
	Modification date	20200315	20200313
	UniProtAcc	O43795	O15439
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000304164, ENST00000339514, ENST00000392316, ENST00000392318, ENST00000439065, ENST00000496992,	ENST00000538287, ENST00000431522, ENST00000474158, ENST00000536256, ENST00000376887, ENST00000412704,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 6=780	20 X 18 X 5=1800
	# samples	16	21
	** MAII score	log2(16/780*10)=-2.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/1800*10)=-3.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MYO1B [Title/Abstract] AND ABCC4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MYO1B(192261223)-ABCC4(95887088), # samples:1
Anticipated loss of major functional domain due to fusion event.	MYO1B-ABCC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1B-ABCC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1B-ABCC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYO1B-ABCC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ABCC4	GO:0032310	prostaglandin secretion	25173977

Fusion gene breakpoints across MYO1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABCC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7211-01A	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000339514	MYO1B	chr2	192261223	-	ENST00000412704	ABCC4	chr13	95887088	-	7932	2655	126	6185	2019
ENST00000339514	MYO1B	chr2	192261223	-	ENST00000376887	ABCC4	chr13	95887088	-	8071	2655	126	6326	2066
ENST00000392318	MYO1B	chr2	192261223	-	ENST00000412704	ABCC4	chr13	95887088	-	7819	2542	13	6072	2019
ENST00000392318	MYO1B	chr2	192261223	-	ENST00000376887	ABCC4	chr13	95887088	-	7958	2542	13	6213	2066
ENST00000304164	MYO1B	chr2	192261223	-	ENST00000412704	ABCC4	chr13	95887088	-	7665	2388	84	5918	1944
ENST00000304164	MYO1B	chr2	192261223	-	ENST00000376887	ABCC4	chr13	95887088	-	7804	2388	84	6059	1991
ENST00000392316	MYO1B	chr2	192261223	-	ENST00000412704	ABCC4	chr13	95887088	-	7583	2306	2	5836	1944
ENST00000392316	MYO1B	chr2	192261223	-	ENST00000376887	ABCC4	chr13	95887088	-	7722	2306	2	5977	1991
ENST00000439065	MYO1B	chr2	192261223	-	ENST00000412704	ABCC4	chr13	95887088	-	5564	287	86	3817	1243
ENST00000439065	MYO1B	chr2	192261223	-	ENST00000376887	ABCC4	chr13	95887088	-	5703	287	86	3958	1290

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000339514	ENST00000412704	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000478843	0.99952114
ENST00000339514	ENST00000376887	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000401081	0.9995989
ENST00000392318	ENST00000412704	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000414584	0.99958545
ENST00000392318	ENST00000376887	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.00034731	0.99965274
ENST00000304164	ENST00000412704	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000318723	0.99968135
ENST00000304164	ENST00000376887	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000267506	0.99973243
ENST00000392316	ENST00000412704	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000292046	0.9997079
ENST00000392316	ENST00000376887	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000245128	0.99975485
ENST00000439065	ENST00000412704	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000293329	0.9997067
ENST00000439065	ENST00000376887	MYO1B	chr2	192261223	-	ABCC4	chr13	95887088	-	0.000246092	0.9997539

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56619_56619_1_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000304164_ABCC4_chr13_95887088_ENST00000376887_length(amino acids)=1991AA_BP=768
METMAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFAL
SDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK
GDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHE
AESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLY
SRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICD
LIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRD
LSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRV
RRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRG
WKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFC
TLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIG
ISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASF
FSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQD
FTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERY
EKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL
QYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPV
TLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVA
TVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWI
AIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDA
ICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFD
NVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKN
LDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFA
HCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQ

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>56619_56619_2_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000304164_ABCC4_chr13_95887088_ENST00000412704_length(amino acids)=1944AA_BP=768
METMAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFAL
SDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK
GDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHE
AESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLY
SRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICD
LIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRD
LSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRV
RRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRG
WKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFC
TLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIG
ISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASF
FSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQD
FTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERY
EKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL
QYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDVAYVLQ
DWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRI
LNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGL
WTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSA
EVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRL
SEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ
RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYK

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>56619_56619_3_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000339514_ABCC4_chr13_95887088_ENST00000376887_length(amino acids)=2066AA_BP=843
MSTPQLGAHGSLNRGAWRQYQSARRAVGRQPRDSLGRTAAAGAPQPRAGPASRSATGERGRRGGGVAPGEVAPGELETMAKMEVKTSLLD
NMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEK
SRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLG
NIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESI
KAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDE
ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKS
LFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCL
ERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQI
VIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHV
QCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP
LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTY
VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ
GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL
LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG
KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQ
AYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYV
LVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLR
RYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLI
LAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLK
HLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNA
LQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTII

