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Fusion Protein:MYO6-NEGR1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: MYO6-NEGR1 | FusionPDB ID: 56754 | FusionGDB2.0 ID: 56754 | Hgene | Tgene | Gene symbol | MYO6 | NEGR1 | Gene ID | 4646 | 257194 |
Gene name | myosin VI | neuronal growth regulator 1 | |
Synonyms | DFNA22|DFNB37 | DMML2433|IGLON4|KILON|Ntra | |
Cytomap | 6q14.1 | 1p31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | unconventional myosin-VIunconventional myosin-6 | neuronal growth regulator 1IgLON family member 4a kindred of IgLONneurotractin | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UM54 | Q7Z3B1 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000369975, ENST00000369977, ENST00000369981, ENST00000369985, ENST00000462633, | ENST00000467479, ENST00000434200, ENST00000306821, ENST00000357731, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 15 X 13 X 10=1950 | 11 X 8 X 5=440 |
# samples | 22 | 10 | |
** MAII score | log2(22/1950*10)=-3.14789869511231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/440*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: MYO6 [Title/Abstract] AND NEGR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MYO6(76558248)-NEGR1(72163822), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MYO6-NEGR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MYO6 | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 16507995 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-HC-8262-01A | MYO6 | chr6 | 76558248 | - | NEGR1 | chr1 | 72163822 | - |
ChimerDB4 | PRAD | TCGA-HC-8262-01A | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - |
ChimerDB4 | PRAD | TCGA-HC-8262 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000369981 | MYO6 | chr6 | 76558248 | + | ENST00000357731 | NEGR1 | chr1 | 72163822 | - | 13393 | 1357 | 279 | 1886 | 535 |
ENST00000369981 | MYO6 | chr6 | 76558248 | + | ENST00000306821 | NEGR1 | chr1 | 72163822 | - | 6389 | 1357 | 279 | 1886 | 535 |
ENST00000369985 | MYO6 | chr6 | 76558248 | + | ENST00000357731 | NEGR1 | chr1 | 72163822 | - | 13376 | 1340 | 262 | 1869 | 535 |
ENST00000369985 | MYO6 | chr6 | 76558248 | + | ENST00000306821 | NEGR1 | chr1 | 72163822 | - | 6372 | 1340 | 262 | 1869 | 535 |
ENST00000369977 | MYO6 | chr6 | 76558248 | + | ENST00000357731 | NEGR1 | chr1 | 72163822 | - | 13253 | 1217 | 139 | 1746 | 535 |
ENST00000369977 | MYO6 | chr6 | 76558248 | + | ENST00000306821 | NEGR1 | chr1 | 72163822 | - | 6249 | 1217 | 139 | 1746 | 535 |
ENST00000369975 | MYO6 | chr6 | 76558248 | + | ENST00000357731 | NEGR1 | chr1 | 72163822 | - | 13139 | 1103 | 25 | 1632 | 535 |
ENST00000369975 | MYO6 | chr6 | 76558248 | + | ENST00000306821 | NEGR1 | chr1 | 72163822 | - | 6135 | 1103 | 25 | 1632 | 535 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000369981 | ENST00000357731 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000655994 | 0.99934405 |
ENST00000369981 | ENST00000306821 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000510973 | 0.99948895 |
ENST00000369985 | ENST00000357731 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000652072 | 0.99934787 |
ENST00000369985 | ENST00000306821 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000508338 | 0.9994917 |
ENST00000369977 | ENST00000357731 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000648212 | 0.9993518 |
ENST00000369977 | ENST00000306821 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000498983 | 0.999501 |
ENST00000369975 | ENST00000357731 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000643812 | 0.9993562 |
ENST00000369975 | ENST00000306821 | MYO6 | chr6 | 76558248 | + | NEGR1 | chr1 | 72163822 | - | 0.000498873 | 0.9995011 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >56754_56754_1_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369975_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_2_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369975_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_3_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369977_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_4_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369977_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_5_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369981_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_6_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369981_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_7_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369985_NEGR1_chr1_72163822_ENST00000306821_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- >56754_56754_8_MYO6-NEGR1_MYO6_chr6_76558248_ENST00000369985_NEGR1_chr1_72163822_ENST00000357731_length(amino acids)=535AA_BP=359 MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:76558248/chr1:72163822) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
