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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MYO6-NEGR1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MYO6-NEGR1
	FusionPDB ID: 56754
	FusionGDB2.0 ID: 56754
		Hgene	Tgene
	Gene symbol	MYO6	NEGR1
	Gene ID	4646	257194
	Gene name	myosin VI	neuronal growth regulator 1
	Synonyms	DFNA22\|DFNB37	DMML2433\|IGLON4\|KILON\|Ntra
	Cytomap	6q14.1	1p31.1
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-VIunconventional myosin-6	neuronal growth regulator 1IgLON family member 4a kindred of IgLONneurotractin
	Modification date	20200313	20200313
	UniProtAcc	Q9UM54	Q7Z3B1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000369975, ENST00000369977, ENST00000369981, ENST00000369985, ENST00000462633,	ENST00000467479, ENST00000434200, ENST00000306821, ENST00000357731,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 13 X 10=1950	11 X 8 X 5=440
	# samples	22	10
	** MAII score	log2(22/1950*10)=-3.14789869511231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/440*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MYO6 [Title/Abstract] AND NEGR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MYO6(76558248)-NEGR1(72163822), # samples:3
Anticipated loss of major functional domain due to fusion event.	MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MYO6	GO:0030330	DNA damage response, signal transduction by p53 class mediator	16507995

Fusion gene breakpoints across MYO6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEGR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-8262-01A	MYO6	chr6	76558248	-	NEGR1	chr1	72163822	-
ChimerDB4	PRAD	TCGA-HC-8262-01A	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-
ChimerDB4	PRAD	TCGA-HC-8262	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369981	MYO6	chr6	76558248	+	ENST00000357731	NEGR1	chr1	72163822	-	13393	1357	279	1886	535
ENST00000369981	MYO6	chr6	76558248	+	ENST00000306821	NEGR1	chr1	72163822	-	6389	1357	279	1886	535
ENST00000369985	MYO6	chr6	76558248	+	ENST00000357731	NEGR1	chr1	72163822	-	13376	1340	262	1869	535
ENST00000369985	MYO6	chr6	76558248	+	ENST00000306821	NEGR1	chr1	72163822	-	6372	1340	262	1869	535
ENST00000369977	MYO6	chr6	76558248	+	ENST00000357731	NEGR1	chr1	72163822	-	13253	1217	139	1746	535
ENST00000369977	MYO6	chr6	76558248	+	ENST00000306821	NEGR1	chr1	72163822	-	6249	1217	139	1746	535
ENST00000369975	MYO6	chr6	76558248	+	ENST00000357731	NEGR1	chr1	72163822	-	13139	1103	25	1632	535
ENST00000369975	MYO6	chr6	76558248	+	ENST00000306821	NEGR1	chr1	72163822	-	6135	1103	25	1632	535

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369981	ENST00000357731	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000655994	0.99934405
ENST00000369981	ENST00000306821	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000510973	0.99948895
ENST00000369985	ENST00000357731	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000652072	0.99934787
ENST00000369985	ENST00000306821	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000508338	0.9994917
ENST00000369977	ENST00000357731	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000648212	0.9993518
ENST00000369977	ENST00000306821	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000498983	0.999501
ENST00000369975	ENST00000357731	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000643812	0.9993562
ENST00000369975	ENST00000306821	MYO6	chr6	76558248	+	NEGR1	chr1	72163822	-	0.000498873	0.9995011

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56754_56754_1_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369975_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_2_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369975_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_3_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369977_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_4_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369977_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_5_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369981_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_6_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369981_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_7_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369985_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

>56754_56754_8_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369985_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV
ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN
FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA
KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:76558248/chr1:72163822)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO6 Q9UM54	NEGR1 Q7Z3B1
FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250\|UniProtKB:Q29122, ECO:0000250\|UniProtKB:Q64331, ECO:0000269\|PubMed:10519557, ECO:0000269\|PubMed:11447109, ECO:0000269\|PubMed:16507995, ECO:0000269\|PubMed:16949370, ECO:0000269\|PubMed:29467281}.	FUNCTION: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

2_53

359.3333333333333

1286.0

Domain

Myosin N-terminal SH3-like

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

2_53

359.3333333333333

1263.0

Domain

Myosin N-terminal SH3-like

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

151_158

359.3333333333333

1286.0

Nucleotide binding

ATP

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

151_158

359.3333333333333

1263.0

Nucleotide binding

ATP

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

273_317

359.3333333333333

1286.0

Region

Responsible for slow ATPase activity

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

273_317

359.3333333333333

1263.0

Region

Responsible for slow ATPase activity

Tgene

NEGR1

chr6:76558248

chr1:72163822

ENST00000357731

225_313

178.33333333333334

355.0

Domain

Note=Ig-like C2-type 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

920_1027

359.3333333333333

1286.0

Compositional bias

Note=Glu-rich

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

920_1027

359.3333333333333

1263.0

Compositional bias

Note=Glu-rich

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

57_771

359.3333333333333

1286.0

Domain

Myosin motor

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

814_834

359.3333333333333

1286.0

Domain

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

57_771

359.3333333333333

1263.0

Domain

Myosin motor

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

814_834

359.3333333333333

1263.0

Domain

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

665_672

359.3333333333333

1286.0

Region

Actin-binding

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

782_810

359.3333333333333

1286.0

Region

Required for binding calmodulin

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

835_916

359.3333333333333

1286.0

Region

Three-helix bundle

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369977

917_984

359.3333333333333

1286.0

Region

SAH

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

665_672

359.3333333333333

1263.0

Region

Actin-binding

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

782_810

359.3333333333333

1263.0

Region

Required for binding calmodulin

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

835_916

359.3333333333333

1263.0

Region

Three-helix bundle

Hgene

MYO6

chr6:76558248

chr1:72163822

ENST00000369985

917_984

359.3333333333333

1263.0

Region

SAH

Tgene

NEGR1

chr6:76558248

chr1:72163822

ENST00000357731

139_221

178.33333333333334

355.0

Domain

Note=Ig-like C2-type 2

Tgene

NEGR1

chr6:76558248

chr1:72163822

ENST00000357731

38_134

178.33333333333334

355.0

Domain

Note=Ig-like C2-type 1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1143_MYO6_76558248_NEGR1_72163822_1143_MYO6_76558248_NEGR1_72163822_ranked_0.pdb	MYO6	76558248	76558248	ENST00000306821	NEGR1	chr1	72163822	-	MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ	535

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MYO6_pLDDT.png

NEGR1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MYO6
NEGR1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MYO6	chr6:76558248	chr1:72163822	ENST00000369977	+	11	35	1116_1118	359.3333333333333	1286.0	OPTN
Hgene	MYO6	chr6:76558248	chr1:72163822	ENST00000369985	+	11	33	1116_1118	359.3333333333333	1263.0	OPTN

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Related Drugs to MYO6-NEGR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MYO6-NEGR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source