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>56619_56619_4_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000339514_ABCC4_chr13_95887088_ENST00000412704_length(amino acids)=2019AA_BP=843
MSTPQLGAHGSLNRGAWRQYQSARRAVGRQPRDSLGRTAAAGAPQPRAGPASRSATGERGRRGGGVAPGEVAPGELETMAKMEVKTSLLD
NMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEK
SRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLG
NIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESI
KAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDE
ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKS
LFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCL
ERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQI
VIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHV
QCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP
LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTY
VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ
GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL
LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG
KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDVAYVLQDWWLSYWANKQSMLN
VTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL
PLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQEL
FDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEY
TDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTT
EIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQ
ILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTE

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>56619_56619_5_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000392316_ABCC4_chr13_95887088_ENST00000376887_length(amino acids)=1991AA_BP=768
LETMAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFAL
SDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK
GDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHE
AESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLY
SRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICD
LIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRD
LSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRV
RRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRG
WKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFC
TLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIG
ISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASF
FSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQD
FTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERY
EKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL
QYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPV
TLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVA
TVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWI
AIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDA
ICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFD
NVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKN
LDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFA
HCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQ

--------------------------------------------------------------

>56619_56619_6_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000392316_ABCC4_chr13_95887088_ENST00000412704_length(amino acids)=1944AA_BP=768
LETMAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFAL
SDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFK
GDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHE
AESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLY
SRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICD
LIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRD
LSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRV
RRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRG
WKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFC
TLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIG
ISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASF
FSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQD
FTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERY
EKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQL
QYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDVAYVLQ
DWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRI
LNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGL
WTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSA
EVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRL
SEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQ
RQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYK

--------------------------------------------------------------

>56619_56619_7_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000392318_ABCC4_chr13_95887088_ENST00000376887_length(amino acids)=2066AA_BP=843
MSTPQLGAHGSLNRGAWRQYQSARRAVGRQPRDSLGRTAAAGAPQPRAGPASRSATGERGRRGGGVAPGEVAPGELETMAKMEVKTSLLD
NMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEK
SRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLG
NIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESI
KAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDE
ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKS
LFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCL
ERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQI
VIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHV
QCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP
LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTY
VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ
GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL
LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG
KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQ
AYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYV
LVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLR
RYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLI
LAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLK
HLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNA
LQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTII

--------------------------------------------------------------

>56619_56619_8_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000392318_ABCC4_chr13_95887088_ENST00000412704_length(amino acids)=2019AA_BP=843
MSTPQLGAHGSLNRGAWRQYQSARRAVGRQPRDSLGRTAAAGAPQPRAGPASRSATGERGRRGGGVAPGEVAPGELETMAKMEVKTSLLD
NMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEK
SRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLG
NIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESI
KAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDE
ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKS
LFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCL
ERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQI
VIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHV
QCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP
LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTY
VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ
GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL
LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDG
KMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDVAYVLQDWWLSYWANKQSMLN
VTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLL
PLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQEL
FDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEY
TDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTT
EIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQ
ILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTE

--------------------------------------------------------------

>56619_56619_9_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000439065_ABCC4_chr13_95887088_ENST00000376887_length(amino acids)=1290AA_BP=67
MRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDP
MDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFL
WAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKK
EISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI
SQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVF
SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE
LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSS
RPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNV
TEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQ
TLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHS
EAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPW
EYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRK
KMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATA
NVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKR

--------------------------------------------------------------

>56619_56619_10_MYO1B-ABCC4_MYO1B_chr2_192261223_ENST00000439065_ABCC4_chr13_95887088_ENST00000412704_length(amino acids)=1243AA_BP=67
MRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKESAKVIQPIFLGKIINYFENYDP
MDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFL
WAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKK
EISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI
SQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVF
SGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE
LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSS
RPSLKDGALESQDVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMF
ESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRL
ESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLA
LSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVG
IVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDL
PGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:192261223/chr13:95887088)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO1B O43795	ABCC4 O15439
FUNCTION: Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. {ECO:0000250}.	FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269\|PubMed:11106685, ECO:0000269\|PubMed:11856762, ECO:0000269\|PubMed:12105214, ECO:0000269\|PubMed:12523936, ECO:0000269\|PubMed:12835412, ECO:0000269\|PubMed:12883481, ECO:0000269\|PubMed:15364914, ECO:0000269\|PubMed:15454390, ECO:0000269\|PubMed:16282361, ECO:0000269\|PubMed:17344354, ECO:0000269\|PubMed:17959747, ECO:0000269\|PubMed:18300232, ECO:0000269\|PubMed:26721430}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

15_701

765.0

1137.0

Domain

Myosin motor

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

704_733

765.0

1137.0

Domain

IQ 1

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

728_748

765.0

1137.0

Domain

IQ 2

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

15_701

765.0

1079.0

Domain

Myosin motor

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

704_733

765.0

1079.0

Domain

IQ 1

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

728_748

765.0

1079.0

Domain

IQ 2

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

15_701

765.0

1137.0

Domain

Myosin motor

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

704_733

765.0

1137.0

Domain

IQ 1

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

728_748

765.0

1137.0

Domain

IQ 2

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

108_115

765.0

1137.0

Nucleotide binding

ATP

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

108_115

765.0

1079.0

Nucleotide binding

ATP

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

108_115

765.0

1137.0

Nucleotide binding

ATP

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

578_600

765.0

1137.0

Region

Actin-binding

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

578_600

765.0

1079.0

Region

Actin-binding

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

578_600

765.0

1137.0

Region

Actin-binding

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

1041_1274

102.0

1326.0

Domain

ABC transporter 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

410_633

102.0

1326.0

Domain

ABC transporter 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

714_1005

102.0

1326.0

Domain

ABC transmembrane type-1 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

1041_1274

102.0

1279.0

Domain

ABC transporter 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

410_633

102.0

1279.0

Domain

ABC transporter 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

714_1005

102.0

1279.0

Domain

ABC transmembrane type-1 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

1041_1274

102.0

860.0

Domain

ABC transporter 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

410_633

102.0

860.0

Domain

ABC transporter 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

714_1005

102.0

860.0

Domain

ABC transmembrane type-1 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

1322_1325

102.0

1326.0

Motif

Note=PDZ-binding

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

1322_1325

102.0

1279.0

Motif

Note=PDZ-binding

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

1322_1325

102.0

860.0

Motif

Note=PDZ-binding

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

1075_1082

102.0

1326.0

Nucleotide binding

ATP 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

445_452

102.0

1326.0

Nucleotide binding

ATP 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

1075_1082

102.0

1279.0

Nucleotide binding

ATP 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

445_452

102.0

1279.0

Nucleotide binding

ATP 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

1075_1082

102.0

860.0

Nucleotide binding

ATP 2

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

445_452

102.0

860.0

Nucleotide binding

ATP 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

1038_1058

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

136_156

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

207_227

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

228_248

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

328_348

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

351_371

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

440_460

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

710_730

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

771_791

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

836_856

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

858_878

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

954_974

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

977_997

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

1038_1058

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

136_156

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

207_227

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

228_248

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

328_348

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

351_371

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

440_460

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

710_730

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

771_791

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

836_856

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

858_878

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

954_974

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

977_997

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

1038_1058

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

136_156

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

207_227

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

228_248

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

328_348

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

351_371

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

440_460

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

710_730

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

771_791

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

836_856

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

858_878

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

954_974

102.0

860.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

977_997

102.0

860.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

750_779

765.0

1137.0

Domain

IQ 3

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

779_808

765.0

1137.0

Domain

IQ 4

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

808_837

765.0

1137.0

Domain

IQ 5

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

837_866

765.0

1137.0

Domain

IQ 6

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000304164

952_1136

765.0

1137.0

Domain

TH1

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

750_779

765.0

1079.0

Domain

IQ 3

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

779_808

765.0

1079.0

Domain

IQ 4

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

808_837

765.0

1079.0

Domain

IQ 5

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

837_866

765.0

1079.0

Domain

IQ 6

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000339514

952_1136

765.0

1079.0

Domain

TH1

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

750_779

765.0

1137.0

Domain

IQ 3

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

779_808

765.0

1137.0

Domain

IQ 4

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

808_837

765.0

1137.0

Domain

IQ 5

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

837_866

765.0

1137.0

Domain

IQ 6

Hgene

MYO1B

chr2:192261223

chr13:95887088

ENST00000392318

952_1136

765.0

1137.0

Domain

TH1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

92_377

102.0

1326.0

Domain

ABC transmembrane type-1 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

92_377

102.0

1279.0

Domain

ABC transmembrane type-1 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

92_377

102.0

860.0

Domain

ABC transmembrane type-1 1

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000376887

93_113

102.0

1326.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000412704

93_113

102.0

1279.0

Transmembrane

Helical

Tgene

ABCC4

chr2:192261223

chr13:95887088

ENST00000431522

93_113

102.0

860.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MYO1B
ABCC4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MYO1B-ABCC4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MYO1B-ABCC4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source