MYO6 | NEGR1 |
FUNCTION: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370). {ECO:0000250|UniProtKB:Q29122, ECO:0000250|UniProtKB:Q64331, ECO:0000269|PubMed:10519557, ECO:0000269|PubMed:11447109, ECO:0000269|PubMed:16507995, ECO:0000269|PubMed:16949370, ECO:0000269|PubMed:29467281}. | FUNCTION: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). {ECO:0000250}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 2_53 | 359.3333333333333 | 1286.0 | Domain | Myosin N-terminal SH3-like |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 2_53 | 359.3333333333333 | 1263.0 | Domain | Myosin N-terminal SH3-like |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 151_158 | 359.3333333333333 | 1286.0 | Nucleotide binding | ATP |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 151_158 | 359.3333333333333 | 1263.0 | Nucleotide binding | ATP |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 273_317 | 359.3333333333333 | 1286.0 | Region | Responsible for slow ATPase activity |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 273_317 | 359.3333333333333 | 1263.0 | Region | Responsible for slow ATPase activity |
Tgene | NEGR1 | chr6:76558248 | chr1:72163822 | ENST00000357731 | 2 | 7 | 225_313 | 178.33333333333334 | 355.0 | Domain | Note=Ig-like C2-type 3 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 920_1027 | 359.3333333333333 | 1286.0 | Compositional bias | Note=Glu-rich |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 920_1027 | 359.3333333333333 | 1263.0 | Compositional bias | Note=Glu-rich |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 57_771 | 359.3333333333333 | 1286.0 | Domain | Myosin motor |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 814_834 | 359.3333333333333 | 1286.0 | Domain | IQ |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 57_771 | 359.3333333333333 | 1263.0 | Domain | Myosin motor |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 814_834 | 359.3333333333333 | 1263.0 | Domain | IQ |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 665_672 | 359.3333333333333 | 1286.0 | Region | Actin-binding |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 782_810 | 359.3333333333333 | 1286.0 | Region | Required for binding calmodulin |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 835_916 | 359.3333333333333 | 1286.0 | Region | Three-helix bundle |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 917_984 | 359.3333333333333 | 1286.0 | Region | SAH |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 665_672 | 359.3333333333333 | 1263.0 | Region | Actin-binding |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 782_810 | 359.3333333333333 | 1263.0 | Region | Required for binding calmodulin |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 835_916 | 359.3333333333333 | 1263.0 | Region | Three-helix bundle |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 917_984 | 359.3333333333333 | 1263.0 | Region | SAH |
Tgene | NEGR1 | chr6:76558248 | chr1:72163822 | ENST00000357731 | 2 | 7 | 139_221 | 178.33333333333334 | 355.0 | Domain | Note=Ig-like C2-type 2 | |
Tgene | NEGR1 | chr6:76558248 | chr1:72163822 | ENST00000357731 | 2 | 7 | 38_134 | 178.33333333333334 | 355.0 | Domain | Note=Ig-like C2-type 1 |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>1143_MYO6_76558248_NEGR1_72163822_1143_MYO6_76558248_NEGR1_72163822_ranked_0.pdb | MYO6 | 76558248 | 76558248 | ENST00000306821 | NEGR1 | chr1 | 72163822 | - | MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYV ANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDN FRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSA KPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ | 535 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
MYO6_pLDDT.png![]() |
NEGR1_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
MYO6 | |
NEGR1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369977 | + | 11 | 35 | 1116_1118 | 359.3333333333333 | 1286.0 | OPTN |
Hgene | MYO6 | chr6:76558248 | chr1:72163822 | ENST00000369985 | + | 11 | 33 | 1116_1118 | 359.3333333333333 | 1263.0 | OPTN |
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Related Drugs to MYO6-NEGR1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MYO6-NEGR1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |